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The map label for this gene is tdh [H]

Identifier: 209400006

GI number: 209400006

Start: 4640257

End: 4641282

Strand: Reverse

Name: tdh [H]

Synonym: ECH74115_4989

Alternate gene names: 209400006

Gene position: 4641282-4640257 (Counterclockwise)

Preceding gene: 209396702

Following gene: 209398528

Centisome position: 83.3

GC content: 52.24

Gene sequence:

>1026_bases
ATGAAAGCGTTATCCAAACTGAAAGCGGAAGAGGGCATCTGGATGACCGACGTTCCTGTACCGGAACTCGGGCATAACGA
TCTGCTGATTAAAATCCGTAAAACAGCCATCTGCGGGACTGACGTTCACATCTATAACTGGGATGAGTGGTCGCAAAAAA
CCATCCCGGTGCCGATGGTCGTAGGCCATGAATATGTCGGTGAAGTGGTAGGTATTGGTCAGGAAGTGAAAGGCTTCAAA
ATCGGCGATCGCGTTTCTGGCGAAGGCCATATCACCTGCGGTCACTGTCGCAACTGTCGTGGCGGTCGTACCCATCTGTG
CCGCAACACCATTGGTGTCGGTGTTAACCGTCCGGGCTGCTTCGCCGAATATCTGGTGATTCCGGCGTTCAACGCTTTCA
AAATCCCCGACAATATCTCCGACGACCTGGCTTCCATTTTTGATCCCTTCGGTAACGCCGTGCATACCGCGCTGTCGTTC
GATCTGGTGGGCGAAGATGTGCTGGTTTCTGGTGCAGGTCCGATAGGTATTATGGCTGCGGCGGTGGCGAAACACGTTGG
TGCACGCAATGTGGTGATCACCGATGTTAACGAATACCGCCTTGAGCTGGCGCGCAAAATGGGTATCACCCGTGCGGTTA
ACGTCGCGAAAGAAAACCTTAATGATGTGATGGCTGAACTGGGCATGACCGAAGGCTTTGATGTCGGTCTGGAAATGTCC
GGCGCGCCGCCAGCGTTTCGTACCATGCTCGATACCATGAACCACGGCGGTCGTATTGCGATGCTGGGTATTCCACCGTC
TGACATGTCTATCGACTGGACCAAAGTGATCTTTAAAGGCTTGTTCATTAAAGGCATTTACGGTCGTGAGATGTTTGAAA
CCTGGTACAAGATGGCGGCGCTGATTCAGTCTGGCCTCGATCTCTCGCCGATCATTACCCATCGTTTCTCTATCGATGAT
TTCCAGAAGGGCTTTGACGCTATGTGTTCGGGCCAGTCCGGGAAAGTTATTCTGAGCTGGGATTAA

Upstream 100 bases:

>100_bases
CCAGATGTCTGCGGCGCATACCCCTGAGCAAATTACGCGTGCAGTAGAAGCATTCACGCGTATTGGTAAACAACTGGGCG
TTATCGCCTGAGGATGTGAG

Downstream 100 bases:

>100_bases
CACGAAAAAGGGCTGGTATTCCAGCCCTTTTGCCTGAGGATAATCTGTTAAATATGTAAAATCCTGTCAGTGTAATAAAG
AGTTCGTAATTGCGCTGATC

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKALSKLKAEEGIWMTDVPVPELGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFK
IGDRVSGEGHITCGHCRNCRGGRTHLCRNTIGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGIMAAAVAKHVGARNVVITDVNEYRLELARKMGITRAVNVAKENLNDVMAELGMTEGFDVGLEMS
GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSIDD
FQKGFDAMCSGQSGKVILSWD

Sequences:

>Translated_341_residues
MKALSKLKAEEGIWMTDVPVPELGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFK
IGDRVSGEGHITCGHCRNCRGGRTHLCRNTIGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGIMAAAVAKHVGARNVVITDVNEYRLELARKMGITRAVNVAKENLNDVMAELGMTEGFDVGLEMS
GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSIDD
FQKGFDAMCSGQSGKVILSWD
>Mature_341_residues
MKALSKLKAEEGIWMTDVPVPELGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFK
IGDRVSGEGHITCGHCRNCRGGRTHLCRNTIGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGIMAAAVAKHVGARNVVITDVNEYRLELARKMGITRAVNVAKENLNDVMAELGMTEGFDVGLEMS
GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSIDD
FQKGFDAMCSGQSGKVILSWD

