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The map label for this gene is lldD [H]

Identifier: 209550452

GI number: 209550452

Start: 2925277

End: 2926419

Strand: Direct

Name: lldD [H]

Synonym: Rleg2_2875

Alternate gene names: 209550452

Gene position: 2925277-2926419 (Clockwise)

Preceding gene: 209550449

Following gene: 209550456

Centisome position: 64.46

GC content: 63.69

Gene sequence:

>1143_bases
ATGGCCACTCCGCTCACCATCGCCGATCTGAAGAAGCTCGCGCAGCGCCGTGTACCGAAGATGTTTTTCGACTATGCGGA
TTCGGGCGCCTGGACGGAGTCGACCTATGCGGCAAACGAGAGTGATTTCAGTGGGATCAAGCTGCGCCAGCGGGTGATGG
TCGACATGACCAACCGCACGCTGGAAACGACGATGATCGGCCAGAATGTGTCGATGCCGGTGGCCCTGGCGCCGACCGGC
CTGACCGGCATGCAGCACGCCGATGGTGAGATGTTGGCGGCGCGCGCCGCCGAGGAGTTCGGCGTTCCCTTCACGCTGTC
GACGATGAGCATCTGCTCGATCGAGGATGTCGCTTCGGTGACGACGCGTCCCTTCTGGTTCCAGCTCTACGTGATGCGGG
ACAAGGATTTCGTCCTTGGGCTGATCAACCGCGCCAAGGCCGCCAAATGCTCGGCACTGGTGCTGACGGCCGATCTGCAG
ATCCTCGGCCAGCGCCACAAGGACCTGCGCAACGGCCTGTCGGCGCCGCCGAGGTTCACCCCGAAGCACATCTGGCAGAT
GGCAAGCCGGCCCTTCTGGTGCCTGGATATGCTTAAGACCAAGCGCCGCACCTTCGGCAACATCATCGGCCACGCGAAAA
ATGTCACCAATATCACCTCGCTCGCCGCATGGACGCACGAGCAGTTCGACCCCCGGCTCTCCTGGGCCGATGTCGCCTGG
ATCAAGGAGCAATGGGGCGGCCCGCTGATCATCAAGGGCGTGCTCGATCCGGAGGACGCGAAGGCAGCCGCCGACACCGG
CGCCGATGCGATCGTCGTCTCCAATCACGGCGGCCGCCAGCTTGACGGCGCCCCTTCCTCGATCAGCATGCTGCCTGCAA
TCGTCGACGCCGTCGGCGACCGCATCGAAGTCCATCTTGACGGCGGCATCCGCTCCGGACAGGACGTCTTGAAGGCCGTG
GCGCTCGGCGCCAAAGGCACCTATATCGGCCGCCCCTTCCTCTACGGCCTCGGCGCCATGGGCAAGGAGGGTGTGACGCT
GGCGCTCGGCATCATCCGCAAGGAGATGGATATTACCATGGCGCTCTGCGGCAAGCGCGACATCAAGCATGTGAATTCGT
CGATCATCGCTGGGCGGCAGTGA

Upstream 100 bases:

>100_bases
TTTCCGCATCGCCGCCGTTGAAGACCTTCGAATTCCCCTCACTCTCCCGCGAATTCCATGTTACGCCGGATAGCCGCATT
CAGATGTGAAGGTTCAATTC

Downstream 100 bases:

>100_bases
CCCTGCTTGAGAAGCCGCTCAGCAGAGCAGCTGCCCATCGGTCGCGTCGAGCAGAAGGATCGCGAAAATCACGAGATAGA
CGGCGAGGGCGAAACGCTGC

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MATPLTIADLKKLAQRRVPKMFFDYADSGAWTESTYAANESDFSGIKLRQRVMVDMTNRTLETTMIGQNVSMPVALAPTG
LTGMQHADGEMLAARAAEEFGVPFTLSTMSICSIEDVASVTTRPFWFQLYVMRDKDFVLGLINRAKAAKCSALVLTADLQ
ILGQRHKDLRNGLSAPPRFTPKHIWQMASRPFWCLDMLKTKRRTFGNIIGHAKNVTNITSLAAWTHEQFDPRLSWADVAW
IKEQWGGPLIIKGVLDPEDAKAAADTGADAIVVSNHGGRQLDGAPSSISMLPAIVDAVGDRIEVHLDGGIRSGQDVLKAV
ALGAKGTYIGRPFLYGLGAMGKEGVTLALGIIRKEMDITMALCGKRDIKHVNSSIIAGRQ

Sequences:

>Translated_380_residues
MATPLTIADLKKLAQRRVPKMFFDYADSGAWTESTYAANESDFSGIKLRQRVMVDMTNRTLETTMIGQNVSMPVALAPTG
LTGMQHADGEMLAARAAEEFGVPFTLSTMSICSIEDVASVTTRPFWFQLYVMRDKDFVLGLINRAKAAKCSALVLTADLQ
ILGQRHKDLRNGLSAPPRFTPKHIWQMASRPFWCLDMLKTKRRTFGNIIGHAKNVTNITSLAAWTHEQFDPRLSWADVAW
IKEQWGGPLIIKGVLDPEDAKAAADTGADAIVVSNHGGRQLDGAPSSISMLPAIVDAVGDRIEVHLDGGIRSGQDVLKAV
ALGAKGTYIGRPFLYGLGAMGKEGVTLALGIIRKEMDITMALCGKRDIKHVNSSIIAGRQ
>Mature_379_residues
ATPLTIADLKKLAQRRVPKMFFDYADSGAWTESTYAANESDFSGIKLRQRVMVDMTNRTLETTMIGQNVSMPVALAPTGL
TGMQHADGEMLAARAAEEFGVPFTLSTMSICSIEDVASVTTRPFWFQLYVMRDKDFVLGLINRAKAAKCSALVLTADLQI
LGQRHKDLRNGLSAPPRFTPKHIWQMASRPFWCLDMLKTKRRTFGNIIGHAKNVTNITSLAAWTHEQFDPRLSWADVAWI
KEQWGGPLIIKGVLDPEDAKAAADTGADAIVVSNHGGRQLDGAPSSISMLPAIVDAVGDRIEVHLDGGIRSGQDVLKAVA
LGAKGTYIGRPFLYGLGAMGKEGVTLALGIIRKEMDITMALCGKRDIKHVNSSIIAGRQ

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=373, Percent_Identity=36.4611260053619, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI54234014, Length=373, Percent_Identity=35.9249329758713, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI7705393, Length=373, Percent_Identity=35.9249329758713, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1790033, Length=373, Percent_Identity=45.8445040214477, Blast_Score=341, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI193208036, Length=375, Percent_Identity=36.2666666666667, Blast_Score=231, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI32566217, Length=290, Percent_Identity=33.1034482758621, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323587, Length=383, Percent_Identity=30.8093994778068, Blast_Score=182, Evalue=6e-47,
Organism=Drosophila melanogaster, GI281363140, Length=373, Percent_Identity=37.5335120643432, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI78707190, Length=373, Percent_Identity=37.5335120643432, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI78707188, Length=373, Percent_Identity=37.5335120643432, Blast_Score=244, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41411; Mature: 41280

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH ; PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPLTIADLKKLAQRRVPKMFFDYADSGAWTESTYAANESDFSGIKLRQRVMVDMTNRT
CCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCE
LETTMIGQNVSMPVALAPTGLTGMQHADGEMLAARAAEEFGVPFTLSTMSICSIEDVASV
EEEEEECCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCHHHHCHHHHHHH
TTRPFWFQLYVMRDKDFVLGLINRAKAAKCSALVLTADLQILGQRHKDLRNGLSAPPRFT
CCCCEEEEEEEEECCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCC
PKHIWQMASRPFWCLDMLKTKRRTFGNIIGHAKNVTNITSLAAWTHEQFDPRLSWADVAW
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
IKEQWGGPLIIKGVLDPEDAKAAADTGADAIVVSNHGGRQLDGAPSSISMLPAIVDAVGD
HHHHCCCCEEEEECCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCC
RIEVHLDGGIRSGQDVLKAVALGAKGTYIGRPFLYGLGAMGKEGVTLALGIIRKEMDITM
EEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCEEEHHHHHHHHHHHH
ALCGKRDIKHVNSSIIAGRQ
HHHCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ATPLTIADLKKLAQRRVPKMFFDYADSGAWTESTYAANESDFSGIKLRQRVMVDMTNRT
CCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCE
LETTMIGQNVSMPVALAPTGLTGMQHADGEMLAARAAEEFGVPFTLSTMSICSIEDVASV
EEEEEECCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCHHHHCHHHHHHH
TTRPFWFQLYVMRDKDFVLGLINRAKAAKCSALVLTADLQILGQRHKDLRNGLSAPPRFT
CCCCEEEEEEEEECCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCC
PKHIWQMASRPFWCLDMLKTKRRTFGNIIGHAKNVTNITSLAAWTHEQFDPRLSWADVAW
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
IKEQWGGPLIIKGVLDPEDAKAAADTGADAIVVSNHGGRQLDGAPSSISMLPAIVDAVGD
HHHHCCCCEEEEECCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCC
RIEVHLDGGIRSGQDVLKAVALGAKGTYIGRPFLYGLGAMGKEGVTLALGIIRKEMDITM
EEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCEEEHHHHHHHHHHHH
ALCGKRDIKHVNSSIIAGRQ
HHHCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA