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The map label for this gene is ffh

Identifier: 209398002

GI number: 209398002

Start: 3570551

End: 3571912

Strand: Reverse

Name: ffh

Synonym: ECH74115_3849

Alternate gene names: 209398002

Gene position: 3571912-3570551 (Counterclockwise)

Preceding gene: 209400581

Following gene: 209395757

Centisome position: 64.1

GC content: 54.26

Gene sequence:

>1362_bases
ATGTTTGATAATTTAACCGATCGTTTGTCGCGCACGCTGCGCAATATCAGTGGCCGTGGACGCCTCACTGAAGACAACGT
AAAAGATACGCTGCGCGAAGTGCGCATGGCGCTGCTGGAGGCGGACGTCGCTCTGCCGGTAGTGCGTGAGTTTATCAATC
GCGTAAAAGAGAAAGCGGTTGGTCATGAAGTTAATAAGAGCCTGACGCCGGGGCAGGAGTTCGTCAAAATCGTCCGTAAC
GAACTGGTTGCGGCGATGGGCGAAGAGAACCAGACCCTGAATCTGGCTGCGCAACCGCCTGCGGTCGTGCTGATGGCAGG
CCTGCAAGGTGCCGGTAAAACAACCAGCGTTGGTAAACTCGGTAAGTTCCTGCGCGAGAAGCACAAGAAGAAAGTGCTGG
TGGTTTCTGCTGACGTCTATCGCCCGGCGGCAATCAAACAGCTTGAGACGCTGGCAGAGCAGGTGGGCGTTGATTTCTTC
CCTTCTGATGTTGGTCAGAAGCCGGTTGATATTGTTAACGCGGCGCTGAAAGAAGCCAAACTGAAATTCTACGACGTGCT
GCTGGTGGATACCGCTGGTCGTCTGCACGTTGACGAAGCGATGATGGACGAGATCAAACAAGTCCATGCGTCGATTAACC
CGGTTGAAACCCTGTTTGTGGTTGACGCCATGACCGGTCAGGATGCGGCCAATACGGCAAAAGCATTCAATGAAGCGTTA
CCGCTTACCGGCGTAGTGTTGACCAAAGTGGACGGCGATGCCCGCGGCGGTGCGGCGCTCTCTATTCGTCACATCACTGG
CAAACCGATCAAGTTCCTCGGTGTTGGCGAGAAAACTGAGGCGCTGGAGCCGTTCCATCCGGACCGCATCGCGTCGCGTA
TTCTCGGCATGGGCGACGTACTGTCGCTGATCGAAGATATCGAAAGCAAAGTTGACCGCGCGCAGGCAGAGAAATTAGCC
AGCAAGCTGAAAAAAGGTGACGGCTTCGATCTCAACGACTTCCTTGAGCAACTGCGCCAGATGAAAAATATGGGCGGCAT
GGCCAGCCTGATGGGCAAACTGCCGGGCATGGGGCAGATCCCGGATAACGTCAAGTCACAGATGGACGATAAAGTGCTGG
TGCGTATGGAAGCCATCATCAACTCGATGACGATGAAAGAGCGCGCTAAGCCAGAAATCATCAAAGGTTCGCGTAAACGC
CGTATTGCTGCCGGTTGCGGTATGCAGGTGCAGGACGTTAACCGTCTTCTGAAACAGTTCGACGACATGCAGCGCATGAT
GAAGAAAATGAAGAAGGGCGGAATGGCGAAGATGATGAGAAGCATGAAGGGGATGATGCCGCCGGGATTTCCTGGTCGCT
AA

Upstream 100 bases:

>100_bases
CCGTTGCATAACAACAAAGACGCCTTCATGTTATACTGCGGCAAAATACTGATGATGTGTCGCGATTGCGGCCAACCGTT
TCCACCCCAGGCGAGAGACA

Downstream 100 bases:

>100_bases
ATGACCTTATGCGACAGAGTTATTAACTGCTGATTGCATTTTCTCCAGAAATCAGTAAAATTTTCGGGCTTTTAATATGA
CACCGGACTCCGTTCCTCGA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAVGHEVNKSLTPGQEFVKIVRN
ELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFF
PSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDVLSLIEDIESKVDRAQAEKLA
SKLKKGDGFDLNDFLEQLRQMKNMGGMASLMGKLPGMGQIPDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKR
RIAAGCGMQVQDVNRLLKQFDDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGR

Sequences:

>Translated_453_residues
MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAVGHEVNKSLTPGQEFVKIVRN
ELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFF
PSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDVLSLIEDIESKVDRAQAEKLA
SKLKKGDGFDLNDFLEQLRQMKNMGGMASLMGKLPGMGQIPDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKR
RIAAGCGMQVQDVNRLLKQFDDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGR
>Mature_453_residues
MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAVGHEVNKSLTPGQEFVKIVRN
ELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFF
PSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDVLSLIEDIESKVDRAQAEKLA
SKLKKGDGFDLNDFLEQLRQMKNMGGMASLMGKLPGMGQIPDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKR
RIAAGCGMQVQDVNRLLKQFDDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family

Homologues:

Organism=Homo sapiens, GI4507215, Length=470, Percent_Identity=32.1276595744681, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI226371618, Length=372, Percent_Identity=34.1397849462366, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=38.125, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI295424842, Length=296, Percent_Identity=27.3648648648649, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI23308697, Length=296, Percent_Identity=27.3648648648649, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1788963, Length=453, Percent_Identity=100, Blast_Score=911, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=33.2075471698113, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17539958, Length=432, Percent_Identity=30.3240740740741, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI193206261, Length=296, Percent_Identity=30.4054054054054, Blast_Score=108, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=440, Percent_Identity=30.6818181818182, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6320498, Length=207, Percent_Identity=29.951690821256, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17647949, Length=450, Percent_Identity=29.5555555555556, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=29.5454545454545, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRP54_ECO57 (P0AGD9)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   A91063
- PIR:   E85907
- RefSeq:   NP_289163.1
- RefSeq:   NP_311500.1
- ProteinModelPortal:   P0AGD9
- SMR:   P0AGD9
- MINT:   MINT-1218587
- EnsemblBacteria:   EBESCT00000025026
- EnsemblBacteria:   EBESCT00000056145
- GeneID:   914815
- GeneID:   959351
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z3904
- KEGG:   ecs:ECs3473
- GeneTree:   EBGT00050000011016
- HOGENOM:   HBG562580
- OMA:   IINGSRR
- ProtClustDB:   PRK10867
- BioCyc:   ECOL83334:ECS3473-MONOMER
- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125
- Gene3D:   G3DSA:1.20.120.140
- Gene3D:   G3DSA:1.10.260.30
- PANTHER:   PTHR11564:SF7
- SMART:   SM00382
- SMART:   SM00962
- SMART:   SM00963
- TIGRFAMs:   TIGR00959

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB; SSF47446 Signal_recog_particle_SRP54_M; SSF47364 SRP54

EC number: NA

Molecular weight: Translated: 49788; Mature: 49788

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKL
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHEEEECCCCCCCCCHHHHH
GKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFFPSDVGQKPVDIVNAALKEAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHH
LKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEAL
HHHHHEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHEEECCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDV
CCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLIEDIESKVDRAQAEKLASKLKKGDGFDLNDFLEQLRQMKNMGGMASLMGKLPGMGQI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
PDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKRRIAAGCGMQVQDVNRLLKQF
CHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHCCCCCHHHHHHHHHHH
DDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGR
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MFDNLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKL
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHEEEECCCCCCCCCHHHHH
GKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFFPSDVGQKPVDIVNAALKEAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHH
LKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEAL
HHHHHEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHEEECCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDV
CCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLIEDIESKVDRAQAEKLASKLKKGDGFDLNDFLEQLRQMKNMGGMASLMGKLPGMGQI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
PDNVKSQMDDKVLVRMEAIINSMTMKERAKPEIIKGSRKRRIAAGCGMQVQDVNRLLKQF
CHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHCCCCCHHHHHHHHHHH
DDMQRMMKKMKKGGMAKMMRSMKGMMPPGFPGR
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796