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The map label for this gene is sopA [H]

Identifier: 209400535

GI number: 209400535

Start: 1520091

End: 1522439

Strand: Direct

Name: sopA [H]

Synonym: ECH74115_1558

Alternate gene names: 209400535

Gene position: 1520091-1522439 (Clockwise)

Preceding gene: 209396117

Following gene: 209396457

Centisome position: 27.28

GC content: 35.46

Gene sequence:

>2349_bases
ATGCTGCCCACTACAAATATCTCTGTAAATTCTGGAGTAATATCTTTTGAAAGTCCTGTAGATTCACCATCTAACGAGGA
TGTTGAAGTTGCCCTCGAAAAGTGGTGTGCTGAGGGAGAATTTAGCGAAAATCGTCATGAGGTTGCATCAAAAATACTTG
ATGTTATAAGTACTAATGGAGAGACTTTATCAATCAGTGAGCCAATAACAACATTACCAGACTTGCTTCCAGGTTCTCTG
AAAGAACTGGTTTTGAATGGATGTACAGAGCTTAAATCAATAAACTGCTTACCCCCCAACTTATCTTCATTAAGTATGGT
TGGATGCTCATCATTAGAGGTTATAAATTGCAGCATACCTGAAAATGTCATTAATTTATCTTTATGCCATTGTAGTTCTT
TGAAACATATAGAAGGTTCCTTTCCTGAGGCACTCAGAAATTCCGTATATTTAAATGGCTGTAATTCATTAAATGAATCG
CAATGTCAATTCCTTGCATATGATGTCAGTCAAGGCCGTGCCTGCCTGAGCAAAGCTGAGCTTACTGCTGACTTAATTTG
GTTGTCAGCTAACCGAACGGGTGAAGAGTCTGCTGAAGAATTGAATTACTCTGGATGTGACTTGTCAGGTCTAAGTCTTG
TAGGGCTGAATTTATCATCAGTAAATTTTTCTGGAGCAGTGCTTGATGATACAGATCTCAGGATGAGTGATTTGTCTCAG
GCTGTATTGGAAAACTGTTCTTTTAAAAACTCGATTTTGAATGAATGTAATTTTTGTTATGCTAATTTATCTAATTGTAT
TATTAGGGCTTTGTTTGAAAACTCTAATTTCAGCAATTCCAATCTTAAAAATGCATCATTTAAAGGATCTTCATATATAC
AATATCCTCCAATTTTGAACGAGGCTGATTTAACAGGAGCTATTATAATTCCTGGAATGGTTTTAAGTGGTGCTATCTTA
GGTGATGTAAAGGAGCTCTTTAGTGAAAAAAGTAATACCATTAATCTAGGAGGGTGTTACATAGATCTATCTGACATACA
GGAAAATATATTATCTGTGTTGGATAACTATACAAAATCAAATAAATCAATTTTATTGACTATGAATACATCTGATGATA
AGTATAACCATGATAAAGTAAGGGCCGCTGAAGAACTTATCAAAAAAATATCTCTTGACGAATTAGCGGCGTTCCGGCCC
TATGTTAAGATGTCTTTGGCTGATTCATTTAGTATTCATCCTTATTTGAACAACGCAAATATACAGCAATGGCTCGAGCC
TATATGTGATGACTTTTTTGATACTATAATGTCTTGGTTTAATAATTCAATAATGATGTATATGGAGAATGGTAGTTTAT
TGCAGGCAGGGATGTATTTTGAGCGACATCCAGGTGCGATGGTATCTTATAATAGTTCCTTTATACAAATTGTAATGAAT
GGTTCACGGCGTGATGGAATGCAGGAACGATTTAGGGAACTCTATGAAGTATATTTAAAAAATGAAAAAGTTTATCCTGT
CACACAGCAGAGTGATTTTGGATTGTGCGATGGCTCTGGGAAGCCTGACTGGGATGATGATTCCGATTTGGCTTATAACT
GGGTTTTGTTATCATCACAGGATGATGGTATGGCAATGATGTGTTCTTTGAGTCATATGGTTGATATGTTATCTCCTAAT
ACATCAACTAATTGGATGTCCTTTTTTTTATATAAGGATGGAGAAGTTCAAAATACATTTGGGTATTCATTGAGCAATCT
TTTTTCTGAATCATTTCCAATTTTCAGTATTCCTTATCATAAAGCTTTTTCCCAGAATTTCGTTTCTGGTATTCTGGATA
TACTCATTTCTGATAATGAACTCAAAGAGAGATTTATTGAGGCACTTAATTCCAATAAATCAGATTATAAAATGATTGCT
GATGATCAGCAAAGGAAACTTGCCTGTGTCTGGAATCCCTTTCTTGATGGTTGGGAACTGAACGCTCAGCATGTAGATAT
GATTATGGGGAGCCATGTATTGAAAGATATGCCACTAAGAAAACAGGCTGAAATATTATTTTGTTTAGGGGGGGTTTTCT
GTAAATACTCATCGAGTGATATGTTTGGTACAGAGTATGATTCTCCTGAGATTCTACGGAGATATGCAAATGGATTGATT
GAACAAGCTTATAAAACAGATCCTCAGGTATTTGGCTCAGTTTATTATTACAATGATATTTTAGACAGGCTACAAGGAAG
AAATAATGTTTTTACTTGTACCGCTGTGCTGACTGATATGCTAACGGAGCATGCAAAAGAATCTTTTCCTGAAATATTTT
CATTGTATTATCCTGTTGCGTGGCGTTGA

Upstream 100 bases:

>100_bases
AATCTGACATCTTATTTGTGGGTACAGGGACAGAAAGTTGTCCCGGCAGTTGTGTTTTCTAATTTTACTTTAGTGGACTA
AGTAAAAAGGAGTGAGATAA

Downstream 100 bases:

>100_bases
TTTAGAGACCATGGATGAATATTATTGTAACACTGTCTTTTTAGGTTTGCACATGTTCAGTGGGAACATTTATTGCTCCG
TTGTTATTATGTCTTGGTTT

Product: hypothetical protein

Products: NA

Alternate protein names: Salmonella outer protein A; Secreted effector protein SopA [H]

Number of amino acids: Translated: 782; Mature: 782

Protein sequence:

>782_residues
MLPTTNISVNSGVISFESPVDSPSNEDVEVALEKWCAEGEFSENRHEVASKILDVISTNGETLSISEPITTLPDLLPGSL
KELVLNGCTELKSINCLPPNLSSLSMVGCSSLEVINCSIPENVINLSLCHCSSLKHIEGSFPEALRNSVYLNGCNSLNES
QCQFLAYDVSQGRACLSKAELTADLIWLSANRTGEESAEELNYSGCDLSGLSLVGLNLSSVNFSGAVLDDTDLRMSDLSQ
AVLENCSFKNSILNECNFCYANLSNCIIRALFENSNFSNSNLKNASFKGSSYIQYPPILNEADLTGAIIIPGMVLSGAIL
GDVKELFSEKSNTINLGGCYIDLSDIQENILSVLDNYTKSNKSILLTMNTSDDKYNHDKVRAAEELIKKISLDELAAFRP
YVKMSLADSFSIHPYLNNANIQQWLEPICDDFFDTIMSWFNNSIMMYMENGSLLQAGMYFERHPGAMVSYNSSFIQIVMN
GSRRDGMQERFRELYEVYLKNEKVYPVTQQSDFGLCDGSGKPDWDDDSDLAYNWVLLSSQDDGMAMMCSLSHMVDMLSPN
TSTNWMSFFLYKDGEVQNTFGYSLSNLFSESFPIFSIPYHKAFSQNFVSGILDILISDNELKERFIEALNSNKSDYKMIA
DDQQRKLACVWNPFLDGWELNAQHVDMIMGSHVLKDMPLRKQAEILFCLGGVFCKYSSSDMFGTEYDSPEILRRYANGLI
EQAYKTDPQVFGSVYYYNDILDRLQGRNNVFTCTAVLTDMLTEHAKESFPEIFSLYYPVAWR

Sequences:

>Translated_782_residues
MLPTTNISVNSGVISFESPVDSPSNEDVEVALEKWCAEGEFSENRHEVASKILDVISTNGETLSISEPITTLPDLLPGSL
KELVLNGCTELKSINCLPPNLSSLSMVGCSSLEVINCSIPENVINLSLCHCSSLKHIEGSFPEALRNSVYLNGCNSLNES
QCQFLAYDVSQGRACLSKAELTADLIWLSANRTGEESAEELNYSGCDLSGLSLVGLNLSSVNFSGAVLDDTDLRMSDLSQ
AVLENCSFKNSILNECNFCYANLSNCIIRALFENSNFSNSNLKNASFKGSSYIQYPPILNEADLTGAIIIPGMVLSGAIL
GDVKELFSEKSNTINLGGCYIDLSDIQENILSVLDNYTKSNKSILLTMNTSDDKYNHDKVRAAEELIKKISLDELAAFRP
YVKMSLADSFSIHPYLNNANIQQWLEPICDDFFDTIMSWFNNSIMMYMENGSLLQAGMYFERHPGAMVSYNSSFIQIVMN
GSRRDGMQERFRELYEVYLKNEKVYPVTQQSDFGLCDGSGKPDWDDDSDLAYNWVLLSSQDDGMAMMCSLSHMVDMLSPN
TSTNWMSFFLYKDGEVQNTFGYSLSNLFSESFPIFSIPYHKAFSQNFVSGILDILISDNELKERFIEALNSNKSDYKMIA
DDQQRKLACVWNPFLDGWELNAQHVDMIMGSHVLKDMPLRKQAEILFCLGGVFCKYSSSDMFGTEYDSPEILRRYANGLI
EQAYKTDPQVFGSVYYYNDILDRLQGRNNVFTCTAVLTDMLTEHAKESFPEIFSLYYPVAWR
>Mature_782_residues
MLPTTNISVNSGVISFESPVDSPSNEDVEVALEKWCAEGEFSENRHEVASKILDVISTNGETLSISEPITTLPDLLPGSL
KELVLNGCTELKSINCLPPNLSSLSMVGCSSLEVINCSIPENVINLSLCHCSSLKHIEGSFPEALRNSVYLNGCNSLNES
QCQFLAYDVSQGRACLSKAELTADLIWLSANRTGEESAEELNYSGCDLSGLSLVGLNLSSVNFSGAVLDDTDLRMSDLSQ
AVLENCSFKNSILNECNFCYANLSNCIIRALFENSNFSNSNLKNASFKGSSYIQYPPILNEADLTGAIIIPGMVLSGAIL
GDVKELFSEKSNTINLGGCYIDLSDIQENILSVLDNYTKSNKSILLTMNTSDDKYNHDKVRAAEELIKKISLDELAAFRP
YVKMSLADSFSIHPYLNNANIQQWLEPICDDFFDTIMSWFNNSIMMYMENGSLLQAGMYFERHPGAMVSYNSSFIQIVMN
GSRRDGMQERFRELYEVYLKNEKVYPVTQQSDFGLCDGSGKPDWDDDSDLAYNWVLLSSQDDGMAMMCSLSHMVDMLSPN
TSTNWMSFFLYKDGEVQNTFGYSLSNLFSESFPIFSIPYHKAFSQNFVSGILDILISDNELKERFIEALNSNKSDYKMIA
DDQQRKLACVWNPFLDGWELNAQHVDMIMGSHVLKDMPLRKQAEILFCLGGVFCKYSSSDMFGTEYDSPEILRRYANGLI
EQAYKTDPQVFGSVYYYNDILDRLQGRNNVFTCTAVLTDMLTEHAKESFPEIFSLYYPVAWR

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Host cell (By similarity). Note=Secreted via type III secretion system 1 (SPI-1 TTSS), and delivered into the host cell (By similarity) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SopA E3 ligase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 87548; Mature: 87548

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPTTNISVNSGVISFESPVDSPSNEDVEVALEKWCAEGEFSENRHEVASKILDVISTNG
CCCCCCEEECCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
ETLSISEPITTLPDLLPGSLKELVLNGCTELKSINCLPPNLSSLSMVGCSSLEVINCSIP
CEEEECCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEECCCC
ENVINLSLCHCSSLKHIEGSFPEALRNSVYLNGCNSLNESQCQFLAYDVSQGRACLSKAE
CHHHEEEEHHCCCCHHCCCCCHHHHHCCEEEECCCCCCCCCCEEEEEEHHCCHHHHHHHH
LTADLIWLSANRTGEESAEELNYSGCDLSGLSLVGLNLSSVNFSGAVLDDTDLRMSDLSQ
HEEEEEEEECCCCCCHHHHHCCCCCCCCCCCEEEEEEEECCCCCCEEECCCCCCHHHHHH
AVLENCSFKNSILNECNFCYANLSNCIIRALFENSNFSNSNLKNASFKGSSYIQYPPILN
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCC
EADLTGAIIIPGMVLSGAILGDVKELFSEKSNTINLGGCYIDLSDIQENILSVLDNYTKS
CCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCEEEECEEEEEHHHHHHHHHHHHHHHCCC
NKSILLTMNTSDDKYNHDKVRAAEELIKKISLDELAAFRPYVKMSLADSFSIHPYLNNAN
CCEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCHHEEECCCCCEECEEECCCC
IQQWLEPICDDFFDTIMSWFNNSIMMYMENGSLLQAGMYFERHPGAMVSYNSSFIQIVMN
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCEEEECCCEEEEEEC
GSRRDGMQERFRELYEVYLKNEKVYPVTQQSDFGLCDGSGKPDWDDDSDLAYNWVLLSSQ
CCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECC
DDGMAMMCSLSHMVDMLSPNTSTNWMSFFLYKDGEVQNTFGYSLSNLFSESFPIFSIPYH
CCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHCHHHHHHHHCCCCEEECCHH
KAFSQNFVSGILDILISDNELKERFIEALNSNKSDYKMIADDQQRKLACVWNPFLDGWEL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEECCCCCCCCC
NAQHVDMIMGSHVLKDMPLRKQAEILFCLGGVFCKYSSSDMFGTEYDSPEILRRYANGLI
CHHHHHHHHHHHHHHCCCCCHHHHHHEEEHHHHEECCCCCCCCCCCCCHHHHHHHHHHHH
EQAYKTDPQVFGSVYYYNDILDRLQGRNNVFTCTAVLTDMLTEHAKESFPEIFSLYYPVA
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
WR
CC
>Mature Secondary Structure
MLPTTNISVNSGVISFESPVDSPSNEDVEVALEKWCAEGEFSENRHEVASKILDVISTNG
CCCCCCEEECCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
ETLSISEPITTLPDLLPGSLKELVLNGCTELKSINCLPPNLSSLSMVGCSSLEVINCSIP
CEEEECCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEECCCC
ENVINLSLCHCSSLKHIEGSFPEALRNSVYLNGCNSLNESQCQFLAYDVSQGRACLSKAE
CHHHEEEEHHCCCCHHCCCCCHHHHHCCEEEECCCCCCCCCCEEEEEEHHCCHHHHHHHH
LTADLIWLSANRTGEESAEELNYSGCDLSGLSLVGLNLSSVNFSGAVLDDTDLRMSDLSQ
HEEEEEEEECCCCCCHHHHHCCCCCCCCCCCEEEEEEEECCCCCCEEECCCCCCHHHHHH
AVLENCSFKNSILNECNFCYANLSNCIIRALFENSNFSNSNLKNASFKGSSYIQYPPILN
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCC
EADLTGAIIIPGMVLSGAILGDVKELFSEKSNTINLGGCYIDLSDIQENILSVLDNYTKS
CCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCEEEECEEEEEHHHHHHHHHHHHHHHCCC
NKSILLTMNTSDDKYNHDKVRAAEELIKKISLDELAAFRPYVKMSLADSFSIHPYLNNAN
CCEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCHHEEECCCCCEECEEECCCC
IQQWLEPICDDFFDTIMSWFNNSIMMYMENGSLLQAGMYFERHPGAMVSYNSSFIQIVMN
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCEEEECCCEEEEEEC
GSRRDGMQERFRELYEVYLKNEKVYPVTQQSDFGLCDGSGKPDWDDDSDLAYNWVLLSSQ
CCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECC
DDGMAMMCSLSHMVDMLSPNTSTNWMSFFLYKDGEVQNTFGYSLSNLFSESFPIFSIPYH
CCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHCHHHHHHHHCCCCEEECCHH
KAFSQNFVSGILDILISDNELKERFIEALNSNKSDYKMIADDQQRKLACVWNPFLDGWEL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEECCCCCCCCC
NAQHVDMIMGSHVLKDMPLRKQAEILFCLGGVFCKYSSSDMFGTEYDSPEILRRYANGLI
CHHHHHHHHHHHHHHCCCCCHHHHHHEEEHHHHEECCCCCCCCCCCCCHHHHHHHHHHHH
EQAYKTDPQVFGSVYYYNDILDRLQGRNNVFTCTAVLTDMLTEHAKESFPEIFSLYYPVA
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
WR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA