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The map label for this gene is epd [H]

Identifier: 209396324

GI number: 209396324

Start: 3914545

End: 3915564

Strand: Reverse

Name: epd [H]

Synonym: ECH74115_4224

Alternate gene names: 209396324

Gene position: 3915564-3914545 (Counterclockwise)

Preceding gene: 209397256

Following gene: 209396737

Centisome position: 70.27

GC content: 51.67

Gene sequence:

>1020_bases
ATGACCGTACGCGTAGCGATAAATGGCTTCGGTCGCATCGGGCGTAATGTGGTTCGTGCTTTGTATGAATCCGGACGCCG
GGCGGAAATTACCGTGGTGGCAATCAACGAACTGGCGGATGCTGCGGGCATGGCGCATTTGTTGAAATACGACACCAGCC
ATGGCCGTTTTGCATGGGAAGTACGACAGGAACGCGATCAACTTTTTGTTGGTGATGACGCCATCCGCGTATTGCATGAA
CGTTCACTGCAATCGCTCCCCTGGCGTGAACTTGGCGTTGATGTAGTCCTCGACTGCACCGGCGTATATGGCTCCCGCGA
GCATGGCGAAGCGCACATTGCCGCCGGGGCTAAAAAAGTGCTCTTTTCACATCCTGGCAGTAACGATCTCGACGCGACCG
TTGTTTACGGCGTCAATCAGGATCAACTTCGTGCGGAGCACCGCATCGTTTCTAACGCTTCCTGTACCACGAATTGCATA
ATTCCCGTCATCAAATTGTTAGATGATGCGTACGGTATTGAGTCCGGCACTGTGACCACAATTCACTCCGCCATGCACGA
TCAACAGGTTATTGATGCATACCATCCTGACCTGCGTCGCACCCGGGCAGCCAGCCAGTCGATCATTCCGGTCGATACTA
AACTGGCCGCCGGTATCACACGATTTTTTCCGCAATTTAACGATCGCTTTGAAGCGATTGCGGTACGTGTGCCAACCATA
AATGTGACGGCAATCGATTTAAGCGTGACGGTGAAGAAACCTGTAAAAGCCAATGAAGTCAACCTGTTGCTGCAAAAAGC
AGCACAAGGTGCATTTCATGGTATAGTTGACTATACGGAATTGCCGTTGGTCTCTGTAGATTTTAACCACGATCCGCACA
GTGCCATTGTCGATGGCACCCAAACCCGGGTCAGTGGCGCACACCTGATCAAAACGTTGGTCTGGTGCGATAACGAATGG
GGCTTTGCTAACCGAATGCTCGACACGACGTTAGCTATGGCTACTGTTGCTTTCAGGTAA

Upstream 100 bases:

>100_bases
ACCAATCAGTCGCAGTTTGCGACAGGTAAGGTTTCCCCGGACGATTTGCTGGATTACTCTGTCTGGCAAATTTGCTCAGG
GAAAACCTTGCAGGAGATCT

Downstream 100 bases:

>100_bases
GACGCAAGCAGCGTCTGCAAAACTTTTAGAATCAACGAGAGGATTCACCATGTCTGTAATTAAGATGACCGATCTGGATC
TTGCTGGGAAACGTGTATTT

Product: erythrose 4-phosphate dehydrogenase

Products: NA

Alternate protein names: E4PDH [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTVRVAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRQERDQLFVGDDAIRVLHE
RSLQSLPWRELGVDVVLDCTGVYGSREHGEAHIAAGAKKVLFSHPGSNDLDATVVYGVNQDQLRAEHRIVSNASCTTNCI
IPVIKLLDDAYGIESGTVTTIHSAMHDQQVIDAYHPDLRRTRAASQSIIPVDTKLAAGITRFFPQFNDRFEAIAVRVPTI
NVTAIDLSVTVKKPVKANEVNLLLQKAAQGAFHGIVDYTELPLVSVDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEW
GFANRMLDTTLAMATVAFR

Sequences:

>Translated_339_residues
MTVRVAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRQERDQLFVGDDAIRVLHE
RSLQSLPWRELGVDVVLDCTGVYGSREHGEAHIAAGAKKVLFSHPGSNDLDATVVYGVNQDQLRAEHRIVSNASCTTNCI
IPVIKLLDDAYGIESGTVTTIHSAMHDQQVIDAYHPDLRRTRAASQSIIPVDTKLAAGITRFFPQFNDRFEAIAVRVPTI
NVTAIDLSVTVKKPVKANEVNLLLQKAAQGAFHGIVDYTELPLVSVDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEW
GFANRMLDTTLAMATVAFR
>Mature_338_residues
TVRVAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRQERDQLFVGDDAIRVLHER
SLQSLPWRELGVDVVLDCTGVYGSREHGEAHIAAGAKKVLFSHPGSNDLDATVVYGVNQDQLRAEHRIVSNASCTTNCII
PVIKLLDDAYGIESGTVTTIHSAMHDQQVIDAYHPDLRRTRAASQSIIPVDTKLAAGITRFFPQFNDRFEAIAVRVPTIN
VTAIDLSVTVKKPVKANEVNLLLQKAAQGAFHGIVDYTELPLVSVDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEWG
FANRMLDTTLAMATVAFR

Specific function: Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate [H]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=336, Percent_Identity=37.5, Blast_Score=251, Evalue=7e-67,
Organism=Homo sapiens, GI7657116, Length=327, Percent_Identity=37.6146788990826, Blast_Score=223, Evalue=2e-58,
Organism=Escherichia coli, GI1789295, Length=339, Percent_Identity=100, Blast_Score=698, Evalue=0.0,
Organism=Escherichia coli, GI1788079, Length=329, Percent_Identity=41.9452887537994, Blast_Score=261, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI17534677, Length=341, Percent_Identity=37.8299120234604, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17534679, Length=340, Percent_Identity=37.9411764705882, Blast_Score=233, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI32566163, Length=342, Percent_Identity=38.0116959064327, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17568413, Length=342, Percent_Identity=38.0116959064327, Blast_Score=231, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6322468, Length=328, Percent_Identity=39.0243902439024, Blast_Score=249, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6321631, Length=330, Percent_Identity=39.6969696969697, Blast_Score=249, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6322409, Length=328, Percent_Identity=37.8048780487805, Blast_Score=241, Evalue=8e-65,
Organism=Drosophila melanogaster, GI17933600, Length=328, Percent_Identity=37.5, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI18110149, Length=328, Percent_Identity=37.5, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI85725000, Length=328, Percent_Identity=37.1951219512195, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI22023983, Length=328, Percent_Identity=37.1951219512195, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI19922412, Length=330, Percent_Identity=34.2424242424242, Blast_Score=217, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006422
- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.72 [H]

Molecular weight: Translated: 37300; Mature: 37169

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRVAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWE
CEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEE
VRQERDQLFVGDDAIRVLHERSLQSLPWRELGVDVVLDCTGVYGSREHGEAHIAAGAKKV
EHHCCCCEEECHHHHHHHHHHHHHCCCHHHCCCEEEEEECCCCCCCCCCCEEECCCCCEE
LFSHPGSNDLDATVVYGVNQDQLRAEHRIVSNASCTTNCIIPVIKLLDDAYGIESGTVTT
EEECCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHH
IHSAMHDQQVIDAYHPDLRRTRAASQSIIPVDTKLAAGITRFFPQFNDRFEAIAVRVPTI
HHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECEE
NVTAIDLSVTVKKPVKANEVNLLLQKAAQGAFHGIVDYTELPLVSVDFNHDPHSAIVDGT
EEEEEEEEEEEECCCCCHHHHHHHHHHHCCHHHCCCCCCCCCEEEEECCCCCCCCEECCC
QTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMATVAFR
HHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVRVAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWE
EEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEE
VRQERDQLFVGDDAIRVLHERSLQSLPWRELGVDVVLDCTGVYGSREHGEAHIAAGAKKV
EHHCCCCEEECHHHHHHHHHHHHHCCCHHHCCCEEEEEECCCCCCCCCCCEEECCCCCEE
LFSHPGSNDLDATVVYGVNQDQLRAEHRIVSNASCTTNCIIPVIKLLDDAYGIESGTVTT
EEECCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHH
IHSAMHDQQVIDAYHPDLRRTRAASQSIIPVDTKLAAGITRFFPQFNDRFEAIAVRVPTI
HHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECEE
NVTAIDLSVTVKKPVKANEVNLLLQKAAQGAFHGIVDYTELPLVSVDFNHDPHSAIVDGT
EEEEEEEEEEEECCCCCHHHHHHHHHHHCCHHHCCCCCCCCCEEEEECCCCCCCCEECCC
QTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMATVAFR
HHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA