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The map label for this gene is yeaE [H]

Identifier: 209550113

GI number: 209550113

Start: 2560600

End: 2561448

Strand: Direct

Name: yeaE [H]

Synonym: Rleg2_2530

Alternate gene names: 209550113

Gene position: 2560600-2561448 (Clockwise)

Preceding gene: 209550111

Following gene: 209550116

Centisome position: 56.43

GC content: 63.72

Gene sequence:

>849_bases
ATGCAGGACGACCCAATTCCATTCGTCAGATTTCCGAACGGCGCGGAAGTGCCGGCGCTCGGCCAGGGAACCTGGGCCAT
GGGCGAGGATGCCGGTCATGCCATGGCCGAGATCGAAAGCCTCAAGGCCGGCATAGATCTGGGGATGACACTGATCGACA
CCGCCGAAATGTATGGCGACGGCGGCGCCGAGGAGATCGTCAGCCAAGCGATCAAGGGACGGCGCGACGAGGTCTTCATC
GTCAGCAAGGTCTATCCCTGGAATGCCAGCCTGAAAGGCACGGTGGAAGCCTGCGAGCACAGCCTGGAGCGGCTCGGCAC
CGACCGCATCGATCTCTATCTCCTGCACTGGCGCGGCAGCCATCCGCTGGCCGAGACCGTCGCGGCCTTCGAAATGCTGA
AGGCCTCCGGCAAGATCGGCGCCTGGGGCGTCTCCAACTTCGACACCGGCGACATGGAGGAACTGCTCGGCGTGCCCGAC
GGCGCCAATGTCGCCGCCAACCAGGTACTCTACAACCTCTCCCGCCGCGGCATCGAATTCGACCTTTTGCCCTGGTGCCA
GAGTCGCAGCATTCCGGTCATGGCCTATTCGCCGATTGAGCAGGGGCACATCCTGCATCATCCCGAGTTGATCCGCATCG
CCAAGGCCTATCGGGCAACACCCGCCCAGTTGGCGCTCGCCTTCCTGCTGGAACGCGACGGCGTCATCGTCATCCCGAAA
ACGTCGAATGCCGCCCGCGCGGCTGAGAATCGCGACTGCGTCTCGCTTGAGATCACCGACGAGGACTGGCAGGCGCTCGA
CGCCGCCTTCCCGCCGCCGGAAAAGAAAAAGCCGCTGGAGATGCTCTGA

Upstream 100 bases:

>100_bases
TAACTGCCCTAAATCACCGATGCCATTACATCATTGTCATGGTGACAGGATTACTTGAAAGATGGCGACGCGGCCCAATC
TCTCTCCCAGGAAAAAACCC

Downstream 100 bases:

>100_bases
ACTCCAGCGGCTTTCAGCACTATTGTGGTGCCCGGCTTACATGCCCTGCGCGCCGCGGTTCATCGCGGCGATGCCGGTGC
GGCAGACCTCGATCAGCCCC

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MQDDPIPFVRFPNGAEVPALGQGTWAMGEDAGHAMAEIESLKAGIDLGMTLIDTAEMYGDGGAEEIVSQAIKGRRDEVFI
VSKVYPWNASLKGTVEACEHSLERLGTDRIDLYLLHWRGSHPLAETVAAFEMLKASGKIGAWGVSNFDTGDMEELLGVPD
GANVAANQVLYNLSRRGIEFDLLPWCQSRSIPVMAYSPIEQGHILHHPELIRIAKAYRATPAQLALAFLLERDGVIVIPK
TSNAARAAENRDCVSLEITDEDWQALDAAFPPPEKKKPLEML

Sequences:

>Translated_282_residues
MQDDPIPFVRFPNGAEVPALGQGTWAMGEDAGHAMAEIESLKAGIDLGMTLIDTAEMYGDGGAEEIVSQAIKGRRDEVFI
VSKVYPWNASLKGTVEACEHSLERLGTDRIDLYLLHWRGSHPLAETVAAFEMLKASGKIGAWGVSNFDTGDMEELLGVPD
GANVAANQVLYNLSRRGIEFDLLPWCQSRSIPVMAYSPIEQGHILHHPELIRIAKAYRATPAQLALAFLLERDGVIVIPK
TSNAARAAENRDCVSLEITDEDWQALDAAFPPPEKKKPLEML
>Mature_282_residues
MQDDPIPFVRFPNGAEVPALGQGTWAMGEDAGHAMAEIESLKAGIDLGMTLIDTAEMYGDGGAEEIVSQAIKGRRDEVFI
VSKVYPWNASLKGTVEACEHSLERLGTDRIDLYLLHWRGSHPLAETVAAFEMLKASGKIGAWGVSNFDTGDMEELLGVPD
GANVAANQVLYNLSRRGIEFDLLPWCQSRSIPVMAYSPIEQGHILHHPELIRIAKAYRATPAQLALAFLLERDGVIVIPK
TSNAARAAENRDCVSLEITDEDWQALDAAFPPPEKKKPLEML

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI223468663, Length=294, Percent_Identity=29.9319727891156, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI310109922, Length=288, Percent_Identity=30.2083333333333, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI24497585, Length=302, Percent_Identity=30.4635761589404, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI5453543, Length=308, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI24497583, Length=302, Percent_Identity=29.1390728476821, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI310109920, Length=308, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI45446745, Length=308, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4503285, Length=308, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4502049, Length=292, Percent_Identity=32.5342465753425, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI24497577, Length=294, Percent_Identity=27.2108843537415, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI5174391, Length=294, Percent_Identity=27.2108843537415, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI291291012, Length=276, Percent_Identity=28.6231884057971, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI5174695, Length=296, Percent_Identity=27.7027027027027, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI300116273, Length=278, Percent_Identity=28.4172661870504, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI41327764, Length=169, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI27436969, Length=291, Percent_Identity=27.1477663230241, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI4504825, Length=291, Percent_Identity=27.1477663230241, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1788081, Length=280, Percent_Identity=50, Blast_Score=291, Evalue=3e-80,
Organism=Escherichia coli, GI1786400, Length=258, Percent_Identity=29.8449612403101, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788070, Length=302, Percent_Identity=29.1390728476821, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87082198, Length=254, Percent_Identity=31.1023622047244, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI87081735, Length=297, Percent_Identity=25.2525252525253, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789375, Length=216, Percent_Identity=30.0925925925926, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1787674, Length=247, Percent_Identity=24.2914979757085, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71998625, Length=273, Percent_Identity=29.3040293040293, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17552492, Length=268, Percent_Identity=31.3432835820896, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17564128, Length=313, Percent_Identity=30.0319488817891, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17561298, Length=284, Percent_Identity=29.2253521126761, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17566692, Length=303, Percent_Identity=25.7425742574257, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17561300, Length=268, Percent_Identity=28.7313432835821, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17538386, Length=281, Percent_Identity=26.6903914590747, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17550248, Length=300, Percent_Identity=26.3333333333333, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17537075, Length=295, Percent_Identity=27.1186440677966, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17537077, Length=295, Percent_Identity=26.7796610169492, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320576, Length=283, Percent_Identity=29.6819787985866, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6322556, Length=270, Percent_Identity=26.6666666666667, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6320079, Length=276, Percent_Identity=26.4492753623188, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24663317, Length=314, Percent_Identity=28.6624203821656, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24644950, Length=304, Percent_Identity=30.9210526315789, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24662789, Length=304, Percent_Identity=30.9210526315789, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI45553081, Length=288, Percent_Identity=26.0416666666667, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21356425, Length=301, Percent_Identity=26.9102990033223, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI20129731, Length=290, Percent_Identity=28.9655172413793, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24657054, Length=303, Percent_Identity=27.3927392739274, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI281366140, Length=248, Percent_Identity=26.2096774193548, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24662781, Length=295, Percent_Identity=29.8305084745763, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24662785, Length=294, Percent_Identity=28.2312925170068, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 30848; Mature: 30848

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDDPIPFVRFPNGAEVPALGQGTWAMGEDAGHAMAEIESLKAGIDLGMTLIDTAEMYGD
CCCCCCCEEECCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHCHHCCHHHHHHHHHHCC
GGAEEIVSQAIKGRRDEVFIVSKVYPWNASLKGTVEACEHSLERLGTDRIDLYLLHWRGS
CCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCC
HPLAETVAAFEMLKASGKIGAWGVSNFDTGDMEELLGVPDGANVAANQVLYNLSRRGIEF
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCEE
DLLPWCQSRSIPVMAYSPIEQGHILHHPELIRIAKAYRATPAQLALAFLLERDGVIVIPK
EECCCCCCCCCCEEEECCCCCCCEECCHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEC
TSNAARAAENRDCVSLEITDEDWQALDAAFPPPEKKKPLEML
CCCHHHHCCCCCEEEEEEECCHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQDDPIPFVRFPNGAEVPALGQGTWAMGEDAGHAMAEIESLKAGIDLGMTLIDTAEMYGD
CCCCCCCEEECCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHCHHCCHHHHHHHHHHCC
GGAEEIVSQAIKGRRDEVFIVSKVYPWNASLKGTVEACEHSLERLGTDRIDLYLLHWRGS
CCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCC
HPLAETVAAFEMLKASGKIGAWGVSNFDTGDMEELLGVPDGANVAANQVLYNLSRRGIEF
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCEE
DLLPWCQSRSIPVMAYSPIEQGHILHHPELIRIAKAYRATPAQLALAFLLERDGVIVIPK
EECCCCCCCCCCEEEECCCCCCCEECCHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEC
TSNAARAAENRDCVSLEITDEDWQALDAAFPPPEKKKPLEML
CCCHHHHCCCCCEEEEEEECCHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]