Click here to switch to the map view.

The map label for this gene is pccB [H]

Identifier: 209551998

GI number: 209551998

Start: 74362

End: 75894

Strand: Reverse

Name: pccB [H]

Synonym: Rleg2_6139

Alternate gene names: 209551998

Gene position: 75894-74362 (Counterclockwise)

Preceding gene: 209552000

Following gene: 209551997

Centisome position: 24.58

GC content: 61.25

Gene sequence:

>1533_bases
ATGCGGAAGGTTATCGAGCTGTTGGAAGAGCGTCGCGTCGAGGCGCGACTTGGCGGTGGGCAAAAGCGCATTGACGCCCA
GCATCGAAAGGGAAAACTCACAGCCCGGGACCGGATCGATGTCCTTCTGGACGAGGGCTCGTTCGAAGAATTAGACATGT
ATGTGACCCACCGCGCGGTGGATTTCGGCATGGCCGAACAGAAGGTCGCGGGCGACGGCGTCGTCACCGGCTGGGGCACG
ATCAACGGCCGCCAGGTCTACGTTTTCTCCCAGGACTTTACCGTCCTAGGCGGCTCGCTGTCGGAAACCCATGCCCAGAA
GATCTGCAAGATCATGGATATGGCAGTCCGCGTCGGGGCGCCGGTGATCGGTCTCAACGACAGCGGCGGTGCCCGTATCC
AGGAAGGCGTCGCCTCGCTTGCCGGTTATGCCGAAGTCTTCCGCCGAAATGCCGAAGGGTCGGGTGTCATCCCGCAGATC
TCGGTCATCATGGGTCCCTGCGCTGGCGGGGCGGTCTATTCGCCGGCCATGACCGACTTCATTTTCATGGTGCGCGACAG
TTCCTACATGTTCGTCACAGGCCCGGACGTCGTGAAGACGGTCACCAATGAGATCGTCACGGCCGAGGAGCTCGGCGGAG
CGGGCACCCATACGAAGAAGTCATCGGTCGCCGACGCCGCCTTCGAAAACGACATCGAAGCCTTGGAAGCGGTGCGGCAG
CTTTTCGATTTTTTACCTCTGAACAACCGCGAAAAGCCGCCCGTCCGTCCCTTCCACGACGATCCGGCCCGCGTCGAGAG
CCGCCTCGACAGCCTGATCCCGGACAGCGCCGCAAAACCCTACGACATGAAGGAGTTGATCTATGCGATCGCCGACGAGG
GCGACTTCTTCGAGATCCAGGAAGCCTATGCGAGAAACATAGTCACCGGCTTCATCCGCCTCGAAGGCCAGACGGTCGGC
GTCGTGGCCAACCAGCCGATGGTGTTGGCCGGCTGCCTCGATATCGACAGCTCGCGCAAGGCGGCCCGCTTCGTGCGCTT
CTGCGACGCTTTCTCGATCCCGATCCTGACGCTTGTCGATGTGCCAGGCTTCCTCCCCGGCGTGGCGCAGGAATATGGGG
GCGTCATCAAGCATGGCGCCAAGCTTCTCTTCGCCTATTCAGAAGCGACTGTCCCGATGGTCACTCTAATCACGCGAAAA
GCCTATGGCGGCGCCTATGACGTGATGGCCTCGAAACATATCGGCGCCGACTTCAATTATGCCTGGCCGACCGCCGAAAT
CGCAGTCATGGGTGCGAAGGGCGCGACCGAGATCCTCTATCGTTCGGAACTCGACGACCCGGAGAAGATCGCGGCACGGA
CGAAGGAATACGAGGAGCGTTTCGCCAATCCGTTCGTGGCGGCCGAACGCGGATTCATCGACGAGGTGATCATGCCGCAT
TCGTCGCGCCGCCGCATCGCCCGCGCGTTTGCCTCGCTGCGCAACAAGCAGGTGACGACGCATTGGAAGAAACACGACAC
GATCCCGTTGTAG

Upstream 100 bases:

>100_bases
GTTTACGATTTACGTTTTTATATTTTCGCCTGAACACCTGTTCAAGGCTTTTTTTGAGGTCGATGGCAATTTAATGCTCG
CCGCTTAGAATGGAGGAAGC

Downstream 100 bases:

>100_bases
AGGTGAACCGATGTGCAGCCACGTTCTCGATGGTCAAAATACGTACACCACGCCGCGCGAACTAGCGCGACTTACAGGCG
GCCCAGATGGTTTGCGCTGG

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MRKVIELLEERRVEARLGGGQKRIDAQHRKGKLTARDRIDVLLDEGSFEELDMYVTHRAVDFGMAEQKVAGDGVVTGWGT
INGRQVYVFSQDFTVLGGSLSETHAQKICKIMDMAVRVGAPVIGLNDSGGARIQEGVASLAGYAEVFRRNAEGSGVIPQI
SVIMGPCAGGAVYSPAMTDFIFMVRDSSYMFVTGPDVVKTVTNEIVTAEELGGAGTHTKKSSVADAAFENDIEALEAVRQ
LFDFLPLNNREKPPVRPFHDDPARVESRLDSLIPDSAAKPYDMKELIYAIADEGDFFEIQEAYARNIVTGFIRLEGQTVG
VVANQPMVLAGCLDIDSSRKAARFVRFCDAFSIPILTLVDVPGFLPGVAQEYGGVIKHGAKLLFAYSEATVPMVTLITRK
AYGGAYDVMASKHIGADFNYAWPTAEIAVMGAKGATEILYRSELDDPEKIAARTKEYEERFANPFVAAERGFIDEVIMPH
SSRRRIARAFASLRNKQVTTHWKKHDTIPL

Sequences:

>Translated_510_residues
MRKVIELLEERRVEARLGGGQKRIDAQHRKGKLTARDRIDVLLDEGSFEELDMYVTHRAVDFGMAEQKVAGDGVVTGWGT
INGRQVYVFSQDFTVLGGSLSETHAQKICKIMDMAVRVGAPVIGLNDSGGARIQEGVASLAGYAEVFRRNAEGSGVIPQI
SVIMGPCAGGAVYSPAMTDFIFMVRDSSYMFVTGPDVVKTVTNEIVTAEELGGAGTHTKKSSVADAAFENDIEALEAVRQ
LFDFLPLNNREKPPVRPFHDDPARVESRLDSLIPDSAAKPYDMKELIYAIADEGDFFEIQEAYARNIVTGFIRLEGQTVG
VVANQPMVLAGCLDIDSSRKAARFVRFCDAFSIPILTLVDVPGFLPGVAQEYGGVIKHGAKLLFAYSEATVPMVTLITRK
AYGGAYDVMASKHIGADFNYAWPTAEIAVMGAKGATEILYRSELDDPEKIAARTKEYEERFANPFVAAERGFIDEVIMPH
SSRRRIARAFASLRNKQVTTHWKKHDTIPL
>Mature_510_residues
MRKVIELLEERRVEARLGGGQKRIDAQHRKGKLTARDRIDVLLDEGSFEELDMYVTHRAVDFGMAEQKVAGDGVVTGWGT
INGRQVYVFSQDFTVLGGSLSETHAQKICKIMDMAVRVGAPVIGLNDSGGARIQEGVASLAGYAEVFRRNAEGSGVIPQI
SVIMGPCAGGAVYSPAMTDFIFMVRDSSYMFVTGPDVVKTVTNEIVTAEELGGAGTHTKKSSVADAAFENDIEALEAVRQ
LFDFLPLNNREKPPVRPFHDDPARVESRLDSLIPDSAAKPYDMKELIYAIADEGDFFEIQEAYARNIVTGFIRLEGQTVG
VVANQPMVLAGCLDIDSSRKAARFVRFCDAFSIPILTLVDVPGFLPGVAQEYGGVIKHGAKLLFAYSEATVPMVTLITRK
AYGGAYDVMASKHIGADFNYAWPTAEIAVMGAKGATEILYRSELDDPEKIAARTKEYEERFANPFVAAERGFIDEVIMPH
SSRRRIARAFASLRNKQVTTHWKKHDTIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=509, Percent_Identity=64.8330058939096, Blast_Score=688, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=530, Percent_Identity=62.2641509433962, Blast_Score=675, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=516, Percent_Identity=31.9767441860465, Blast_Score=226, Evalue=4e-59,
Organism=Escherichia coli, GI1788655, Length=186, Percent_Identity=29.5698924731183, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=508, Percent_Identity=62.2047244094488, Blast_Score=672, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=508, Percent_Identity=62.2047244094488, Blast_Score=671, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=519, Percent_Identity=31.7919075144509, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71997163, Length=322, Percent_Identity=26.0869565217391, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24586065, Length=511, Percent_Identity=32.6810176125245, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55926; Mature: 55926

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKVIELLEERRVEARLGGGQKRIDAQHRKGKLTARDRIDVLLDEGSFEELDMYVTHRAV
CHHHHHHHHHHHHHHHCCCCHHHHCHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHH
DFGMAEQKVAGDGVVTGWGTINGRQVYVFSQDFTVLGGSLSETHAQKICKIMDMAVRVGA
HCCCHHHHHCCCCEEEEEECCCCCEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHCC
PVIGLNDSGGARIQEGVASLAGYAEVFRRNAEGSGVIPQISVIMGPCAGGAVYSPAMTDF
CEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHE
IFMVRDSSYMFVTGPDVVKTVTNEIVTAEELGGAGTHTKKSSVADAAFENDIEALEAVRQ
EEEEECCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LFDFLPLNNREKPPVRPFHDDPARVESRLDSLIPDSAAKPYDMKELIYAIADEGDFFEIQ
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCHHHH
EAYARNIVTGFIRLEGQTVGVVANQPMVLAGCLDIDSSRKAARFVRFCDAFSIPILTLVD
HHHHHHHHEEEEEECCEEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHC
VPGFLPGVAQEYGGVIKHGAKLLFAYSEATVPMVTLITRKAYGGAYDVMASKHIGADFNY
CCCCCCHHHHHHCHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
AWPTAEIAVMGAKGATEILYRSELDDPEKIAARTKEYEERFANPFVAAERGFIDEVIMPH
CCCCCEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHCCC
SSRRRIARAFASLRNKQVTTHWKKHDTIPL
CHHHHHHHHHHHHHCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MRKVIELLEERRVEARLGGGQKRIDAQHRKGKLTARDRIDVLLDEGSFEELDMYVTHRAV
CHHHHHHHHHHHHHHHCCCCHHHHCHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHH
DFGMAEQKVAGDGVVTGWGTINGRQVYVFSQDFTVLGGSLSETHAQKICKIMDMAVRVGA
HCCCHHHHHCCCCEEEEEECCCCCEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHCC
PVIGLNDSGGARIQEGVASLAGYAEVFRRNAEGSGVIPQISVIMGPCAGGAVYSPAMTDF
CEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHE
IFMVRDSSYMFVTGPDVVKTVTNEIVTAEELGGAGTHTKKSSVADAAFENDIEALEAVRQ
EEEEECCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LFDFLPLNNREKPPVRPFHDDPARVESRLDSLIPDSAAKPYDMKELIYAIADEGDFFEIQ
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCHHHH
EAYARNIVTGFIRLEGQTVGVVANQPMVLAGCLDIDSSRKAARFVRFCDAFSIPILTLVD
HHHHHHHHEEEEEECCEEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHC
VPGFLPGVAQEYGGVIKHGAKLLFAYSEATVPMVTLITRKAYGGAYDVMASKHIGADFNY
CCCCCCHHHHHHCHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
AWPTAEIAVMGAKGATEILYRSELDDPEKIAARTKEYEERFANPFVAAERGFIDEVIMPH
CCCCCEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHCCC
SSRRRIARAFASLRNKQVTTHWKKHDTIPL
CHHHHHHHHHHHHHCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]