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The map label for this gene is adhc1 [H]

Identifier: 209550082

GI number: 209550082

Start: 2532164

End: 2533210

Strand: Direct

Name: adhc1 [H]

Synonym: Rleg2_2499

Alternate gene names: 209550082

Gene position: 2532164-2533210 (Clockwise)

Preceding gene: 209550077

Following gene: 209550089

Centisome position: 55.8

GC content: 60.94

Gene sequence:

>1047_bases
ATGGCTATCGCAAAAGGCTATGCCGCAACCGACGCGTCGCAACCGCTGACCCCCTTCACCTTCGAGCGCCGCGAACCCAA
TGATGACGACGTCGTCATCGCAGTTCAATATTGCGGCGTCTGCCACTCCGACATTCACCAGGCCCGCAACGAGTGGGGCA
ATTCCATATTCCCGATGGTACCGGGCCACGAGGTCGCCGGCGTGGTTTCCGCCGTCGGCTCCAAGGTGACGAAATTCAAG
GTCGGCGACCGCGTCGGCGTCGGCTGCTTCGTCGCTTCCTGCGTCGGCTGCGCCACGCGGGATCTGGATTACGAGCACTA
CATGCCGGGCCTCGTCCCGACCTATAACGGCTATGAAGCGGATGGCACGACCCCGACTTTCGGCGGCTACTCCGACTCGA
TCGTCGTTAAGGAAGGTTATGTGCTGCGCTTCCCCGACAATATTCCGCTCGATTCCGGCGCCCCGCTGCTTTGCGCCGGT
ATCACGCTTTATTCGCCGCTCGCGCATTGGAAGGCCGGCCCCGGCAAGAAGATCGCGATCGTCGGCATGGGCGGTCTCGG
CCATATGGGCGTGAAGATCGGTGCTGCCATGGGCGCCGACATCACCGTCCTCTCCCAATCGCTGTCGAAGAAGGAAGACG
GCCTCAAGCTCGGCGCCAAGGACTATTATGCAACGAGCGACGCTGAGACCTTCACCAAGCTCGCCGGCACCTTCGACCTG
ATCATCAACACGGTCGGCACCACAATCGACTGGAACGCCTATCTCAACCTGCTGAAGTCTGACGGCACGATGGTTCTGGT
CGGCGTTCCCGAGCATCCGGTTCCGGTCCACGCCTTCTCGGTCATCGGCGGGCGCAAGAGCCTGGCGGGCTCGATGATCG
GCTCGATCAAGGAAACCCAGGAAATGCTCGACTTCTGCGGCAAGCACAACATCGTCTCGGAGATCGAGAAGATCGACATC
CAGAATATCAACGAAGCCTATGAGCGGGTCGTCAAGAGCGACGTCCGCTACCGCTTCGTCATCGATATTGCCTCGCTGGC
GGCTTGA

Upstream 100 bases:

>100_bases
GTGCAAGAAGCTGAGAGGATCACTCTAACGCCCTTGCCAGCATCCGGGCAATAGTCCGCCATCCCGCTCAACCCCTCCCA
ACCCCAAAAGGAAGCTTCAG

Downstream 100 bases:

>100_bases
GGAATGAGAGGCGGCTCCTTCGGGGGCCGCCCCGCATGGGCGACTAGATCGGCCTCCAGCGAAGCCACAACTTCCGACCA
GGGGACTGGATCGAGACGGC

Product: alcohol dehydrogenase zinc-binding domain-containing protein

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MAIAKGYAATDASQPLTPFTFERREPNDDDVVIAVQYCGVCHSDIHQARNEWGNSIFPMVPGHEVAGVVSAVGSKVTKFK
VGDRVGVGCFVASCVGCATRDLDYEHYMPGLVPTYNGYEADGTTPTFGGYSDSIVVKEGYVLRFPDNIPLDSGAPLLCAG
ITLYSPLAHWKAGPGKKIAIVGMGGLGHMGVKIGAAMGADITVLSQSLSKKEDGLKLGAKDYYATSDAETFTKLAGTFDL
IINTVGTTIDWNAYLNLLKSDGTMVLVGVPEHPVPVHAFSVIGGRKSLAGSMIGSIKETQEMLDFCGKHNIVSEIEKIDI
QNINEAYERVVKSDVRYRFVIDIASLAA

Sequences:

>Translated_348_residues
MAIAKGYAATDASQPLTPFTFERREPNDDDVVIAVQYCGVCHSDIHQARNEWGNSIFPMVPGHEVAGVVSAVGSKVTKFK
VGDRVGVGCFVASCVGCATRDLDYEHYMPGLVPTYNGYEADGTTPTFGGYSDSIVVKEGYVLRFPDNIPLDSGAPLLCAG
ITLYSPLAHWKAGPGKKIAIVGMGGLGHMGVKIGAAMGADITVLSQSLSKKEDGLKLGAKDYYATSDAETFTKLAGTFDL
IINTVGTTIDWNAYLNLLKSDGTMVLVGVPEHPVPVHAFSVIGGRKSLAGSMIGSIKETQEMLDFCGKHNIVSEIEKIDI
QNINEAYERVVKSDVRYRFVIDIASLAA
>Mature_347_residues
AIAKGYAATDASQPLTPFTFERREPNDDDVVIAVQYCGVCHSDIHQARNEWGNSIFPMVPGHEVAGVVSAVGSKVTKFKV
GDRVGVGCFVASCVGCATRDLDYEHYMPGLVPTYNGYEADGTTPTFGGYSDSIVVKEGYVLRFPDNIPLDSGAPLLCAGI
TLYSPLAHWKAGPGKKIAIVGMGGLGHMGVKIGAAMGADITVLSQSLSKKEDGLKLGAKDYYATSDAETFTKLAGTFDLI
INTVGTTIDWNAYLNLLKSDGTMVLVGVPEHPVPVHAFSVIGGRKSLAGSMIGSIKETQEMLDFCGKHNIVSEIEKIDIQ
NINEAYERVVKSDVRYRFVIDIASLAA

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI262073058, Length=290, Percent_Identity=28.6206896551724, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI71743840, Length=290, Percent_Identity=28.6206896551724, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4501933, Length=366, Percent_Identity=26.5027322404372, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI34577061, Length=351, Percent_Identity=26.7806267806268, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4501939, Length=356, Percent_Identity=26.4044943820225, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI156523966, Length=356, Percent_Identity=26.4044943820225, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1786518, Length=344, Percent_Identity=50, Blast_Score=316, Evalue=1e-87,
Organism=Escherichia coli, GI87082401, Length=347, Percent_Identity=34.5821325648415, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI87081918, Length=324, Percent_Identity=25, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788073, Length=263, Percent_Identity=30.7984790874525, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1788075, Length=312, Percent_Identity=25.3205128205128, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI226510992, Length=269, Percent_Identity=26.3940520446097, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788407, Length=207, Percent_Identity=26.5700483091787, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=333, Percent_Identity=24.3243243243243, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17562584, Length=338, Percent_Identity=26.3313609467456, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17562582, Length=330, Percent_Identity=26.3636363636364, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17562876, Length=338, Percent_Identity=23.6686390532544, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=186, Percent_Identity=28.494623655914, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=366, Percent_Identity=24.0437158469945, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71997431, Length=368, Percent_Identity=24.1847826086957, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=320, Percent_Identity=40.9375, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6319949, Length=347, Percent_Identity=33.4293948126801, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6319621, Length=328, Percent_Identity=30.4878048780488, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6323961, Length=328, Percent_Identity=30.4878048780488, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324486, Length=328, Percent_Identity=29.8780487804878, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6323729, Length=330, Percent_Identity=30.9090909090909, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319258, Length=338, Percent_Identity=26.3313609467456, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=361, Percent_Identity=25.7617728531856, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=320, Percent_Identity=26.875, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=320, Percent_Identity=26.875, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=259, Percent_Identity=25.0965250965251, Blast_Score=62, Evalue=1e-10,
Organism=Drosophila melanogaster, GI17137530, Length=212, Percent_Identity=30.188679245283, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17737897, Length=224, Percent_Identity=29.9107142857143, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 37179; Mature: 37048

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIAKGYAATDASQPLTPFTFERREPNDDDVVIAVQYCGVCHSDIHQARNEWGNSIFPMV
CCCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEEHHCCHHHHHHHHHHHHCCEECCCC
PGHEVAGVVSAVGSKVTKFKVGDRVGVGCFVASCVGCATRDLDYEHYMPGLVPTYNGYEA
CCHHHHHHHHHHCCHHEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEC
DGTTPTFGGYSDSIVVKEGYVLRFPDNIPLDSGAPLLCAGITLYSPLAHWKAGPGKKIAI
CCCCCCCCCCCCCEEEECCEEEECCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCEEEE
VGMGGLGHMGVKIGAAMGADITVLSQSLSKKEDGLKLGAKDYYATSDAETFTKLAGTFDL
EEECCCCCCCEEEHHHCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHH
IINTVGTTIDWNAYLNLLKSDGTMVLVGVPEHPVPVHAFSVIGGRKSLAGSMIGSIKETQ
HHHHHCCEEEHHHHHHHEECCCCEEEEECCCCCCCEEHEEECCCHHHHHHHHHHHHHHHH
EMLDFCGKHNIVSEIEKIDIQNINEAYERVVKSDVRYRFVIDIASLAA
HHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEHHHHCC
>Mature Secondary Structure 
AIAKGYAATDASQPLTPFTFERREPNDDDVVIAVQYCGVCHSDIHQARNEWGNSIFPMV
CCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEEHHCCHHHHHHHHHHHHCCEECCCC
PGHEVAGVVSAVGSKVTKFKVGDRVGVGCFVASCVGCATRDLDYEHYMPGLVPTYNGYEA
CCHHHHHHHHHHCCHHEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEC
DGTTPTFGGYSDSIVVKEGYVLRFPDNIPLDSGAPLLCAGITLYSPLAHWKAGPGKKIAI
CCCCCCCCCCCCCEEEECCEEEECCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCEEEE
VGMGGLGHMGVKIGAAMGADITVLSQSLSKKEDGLKLGAKDYYATSDAETFTKLAGTFDL
EEECCCCCCCEEEHHHCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHH
IINTVGTTIDWNAYLNLLKSDGTMVLVGVPEHPVPVHAFSVIGGRKSLAGSMIGSIKETQ
HHHHHCCEEEHHHHHHHEECCCCEEEEECCCCCCCEEHEEECCCHHHHHHHHHHHHHHHH
EMLDFCGKHNIVSEIEKIDIQNINEAYERVVKSDVRYRFVIDIASLAA
HHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]