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The map label for this gene is cadB [H]

Identifier: 209695910

GI number: 209695910

Start: 2669762

End: 2671096

Strand: Reverse

Name: cadB [H]

Synonym: VSAL_I2492

Alternate gene names: 209695910

Gene position: 2671096-2669762 (Counterclockwise)

Preceding gene: 209695912

Following gene: 209695909

Centisome position: 80.33

GC content: 43.6

Gene sequence:

>1335_bases
ATGGAATCGAATACCAAAAAAATTGGCTTAATTGCCTGTACTGGCGTTGTTGCCGGCAACATGATGGGGAGCGGTATTGC
ACTATTACCTTCTTCATTAGCAGCTGTTGGCTCAATTTCAATTTTTAGTTGGATCATTTGTTTAGTTGGTGCGTTGAGTT
TGGCATTTGTTTTTGCTCGCTTAGCAACAAAGAACCCACAAGAAGGTGGTCCAATCGCTTACGCTGGTGAAGTTGCTCCT
GTGTTTGGTTTCCAAACTGGGGTTCTTTACTACCACGCAAACTGGATTGGTAACTTAGCCATCGCCATTACTGGTGTGTC
TTATTTATCTGTTTTCTTCCCAGCTTTAAGTCATCCAATCCCTGCTGCAATAGCAACGGTTGCGTCTGTATGGATATTTA
CCTTTGTAAACTTACTCGGTGGTAGCTGGGTTAGTCGTCTTTGTACTCTAGGTCTCGGGCTTATCCTTATTCCAGTTGTT
GGTACCGCTGTTGCTGGTTGGGGGCATTTTGATATGGCCATTTACAACCAAAACTGGAACGTATCATCAGGCACAAACAG
CCATGCTGTTATCAGTGCGGTATTGATTTGTTTATGGTCATTTGTTGGTGTTGAATCAGCCGCTGTATCATCTGGTATGG
TAAAAAATCCAAAACGCACGGTTCCTCTAGCAACCATGTTGGGTACAGCGATTGCGGGTATTATTTATATCCTATCTACT
CAAGTTATTGGTGGTATGTTCCCGGCGTCTGAAGTCGCTGCATCAAGTGCACCTTTCGCACTGGCAACAACAGAAATCTT
CGGTAGCTGGTCTGCTCCATTCGTTTCTGCATTTACTGCACTTGCGTGTTTCACTTCTCTTGGTTCTTGGATGATGTTGG
TTGGTGAGGCCGGTAAACGTGCTGCTAACGATGGCAACTTCCCTAAAATCTATGGCGAAACTGATAAAAATGGCGTAGCG
AAAAAAGGGCTTATCTTAGCATCGTTAAAAATGACAGCGCTAATGATTGTACTTACTGCGTTCAGTTCTCAATCTGCTCA
TACTGCTGACTTATTTAATCAGCTAACAACAGATGCCGTACTACTAACAATGCTTCCTTACTTCTACTCAAGCATTAACT
TAATTCGCTTTGAAGGTATGACTACTCGTAGTGGCTTTACGATGATGTTCTCTGGCGTGGCTTGTGTGTTCTGTATGATT
GCGCTTGCTGGTGCAGAAGGTGCAACACTGACTGCAACCTTTATCGTGTCACTGGTTATCCTTATGTTCTACGCAAAAAA
AATGGGCTTGAAACAAGCCGAGCAACACATAAGCACTGAAGCTGCTGCCCATTAA

Upstream 100 bases:

>100_bases
AGTTTTTATAATTTGGTTTAAATAATGTCTCCCCTTTTTAATGAACATTTAAGTATAACGGGCACGAAAAAAGGCCCATT
CGATAATCCCTGGAGATATG

Downstream 100 bases:

>100_bases
TTATCACACGATAGCGTAAACACTTAACGCTACCAACTTAGTAAGTTTACCCCCTGGCGCTCCACTACCTCACCATCAAA
AAGATGGGGAGCGCCTTGTT

Product: lysine/cadaverine antiporter

Products: cadaverine [Cytoplasm]; L-lysine [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MESNTKKIGLIACTGVVAGNMMGSGIALLPSSLAAVGSISIFSWIICLVGALSLAFVFARLATKNPQEGGPIAYAGEVAP
VFGFQTGVLYYHANWIGNLAIAITGVSYLSVFFPALSHPIPAAIATVASVWIFTFVNLLGGSWVSRLCTLGLGLILIPVV
GTAVAGWGHFDMAIYNQNWNVSSGTNSHAVISAVLICLWSFVGVESAAVSSGMVKNPKRTVPLATMLGTAIAGIIYILST
QVIGGMFPASEVAASSAPFALATTEIFGSWSAPFVSAFTALACFTSLGSWMMLVGEAGKRAANDGNFPKIYGETDKNGVA
KKGLILASLKMTALMIVLTAFSSQSAHTADLFNQLTTDAVLLTMLPYFYSSINLIRFEGMTTRSGFTMMFSGVACVFCMI
ALAGAEGATLTATFIVSLVILMFYAKKMGLKQAEQHISTEAAAH

Sequences:

>Translated_444_residues
MESNTKKIGLIACTGVVAGNMMGSGIALLPSSLAAVGSISIFSWIICLVGALSLAFVFARLATKNPQEGGPIAYAGEVAP
VFGFQTGVLYYHANWIGNLAIAITGVSYLSVFFPALSHPIPAAIATVASVWIFTFVNLLGGSWVSRLCTLGLGLILIPVV
GTAVAGWGHFDMAIYNQNWNVSSGTNSHAVISAVLICLWSFVGVESAAVSSGMVKNPKRTVPLATMLGTAIAGIIYILST
QVIGGMFPASEVAASSAPFALATTEIFGSWSAPFVSAFTALACFTSLGSWMMLVGEAGKRAANDGNFPKIYGETDKNGVA
KKGLILASLKMTALMIVLTAFSSQSAHTADLFNQLTTDAVLLTMLPYFYSSINLIRFEGMTTRSGFTMMFSGVACVFCMI
ALAGAEGATLTATFIVSLVILMFYAKKMGLKQAEQHISTEAAAH
>Mature_444_residues
MESNTKKIGLIACTGVVAGNMMGSGIALLPSSLAAVGSISIFSWIICLVGALSLAFVFARLATKNPQEGGPIAYAGEVAP
VFGFQTGVLYYHANWIGNLAIAITGVSYLSVFFPALSHPIPAAIATVASVWIFTFVNLLGGSWVSRLCTLGLGLILIPVV
GTAVAGWGHFDMAIYNQNWNVSSGTNSHAVISAVLICLWSFVGVESAAVSSGMVKNPKRTVPLATMLGTAIAGIIYILST
QVIGGMFPASEVAASSAPFALATTEIFGSWSAPFVSAFTALACFTSLGSWMMLVGEAGKRAANDGNFPKIYGETDKNGVA
KKGLILASLKMTALMIVLTAFSSQSAHTADLFNQLTTDAVLLTMLPYFYSSINLIRFEGMTTRSGFTMMFSGVACVFCMI
ALAGAEGATLTATFIVSLVILMFYAKKMGLKQAEQHISTEAAAH

Specific function: Probable cadaverine/lysine antiporter or part of it [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI115648063, Length=328, Percent_Identity=27.4390243902439, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI115648022, Length=328, Percent_Identity=27.4390243902439, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI186910308, Length=327, Percent_Identity=27.5229357798165, Blast_Score=66, Evalue=8e-11,
Organism=Homo sapiens, GI186910306, Length=327, Percent_Identity=27.5229357798165, Blast_Score=66, Evalue=8e-11,
Organism=Homo sapiens, GI186910304, Length=327, Percent_Identity=27.5229357798165, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1790575, Length=442, Percent_Identity=66.5158371040724, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI2367353, Length=428, Percent_Identity=38.5514018691589, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI1786908, Length=383, Percent_Identity=33.9425587467363, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI1787890, Length=384, Percent_Identity=27.0833333333333, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790584, Length=293, Percent_Identity=26.2798634812287, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221331183, Length=299, Percent_Identity=27.0903010033445, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17647653, Length=299, Percent_Identity=27.0903010033445, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24664379, Length=299, Percent_Identity=27.0903010033445, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004754 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46440; Mature: 46440

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESNTKKIGLIACTGVVAGNMMGSGIALLPSSLAAVGSISIFSWIICLVGALSLAFVFAR
CCCCCCEEEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATKNPQEGGPIAYAGEVAPVFGFQTGVLYYHANWIGNLAIAITGVSYLSVFFPALSHPI
HHCCCCCCCCCEEEECCCCHHHCCHHCEEEEECCHHHCHHHHHHHHHHHHHHHHHHCCCH
PAAIATVASVWIFTFVNLLGGSWVSRLCTLGLGLILIPVVGTAVAGWGHFDMAIYNQNWN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
VSSGTNSHAVISAVLICLWSFVGVESAAVSSGMVKNPKRTVPLATMLGTAIAGIIYILST
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QVIGGMFPASEVAASSAPFALATTEIFGSWSAPFVSAFTALACFTSLGSWMMLVGEAGKR
HHHHCCCCHHHHHCCCCCCEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AANDGNFPKIYGETDKNGVAKKGLILASLKMTALMIVLTAFSSQSAHTADLFNQLTTDAV
CCCCCCCCEEECCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LLTMLPYFYSSINLIRFEGMTTRSGFTMMFSGVACVFCMIALAGAEGATLTATFIVSLVI
HHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LMFYAKKMGLKQAEQHISTEAAAH
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MESNTKKIGLIACTGVVAGNMMGSGIALLPSSLAAVGSISIFSWIICLVGALSLAFVFAR
CCCCCCEEEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATKNPQEGGPIAYAGEVAPVFGFQTGVLYYHANWIGNLAIAITGVSYLSVFFPALSHPI
HHCCCCCCCCCEEEECCCCHHHCCHHCEEEEECCHHHCHHHHHHHHHHHHHHHHHHCCCH
PAAIATVASVWIFTFVNLLGGSWVSRLCTLGLGLILIPVVGTAVAGWGHFDMAIYNQNWN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
VSSGTNSHAVISAVLICLWSFVGVESAAVSSGMVKNPKRTVPLATMLGTAIAGIIYILST
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QVIGGMFPASEVAASSAPFALATTEIFGSWSAPFVSAFTALACFTSLGSWMMLVGEAGKR
HHHHCCCCHHHHHCCCCCCEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AANDGNFPKIYGETDKNGVAKKGLILASLKMTALMIVLTAFSSQSAHTADLFNQLTTDAV
CCCCCCCCEEECCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LLTMLPYFYSSINLIRFEGMTTRSGFTMMFSGVACVFCMIALAGAEGATLTATFIVSLVI
HHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LMFYAKKMGLKQAEQHISTEAAAH
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: cadaverine [Cytoplasm]; Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: cadaverine [Cytoplasm] + Proton [Periplasm] + L-lysine [Periplasm] = cadaverine [Cytoplasm] + L-lysine [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]