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The map label for this gene is bhbA [H]

Identifier: 209551995

GI number: 209551995

Start: 69975

End: 72128

Strand: Reverse

Name: bhbA [H]

Synonym: Rleg2_6136

Alternate gene names: 209551995

Gene position: 72128-69975 (Counterclockwise)

Preceding gene: 209551996

Following gene: 209551994

Centisome position: 23.36

GC content: 62.67

Gene sequence:

>2154_bases
ATGGCCGAGAAGACCGTGAAAGCCGGAGCGACCGTGAAAGACTGGGAAGCGCTTGCCGAGAAGGAACTGAAGGCTTCGCC
GGACACGCTCGTCTGGCGCACGCCTGAAGGCATCGACCTCAAGCCGCTTTATACGGCCGAAGATCTCGAAGGCATCGGTC
ACCTTAATTCGCTGCCCGGCATGAAACCTTTCGTGCGCGGCCCGCGTGCCACCATGTATGCCGGCCGACCCTGGACGATC
CGCCAATATGCCGGTTTCTCGACTGCGGAAGCATCGAACGCCTTCTACCGCCGCAATCTTGCCGCCGGCCAGAAGGGCCT
GTCGGTCGCCTTCGACCTCGCCACCCATCGCGGCTATGACAGCGATCATCCACGCGTCGAGGGTGATGTCGGCAAGGCCG
GCGTGGCGATCGATTCGGTCGAGGACATGAAGATCCTGTTCGACTGCATCCCGCTGAAAGAGATGTCGGTGTCGATGACC
ATGAACGGCGCCGTCATCCCGATCCTCGCCTCCTTCGTCGTCGCAGGCGAGGAGCAGGGCTGTTCTCGGGCCGAGCTTTC
CGGGACGATCCAGAACGACATTTTGAAGGAGTTCATGGTCCGCAACACCTATATCTATCCGCCCGAGCCTTCGATGCGGA
TCGTCGCCGACATCATCGAATATACGGCGAAGGAAATGCCGAAATTCAATTCGATTTCAATCTCCGGCTACCATATGCAG
GAAGCGGGCGCGACGCTCGTCCAGGAACTCGCCTTCACGCTGGCCAACGGGCGCGAATATGTGCGAGCAGCACTTGCCAA
GGGCCTGAGCGTCGACGAGTTTGCCGGACGGCTGTCCTTCTTCTTCGCGATCGGCATGAACTTCTTCATGGAGGCCGCCA
AGCTGCGGGCCGCCCGGCTTCTATGGTCGCGTATCATGGAGGAGTTCAAGCCGCAGAAGGCATCATCGCTGATGTTGCGC
ACCCATTGCCAGACATCGGGCGTTTCGCTGCAGGAGCAGGACCCCTATAACAACGTCATCCGCACCGCCTATGAAGCGCT
GTCGGCGGTGCTTGGCGGCACCCAGTCGCTGCACACCAATGCGCTCGACGAGGCGATGGCGCTGCCGACCGATTTCTCTG
CCCGCATCGCCCGCAACACCCAACTGATCCTGAACCACGAGACCGGCATCACCAAGGTCGTCGATCCGCTCGCCGGCTCC
TATTACGTCGAGAACCTGACCAAGGAGCTCGCCGAAAAGGCCTGGGCACTGATCGAAGAGGTCGAGGCCATGGGCGGCAT
GACCAGGGCGGTCGCAGACGGCCTGCCGAAACGCCTGATCGAGGAGGCGGCAACGCTTCGTCAGGCCCGTGTCGATCGCG
GCGAGGAGATCATCGTCGGCGTCAACAAATACAGGCTGGAAAACGAGGACGAACTCGACATCCTGGCGATTGACAATACC
GCGGTGCGCAACAGGCAGATCAAACGGCTCGAGGAAGTCCGCCGGCAGCGGGATCCGAAGCGCGTGGCGGCGACGCTCGC
CGTTCTGGAGGAAGCTGCGGAGACCGGGGAGGGGAACCTGCTGGAAGTCGCGATCGAGGCGGCCCGCGCCCGCGCCACCG
TCGGTGAAATCTCTGACGCGATGCGCCAAGCCTTTGGCGACCATTCCGCTGTGCCGGAAGTGGTCGGCGATATCTATGGC
CCGGCCTATGAGGACGATCCGGAATACAGGACGATCGTCGACCGCCTATCCGGTTATGCCGAAAAATCCGGCCGGCCGAA
GATCATGGTCGCCAAGCTCGGCCAGGACGGCCACGACCGCGGCGCCAAGGTGATCGCCTCCGCCTTCGGCGATATCGGTT
TCGAGGTTCTCGCCGGCCCGCTGTTCCAGACGCCCGAAGAGGCGGCCGACCTTGCGGTCAAAGAGAAGGTCCAGGTCGTC
GGCATGTCATCACTGGCCGCCGGCCACAGGACGCTTGCCCCGCAGCTGGTCGAGGCGCTGAAGCAGAAAGGCGCCGAAAA
CGTCATCGTCGTGGTCGGCGGCGTCGTGCCACGGCCGGACTACGGCTACCTGATGGAACACGGCGTCGCCGCCGTCTTCG
GCCCCGGCACCAATGTGCTCGATGCCGCGAACAGGATCATGGACCTGCTCGAAGGCAAACGGCGGAACAACTGA

Upstream 100 bases:

>100_bases
AAAACGTGCTGAAGGCTGAGCGCAGAGGCATCGTCAAGCACGTCGCCGCAAGCGAGGGCCAAAGCCTGGCGGTCGACGAG
TTAATCATGGAGTTCGAGTG

Downstream 100 bases:

>100_bases
GGATAAGATGCTCAAACGTGTCAATCATATCGCCATTGCGGTGCCGGATCTCGGCGAGGCCTCTGAAGTCTACAGGGCTT
TGGGCGTTCCCATATCCGAG

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 717; Mature: 716

Protein sequence:

>717_residues
MAEKTVKAGATVKDWEALAEKELKASPDTLVWRTPEGIDLKPLYTAEDLEGIGHLNSLPGMKPFVRGPRATMYAGRPWTI
RQYAGFSTAEASNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVEGDVGKAGVAIDSVEDMKILFDCIPLKEMSVSMT
MNGAVIPILASFVVAGEEQGCSRAELSGTIQNDILKEFMVRNTYIYPPEPSMRIVADIIEYTAKEMPKFNSISISGYHMQ
EAGATLVQELAFTLANGREYVRAALAKGLSVDEFAGRLSFFFAIGMNFFMEAAKLRAARLLWSRIMEEFKPQKASSLMLR
THCQTSGVSLQEQDPYNNVIRTAYEALSAVLGGTQSLHTNALDEAMALPTDFSARIARNTQLILNHETGITKVVDPLAGS
YYVENLTKELAEKAWALIEEVEAMGGMTRAVADGLPKRLIEEAATLRQARVDRGEEIIVGVNKYRLENEDELDILAIDNT
AVRNRQIKRLEEVRRQRDPKRVAATLAVLEEAAETGEGNLLEVAIEAARARATVGEISDAMRQAFGDHSAVPEVVGDIYG
PAYEDDPEYRTIVDRLSGYAEKSGRPKIMVAKLGQDGHDRGAKVIASAFGDIGFEVLAGPLFQTPEEAADLAVKEKVQVV
GMSSLAAGHRTLAPQLVEALKQKGAENVIVVVGGVVPRPDYGYLMEHGVAAVFGPGTNVLDAANRIMDLLEGKRRNN

Sequences:

>Translated_717_residues
MAEKTVKAGATVKDWEALAEKELKASPDTLVWRTPEGIDLKPLYTAEDLEGIGHLNSLPGMKPFVRGPRATMYAGRPWTI
RQYAGFSTAEASNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVEGDVGKAGVAIDSVEDMKILFDCIPLKEMSVSMT
MNGAVIPILASFVVAGEEQGCSRAELSGTIQNDILKEFMVRNTYIYPPEPSMRIVADIIEYTAKEMPKFNSISISGYHMQ
EAGATLVQELAFTLANGREYVRAALAKGLSVDEFAGRLSFFFAIGMNFFMEAAKLRAARLLWSRIMEEFKPQKASSLMLR
THCQTSGVSLQEQDPYNNVIRTAYEALSAVLGGTQSLHTNALDEAMALPTDFSARIARNTQLILNHETGITKVVDPLAGS
YYVENLTKELAEKAWALIEEVEAMGGMTRAVADGLPKRLIEEAATLRQARVDRGEEIIVGVNKYRLENEDELDILAIDNT
AVRNRQIKRLEEVRRQRDPKRVAATLAVLEEAAETGEGNLLEVAIEAARARATVGEISDAMRQAFGDHSAVPEVVGDIYG
PAYEDDPEYRTIVDRLSGYAEKSGRPKIMVAKLGQDGHDRGAKVIASAFGDIGFEVLAGPLFQTPEEAADLAVKEKVQVV
GMSSLAAGHRTLAPQLVEALKQKGAENVIVVVGGVVPRPDYGYLMEHGVAAVFGPGTNVLDAANRIMDLLEGKRRNN
>Mature_716_residues
AEKTVKAGATVKDWEALAEKELKASPDTLVWRTPEGIDLKPLYTAEDLEGIGHLNSLPGMKPFVRGPRATMYAGRPWTIR
QYAGFSTAEASNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVEGDVGKAGVAIDSVEDMKILFDCIPLKEMSVSMTM
NGAVIPILASFVVAGEEQGCSRAELSGTIQNDILKEFMVRNTYIYPPEPSMRIVADIIEYTAKEMPKFNSISISGYHMQE
AGATLVQELAFTLANGREYVRAALAKGLSVDEFAGRLSFFFAIGMNFFMEAAKLRAARLLWSRIMEEFKPQKASSLMLRT
HCQTSGVSLQEQDPYNNVIRTAYEALSAVLGGTQSLHTNALDEAMALPTDFSARIARNTQLILNHETGITKVVDPLAGSY
YVENLTKELAEKAWALIEEVEAMGGMTRAVADGLPKRLIEEAATLRQARVDRGEEIIVGVNKYRLENEDELDILAIDNTA
VRNRQIKRLEEVRRQRDPKRVAATLAVLEEAAETGEGNLLEVAIEAARARATVGEISDAMRQAFGDHSAVPEVVGDIYGP
AYEDDPEYRTIVDRLSGYAEKSGRPKIMVAKLGQDGHDRGAKVIASAFGDIGFEVLAGPLFQTPEEAADLAVKEKVQVVG
MSSLAAGHRTLAPQLVEALKQKGAENVIVVVGGVVPRPDYGYLMEHGVAAVFGPGTNVLDAANRIMDLLEGKRRNN

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=701, Percent_Identity=60.7703281027104, Blast_Score=897, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=710, Percent_Identity=60.8450704225352, Blast_Score=867, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=703, Percent_Identity=60.1706970128023, Blast_Score=863, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 78255; Mature: 78124

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKTVKAGATVKDWEALAEKELKASPDTLVWRTPEGIDLKPLYTAEDLEGIGHLNSLPG
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCC
MKPFVRGPRATMYAGRPWTIRQYAGFSTAEASNAFYRRNLAAGQKGLSVAFDLATHRGYD
CCHHHCCCCCEEECCCCEEEHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCC
SDHPRVEGDVGKAGVAIDSVEDMKILFDCIPLKEMSVSMTMNGAVIPILASFVVAGEEQG
CCCCCCCCCCCCCCEEECCHHHHHHHHHHCCHHHCEEEEEECCCHHHHHHHHHHCCCCCC
CSRAELSGTIQNDILKEFMVRNTYIYPPEPSMRIVADIIEYTAKEMPKFNSISISGYHMQ
CCHHHHCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCHH
EAGATLVQELAFTLANGREYVRAALAKGLSVDEFAGRLSFFFAIGMNFFMEAAKLRAARL
HHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWSRIMEEFKPQKASSLMLRTHCQTSGVSLQEQDPYNNVIRTAYEALSAVLGGTQSLHTN
HHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
ALDEAMALPTDFSARIARNTQLILNHETGITKVVDPLAGSYYVENLTKELAEKAWALIEE
HHHHHHCCCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEAMGGMTRAVADGLPKRLIEEAATLRQARVDRGEEIIVGVNKYRLENEDELDILAIDNT
HHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECHHHCCCCCCCEEEEEECCH
AVRNRQIKRLEEVRRQRDPKRVAATLAVLEEAAETGEGNLLEVAIEAARARATVGEISDA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHH
MRQAFGDHSAVPEVVGDIYGPAYEDDPEYRTIVDRLSGYAEKSGRPKIMVAKLGQDGHDR
HHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHH
GAKVIASAFGDIGFEVLAGPLFQTPEEAADLAVKEKVQVVGMSSLAAGHRTLAPQLVEAL
HHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHH
KQKGAENVIVVVGGVVPRPDYGYLMEHGVAAVFGPGTNVLDAANRIMDLLEGKRRNN
HHCCCCEEEEEECCCCCCCCCCHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AEKTVKAGATVKDWEALAEKELKASPDTLVWRTPEGIDLKPLYTAEDLEGIGHLNSLPG
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCC
MKPFVRGPRATMYAGRPWTIRQYAGFSTAEASNAFYRRNLAAGQKGLSVAFDLATHRGYD
CCHHHCCCCCEEECCCCEEEHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCC
SDHPRVEGDVGKAGVAIDSVEDMKILFDCIPLKEMSVSMTMNGAVIPILASFVVAGEEQG
CCCCCCCCCCCCCCEEECCHHHHHHHHHHCCHHHCEEEEEECCCHHHHHHHHHHCCCCCC
CSRAELSGTIQNDILKEFMVRNTYIYPPEPSMRIVADIIEYTAKEMPKFNSISISGYHMQ
CCHHHHCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCHH
EAGATLVQELAFTLANGREYVRAALAKGLSVDEFAGRLSFFFAIGMNFFMEAAKLRAARL
HHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWSRIMEEFKPQKASSLMLRTHCQTSGVSLQEQDPYNNVIRTAYEALSAVLGGTQSLHTN
HHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
ALDEAMALPTDFSARIARNTQLILNHETGITKVVDPLAGSYYVENLTKELAEKAWALIEE
HHHHHHCCCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEAMGGMTRAVADGLPKRLIEEAATLRQARVDRGEEIIVGVNKYRLENEDELDILAIDNT
HHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECHHHCCCCCCCEEEEEECCH
AVRNRQIKRLEEVRRQRDPKRVAATLAVLEEAAETGEGNLLEVAIEAARARATVGEISDA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHH
MRQAFGDHSAVPEVVGDIYGPAYEDDPEYRTIVDRLSGYAEKSGRPKIMVAKLGQDGHDR
HHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHH
GAKVIASAFGDIGFEVLAGPLFQTPEEAADLAVKEKVQVVGMSSLAAGHRTLAPQLVEAL
HHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHH
KQKGAENVIVVVGGVVPRPDYGYLMEHGVAAVFGPGTNVLDAANRIMDLLEGKRRNN
HHCCCCEEEEEECCCCCCCCCCHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]