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The map label for this gene is nuoC [H]

Identifier: 209398773

GI number: 209398773

Start: 3169587

End: 3171389

Strand: Reverse

Name: nuoC [H]

Synonym: ECH74115_3425

Alternate gene names: 209398773

Gene position: 3171389-3169587 (Counterclockwise)

Preceding gene: 209400872

Following gene: 209399385

Centisome position: 56.92

GC content: 56.07

Gene sequence:

>1803_bases
ATGGTGAACAATATGACCGACTTAACCGCGCAAGAACCCGCCTGGCAGACCCGCGATCATCTTGATGATCCGGTAATTGG
CGAACTGCGCAACCGTTTTGGGCCGGATGCCTTTACTGTTCAGGCGACTCGCACCGGGGTTCCCGTTGTGTGGATCAAGC
GTGAACAATTACTGGAAGTTGGCGATTTCTTAAAGAAACTGCCGAAACCTTACGTCATGCTGTTTGACTTACACGGCATG
GACGAACGTCTGCGCACGCACCGCGAAGGGTTACCTGCCGCGGATTTTTCCGTTTTCTACCATCTGATTTCTATCGATCG
TAACCGCGACATCATGCTGAAGGTGGCGCTGGCAGAAAACGACCTGCACGTACCGACCTTCACCAAACTGTTCCCGAACG
CTAACTGGTATGAGCGTGAAACCTGGGATCTGTTTGGCATTACATTCGACGGTCACCCGAACCTGCGCCGCATCATGATG
CCGCAAACCTGGAAAGGTCACCCGCTGCGTAAAGATTACCCGGCGCGCGCTACCGAATTCTCGCCGTTTGAGCTGACCAA
AGCCAAACAGGATCTGGAGATGGAAGCCCTGACCTTCAAACCGGAAGAGTGGGGGATGAAGCGCGGCACCGAAAACGAGG
ACTTCATGTTCCTCAACCTCGGTCCGAACCACCCGTCGGCGCACGGTGCTTTCCGTATCGTTTTGCAGCTCGACGGCGAA
GAGATTGTCGACTGCGTACCAGACATCGGCTACCACCACCGTGGTGCGGAGAAAATGGGCGAACGCCAGTCCTGGCACAG
CTACATTCCGTATACCGACCGTATCGAATACCTCGGCGGCTGCGTTAACGAAATGCCTTACGTGCTGGCGGTAGAGAAAC
TGGCCGGGATCACCGTGCCGGCTCGCGTTAACGTCATTCGCGTAATGCTCTCCGAACTGTTCCGCATCAACAGCCACCTG
CTGTATATCTCGACCTTTATTCAGGACGTCGGCGCAATGACGCCCGTGTTCTTCGCCTTTACCGATCGTCAGAAAATTTA
CGATCTGGTGGAAGCGATCACGGGTTTCCGTATGCACCCGGCGTGGTTCCGTATTGGCGGCGTAGCGCACGACCTGCCGC
GCGGCTGGGATCGCCTGCTGCGTGAGTTCCTCGACTGGATGCCGAAACGTCTGGCGTCTTACGAGAAAGCGGCGCTGCAA
AATACCATTCTGAAAGGTCGTTCCCAGGGCGTTGCCGCCTATGGCGCGAAAGAGGCGCTGGAGTGGGGCACCACTGGCGC
GGGCCTGCGTGCTACCGGGATCGACTTCGACGTGCGTAAGGCGCGTCCTTATTCTGGCTATGAAAACTTCGACTTTGAAA
TCCCGGTTGGTGGTGGTGTTTCTGACTGCTACACCCGCGTAATGCTTAAAGTGGAAGAGCTGCGCCAGAGTCTGCGCATT
CTTGAGCAGTGCCTCAACAACATGCCGGAAGGCCCGTTCAAAGCGGATCACCCGCTGACCACGCCGCCGCCGAAAGAGCG
CACGCTGCAACATATCGAAACCCTGATCACCCACTTCCTGCAAGTGTCGTGGGGGCCGGTGATGCCTGCCAATGAATCCT
TCCAGATGATTGAGGCGACCAAAGGGATCAACAGTTACTACCTGACCAGCGACGGTAGCACCATGAGTTATCGCACTCGT
ATCCGCACGCCGAGTTATGCGCATTTGCAGCAAATTCCGGCGGCGATCCGCGGCAGCCTGGTGTCTGACCTGATTGTTTA
TCTGGGCAGTATCGATTTTGTTATGTCAGATGTGGACCGCTAA

Upstream 100 bases:

>100_bases
GATTTAATTTGCGCCTGTCGGCAAAGGGATTTTTCTTCGCTTATTCCTAAATCTATTTCGCGAAGCTTGCTGCGCCGACA
GTCACCACGGACCATTTGCA

Downstream 100 bases:

>100_bases
TTATGCACGAGAATCAACAACCACAAACCGAGGCTTTTGAGCTGAGTGCGGCAGAGCGTGAAGCGATCGAGCACGAGATG
CACCACTACGAAGACCCGCG

Product: bifunctional NADH:ubiquinone oxidoreductase subunit C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D [H]

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MVNNMTDLTAQEPAWQTRDHLDDPVIGELRNRFGPDAFTVQATRTGVPVVWIKREQLLEVGDFLKKLPKPYVMLFDLHGM
DERLRTHREGLPAADFSVFYHLISIDRNRDIMLKVALAENDLHVPTFTKLFPNANWYERETWDLFGITFDGHPNLRRIMM
PQTWKGHPLRKDYPARATEFSPFELTKAKQDLEMEALTFKPEEWGMKRGTENEDFMFLNLGPNHPSAHGAFRIVLQLDGE
EIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPARVNVIRVMLSELFRINSHL
LYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLDWMPKRLASYEKAALQ
NTILKGRSQGVAAYGAKEALEWGTTGAGLRATGIDFDVRKARPYSGYENFDFEIPVGGGVSDCYTRVMLKVEELRQSLRI
LEQCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTR
IRTPSYAHLQQIPAAIRGSLVSDLIVYLGSIDFVMSDVDR

Sequences:

>Translated_600_residues
MVNNMTDLTAQEPAWQTRDHLDDPVIGELRNRFGPDAFTVQATRTGVPVVWIKREQLLEVGDFLKKLPKPYVMLFDLHGM
DERLRTHREGLPAADFSVFYHLISIDRNRDIMLKVALAENDLHVPTFTKLFPNANWYERETWDLFGITFDGHPNLRRIMM
PQTWKGHPLRKDYPARATEFSPFELTKAKQDLEMEALTFKPEEWGMKRGTENEDFMFLNLGPNHPSAHGAFRIVLQLDGE
EIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPARVNVIRVMLSELFRINSHL
LYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLDWMPKRLASYEKAALQ
NTILKGRSQGVAAYGAKEALEWGTTGAGLRATGIDFDVRKARPYSGYENFDFEIPVGGGVSDCYTRVMLKVEELRQSLRI
LEQCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTR
IRTPSYAHLQQIPAAIRGSLVSDLIVYLGSIDFVMSDVDR
>Mature_600_residues
MVNNMTDLTAQEPAWQTRDHLDDPVIGELRNRFGPDAFTVQATRTGVPVVWIKREQLLEVGDFLKKLPKPYVMLFDLHGM
DERLRTHREGLPAADFSVFYHLISIDRNRDIMLKVALAENDLHVPTFTKLFPNANWYERETWDLFGITFDGHPNLRRIMM
PQTWKGHPLRKDYPARATEFSPFELTKAKQDLEMEALTFKPEEWGMKRGTENEDFMFLNLGPNHPSAHGAFRIVLQLDGE
EIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPARVNVIRVMLSELFRINSHL
LYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLDWMPKRLASYEKAALQ
NTILKGRSQGVAAYGAKEALEWGTTGAGLRATGIDFDVRKARPYSGYENFDFEIPVGGGVSDCYTRVMLKVEELRQSLRI
LEQCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTR
IRTPSYAHLQQIPAAIRGSLVSDLIVYLGSIDFVMSDVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=383, Percent_Identity=40.7310704960835, Blast_Score=309, Evalue=4e-84,
Organism=Homo sapiens, GI260898743, Length=373, Percent_Identity=40.4825737265416, Blast_Score=300, Evalue=3e-81,
Organism=Homo sapiens, GI4758788, Length=101, Percent_Identity=39.6039603960396, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI145693162, Length=596, Percent_Identity=99.496644295302, Blast_Score=1236, Evalue=0.0,
Organism=Escherichia coli, GI1789076, Length=563, Percent_Identity=25.9325044404973, Blast_Score=159, Evalue=5e-40,
Organism=Escherichia coli, GI1788832, Length=493, Percent_Identity=28.6004056795132, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17555284, Length=397, Percent_Identity=41.3098236775819, Blast_Score=330, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17568379, Length=402, Percent_Identity=40.547263681592, Blast_Score=328, Evalue=5e-90,
Organism=Caenorhabditis elegans, GI32563621, Length=127, Percent_Identity=30.7086614173228, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71990788, Length=127, Percent_Identity=30.7086614173228, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221459469, Length=384, Percent_Identity=39.0625, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24638644, Length=383, Percent_Identity=40.4699738903394, Blast_Score=317, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24656494, Length=169, Percent_Identity=32.5443786982249, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR010218
- InterPro:   IPR023062
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR020396
- InterPro:   IPR022885
- ProDom:   PD001581 [H]

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68682; Mature: 68682

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00542 COMPLEX1_30K ; PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNNMTDLTAQEPAWQTRDHLDDPVIGELRNRFGPDAFTVQATRTGVPVVWIKREQLLEV
CCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEECHHHHHHH
GDFLKKLPKPYVMLFDLHGMDERLRTHREGLPAADFSVFYHLISIDRNRDIMLKVALAEN
HHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECC
DLHVPTFTKLFPNANWYERETWDLFGITFDGHPNLRRIMMPQTWKGHPLRKDYPARATEF
CCCCCHHHHHCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCC
SPFELTKAKQDLEMEALTFKPEEWGMKRGTENEDFMFLNLGPNHPSAHGAFRIVLQLDGE
CCHHHHHHHHCCCCHHEEECCHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCH
EIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVP
HHHHHHCCCCCCCCCHHHHCCHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
ARVNVIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHP
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCC
AWFRIGGVAHDLPRGWDRLLREFLDWMPKRLASYEKAALQNTILKGRSQGVAAYGAKEAL
HHHEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHCHHHHH
EWGTTGAGLRATGIDFDVRKARPYSGYENFDFEIPVGGGVSDCYTRVMLKVEELRQSLRI
HCCCCCCCCEECCCCCCHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
LEQCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEAT
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
KGINSYYLTSDGSTMSYRTRIRTPSYAHLQQIPAAIRGSLVSDLIVYLGSIDFVMSDVDR
CCCCEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVNNMTDLTAQEPAWQTRDHLDDPVIGELRNRFGPDAFTVQATRTGVPVVWIKREQLLEV
CCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEECHHHHHHH
GDFLKKLPKPYVMLFDLHGMDERLRTHREGLPAADFSVFYHLISIDRNRDIMLKVALAEN
HHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECC
DLHVPTFTKLFPNANWYERETWDLFGITFDGHPNLRRIMMPQTWKGHPLRKDYPARATEF
CCCCCHHHHHCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCC
SPFELTKAKQDLEMEALTFKPEEWGMKRGTENEDFMFLNLGPNHPSAHGAFRIVLQLDGE
CCHHHHHHHHCCCCHHEEECCHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCH
EIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVP
HHHHHHCCCCCCCCCHHHHCCHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
ARVNVIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHP
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCC
AWFRIGGVAHDLPRGWDRLLREFLDWMPKRLASYEKAALQNTILKGRSQGVAAYGAKEAL
HHHEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHCHHHHH
EWGTTGAGLRATGIDFDVRKARPYSGYENFDFEIPVGGGVSDCYTRVMLKVEELRQSLRI
HCCCCCCCCEECCCCCCHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
LEQCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEAT
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
KGINSYYLTSDGSTMSYRTRIRTPSYAHLQQIPAAIRGSLVSDLIVYLGSIDFVMSDVDR
CCCCEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA