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The map label for this gene is asnC [H]

Identifier: 209397026

GI number: 209397026

Start: 1120412

End: 1121812

Strand: Reverse

Name: asnC [H]

Synonym: ECH74115_1091

Alternate gene names: 209397026

Gene position: 1121812-1120412 (Counterclockwise)

Preceding gene: 209400389

Following gene: 209397832

Centisome position: 20.13

GC content: 52.68

Gene sequence:

>1401_bases
ATGAGCGTTGTGCCTGTAGCCGACGTACTCCAGGGCCGCGTAGCCGTTGACAGCGAAGTCACCGTACGCGGATGGGTACG
TACCCGCCGAGATTCAAAAGCTGGCATCTCCTTCCTCGCCGTTTATGACGGTTCCTGCTTTGATCCTGTACAGGCTGTCA
TCAATAATTCTCTGCCCAATTACAATGAAGACGTCCTGCGTCTGACCACCGGCTGCTCGGTCATTGTGACGGGTAAAGTC
GTGGCGTCGCCGGGCCAGGGGCAACAATTTGAAATTCAGACCAGCAAGGTTGAAGTTGCTGGTTGGGTTGAAGATCCAGA
CACTTACCCGATGGCGGCAAAACGCCACAGCATTGAGTATCTGCGTGAAGTCGCTCACCTGCGTCCGCGCACAAACCTGA
TTGGTGCCGTCGCGCGCGTTCGCCATACGCTGGCGCAGGCGCTGCATCGCTTCTTTAACGAGCAGGGATTCTTCTGGGTT
TCAACGCCACTGATTACTGCGTCTGATACCGAAGGGGCTGGCGAAATGTTCCGCGTTTCTACGCTGGATCTGGAAAATCT
GCCGCGTAACGATCAGGGCAAAGTGGATTTCGACAAAGACTTCTTTGGTAAAGAGTCTTTCCTGACCGTATCTGGCCAGT
TGAACGGCGAAACCTACGCTTGCGCATTATCCAAAATTTATACCTTCGGCCCGACTTTCCGTGCTGAAAACTCCAACACC
AGCCGTCACCTGGCGGAATTCTGGATGCTGGAGCCGGAAGTGGCGTTTGCTAACCTGAACGATATCGCGGGTCTGGCTGA
AGCCATGCTGAAATATGTCTTCAAAGCGGTTCTCGAAGAACGCGCTGACGACATGAAATTCTTCGCTGAACGCGTAGATA
AAGATGCCGTTTCACGTCTGGAACGCTTTATTGAGGCCGATTTCGCGCAGGTGGATTACACCGAAGCAGTAACCATTCTC
GAAAACTGCGGCAGGAAGTTTGAAAACCCGGTTTACTGGGGCGTCGATCTCTCTTCTGAGCATGAGCGTTATCTGGCGGA
AGAACACTTTAAAGCACCGGTAGTGGTTAAAAACTATCCGAAAGATATTAAAGCGTTCTATATGCGCCTCAACGAAGACG
GTAAAACCGTTGCGGCTATGGATGTTCTGGCTCCGGGCATCGGTGAGATCATTGGTGGCTCCCAGCGTGAAGAGCGTCTG
GACGTGCTGGACGAGCGTATGCTGGAAATGGGCCTGAACAAAGAAGATTACTGGTGGTATCGCGATCTGCGTCGCTACGG
TACTGTTCCGCATTCCGGTTTCGGTCTTGGTTTTGAACGCCTGATTGCTTACGTAACTGGTGTGCAAAACGTGCGTGATG
TGATTCCGTTCCCACGAACTCCGCGTAACGCCAGCTTCTAA

Upstream 100 bases:

>100_bases
ATTCTGCTTGTCTGATTGCAGATGCCAGGTAACATAGGTATCCCCCCATTTACGGGTGGACAAGTGTTTATTTTTTCCGA
CTATTAACAGAGAGAATATT

Downstream 100 bases:

>100_bases
TTTAGCGTCTACAAGAGCCAGCACCCGCTGGCTCTTTTTTATCCTTTCTGTCAAGTTATCTGTTTGTTAAGTCAATCAAT
CTATTTGCAACCCCGCCATA

Product: asparaginyl-tRNA synthetase

Products: NA

Alternate protein names: Asparagine--tRNA ligase; AsnRS [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSVVPVADVLQGRVAVDSEVTVRGWVRTRRDSKAGISFLAVYDGSCFDPVQAVINNSLPNYNEDVLRLTTGCSVIVTGKV
VASPGQGQQFEIQTSKVEVAGWVEDPDTYPMAAKRHSIEYLREVAHLRPRTNLIGAVARVRHTLAQALHRFFNEQGFFWV
STPLITASDTEGAGEMFRVSTLDLENLPRNDQGKVDFDKDFFGKESFLTVSGQLNGETYACALSKIYTFGPTFRAENSNT
SRHLAEFWMLEPEVAFANLNDIAGLAEAMLKYVFKAVLEERADDMKFFAERVDKDAVSRLERFIEADFAQVDYTEAVTIL
ENCGRKFENPVYWGVDLSSEHERYLAEEHFKAPVVVKNYPKDIKAFYMRLNEDGKTVAAMDVLAPGIGEIIGGSQREERL
DVLDERMLEMGLNKEDYWWYRDLRRYGTVPHSGFGLGFERLIAYVTGVQNVRDVIPFPRTPRNASF

Sequences:

>Translated_466_residues
MSVVPVADVLQGRVAVDSEVTVRGWVRTRRDSKAGISFLAVYDGSCFDPVQAVINNSLPNYNEDVLRLTTGCSVIVTGKV
VASPGQGQQFEIQTSKVEVAGWVEDPDTYPMAAKRHSIEYLREVAHLRPRTNLIGAVARVRHTLAQALHRFFNEQGFFWV
STPLITASDTEGAGEMFRVSTLDLENLPRNDQGKVDFDKDFFGKESFLTVSGQLNGETYACALSKIYTFGPTFRAENSNT
SRHLAEFWMLEPEVAFANLNDIAGLAEAMLKYVFKAVLEERADDMKFFAERVDKDAVSRLERFIEADFAQVDYTEAVTIL
ENCGRKFENPVYWGVDLSSEHERYLAEEHFKAPVVVKNYPKDIKAFYMRLNEDGKTVAAMDVLAPGIGEIIGGSQREERL
DVLDERMLEMGLNKEDYWWYRDLRRYGTVPHSGFGLGFERLIAYVTGVQNVRDVIPFPRTPRNASF
>Mature_465_residues
SVVPVADVLQGRVAVDSEVTVRGWVRTRRDSKAGISFLAVYDGSCFDPVQAVINNSLPNYNEDVLRLTTGCSVIVTGKVV
ASPGQGQQFEIQTSKVEVAGWVEDPDTYPMAAKRHSIEYLREVAHLRPRTNLIGAVARVRHTLAQALHRFFNEQGFFWVS
TPLITASDTEGAGEMFRVSTLDLENLPRNDQGKVDFDKDFFGKESFLTVSGQLNGETYACALSKIYTFGPTFRAENSNTS
RHLAEFWMLEPEVAFANLNDIAGLAEAMLKYVFKAVLEERADDMKFFAERVDKDAVSRLERFIEADFAQVDYTEAVTILE
NCGRKFENPVYWGVDLSSEHERYLAEEHFKAPVVVKNYPKDIKAFYMRLNEDGKTVAAMDVLAPGIGEIIGGSQREERLD
VLDERMLEMGLNKEDYWWYRDLRRYGTVPHSGFGLGFERLIAYVTGVQNVRDVIPFPRTPRNASF

Specific function: Unknown

COG id: COG0017

COG function: function code J; Aspartyl/asparaginyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI226491502, Length=463, Percent_Identity=41.9006479481641, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI4758762, Length=455, Percent_Identity=27.9120879120879, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI45439306, Length=350, Percent_Identity=29.7142857142857, Blast_Score=130, Evalue=4e-30,
Organism=Escherichia coli, GI1787161, Length=466, Percent_Identity=99.5708154506438, Blast_Score=961, Evalue=0.0,
Organism=Escherichia coli, GI1789256, Length=472, Percent_Identity=21.1864406779661, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788173, Length=111, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71984122, Length=471, Percent_Identity=28.6624203821656, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17556372, Length=433, Percent_Identity=31.1778290993072, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17551876, Length=342, Percent_Identity=27.1929824561404, Blast_Score=114, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319872, Length=470, Percent_Identity=36.3829787234043, Blast_Score=288, Evalue=9e-79,
Organism=Saccharomyces cerevisiae, GI6321807, Length=457, Percent_Identity=29.7592997811816, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6323011, Length=487, Percent_Identity=24.6406570841889, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI19922416, Length=464, Percent_Identity=35.5603448275862, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI19921528, Length=467, Percent_Identity=28.9079229122056, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17136276, Length=489, Percent_Identity=26.1758691206544, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: 80 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR004522
- InterPro:   IPR002312
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.22 [H]

Molecular weight: Translated: 52615; Mature: 52484

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVPVADVLQGRVAVDSEVTVRGWVRTRRDSKAGISFLAVYDGSCFDPVQAVINNSLPN
CCCCCHHHHHCCCEECCCCEEEHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCC
YNEDVLRLTTGCSVIVTGKVVASPGQGQQFEIQTSKVEVAGWVEDPDTYPMAAKRHSIEY
CCCHHHEEECCCEEEEECEEEECCCCCCEEEEEECEEEEEEECCCCCCCCCHHHHHHHHH
LREVAHLRPRTNLIGAVARVRHTLAQALHRFFNEQGFFWVSTPLITASDTEGAGEMFRVS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEEEECCCCCCCCEEEEE
TLDLENLPRNDQGKVDFDKDFFGKESFLTVSGQLNGETYACALSKIYTFGPTFRAENSNT
EECHHHCCCCCCCCCCCCHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEECCCCCC
SRHLAEFWMLEPEVAFANLNDIAGLAEAMLKYVFKAVLEERADDMKFFAERVDKDAVSRL
HHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ERFIEADFAQVDYTEAVTILENCGRKFENPVYWGVDLSSEHERYLAEEHFKAPVVVKNYP
HHHHHHHHHHCCHHHHHHHHHHCCHHHCCCEEEEECCCCHHHHHHHHHHCCCCEEECCCC
KDIKAFYMRLNEDGKTVAAMDVLAPGIGEIIGGSQREERLDVLDERMLEMGLNKEDYWWY
HHHHHHHHHCCCCCCEEEHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHH
RDLRRYGTVPHSGFGLGFERLIAYVTGVQNVRDVIPFPRTPRNASF
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SVVPVADVLQGRVAVDSEVTVRGWVRTRRDSKAGISFLAVYDGSCFDPVQAVINNSLPN
CCCCHHHHHCCCEECCCCEEEHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCC
YNEDVLRLTTGCSVIVTGKVVASPGQGQQFEIQTSKVEVAGWVEDPDTYPMAAKRHSIEY
CCCHHHEEECCCEEEEECEEEECCCCCCEEEEEECEEEEEEECCCCCCCCCHHHHHHHHH
LREVAHLRPRTNLIGAVARVRHTLAQALHRFFNEQGFFWVSTPLITASDTEGAGEMFRVS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEEEECCCCCCCCEEEEE
TLDLENLPRNDQGKVDFDKDFFGKESFLTVSGQLNGETYACALSKIYTFGPTFRAENSNT
EECHHHCCCCCCCCCCCCHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEECCCCCC
SRHLAEFWMLEPEVAFANLNDIAGLAEAMLKYVFKAVLEERADDMKFFAERVDKDAVSRL
HHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ERFIEADFAQVDYTEAVTILENCGRKFENPVYWGVDLSSEHERYLAEEHFKAPVVVKNYP
HHHHHHHHHHCCHHHHHHHHHHCCHHHCCCEEEEECCCCHHHHHHHHHHCCCCEEECCCC
KDIKAFYMRLNEDGKTVAAMDVLAPGIGEIIGGSQREERLDVLDERMLEMGLNKEDYWWY
HHHHHHHHHCCCCCCEEEHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHH
RDLRRYGTVPHSGFGLGFERLIAYVTGVQNVRDVIPFPRTPRNASF
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA