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The map label for this gene is lspL [H]

Identifier: 209550573

GI number: 209550573

Start: 3061614

End: 3062630

Strand: Direct

Name: lspL [H]

Synonym: Rleg2_2997

Alternate gene names: 209550573

Gene position: 3061614-3062630 (Clockwise)

Preceding gene: 209550571

Following gene: 209550575

Centisome position: 67.47

GC content: 60.18

Gene sequence:

>1017_bases
ATGCGCTACTTCATTACCGGGACGGCCGGCTTTATCGGTTTTCATCTGGCCAGGCGCCTGCTGCAGGAAGGCCACGAGGT
CACCGGCTTCGACGGCCTCACTCCCTATTACAACGTCAAGCTCAAGGAGATGCGCCATGCAGCACTCTCCCAGTTCCCGG
CCTTCAAACCGGTCATCGCTATGCTCGAGGATCGCGAAGCGCTTGAGGCAGCGGTTGTCGCGGCCAAGCCGGACATATTG
ATTCACCTCGCTGCCCAGGCCGGCGTGCGATACAGCCTGGAAAATCCCGAGGCCTATCTTCGATCGAACGTCGAAGGCTC
GTGGAACATCATGGAAATCGCCCGGCGCGTCGAAATCCGTCACCTGATGCTGGCCTCGACGTCATCGATCTACGGCGCCA
ATGCGACCGTTCCCTTTCATGAGACCGATCGCGCCGACGAACCGCTGACCATCTATGCCGCGACGAAGAAATCGATGGAG
CTGATGGCGCACAGTTATGCCCATCTGCACAAGATCCCGACGACGGCCTTTCGCTTCTTCACCGTTTACGGCCCGTGGGG
CCGGCCCGACATGGCGCTGTTCAAATTCACCAAGAACATGCTCGAGGGACAGCCGATCGAGATCTACGGCGAAGGCAATA
TGAGCCGTGACTTCACCTATATCGACGATCTCGTCGAGGGGATCGTCAGGCTGTCGGCAATCGCCCCTGGTGAGGATAAC
CGTCTGGACAATGTGGCTGTCGAAACGCTTTCGCGCCAGGCGCCCTTTCGGGTCGTCAATATTGGCGGCGGCCAGCCGGT
CAGCCTGATGGATTTCGTCGAAACGGTGGAAAAGGCGCTCGGCCGTCCGGCCATCCGCAAGATGCTGGCAATGCAGAAGG
GCGACGTCCCGCGCACCTTCGCGGCCCCCGATCTGCTCGTTGCGCTGACGGGTTACAAGCCGGATACAACCTTGGATGTC
GGCGTCAAGGCCTTCGTCGACTGGTATCTCGACGTCCGCGGCGAACTCGACGCCTAA

Upstream 100 bases:

>100_bases
TTCAAAGATCTATCGACTCGGCCTCTTCTTATCTTGTAAGTGGGGTCACGCGATACGGAATCGGCTTTTGCCGTCGGCAA
CGAGCCGAGAGAAGGTGGGA

Downstream 100 bases:

>100_bases
TTGGGTTATCCCCGGCGCCGACCCGAATTGTGTTTCCTATGACCAGGAATATCAGCGCAGAAACGCCACCGCCTCAACCG
CCTTCGAAAACACATAGTCG

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: UDP-glucuronic acid epimerase [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MRYFITGTAGFIGFHLARRLLQEGHEVTGFDGLTPYYNVKLKEMRHAALSQFPAFKPVIAMLEDREALEAAVVAAKPDIL
IHLAAQAGVRYSLENPEAYLRSNVEGSWNIMEIARRVEIRHLMLASTSSIYGANATVPFHETDRADEPLTIYAATKKSME
LMAHSYAHLHKIPTTAFRFFTVYGPWGRPDMALFKFTKNMLEGQPIEIYGEGNMSRDFTYIDDLVEGIVRLSAIAPGEDN
RLDNVAVETLSRQAPFRVVNIGGGQPVSLMDFVETVEKALGRPAIRKMLAMQKGDVPRTFAAPDLLVALTGYKPDTTLDV
GVKAFVDWYLDVRGELDA

Sequences:

>Translated_338_residues
MRYFITGTAGFIGFHLARRLLQEGHEVTGFDGLTPYYNVKLKEMRHAALSQFPAFKPVIAMLEDREALEAAVVAAKPDIL
IHLAAQAGVRYSLENPEAYLRSNVEGSWNIMEIARRVEIRHLMLASTSSIYGANATVPFHETDRADEPLTIYAATKKSME
LMAHSYAHLHKIPTTAFRFFTVYGPWGRPDMALFKFTKNMLEGQPIEIYGEGNMSRDFTYIDDLVEGIVRLSAIAPGEDN
RLDNVAVETLSRQAPFRVVNIGGGQPVSLMDFVETVEKALGRPAIRKMLAMQKGDVPRTFAAPDLLVALTGYKPDTTLDV
GVKAFVDWYLDVRGELDA
>Mature_338_residues
MRYFITGTAGFIGFHLARRLLQEGHEVTGFDGLTPYYNVKLKEMRHAALSQFPAFKPVIAMLEDREALEAAVVAAKPDIL
IHLAAQAGVRYSLENPEAYLRSNVEGSWNIMEIARRVEIRHLMLASTSSIYGANATVPFHETDRADEPLTIYAATKKSME
LMAHSYAHLHKIPTTAFRFFTVYGPWGRPDMALFKFTKNMLEGQPIEIYGEGNMSRDFTYIDDLVEGIVRLSAIAPGEDN
RLDNVAVETLSRQAPFRVVNIGGGQPVSLMDFVETVEKALGRPAIRKMLAMQKGDVPRTFAAPDLLVALTGYKPDTTLDV
GVKAFVDWYLDVRGELDA

Specific function: INVOLVED IN THE SYNTHESIS OF ENTEROBACTERIAL COMMON ANTIGEN (ECA) AND REQUIRED FOR SYNTHESIS OF LIPOPOLYSACCHARIDE O-SIDE CHAINS. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=347, Percent_Identity=27.0893371757925, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI7657641, Length=337, Percent_Identity=22.5519287833828, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI48994969, Length=353, Percent_Identity=26.628895184136, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788353, Length=361, Percent_Identity=26.0387811634349, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786974, Length=322, Percent_Identity=24.8447204968944, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788589, Length=263, Percent_Identity=28.5171102661597, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17539532, Length=239, Percent_Identity=30.9623430962343, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982035, Length=353, Percent_Identity=24.3626062322946, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71982038, Length=355, Percent_Identity=24.5070422535211, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17568069, Length=240, Percent_Identity=28.75, Blast_Score=88, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6319493, Length=357, Percent_Identity=21.5686274509804, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356223, Length=349, Percent_Identity=26.647564469914, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19923002, Length=337, Percent_Identity=24.0356083086053, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.12 [H]

Molecular weight: Translated: 37674; Mature: 37674

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYFITGTAGFIGFHLARRLLQEGHEVTGFDGLTPYYNVKLKEMRHAALSQFPAFKPVIA
CEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHH
MLEDREALEAAVVAAKPDILIHLAAQAGVRYSLENPEAYLRSNVEGSWNIMEIARRVEIR
HHHHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCHHHHHCCCCCCCHHHHHHHHHHHH
HLMLASTSSIYGANATVPFHETDRADEPLTIYAATKKSMELMAHSYAHLHKIPTTAFRFF
HHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCHHHEEEE
TVYGPWGRPDMALFKFTKNMLEGQPIEIYGEGNMSRDFTYIDDLVEGIVRLSAIAPGEDN
EEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
RLDNVAVETLSRQAPFRVVNIGGGQPVSLMDFVETVEKALGRPAIRKMLAMQKGDVPRTF
CHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC
AAPDLLVALTGYKPDTTLDVGVKAFVDWYLDVRGELDA
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRYFITGTAGFIGFHLARRLLQEGHEVTGFDGLTPYYNVKLKEMRHAALSQFPAFKPVIA
CEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHH
MLEDREALEAAVVAAKPDILIHLAAQAGVRYSLENPEAYLRSNVEGSWNIMEIARRVEIR
HHHHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCHHHHHCCCCCCCHHHHHHHHHHHH
HLMLASTSSIYGANATVPFHETDRADEPLTIYAATKKSMELMAHSYAHLHKIPTTAFRFF
HHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCHHHEEEE
TVYGPWGRPDMALFKFTKNMLEGQPIEIYGEGNMSRDFTYIDDLVEGIVRLSAIAPGEDN
EEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
RLDNVAVETLSRQAPFRVVNIGGGQPVSLMDFVETVEKALGRPAIRKMLAMQKGDVPRTF
CHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC
AAPDLLVALTGYKPDTTLDVGVKAFVDWYLDVRGELDA
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]