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=335, Percent_Identity=27.4626865671642, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=25.201072386059, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI34577061, Length=362, Percent_Identity=24.585635359116, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI262073058, Length=353, Percent_Identity=26.628895184136, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI71743840, Length=353, Percent_Identity=26.628895184136, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=23.5924932975871, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI156523966, Length=360, Percent_Identity=23.6111111111111, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4501939, Length=354, Percent_Identity=23.4463276836158, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI71565154, Length=371, Percent_Identity=24.7978436657682, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=99.4134897360704, Blast_Score=697, Evalue=0.0,
Organism=Escherichia coli, GI1788075, Length=366, Percent_Identity=30.6010928961749, Blast_Score=161, Evalue=6e-41,
Organism=Escherichia coli, GI1788073, Length=329, Percent_Identity=29.1793313069909, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1787863, Length=318, Percent_Identity=29.874213836478, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI87082125, Length=344, Percent_Identity=31.6860465116279, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI226510992, Length=330, Percent_Identity=27.8787878787879, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI87081918, Length=286, Percent_Identity=31.1188811188811, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788407, Length=344, Percent_Identity=26.1627906976744, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790718, Length=307, Percent_Identity=26.0586319218241, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786825, Length=386, Percent_Identity=27.720207253886, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1786552, Length=358, Percent_Identity=27.6536312849162, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1786518, Length=282, Percent_Identity=26.5957446808511, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=321, Percent_Identity=33.6448598130841, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17562878, Length=334, Percent_Identity=31.437125748503, Blast_Score=150, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI71988145, Length=233, Percent_Identity=31.7596566523605, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=273, Percent_Identity=26.7399267399267, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=282, Percent_Identity=27.6595744680851, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=380, Percent_Identity=24.7368421052632, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323099, Length=323, Percent_Identity=31.8885448916409, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6322619, Length=325, Percent_Identity=28.3076923076923, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6319955, Length=325, Percent_Identity=28, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319258, Length=372, Percent_Identity=26.3440860215054, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6319257, Length=335, Percent_Identity=27.7611940298507, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=279, Percent_Identity=31.5412186379928, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=375, Percent_Identity=26.4, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=279, Percent_Identity=31.8996415770609, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=326, Percent_Identity=28.8343558282209, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=270, Percent_Identity=28.5185185185185, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323980, Length=258, Percent_Identity=30.2325581395349, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=288, Percent_Identity=27.0833333333333, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17737897, Length=332, Percent_Identity=25.6024096385542, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI17137530, Length=332, Percent_Identity=25.6024096385542, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI17737895, Length=377, Percent_Identity=25.1989389920424, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221457811, Length=168, Percent_Identity=26.7857142857143, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45551930, Length=168, Percent_Identity=26.7857142857143, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550770, Length=168, Percent_Identity=26.7857142857143, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37202; Mature: 37202

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALSKLKAEEGIWMTDVPVPELGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMV
CCHHHHHHHHCCCEEECCCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCEEE
VGHEYVGEVVGIGQEVKGFKIGDRVSGEGHITCGHCRNCRGGRTHLCRNTIGVGVNRPGC
ECHHHHHHHHCCCCCCCCEECCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCH
FAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGIMAA
HHHHHEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCHHHHHHH
AVAKHVGARNVVITDVNEYRLELARKMGITRAVNVAKENLNDVMAELGMTEGFDVGLEMS
HHHHHCCCCCEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC
GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAA
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LIQSGLDLSPIITHRFSIDDFQKGFDAMCSGQSGKVILSWD
HHHCCCCCCHHHHEECCHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MKALSKLKAEEGIWMTDVPVPELGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMV
CCHHHHHHHHCCCEEECCCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCEEE
VGHEYVGEVVGIGQEVKGFKIGDRVSGEGHITCGHCRNCRGGRTHLCRNTIGVGVNRPGC
ECHHHHHHHHCCCCCCCCEECCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCH
FAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGIMAA
HHHHHEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCHHHHHHH
AVAKHVGARNVVITDVNEYRLELARKMGITRAVNVAKENLNDVMAELGMTEGFDVGLEMS
HHHHHCCCCCEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC
GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAA
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LIQSGLDLSPIITHRFSIDDFQKGFDAMCSGQSGKVILSWD
HHHCCCCCCHHHHEECCHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA