Click here to switch to the map view.

The map label for this gene is hmuU [H]

Identifier: 209396092

GI number: 209396092

Start: 4498692

End: 4499648

Strand: Direct

Name: hmuU [H]

Synonym: ECH74115_4865

Alternate gene names: 209396092

Gene position: 4498692-4499648 (Clockwise)

Preceding gene: 209396759

Following gene: 209400972

Centisome position: 80.74

GC content: 52.56

Gene sequence:

>957_bases
ATGGGGCTATCACTATTATTGCTTGCCCTGGTGCTGTTCGGTGCTAGTCAGGGAGCGTTAAAGATCAGTTTTGATGCCCT
TTTTGATGAGGAATACCGCGATATCTGGCTCAATATTCGTCTACCACGGGTTTTGCTGGCGGTGCTGGTAGGTGCAGCGT
TGGCAACCGCAGGGGTAATTATGCAGGGGCTTTTTCGCAACCCAATGGCTGACCCAGGATTACTCGGCGTCAGTAGCGGT
TCTGCATTAATGGTTGGCGTTGCAATTGTGCTGCCCTTCTCCTTCCCAGTGGTGCTGGTGCTCTATGAGCAAATGGTGTT
TGCCATTGCCGGAAGTTTAGTAGTCTGCGCCATCATTTTTCTCATCACGCAGCGCCATCGCGATGGCAGCATGATGCAAT
TATTACTCGCCGGTATCGCCATCAATGCCCTGTGCGGCGCAGCGATCGGCATCCTGAGCTATATTGGCGATGAGCCGCAG
CTACGACAACTCACATTGTGGATGATGGGCAATCTTGGACAGGCGCAATGGCCGACGTTATTGGTTGCCAGTTCATTCAT
CCTTCCGGCCATTATCGCAACAACTTGTCTCGCCGGAACGCTGAATTTACTGCAGCTCGGTGATGAAGAAGCCCATTACC
TCGGCGTGAACGTTAAGCGTAAACGCCAGCAATTACTATTAGTGAGCTCACTGCTCGTTGGTGCTGCCGTATCGGTAAGC
GGCATTATCGGCTTTATTGGCCTGGTGATCCCGCATCTGATTCGCATGACTACCGGAGCAAATCACCGCTGGCTCATCCC
TTGTTCCGCCCTCGCCGGAGCCTGTTTATTGCTGATGGCAGACACGCTTGCCCGCACGCTGGTACAGCCAGCAGAAATGC
CCGTGGGATTATTAACCAGCCTGCTTGGTGGCCCTTATTTTATGTGGTTGATTCTGCGAAATCGGAGGATCACATGA

Upstream 100 bases:

>100_bases
CCTGAAACCGGCGTGATACCCCGGCGCGGCATGTCCGCGCCGTAATGTCGTAACGGAGTTTTGCGTGCTCAAGGATTCAT
TTTCATCCGCCAGGGTCTTT

Downstream 100 bases:

>100_bases
TCAGCGCCCAGAATCTGGTTTATAGCCTTCAGGGGCGGCGTCTGACTGATAATGTCTCGCTGACTTTTCCCGGTGGGGAA
ATTGTTGCCATTCTCGGCCC

Product: ABC transporter, iron chelate uptake transporter (FeCT) family, permease protein

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MGLSLLLLALVLFGASQGALKISFDALFDEEYRDIWLNIRLPRVLLAVLVGAALATAGVIMQGLFRNPMADPGLLGVSSG
SALMVGVAIVLPFSFPVVLVLYEQMVFAIAGSLVVCAIIFLITQRHRDGSMMQLLLAGIAINALCGAAIGILSYIGDEPQ
LRQLTLWMMGNLGQAQWPTLLVASSFILPAIIATTCLAGTLNLLQLGDEEAHYLGVNVKRKRQQLLLVSSLLVGAAVSVS
GIIGFIGLVIPHLIRMTTGANHRWLIPCSALAGACLLLMADTLARTLVQPAEMPVGLLTSLLGGPYFMWLILRNRRIT

Sequences:

>Translated_318_residues
MGLSLLLLALVLFGASQGALKISFDALFDEEYRDIWLNIRLPRVLLAVLVGAALATAGVIMQGLFRNPMADPGLLGVSSG
SALMVGVAIVLPFSFPVVLVLYEQMVFAIAGSLVVCAIIFLITQRHRDGSMMQLLLAGIAINALCGAAIGILSYIGDEPQ
LRQLTLWMMGNLGQAQWPTLLVASSFILPAIIATTCLAGTLNLLQLGDEEAHYLGVNVKRKRQQLLLVSSLLVGAAVSVS
GIIGFIGLVIPHLIRMTTGANHRWLIPCSALAGACLLLMADTLARTLVQPAEMPVGLLTSLLGGPYFMWLILRNRRIT
>Mature_317_residues
GLSLLLLALVLFGASQGALKISFDALFDEEYRDIWLNIRLPRVLLAVLVGAALATAGVIMQGLFRNPMADPGLLGVSSGS
ALMVGVAIVLPFSFPVVLVLYEQMVFAIAGSLVVCAIIFLITQRHRDGSMMQLLLAGIAINALCGAAIGILSYIGDEPQL
RQLTLWMMGNLGQAQWPTLLVASSFILPAIIATTCLAGTLNLLQLGDEEAHYLGVNVKRKRQQLLLVSSLLVGAAVSVSG
IIGFIGLVIPHLIRMTTGANHRWLIPCSALAGACLLLMADTLARTLVQPAEMPVGLLTSLLGGPYFMWLILRNRRIT

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=319, Percent_Identity=36.0501567398119, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI1788004, Length=279, Percent_Identity=41.2186379928315, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1790741, Length=279, Percent_Identity=39.0681003584229, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1786805, Length=300, Percent_Identity=37.3333333333333, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786804, Length=313, Percent_Identity=34.5047923322684, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1786347, Length=326, Percent_Identity=33.7423312883436, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 33952; Mature: 33820

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLSLLLLALVLFGASQGALKISFDALFDEEYRDIWLNIRLPRVLLAVLVGAALATAGVI
CCHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHH
MQGLFRNPMADPGLLGVSSGSALMVGVAIVLPFSFPVVLVLYEQMVFAIAGSLVVCAIIF
HHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LITQRHRDGSMMQLLLAGIAINALCGAAIGILSYIGDEPQLRQLTLWMMGNLGQAQWPTL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHH
LVASSFILPAIIATTCLAGTLNLLQLGDEEAHYLGVNVKRKRQQLLLVSSLLVGAAVSVS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHH
GIIGFIGLVIPHLIRMTTGANHRWLIPCSALAGACLLLMADTLARTLVQPAEMPVGLLTS
HHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHH
LLGGPYFMWLILRNRRIT
HHCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
GLSLLLLALVLFGASQGALKISFDALFDEEYRDIWLNIRLPRVLLAVLVGAALATAGVI
CHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHH
MQGLFRNPMADPGLLGVSSGSALMVGVAIVLPFSFPVVLVLYEQMVFAIAGSLVVCAIIF
HHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LITQRHRDGSMMQLLLAGIAINALCGAAIGILSYIGDEPQLRQLTLWMMGNLGQAQWPTL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHH
LVASSFILPAIIATTCLAGTLNLLQLGDEEAHYLGVNVKRKRQQLLLVSSLLVGAAVSVS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHH
GIIGFIGLVIPHLIRMTTGANHRWLIPCSALAGACLLLMADTLARTLVQPAEMPVGLLTS
HHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHH
LLGGPYFMWLILRNRRIT
HHCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]