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The map label for this gene is phbA [H]

Identifier: 209551988

GI number: 209551988

Start: 61607

End: 62776

Strand: Reverse

Name: phbA [H]

Synonym: Rleg2_6128

Alternate gene names: 209551988

Gene position: 62776-61607 (Counterclockwise)

Preceding gene: 209551989

Following gene: 209551987

Centisome position: 20.33

GC content: 61.11

Gene sequence:

>1170_bases
ATGCAAGAAAACACAAATCCTGTTGTCATTGTTTCGGCGGCTCGCACACCGATCGGCTCGTTTCAGGGTGGTTTGAAGTC
GCATTCCGCTCCCGAACTCGGAGGCATCGCGATCAGGGCCGTTCTAGACCGGTCCGGCCTGATGCCGGATAAGCTGGATG
AGGTCCTGATGGGATGCGTCCTGCCCGCCGGTGTGGGCCAAGCGCCGGCAAGGCAGGCTGCGCATCATGCCGGGCTGCCT
TGGGCTGTCCCATGCTCTACCGTCAACAAAGTCTGCGGTTCGGGCATGAAGACGATCATCCTAGCGCACGACACGCTGGC
TACAGGCGATGCACGCTTCATTGTCGCCGGTGGCATGGAAAGCATGACGAATGCCCCTTATCTGCTCGAGAAGCATCGAA
CGGGTGCCCGCATGGGACATGGAAGGGTCATGGATCACATGTTCCTCGATGGATTGGAGGATGTCTATGATCGCGGGCGT
TCAATGGGGACGTTCGCCGAGGAAACCGCAGAGGCCTATCAGTTCTCCAGGGTCCAGCAGGATTCCTATGCGATCGAAAG
CCTCGCCAGAGCGAATAGGGCGATTGCGGAGGGAGCCTTCAGGGGGGAGACCGTGACCGTCGGAGACGTCAGCGCCGATG
AACAACCGGGAAAGTCAAAGCCCGAGAAGATCCCGCAGCTGCGCCCGGCTTTCAAGGAGAATGGGACTGTGACAGCCGCT
AGCTCGGCATCGATTTCGGACGGAGGAGCGGCCGTTCTCCTCTCACGCCGCTCGGTGGCGGAGCAGCAGAGGTTGGAAAC
GCTCGCCTACATTCGCGGAACCGCCAGCTTCGCACAGGAGCCCAGCCGGTTCACTACCGCGCCCGTCTTCGCGATCAACC
GCTTGCTGGAGAAGGTGGGTTGGAGCACTAGCGACGTTGACCTATTCGAGATCAACGAAGCTTTCGCAGTCGTTCCCATG
GCCGCAATGCGCGAACTCGACATTGGCCACGAGAGGATGAACGTGAACGGCGGCGCCTGCGCCCTCGGTCATCCACTCGG
TTGTTCGGGTACTCGCGTCGTGGTGACGCTGCTCTCCGCACTCCAGGCGCGCGGCCTGAAGAAGGGCGTGGCTTCTGTGT
GCATCGGCGGAGGCGAGGCGACCGCGATCGCGGTCGAATTGCTCAATTAG

Upstream 100 bases:

>100_bases
ACGCATTCGCAGTCGGAGTCCTTTCAAAACGGCGTCGGCAGCTTTTTGACGCGTAACAAGCGCGGCTAACCAGAACCGTC
TAAATTGCAGGAGTATGAAT

Downstream 100 bases:

>100_bases
CCTCGAAAGGAGGCGGACGATGAAGTGTTTTGCAGGTTCGGGCCTCAGTTCCCTTGAGGAGTTCAGCTTTGTCGACGTGC
CGACGCCGGTCCCCGGGTCC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MQENTNPVVIVSAARTPIGSFQGGLKSHSAPELGGIAIRAVLDRSGLMPDKLDEVLMGCVLPAGVGQAPARQAAHHAGLP
WAVPCSTVNKVCGSGMKTIILAHDTLATGDARFIVAGGMESMTNAPYLLEKHRTGARMGHGRVMDHMFLDGLEDVYDRGR
SMGTFAEETAEAYQFSRVQQDSYAIESLARANRAIAEGAFRGETVTVGDVSADEQPGKSKPEKIPQLRPAFKENGTVTAA
SSASISDGGAAVLLSRRSVAEQQRLETLAYIRGTASFAQEPSRFTTAPVFAINRLLEKVGWSTSDVDLFEINEAFAVVPM
AAMRELDIGHERMNVNGGACALGHPLGCSGTRVVVTLLSALQARGLKKGVASVCIGGGEATAIAVELLN

Sequences:

>Translated_389_residues
MQENTNPVVIVSAARTPIGSFQGGLKSHSAPELGGIAIRAVLDRSGLMPDKLDEVLMGCVLPAGVGQAPARQAAHHAGLP
WAVPCSTVNKVCGSGMKTIILAHDTLATGDARFIVAGGMESMTNAPYLLEKHRTGARMGHGRVMDHMFLDGLEDVYDRGR
SMGTFAEETAEAYQFSRVQQDSYAIESLARANRAIAEGAFRGETVTVGDVSADEQPGKSKPEKIPQLRPAFKENGTVTAA
SSASISDGGAAVLLSRRSVAEQQRLETLAYIRGTASFAQEPSRFTTAPVFAINRLLEKVGWSTSDVDLFEINEAFAVVPM
AAMRELDIGHERMNVNGGACALGHPLGCSGTRVVVTLLSALQARGLKKGVASVCIGGGEATAIAVELLN
>Mature_389_residues
MQENTNPVVIVSAARTPIGSFQGGLKSHSAPELGGIAIRAVLDRSGLMPDKLDEVLMGCVLPAGVGQAPARQAAHHAGLP
WAVPCSTVNKVCGSGMKTIILAHDTLATGDARFIVAGGMESMTNAPYLLEKHRTGARMGHGRVMDHMFLDGLEDVYDRGR
SMGTFAEETAEAYQFSRVQQDSYAIESLARANRAIAEGAFRGETVTVGDVSADEQPGKSKPEKIPQLRPAFKENGTVTAA
SSASISDGGAAVLLSRRSVAEQQRLETLAYIRGTASFAQEPSRFTTAPVFAINRLLEKVGWSTSDVDLFEINEAFAVVPM
AAMRELDIGHERMNVNGGACALGHPLGCSGTRVVVTLLSALQARGLKKGVASVCIGGGEATAIAVELLN

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=43.3249370277078, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI4557237, Length=391, Percent_Identity=43.4782608695652, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=34.6938775510204, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI4501853, Length=401, Percent_Identity=36.6583541147132, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4504327, Length=433, Percent_Identity=29.3302540415704, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI194353979, Length=387, Percent_Identity=31.5245478036176, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI87082165, Length=388, Percent_Identity=43.5567010309278, Blast_Score=314, Evalue=5e-87,
Organism=Escherichia coli, GI1788554, Length=391, Percent_Identity=46.2915601023018, Blast_Score=291, Evalue=4e-80,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=37.5, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1787663, Length=395, Percent_Identity=34.1772151898734, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1788683, Length=400, Percent_Identity=27.75, Blast_Score=127, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=39.7932816537468, Blast_Score=274, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI17535921, Length=391, Percent_Identity=40.153452685422, Blast_Score=259, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=34.7938144329897, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI17535917, Length=388, Percent_Identity=32.7319587628866, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=28.7058823529412, Blast_Score=167, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=46.4019851116625, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=32.9974811083123, Blast_Score=178, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=45.0127877237852, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=43.7340153452685, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI17648125, Length=397, Percent_Identity=33.5012594458438, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI17137578, Length=428, Percent_Identity=29.6728971962617, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40943; Mature: 40943

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQENTNPVVIVSAARTPIGSFQGGLKSHSAPELGGIAIRAVLDRSGLMPDKLDEVLMGCV
CCCCCCCEEEEEECCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
LPAGVGQAPARQAAHHAGLPWAVPCSTVNKVCGSGMKTIILAHDTLATGDARFIVAGGME
CCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEECCHH
SMTNAPYLLEKHRTGARMGHGRVMDHMFLDGLEDVYDRGRSMGTFAEETAEAYQFSRVQQ
HHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
DSYAIESLARANRAIAEGAFRGETVTVGDVSADEQPGKSKPEKIPQLRPAFKENGTVTAA
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHCCCCCCHHHCCCCEEEE
SSASISDGGAAVLLSRRSVAEQQRLETLAYIRGTASFAQEPSRFTTAPVFAINRLLEKVG
CCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHC
WSTSDVDLFEINEAFAVVPMAAMRELDIGHERMNVNGGACALGHPLGCSGTRVVVTLLSA
CCCCCEEEEECCCHHHHHHHHHHHHHCCCCCEECCCCCEEECCCCCCCCCHHHHHHHHHH
LQARGLKKGVASVCIGGGEATAIAVELLN
HHHHHHHHHHHHHEECCCCEEEEEEEECC
>Mature Secondary Structure
MQENTNPVVIVSAARTPIGSFQGGLKSHSAPELGGIAIRAVLDRSGLMPDKLDEVLMGCV
CCCCCCCEEEEEECCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
LPAGVGQAPARQAAHHAGLPWAVPCSTVNKVCGSGMKTIILAHDTLATGDARFIVAGGME
CCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEECCHH
SMTNAPYLLEKHRTGARMGHGRVMDHMFLDGLEDVYDRGRSMGTFAEETAEAYQFSRVQQ
HHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
DSYAIESLARANRAIAEGAFRGETVTVGDVSADEQPGKSKPEKIPQLRPAFKENGTVTAA
HHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHCCCCCCHHHCCCCEEEE
SSASISDGGAAVLLSRRSVAEQQRLETLAYIRGTASFAQEPSRFTTAPVFAINRLLEKVG
CCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHC
WSTSDVDLFEINEAFAVVPMAAMRELDIGHERMNVNGGACALGHPLGCSGTRVVVTLLSA
CCCCCEEEEECCCHHHHHHHHHHHHHCCCCCEECCCCCEEECCCCCCCCCHHHHHHHHHH
LQARGLKKGVASVCIGGGEATAIAVELLN
HHHHHHHHHHHHHEECCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1396692 [H]