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The map label for this gene is aas [H]

Identifier: 209399601

GI number: 209399601

Start: 3800652

End: 3802811

Strand: Reverse

Name: aas [H]

Synonym: ECH74115_4103

Alternate gene names: 209399601

Gene position: 3802811-3800652 (Counterclockwise)

Preceding gene: 209399305

Following gene: 209396999

Centisome position: 68.25

GC content: 52.13

Gene sequence:

>2160_bases
ATGCTTTTTAGCTTTTTTCGAAATTTGTGCCGTGTTTTGTATCGCGTTCGCGTTACGGGTGACCCCCAGGCACTGAAGGG
CGAGCGCGTTCTAATTACGCCTAATCACGTCTCTTTTATTGATGGCATTTTGCTTGGACTGTTTTTACCTGTGCGTCCAG
TGTTTGCCGTTTACACCTCAATAAGCCAACAGTGGTATATGCGTTGGCTGAAATCATTTATCGACTTTGTTCCTCTCGAC
CCGACGCAACCTATGGCGATTAAACATCTGGTACGTCTGGTGGAACAGGGCCGACCAGTGGTGATTTTCCCTGAAGGACG
CATCACCACCACAGGCTCGCTGATGAAAATCTACGATGGCGCGGGTTTTGTCGCGGCGAAGTCTGGTGCAACGGTTATTC
CTGTGCGTATTGAAGGGGCGGAACTTACGCACTTCAGCCGCCTGAAAGGTCTGGTTAAACGTCGCTTGTTCCCGCAAATT
ACTCTGCATATTTTGCCACCAACGCAGGTGGAGATGCCGGATGCGCCGCGTGCCCGTGACCGTCGCAAAATCGCTGGCGA
AATGCTGCATCAAATAATGATGGAAGCGCGAATGGCGGTGCGCCCGCGTGAAACGCTGTACGAATCTTTACTGAGTGCAA
TGTACCGCTTCGGAGCAGGGAAGAAATGTGTCGAAGACGTCAATTTTACCCCAGACTCCTATCGCAAATTGCTTACGAAA
ACGCTGTTTGTTGGACGCATCCTTGAAAAATACAGTGTTGAAGGCGAACGCATCGGCTTAATGCTGCCCAATGCAGGCAT
CAGTGCGGCAGTGATTTTTGGGGCCATCGCCCGTCGCCGCATTCCCGCAATGATGAACTACACTGCTGGGGTAAAAGGGC
TGACCAGTGCTATTACGGCGGCTGAAATCAAAACCATCTTCACTTCCCGCCAGTTTCTCGATAAAGGCAAACTCTGGCAT
CTGCCGGAGCAACTTACTCAGGTACGCTGGGTCTATCTGGAAGATTTAAAAGCAGATGTCACCACTGCCGACAAAGTATG
GATCTTCGCTCATTTGCTGATGCCGCGTCTGGCACAGGTTAAACAGCAGCCGGAAGAAGAGGCGCTGATCCTTTTTACCT
CCGGTTCTGAAGGCCATCCAAAAGGCGTCGTCCATAGCCATAAAAGCATTCTGGCGAATGTCGAGCAGATTAAAACGATT
GCCGACTTCACCACCAACGATCGCTTTATGTCGGCGTTACCGCTGTTTCACTCCTTTGGGCTGACGGTAGGCCTGTTTAC
GCCACTGCTCACAGGTGCAGAAGTGTTTCTTTATCCAAGCCCGCTGCATTACCGTATTGTGCCGGAGTTGGTGTATGACC
GCAGTTGCACCGTGTTGTTCGGCACTTCGACTTTCCTCGGTCACTACGCGCGTTTCGCCAACCCGTATGACTTCTATCGT
CTACGCTATGTGGTGGCAGGCGCAGAAAAACTACAAGAAAGTACCAAACAGCTTTGGCAGGATAAATTTGGCCTGCGCAT
CCTTGAAGGCTACGGTGTGACCGAATGCGCGCCTGTCGTTTCTATCAACGTACCGATGGCGGCGAAACCCGGTACGGTAG
GGCGTATTCTACCAGGAATGGATGCGCGCCTGTTGTCGGTCCCTGGTATCGAAGAGGGCGGACGCCTGCAACTGAAAGGG
CCGAACATAATGAACGGCTATCTGCGGGTGGAGAAGCCAGGTGTACTGGAAGTGCCCACCGCCGAGAATGTTCGCGGCGA
AATGGAGCGCGGCTGGTATGACACTGGCGATATTGTGCGTTTTGACGAGCAGGGCTTTGTGCAGATTCAGGGCCGCGCAA
AACGCTTTGCCAAAATTGCAGGCGAAATGGTGTCGCTGGAAATGGTGGAACAACTGGCACTTGGTGTTTCGCCAGATAAA
GTCCATGCCACTGCGATTAAGAGCGATGCCAGCAAAGGCGAGGCACTGGTGCTTTTCACCACAGATAACGAACTGACGCG
CGATAAGTTGCAACAGTATGCCCGTGAGCACGGCGTGCCGGAGCTTGCTGTACCGCGTGATATTCGCTATTTGAAACAGA
TGCCATTACTTGGCAGCGGCAAACCTGACTTTGTCACGTTGAAAAGCTGGGTAGACGAAGTGGAACAACACGATGAGTGA

Upstream 100 bases:

>100_bases
GCAGGTTTTTTTTCGCACCTAATTTACTGTCGCTCGCGTTCTTTATCTCGTGTAATCTCCCTCCATTCGCTTTTACTGAA
TCAGAGCAAAGGGAGTTGGA

Downstream 100 bases:

>100_bases
GTCAGTGCACACTAACACTTCGTTGTGGTCGAAGGGGATGAAAGCGGTTATCGTGGCGCAGTTTCTCTCTGCGTTTGGCG
ATAATGCCCTACTGTTTGCC

Product: bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase

Products: NA

Alternate protein names: 2-acylglycerophosphoethanolamine acyltransferase; 2-acyl-GPE acyltransferase; Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase; Acyl-[acyl-carrier-protein] synthetase; Acyl-ACP synthetase; Long-chain-fatty-acid--[acyl-carrier-protein] ligase [H]

Number of amino acids: Translated: 719; Mature: 719

Protein sequence:

>719_residues
MLFSFFRNLCRVLYRVRVTGDPQALKGERVLITPNHVSFIDGILLGLFLPVRPVFAVYTSISQQWYMRWLKSFIDFVPLD
PTQPMAIKHLVRLVEQGRPVVIFPEGRITTTGSLMKIYDGAGFVAAKSGATVIPVRIEGAELTHFSRLKGLVKRRLFPQI
TLHILPPTQVEMPDAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLSAMYRFGAGKKCVEDVNFTPDSYRKLLTK
TLFVGRILEKYSVEGERIGLMLPNAGISAAVIFGAIARRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWH
LPEQLTQVRWVYLEDLKADVTTADKVWIFAHLLMPRLAQVKQQPEEEALILFTSGSEGHPKGVVHSHKSILANVEQIKTI
ADFTTNDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRSCTVLFGTSTFLGHYARFANPYDFYR
LRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLSVPGIEEGGRLQLKG
PNIMNGYLRVEKPGVLEVPTAENVRGEMERGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSPDK
VHATAIKSDASKGEALVLFTTDNELTRDKLQQYAREHGVPELAVPRDIRYLKQMPLLGSGKPDFVTLKSWVDEVEQHDE

Sequences:

>Translated_719_residues
MLFSFFRNLCRVLYRVRVTGDPQALKGERVLITPNHVSFIDGILLGLFLPVRPVFAVYTSISQQWYMRWLKSFIDFVPLD
PTQPMAIKHLVRLVEQGRPVVIFPEGRITTTGSLMKIYDGAGFVAAKSGATVIPVRIEGAELTHFSRLKGLVKRRLFPQI
TLHILPPTQVEMPDAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLSAMYRFGAGKKCVEDVNFTPDSYRKLLTK
TLFVGRILEKYSVEGERIGLMLPNAGISAAVIFGAIARRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWH
LPEQLTQVRWVYLEDLKADVTTADKVWIFAHLLMPRLAQVKQQPEEEALILFTSGSEGHPKGVVHSHKSILANVEQIKTI
ADFTTNDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRSCTVLFGTSTFLGHYARFANPYDFYR
LRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLSVPGIEEGGRLQLKG
PNIMNGYLRVEKPGVLEVPTAENVRGEMERGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSPDK
VHATAIKSDASKGEALVLFTTDNELTRDKLQQYAREHGVPELAVPRDIRYLKQMPLLGSGKPDFVTLKSWVDEVEQHDE
>Mature_719_residues
MLFSFFRNLCRVLYRVRVTGDPQALKGERVLITPNHVSFIDGILLGLFLPVRPVFAVYTSISQQWYMRWLKSFIDFVPLD
PTQPMAIKHLVRLVEQGRPVVIFPEGRITTTGSLMKIYDGAGFVAAKSGATVIPVRIEGAELTHFSRLKGLVKRRLFPQI
TLHILPPTQVEMPDAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLSAMYRFGAGKKCVEDVNFTPDSYRKLLTK
TLFVGRILEKYSVEGERIGLMLPNAGISAAVIFGAIARRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWH
LPEQLTQVRWVYLEDLKADVTTADKVWIFAHLLMPRLAQVKQQPEEEALILFTSGSEGHPKGVVHSHKSILANVEQIKTI
ADFTTNDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRSCTVLFGTSTFLGHYARFANPYDFYR
LRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLSVPGIEEGGRLQLKG
PNIMNGYLRVEKPGVLEVPTAENVRGEMERGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSPDK
VHATAIKSDASKGEALVLFTTDNELTRDKLQQYAREHGVPELAVPRDIRYLKQMPLLGSGKPDFVTLKSWVDEVEQHDE

Specific function: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=386, Percent_Identity=28.2383419689119, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI187761343, Length=386, Percent_Identity=28.2383419689119, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI156151445, Length=369, Percent_Identity=25.7452574525745, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI40807491, Length=389, Percent_Identity=25.706940874036, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI42544132, Length=365, Percent_Identity=26.3013698630137, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI57165410, Length=409, Percent_Identity=25.4278728606357, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI57165412, Length=409, Percent_Identity=25.1833740831296, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI157311624, Length=383, Percent_Identity=27.154046997389, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI157311622, Length=383, Percent_Identity=27.154046997389, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI38505220, Length=362, Percent_Identity=25.414364640884, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI58082049, Length=362, Percent_Identity=25.6906077348066, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI42544134, Length=196, Percent_Identity=27.5510204081633, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1789201, Length=719, Percent_Identity=99.4436717663421, Blast_Score=1467, Evalue=0.0,
Organism=Escherichia coli, GI1788107, Length=489, Percent_Identity=27.4028629856851, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI145693145, Length=358, Percent_Identity=29.608938547486, Blast_Score=128, Evalue=2e-30,
Organism=Escherichia coli, GI1786810, Length=360, Percent_Identity=22.2222222222222, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17558820, Length=340, Percent_Identity=27.3529411764706, Blast_Score=119, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI32563687, Length=340, Percent_Identity=27.0588235294118, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71994703, Length=442, Percent_Identity=24.8868778280543, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71994694, Length=442, Percent_Identity=24.8868778280543, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71994690, Length=442, Percent_Identity=24.8868778280543, Blast_Score=99, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17510401, Length=352, Percent_Identity=24.7159090909091, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560308, Length=365, Percent_Identity=24.3835616438356, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531443, Length=343, Percent_Identity=27.9883381924198, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17559526, Length=375, Percent_Identity=24.2666666666667, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71985884, Length=321, Percent_Identity=24.6105919003115, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6319699, Length=358, Percent_Identity=25.6983240223464, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320852, Length=346, Percent_Identity=23.4104046242775, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21355181, Length=521, Percent_Identity=24.1842610364683, Blast_Score=106, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24581924, Length=361, Percent_Identity=23.8227146814404, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19922652, Length=390, Percent_Identity=23.5897435897436, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24648260, Length=394, Percent_Identity=25.1269035532995, Blast_Score=76, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF01553 Acyltransferase; PF00501 AMP-binding [H]

EC number: =2.3.1.40; =6.2.1.20 [H]

Molecular weight: Translated: 80765; Mature: 80765

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFSFFRNLCRVLYRVRVTGDPQALKGERVLITPNHVSFIDGILLGLFLPVRPVFAVYTS
CHHHHHHHHHHHHHEEEECCCCHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
ISQQWYMRWLKSFIDFVPLDPTQPMAIKHLVRLVEQGRPVVIFPEGRITTTGSLMKIYDG
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCEEECCCEEEEECC
AGFVAAKSGATVIPVRIEGAELTHFSRLKGLVKRRLFPQITLHILPPTQVEMPDAPRARD
CCEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHH
RRKIAGEMLHQIMMEARMAVRPRETLYESLLSAMYRFGAGKKCVEDVNFTPDSYRKLLTK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHH
TLFVGRILEKYSVEGERIGLMLPNAGISAAVIFGAIARRRIPAMMNYTAGVKGLTSAITA
HHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHH
AEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTTADKVWIFAHLLMPRLAQV
HHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KQQPEEEALILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTTNDRFMSALPLFHSFG
HHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRSCTVLFGTSTFLGHYARFANPYDFYR
HHHHHHHHHHCCCEEEEECCCCCEEECHHHHCCCCCEEEEECHHHHHHHHHHCCCHHHHH
LRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGM
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
DARLLSVPGIEEGGRLQLKGPNIMNGYLRVEKPGVLEVPTAENVRGEMERGWYDTGDIVR
CCEEEECCCCCCCCEEEECCCCEEECEEEECCCCEEECCCCCCCCHHHHCCCCCCCCEEE
FDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSPDKVHATAIKSDASKGEALVLFT
ECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHCCCCCCCEEEEEE
TDNELTRDKLQQYAREHGVPELAVPRDIRYLKQMPLLGSGKPDFVTLKSWVDEVEQHDE
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHCCC
>Mature Secondary Structure
MLFSFFRNLCRVLYRVRVTGDPQALKGERVLITPNHVSFIDGILLGLFLPVRPVFAVYTS
CHHHHHHHHHHHHHEEEECCCCHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
ISQQWYMRWLKSFIDFVPLDPTQPMAIKHLVRLVEQGRPVVIFPEGRITTTGSLMKIYDG
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCEEECCCEEEEECC
AGFVAAKSGATVIPVRIEGAELTHFSRLKGLVKRRLFPQITLHILPPTQVEMPDAPRARD
CCEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHH
RRKIAGEMLHQIMMEARMAVRPRETLYESLLSAMYRFGAGKKCVEDVNFTPDSYRKLLTK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHH
TLFVGRILEKYSVEGERIGLMLPNAGISAAVIFGAIARRRIPAMMNYTAGVKGLTSAITA
HHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHH
AEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTTADKVWIFAHLLMPRLAQV
HHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KQQPEEEALILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTTNDRFMSALPLFHSFG
HHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRSCTVLFGTSTFLGHYARFANPYDFYR
HHHHHHHHHHCCCEEEEECCCCCEEECHHHHCCCCCEEEEECHHHHHHHHHHCCCHHHHH
LRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGM
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
DARLLSVPGIEEGGRLQLKGPNIMNGYLRVEKPGVLEVPTAENVRGEMERGWYDTGDIVR
CCEEEECCCCCCCCEEEECCCCEEECEEEECCCCEEECCCCCCCCHHHHCCCCCCCCEEE
FDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSPDKVHATAIKSDASKGEALVLFT
ECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHCCCCCCCEEEEEE
TDNELTRDKLQQYAREHGVPELAVPRDIRYLKQMPLLGSGKPDFVTLKSWVDEVEQHDE
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA