| Definition | Escherichia coli O157:H7 str. EC4115, complete genome. |
|---|---|
| Accession | NC_011353 |
| Length | 5,572,075 |
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The map label for this gene is sorD [H]
Identifier: 209395780
GI number: 209395780
Start: 5145929
End: 5146735
Strand: Reverse
Name: sorD [H]
Synonym: ECH74115_5498
Alternate gene names: 209395780
Gene position: 5146735-5145929 (Counterclockwise)
Preceding gene: 209396331
Following gene: 209397359
Centisome position: 92.37
GC content: 51.55
Gene sequence:
>807_bases ATGCAAACGTGGTTAAATTTGCAGGATAAAATCATTATCGTCACCGGCGGCGCATCCGGTATTGGTCTGGCGATTGTAGA GGAATTATTAGCACAAGGCGCAAACGTACAGATGGTAGATATTCACGGTGGCGATGGACAATATGAAGGTCATAAAGGCT ATCAGTTTTGGCCGACCGATATTTCCAGCGCCAAAGAGGTAAATCATACGGTAGCGGAAATTATCCAGCGTTTTGGTCGC ATCGACGGTCTGGTCAATAACGCCGGGGTCAATTTCCCGCGTCTGCTGGTCGATGAGAAAGCGCCTGCCGGGCAGTATGA ACTCAACGAAGCTGCATTCGAAAAAATGGTCAATATCAACCAGAAAGGCGTTTTTCTGATGTCGCAGGCGGTGGCGCGAC AGATGGTCAAACAACATGATGGCGTGATTGTGAATGTTTCCTCAGAAAGTGGGCTGGAAGGCTCAGAAGGCCAAAGCTGT TACGCCGCTACCAAAGCCGCGCTCAATAGCTTCACGCGCTCCTGGTCGAAAGAGCTGGGTAAACACGGTATCCGTGTGGT CGGTATCGCGCCGGGGATTCTGGAAAAAACCGGGCTACGCACGCCGGAATATGAAGAGGCGCTGGCGTGGACGCGCAATA TCACCGTCGAGCAGCTGCGTGAAGGCTATACCAAAAACGCCATTCCTATTGGGCGCGCCGGAAGATTAGCAGAAATCGCT GATTTTGTTTGTTATCTGCTGTCTGAACGCGCCAGCTATATCACCGGAGTAACCACTAACATTGCGGGCGGCAAAACGCG CGGCTAA
Upstream 100 bases:
>100_bases TAGCAGCACAGCTGAACTATTACTGAAATAAAAATCTTCCCGATGTTTATCGTAATAAAAATTACGGCGGGTCCCTATTA TCTAAAATCAGGAGTCTGTT
Downstream 100 bases:
>100_bases GGAGGCTTTATGGTCAACGCCATTTTTTGTGCCCACGGCAAATTAGCTTGCGCCATGCTGGAATCGGTTCAGATGGTTTA CGGCAACGCCAATGTTGAAG
Product: sorbitol-6-phosphate 2-dehydrogenase
Products: NA
Alternate protein names: Glucitol-6-phosphate dehydrogenase; Ketosephosphate reductase [H]
Number of amino acids: Translated: 268; Mature: 268
Protein sequence:
>268_residues MQTWLNLQDKIIIVTGGASGIGLAIVEELLAQGANVQMVDIHGGDGQYEGHKGYQFWPTDISSAKEVNHTVAEIIQRFGR IDGLVNNAGVNFPRLLVDEKAPAGQYELNEAAFEKMVNINQKGVFLMSQAVARQMVKQHDGVIVNVSSESGLEGSEGQSC YAATKAALNSFTRSWSKELGKHGIRVVGIAPGILEKTGLRTPEYEEALAWTRNITVEQLREGYTKNAIPIGRAGRLAEIA DFVCYLLSERASYITGVTTNIAGGKTRG
Sequences:
>Translated_268_residues MQTWLNLQDKIIIVTGGASGIGLAIVEELLAQGANVQMVDIHGGDGQYEGHKGYQFWPTDISSAKEVNHTVAEIIQRFGR IDGLVNNAGVNFPRLLVDEKAPAGQYELNEAAFEKMVNINQKGVFLMSQAVARQMVKQHDGVIVNVSSESGLEGSEGQSC YAATKAALNSFTRSWSKELGKHGIRVVGIAPGILEKTGLRTPEYEEALAWTRNITVEQLREGYTKNAIPIGRAGRLAEIA DFVCYLLSERASYITGVTTNIAGGKTRG >Mature_268_residues MQTWLNLQDKIIIVTGGASGIGLAIVEELLAQGANVQMVDIHGGDGQYEGHKGYQFWPTDISSAKEVNHTVAEIIQRFGR IDGLVNNAGVNFPRLLVDEKAPAGQYELNEAAFEKMVNINQKGVFLMSQAVARQMVKQHDGVIVNVSSESGLEGSEGQSC YAATKAALNSFTRSWSKELGKHGIRVVGIAPGILEKTGLRTPEYEEALAWTRNITVEQLREGYTKNAIPIGRAGRLAEIA DFVCYLLSERASYITGVTTNIAGGKTRG
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=276, Percent_Identity=30.7971014492754, Blast_Score=112, Evalue=3e-25, Organism=Homo sapiens, GI40254992, Length=262, Percent_Identity=31.6793893129771, Blast_Score=112, Evalue=3e-25, Organism=Homo sapiens, GI10190704, Length=266, Percent_Identity=32.3308270676692, Blast_Score=111, Evalue=7e-25, Organism=Homo sapiens, GI4758504, Length=193, Percent_Identity=33.6787564766839, Blast_Score=102, Evalue=3e-22, Organism=Homo sapiens, GI19923817, Length=273, Percent_Identity=30.4029304029304, Blast_Score=101, Evalue=6e-22, Organism=Homo sapiens, GI32483357, Length=267, Percent_Identity=31.4606741573034, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI59889578, Length=245, Percent_Identity=29.7959183673469, Blast_Score=95, Evalue=7e-20, Organism=Homo sapiens, GI31542939, Length=218, Percent_Identity=33.0275229357798, Blast_Score=94, Evalue=1e-19, Organism=Homo sapiens, GI83715985, Length=183, Percent_Identity=31.6939890710383, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI7705925, Length=264, Percent_Identity=28.030303030303, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI224922801, Length=182, Percent_Identity=34.0659340659341, Blast_Score=82, Evalue=5e-16, Organism=Homo sapiens, GI66933014, Length=260, Percent_Identity=29.6153846153846, Blast_Score=82, Evalue=7e-16, Organism=Homo sapiens, GI20149619, Length=202, Percent_Identity=26.2376237623762, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI5031737, Length=269, Percent_Identity=28.2527881040892, Blast_Score=71, Evalue=8e-13, Organism=Homo sapiens, GI126723750, Length=270, Percent_Identity=27.037037037037, Blast_Score=71, Evalue=9e-13, Organism=Homo sapiens, GI4503817, Length=236, Percent_Identity=27.5423728813559, Blast_Score=66, Evalue=3e-11, Organism=Escherichia coli, GI1787335, Length=271, Percent_Identity=34.3173431734317, Blast_Score=124, Evalue=8e-30, Organism=Escherichia coli, GI87082100, Length=269, Percent_Identity=31.2267657992565, Blast_Score=102, Evalue=2e-23, Organism=Escherichia coli, GI1790717, Length=271, Percent_Identity=29.1512915129151, Blast_Score=102, Evalue=3e-23, Organism=Escherichia coli, GI87082160, Length=266, Percent_Identity=28.5714285714286, Blast_Score=98, Evalue=5e-22, Organism=Escherichia coli, GI1788459, Length=206, Percent_Identity=34.4660194174757, Blast_Score=93, Evalue=2e-20, Organism=Escherichia coli, GI1789208, Length=265, Percent_Identity=27.5471698113208, Blast_Score=91, Evalue=8e-20, Organism=Escherichia coli, GI1786812, Length=267, Percent_Identity=28.8389513108614, Blast_Score=91, Evalue=1e-19, Organism=Escherichia coli, GI2367175, Length=267, Percent_Identity=32.2097378277154, Blast_Score=90, Evalue=1e-19, Organism=Escherichia coli, GI1787905, Length=269, Percent_Identity=28.996282527881, Blast_Score=88, Evalue=5e-19, Organism=Escherichia coli, GI1789057, Length=273, Percent_Identity=26.7399267399267, Blast_Score=87, Evalue=1e-18, Organism=Escherichia coli, GI1789378, Length=280, Percent_Identity=28.2142857142857, Blast_Score=80, Evalue=1e-16, Organism=Escherichia coli, GI2367365, Length=256, Percent_Identity=26.171875, Blast_Score=72, Evalue=5e-14, Organism=Escherichia coli, GI1787820, Length=194, Percent_Identity=28.3505154639175, Blast_Score=71, Evalue=9e-14, Organism=Caenorhabditis elegans, GI25147288, Length=265, Percent_Identity=34.3396226415094, Blast_Score=122, Evalue=2e-28, Organism=Caenorhabditis elegans, GI17555706, Length=267, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=7e-26, Organism=Caenorhabditis elegans, GI17561402, Length=271, Percent_Identity=30.9963099630996, Blast_Score=100, Evalue=6e-22, Organism=Caenorhabditis elegans, GI17562908, Length=275, Percent_Identity=29.4545454545455, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17562906, Length=276, Percent_Identity=30.0724637681159, Blast_Score=94, Evalue=6e-20, Organism=Caenorhabditis elegans, GI115534694, Length=273, Percent_Identity=28.9377289377289, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17562990, Length=277, Percent_Identity=31.0469314079422, Blast_Score=91, Evalue=7e-19, Organism=Caenorhabditis elegans, GI17544670, Length=268, Percent_Identity=29.1044776119403, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17560150, Length=277, Percent_Identity=28.5198555956679, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI72000259, Length=272, Percent_Identity=29.0441176470588, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17562910, Length=279, Percent_Identity=28.3154121863799, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17538480, Length=266, Percent_Identity=29.3233082706767, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17538182, Length=214, Percent_Identity=29.9065420560748, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17562904, Length=277, Percent_Identity=30.3249097472924, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17551412, Length=271, Percent_Identity=30.9963099630996, Blast_Score=86, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17559104, Length=276, Percent_Identity=27.1739130434783, Blast_Score=86, Evalue=3e-17, Organism=Caenorhabditis elegans, GI71994604, Length=265, Percent_Identity=26.7924528301887, Blast_Score=84, Evalue=5e-17, Organism=Caenorhabditis elegans, GI71994600, Length=206, Percent_Identity=26.6990291262136, Blast_Score=84, Evalue=7e-17, Organism=Caenorhabditis elegans, GI17560332, Length=280, Percent_Identity=29.6428571428571, Blast_Score=84, Evalue=9e-17, Organism=Caenorhabditis elegans, GI17538486, Length=275, Percent_Identity=28.7272727272727, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17531453, Length=276, Percent_Identity=28.2608695652174, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17563726, Length=271, Percent_Identity=28.0442804428044, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17565030, Length=277, Percent_Identity=29.6028880866426, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI193204405, Length=279, Percent_Identity=29.7491039426523, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17560676, Length=277, Percent_Identity=25.9927797833935, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17560220, Length=274, Percent_Identity=28.4671532846715, Blast_Score=77, Evalue=6e-15, Organism=Caenorhabditis elegans, GI17536025, Length=274, Percent_Identity=25.5474452554745, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17508895, Length=201, Percent_Identity=26.865671641791, Blast_Score=68, Evalue=6e-12, Organism=Caenorhabditis elegans, GI17561272, Length=209, Percent_Identity=24.8803827751196, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17567345, Length=205, Percent_Identity=26.8292682926829, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17508651, Length=211, Percent_Identity=24.1706161137441, Blast_Score=65, Evalue=5e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=273, Percent_Identity=27.4725274725275, Blast_Score=75, Evalue=8e-15, Organism=Saccharomyces cerevisiae, GI6322861, Length=201, Percent_Identity=30.3482587064677, Blast_Score=73, Evalue=5e-14, Organism=Saccharomyces cerevisiae, GI6323882, Length=263, Percent_Identity=28.1368821292776, Blast_Score=68, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6322227, Length=195, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=3e-12, Organism=Drosophila melanogaster, GI23397609, Length=267, Percent_Identity=32.9588014981273, Blast_Score=128, Evalue=5e-30, Organism=Drosophila melanogaster, GI24639444, Length=265, Percent_Identity=33.5849056603774, Blast_Score=117, Evalue=7e-27, Organism=Drosophila melanogaster, GI24643142, Length=266, Percent_Identity=31.9548872180451, Blast_Score=101, Evalue=6e-22, Organism=Drosophila melanogaster, GI21357041, Length=268, Percent_Identity=29.8507462686567, Blast_Score=99, Evalue=3e-21, Organism=Drosophila melanogaster, GI21355319, Length=276, Percent_Identity=29.7101449275362, Blast_Score=99, Evalue=3e-21, Organism=Drosophila melanogaster, GI28571526, Length=282, Percent_Identity=29.0780141843972, Blast_Score=96, Evalue=3e-20, Organism=Drosophila melanogaster, GI17737361, Length=209, Percent_Identity=33.0143540669856, Blast_Score=96, Evalue=3e-20, Organism=Drosophila melanogaster, GI24644339, Length=277, Percent_Identity=26.3537906137184, Blast_Score=92, Evalue=5e-19, Organism=Drosophila melanogaster, GI24644337, Length=223, Percent_Identity=30.4932735426009, Blast_Score=88, Evalue=6e-18, Organism=Drosophila melanogaster, GI24665243, Length=204, Percent_Identity=31.3725490196078, Blast_Score=78, Evalue=6e-15, Organism=Drosophila melanogaster, GI221331218, Length=201, Percent_Identity=30.8457711442786, Blast_Score=74, Evalue=7e-14, Organism=Drosophila melanogaster, GI24665247, Length=205, Percent_Identity=31.219512195122, Blast_Score=74, Evalue=9e-14, Organism=Drosophila melanogaster, GI21356301, Length=207, Percent_Identity=29.4685990338164, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI221331216, Length=202, Percent_Identity=30.6930693069307, Blast_Score=70, Evalue=1e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.140 [H]
Molecular weight: Translated: 29023; Mature: 29023
Theoretical pI: Translated: 6.37; Mature: 6.37
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQTWLNLQDKIIIVTGGASGIGLAIVEELLAQGANVQMVDIHGGDGQYEGHKGYQFWPTD CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEECCCC ISSAKEVNHTVAEIIQRFGRIDGLVNNAGVNFPRLLVDEKAPAGQYELNEAAFEKMVNIN CCHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCHHEECCCCCCCCCHHHHHHHHHHHCCC QKGVFLMSQAVARQMVKQHDGVIVNVSSESGLEGSEGQSCYAATKAALNSFTRSWSKELG CCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH KHGIRVVGIAPGILEKTGLRTPEYEEALAWTRNITVEQLREGYTKNAIPIGRAGRLAEIA HCCCEEEEECCCHHHHCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCHHHHH DFVCYLLSERASYITGVTTNIAGGKTRG HHHHHHHHHHHHHHHCCEEECCCCCCCC >Mature Secondary Structure MQTWLNLQDKIIIVTGGASGIGLAIVEELLAQGANVQMVDIHGGDGQYEGHKGYQFWPTD CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEECCCC ISSAKEVNHTVAEIIQRFGRIDGLVNNAGVNFPRLLVDEKAPAGQYELNEAAFEKMVNIN CCHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCHHEECCCCCCCCCHHHHHHHHHHHCCC QKGVFLMSQAVARQMVKQHDGVIVNVSSESGLEGSEGQSCYAATKAALNSFTRSWSKELG CCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH KHGIRVVGIAPGILEKTGLRTPEYEEALAWTRNITVEQLREGYTKNAIPIGRAGRLAEIA HCCCEEEEECCCHHHHCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCHHHHH DFVCYLLSERASYITGVTTNIAGGKTRG HHHHHHHHHHHHHHHCCEEECCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7947968; 7652212 [H]