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The map label for this gene is czcR [H]

Identifier: 209550642

GI number: 209550642

Start: 3128780

End: 3129697

Strand: Direct

Name: czcR [H]

Synonym: Rleg2_3066

Alternate gene names: 209550642

Gene position: 3128780-3129697 (Clockwise)

Preceding gene: 209550641

Following gene: 209550649

Centisome position: 68.95

GC content: 65.8

Gene sequence:

>918_bases
TTGGCTGAGCCGGCCCTGCCCCGCGACATCGTTCTGCTCGTCGACGACTCGCCCGAAGCGTTGGGCTTCCTGACCGACGC
GCTCGAACAATCCGGCTTCTCCGTACTGATCGCCACATCCGGCGCGGCAGCCCTTGGCATCGTCGAGCGCATCACACCCG
ATCTCATCCTGCTCGACGCCGTCATGCCCGCCATGGATGGCTTCGAGACCTGCCGCAGGCTGAAGGCAAATGCGGCGGTG
GCGCAGGTCCCCGTCATCTTCATGACCGGCCTGACCGAGACCGAGCATGTCGTGCACGCGCTGGAATCCGGCGGCGTCGA
CTATCTCGCCAAGCCGATCAATATCGACGAGCTGCGCGCCCGCATCCGTGTCCATCTGCGCAATGCCCGCTCGGCGCAAA
GCGCCCGCGTCGCGCTCGACGCCGCCGGCCGCCATCTGCTGGCAGTCAAGGGCGACGGCGCAATCCATTGGTCGACGCCG
CAGGCAACACGGCTGGTCAATGCCGCCATGGGCAGCGACGAGGGCATGGAAATCGTCGTCCGCCATATCGCCGGCTGGAT
GCGCGAGCGTGCAGCCGCCGGGCGCGACGGCATCATCTCCATCGCCCATGCCGGCCAGGCGGCGCTGCAGCTTGCTTTTC
TCGGCGCGATTGGCCCGGACGAATATCTTTTCCGCCTGACCGCCGCCAATCAGCGCAGCGACGACGAGATGCTGCGCCAG
CGCTTCTCGCTCACCCAGCGCGAATCCGAAGTGCTGCTCTGGATTGCCAAGGGCAAGGCCAACCGCGACATCGGCGAAAT
ATTGGGACTGTCGGCGCGCACGGTGAACAAGCACCTCGAACAGATCTACGTGAAGCTCGGCGTCGAGAACCGGGCATCGG
CCGCCGTCAAGGCCACGCATGTACTGCACGAGATGTGA

Upstream 100 bases:

>100_bases
AATCAGCCATTCACCGACAAACTCTACGCCTATGTCGCCGTCTTCGATCTCGCCGGCTTCATGACCTTCCTGCACGACTT
CGACGAAAAGGTGGAATCCA

Downstream 100 bases:

>100_bases
GGGATATTGGGCGGCATCGCCACCGGGATTGCCGAGGACCTTCGTGAGGGCCGGCAATTGACGGAAATCGTCGGCGCCAG
ATAAGCGGCACGGAGACGGA

Product: LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MAEPALPRDIVLLVDDSPEALGFLTDALEQSGFSVLIATSGAAALGIVERITPDLILLDAVMPAMDGFETCRRLKANAAV
AQVPVIFMTGLTETEHVVHALESGGVDYLAKPINIDELRARIRVHLRNARSAQSARVALDAAGRHLLAVKGDGAIHWSTP
QATRLVNAAMGSDEGMEIVVRHIAGWMRERAAAGRDGIISIAHAGQAALQLAFLGAIGPDEYLFRLTAANQRSDDEMLRQ
RFSLTQRESEVLLWIAKGKANRDIGEILGLSARTVNKHLEQIYVKLGVENRASAAVKATHVLHEM

Sequences:

>Translated_305_residues
MAEPALPRDIVLLVDDSPEALGFLTDALEQSGFSVLIATSGAAALGIVERITPDLILLDAVMPAMDGFETCRRLKANAAV
AQVPVIFMTGLTETEHVVHALESGGVDYLAKPINIDELRARIRVHLRNARSAQSARVALDAAGRHLLAVKGDGAIHWSTP
QATRLVNAAMGSDEGMEIVVRHIAGWMRERAAAGRDGIISIAHAGQAALQLAFLGAIGPDEYLFRLTAANQRSDDEMLRQ
RFSLTQRESEVLLWIAKGKANRDIGEILGLSARTVNKHLEQIYVKLGVENRASAAVKATHVLHEM
>Mature_304_residues
AEPALPRDIVLLVDDSPEALGFLTDALEQSGFSVLIATSGAAALGIVERITPDLILLDAVMPAMDGFETCRRLKANAAVA
QVPVIFMTGLTETEHVVHALESGGVDYLAKPINIDELRARIRVHLRNARSAQSARVALDAAGRHLLAVKGDGAIHWSTPQ
ATRLVNAAMGSDEGMEIVVRHIAGWMRERAAAGRDGIISIAHAGQAALQLAFLGAIGPDEYLFRLTAANQRSDDEMLRQR
FSLTQRESEVLLWIAKGKANRDIGEILGLSARTVNKHLEQIYVKLGVENRASAAVKATHVLHEM

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=37.037037037037, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790437, Length=185, Percent_Identity=34.0540540540541, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790860, Length=128, Percent_Identity=34.375, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786599, Length=122, Percent_Identity=35.2459016393443, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786911, Length=163, Percent_Identity=35.5828220858896, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786784, Length=117, Percent_Identity=35.8974358974359, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788394, Length=124, Percent_Identity=29.8387096774194, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87082012, Length=125, Percent_Identity=31.2, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790299, Length=131, Percent_Identity=32.824427480916, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789809, Length=117, Percent_Identity=34.1880341880342, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI2367329, Length=126, Percent_Identity=40.4761904761905, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787229, Length=118, Percent_Identity=32.2033898305085, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 32910; Mature: 32779

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEPALPRDIVLLVDDSPEALGFLTDALEQSGFSVLIATSGAAALGIVERITPDLILLDA
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCHHHHHHH
VMPAMDGFETCRRLKANAAVAQVPVIFMTGLTETEHVVHALESGGVDYLAKPINIDELRA
HHHHHHHHHHHHHHHHCCHHHHCCEEEEECCCHHHHHHHHHHHCCHHEEECCCCHHHHHH
RIRVHLRNARSAQSARVALDAAGRHLLAVKGDGAIHWSTPQATRLVNAAMGSDEGMEIVV
HHHHHHHCCCCHHHHEEEEECCCCEEEEEECCCEEEECCCHHHHHHHHHCCCCCCHHHHH
RHIAGWMRERAAAGRDGIISIAHAGQAALQLAFLGAIGPDEYLFRLTAANQRSDDEMLRQ
HHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCHHEEEEECCCCCCHHHHHHH
RFSLTQRESEVLLWIAKGKANRDIGEILGLSARTVNKHLEQIYVKLGVENRASAAVKATH
HHHHCCCCCEEEEEEECCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VLHEM
HHHCC
>Mature Secondary Structure 
AEPALPRDIVLLVDDSPEALGFLTDALEQSGFSVLIATSGAAALGIVERITPDLILLDA
CCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCHHHHHHH
VMPAMDGFETCRRLKANAAVAQVPVIFMTGLTETEHVVHALESGGVDYLAKPINIDELRA
HHHHHHHHHHHHHHHHCCHHHHCCEEEEECCCHHHHHHHHHHHCCHHEEECCCCHHHHHH
RIRVHLRNARSAQSARVALDAAGRHLLAVKGDGAIHWSTPQATRLVNAAMGSDEGMEIVV
HHHHHHHCCCCHHHHEEEEECCCCEEEEEECCCEEEECCCHHHHHHHHHCCCCCCHHHHH
RHIAGWMRERAAAGRDGIISIAHAGQAALQLAFLGAIGPDEYLFRLTAANQRSDDEMLRQ
HHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCHHEEEEECCCCCCHHHHHHH
RFSLTQRESEVLLWIAKGKANRDIGEILGLSARTVNKHLEQIYVKLGVENRASAAVKATH
HHHHCCCCCEEEEEEECCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VLHEM
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]