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The map label for this gene is gbsB [H]

Identifier: 209551978

GI number: 209551978

Start: 42865

End: 44058

Strand: Reverse

Name: gbsB [H]

Synonym: Rleg2_6116

Alternate gene names: 209551978

Gene position: 44058-42865 (Counterclockwise)

Preceding gene: 209551979

Following gene: 209551977

Centisome position: 14.27

GC content: 52.85

Gene sequence:

>1194_bases
ATGAGAAGAGATTTTTATATGCCAACGCGGATCGTTTGGGGAGAAGACGTGTTGGTCCATATTGGCAGCTTTTTGCGCGA
TCTGCCTGTCAAGAACATCTTGGTTGTAACAGATCCGATTATAGCCGGTCAGCCATTTTTTACTGAAACGATAGCGCGAC
TGTCCGACGACGGTTTTCGGATCTCGGTGTTCGATGAGTGTGGGATTGACGCGCGTGTTGCTCACATTGATGAGCAGGCT
GCTCGATGCCGCCGCGAATCCATTTCTGCCATTGTTTCTATTGGTGGGGGCTCGGTCATGTGTACCGGCAAGGGTATCGC
AATTGTTGCGACGAATTCGGAAAGCTTTCGAGAGGTTACCGGAGTAGGCAATTTCCAGAAGGAAGCGCTGCCGATGGTGA
TGGTTCCAACAACTGCGGGATCAGGATCGGAGGTCTCTCAATTTACCATCGTGAAAGACGACGAGCGACATCTCAAGCTT
CTTGGAGGAGGGCCCCTTAGCTTTCCAACGGTGGCCATACTTGATCCCGTTGTGCTGTTATCTTTGCCTCAACGGGCAGC
CACATTTTCTGCAATCGATGCTCTATCGCATGCCATCGAGGCCTATCTTACGGATCTCTCTACGCCGTTTACCGACGCTA
TTGCTCTTGAGGCCGCTCGGCTCCAGATGGCATCAATGCGCGGATCAATTCTGGATTCCGACGCTAAGGCGCGCGGCAAC
AATCTTCTTGCTTCCGCGATGGCGAACATTGCATGCGGAAATGCACGTCTTGGGCATGCGCACGCACTGTCTCTTCCCCT
GGAGGGGCATCTGGATTTGCCCCACCCTCTCGGTGTCGGAAGCTTGGTCCCTTGGACATTTAAATTTAATGCTGAGGTCG
TTCCGGAAAAGGGCACGACTTTTGCTCAAGGTTTGGGCGTCGATATAAAAGGCCTGTCAGCCGCAGAGGCTGTAGATGCC
GCTGTTGATACGATTTTTGAGTTGTACGATGCGCTTGGATTCCCCAGGCATCTGTCCAATGAACAATTGCCCCGTGATCG
CATTCCCGACATGGCAAAGCTGGCCGTACCGGGCATGTATGGTTCGACGGTACCTGTTGTCATTGATCAGACCACGGTGA
TCGCGTCCCCGTCAGTGCGGGCGATGACAGTAAAGCATGCCACCGAAATCTATGAATTGGCTTCCGGCCGATAG

Upstream 100 bases:

>100_bases
AGCGGATCTCTCCGGAGATTGATTGCGATTACCCGCGATCAAGCACTTCACGCCCGGTGAGATACGGCGCAGAGCACAAT
AAAGGCTTACGGAGCTATAC

Downstream 100 bases:

>100_bases
CTTTTGGTCGTGACGACGGTGATGAGCGTGCCGATCGGATAGACATGTTGATCGGCAAAATTGAGTTTTTCGGGTCTCGG
CGAGCGAGTCGAGACCGCAT

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MRRDFYMPTRIVWGEDVLVHIGSFLRDLPVKNILVVTDPIIAGQPFFTETIARLSDDGFRISVFDECGIDARVAHIDEQA
ARCRRESISAIVSIGGGSVMCTGKGIAIVATNSESFREVTGVGNFQKEALPMVMVPTTAGSGSEVSQFTIVKDDERHLKL
LGGGPLSFPTVAILDPVVLLSLPQRAATFSAIDALSHAIEAYLTDLSTPFTDAIALEAARLQMASMRGSILDSDAKARGN
NLLASAMANIACGNARLGHAHALSLPLEGHLDLPHPLGVGSLVPWTFKFNAEVVPEKGTTFAQGLGVDIKGLSAAEAVDA
AVDTIFELYDALGFPRHLSNEQLPRDRIPDMAKLAVPGMYGSTVPVVIDQTTVIASPSVRAMTVKHATEIYELASGR

Sequences:

>Translated_397_residues
MRRDFYMPTRIVWGEDVLVHIGSFLRDLPVKNILVVTDPIIAGQPFFTETIARLSDDGFRISVFDECGIDARVAHIDEQA
ARCRRESISAIVSIGGGSVMCTGKGIAIVATNSESFREVTGVGNFQKEALPMVMVPTTAGSGSEVSQFTIVKDDERHLKL
LGGGPLSFPTVAILDPVVLLSLPQRAATFSAIDALSHAIEAYLTDLSTPFTDAIALEAARLQMASMRGSILDSDAKARGN
NLLASAMANIACGNARLGHAHALSLPLEGHLDLPHPLGVGSLVPWTFKFNAEVVPEKGTTFAQGLGVDIKGLSAAEAVDA
AVDTIFELYDALGFPRHLSNEQLPRDRIPDMAKLAVPGMYGSTVPVVIDQTTVIASPSVRAMTVKHATEIYELASGR
>Mature_397_residues
MRRDFYMPTRIVWGEDVLVHIGSFLRDLPVKNILVVTDPIIAGQPFFTETIARLSDDGFRISVFDECGIDARVAHIDEQA
ARCRRESISAIVSIGGGSVMCTGKGIAIVATNSESFREVTGVGNFQKEALPMVMVPTTAGSGSEVSQFTIVKDDERHLKL
LGGGPLSFPTVAILDPVVLLSLPQRAATFSAIDALSHAIEAYLTDLSTPFTDAIALEAARLQMASMRGSILDSDAKARGN
NLLASAMANIACGNARLGHAHALSLPLEGHLDLPHPLGVGSLVPWTFKFNAEVVPEKGTTFAQGLGVDIKGLSAAEAVDA
AVDTIFELYDALGFPRHLSNEQLPRDRIPDMAKLAVPGMYGSTVPVVIDQTTVIASPSVRAMTVKHATEIYELASGR

Specific function: Essential for the utilization of choline as a precursor [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=398, Percent_Identity=26.8844221105528, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI48994951, Length=372, Percent_Identity=28.7634408602151, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1789163, Length=328, Percent_Identity=28.0487804878049, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI87082107, Length=331, Percent_Identity=29.3051359516616, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1787493, Length=286, Percent_Identity=28.6713286713287, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1789386, Length=363, Percent_Identity=23.4159779614325, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17537053, Length=345, Percent_Identity=28.695652173913, Blast_Score=125, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6321181, Length=373, Percent_Identity=29.2225201072386, Blast_Score=159, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24657991, Length=401, Percent_Identity=26.4339152119701, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 42331; Mature: 42331

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRDFYMPTRIVWGEDVLVHIGSFLRDLPVKNILVVTDPIIAGQPFFTETIARLSDDGFR
CCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCE
ISVFDECGIDARVAHIDEQAARCRRESISAIVSIGGGSVMCTGKGIAIVATNSESFREVT
EEEECCCCCCEEEHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCEEEEEECCHHHHHHH
GVGNFQKEALPMVMVPTTAGSGSEVSQFTIVKDDERHLKLLGGGPLSFPTVAILDPVVLL
CCCCCHHHCCCEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHH
SLPQRAATFSAIDALSHAIEAYLTDLSTPFTDAIALEAARLQMASMRGSILDSDAKARGN
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHCCC
NLLASAMANIACGNARLGHAHALSLPLEGHLDLPHPLGVGSLVPWTFKFNAEVVPEKGTT
HHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEECCEECCCCCCH
FAQGLGVDIKGLSAAEAVDAAVDTIFELYDALGFPRHLSNEQLPRDRIPDMAKLAVPGMY
HHHCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHCCCCCC
GSTVPVVIDQTTVIASPSVRAMTVKHATEIYELASGR
CCCCEEEEECEEEEECCCCEEEEHHHHHHHHHHHCCC
>Mature Secondary Structure
MRRDFYMPTRIVWGEDVLVHIGSFLRDLPVKNILVVTDPIIAGQPFFTETIARLSDDGFR
CCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCE
ISVFDECGIDARVAHIDEQAARCRRESISAIVSIGGGSVMCTGKGIAIVATNSESFREVT
EEEECCCCCCEEEHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCEEEEEECCHHHHHHH
GVGNFQKEALPMVMVPTTAGSGSEVSQFTIVKDDERHLKLLGGGPLSFPTVAILDPVVLL
CCCCCHHHCCCEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHH
SLPQRAATFSAIDALSHAIEAYLTDLSTPFTDAIALEAARLQMASMRGSILDSDAKARGN
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHCCC
NLLASAMANIACGNARLGHAHALSLPLEGHLDLPHPLGVGSLVPWTFKFNAEVVPEKGTT
HHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEECCEECCCCCCH
FAQGLGVDIKGLSAAEAVDAAVDTIFELYDALGFPRHLSNEQLPRDRIPDMAKLAVPGMY
HHHCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHCCCCCC
GSTVPVVIDQTTVIASPSVRAMTVKHATEIYELASGR
CCCCEEEEECEEEEECCCCEEEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8752328; 9384377 [H]