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The map label for this gene is dxr

Identifier: 209695845

GI number: 209695845

Start: 2591804

End: 2593006

Strand: Reverse

Name: dxr

Synonym: VSAL_I2421

Alternate gene names: 209695845

Gene position: 2593006-2591804 (Counterclockwise)

Preceding gene: 209695846

Following gene: 209695844

Centisome position: 77.98

GC content: 39.9

Gene sequence:

>1203_bases
ATGCGCAAGTTAACCGTTCTTGGGGCTACAGGCTCTATTGGTAGTAGTACACTTTCAGTCGCAAAACAAAATTCACATCA
ATTTGAAATCGTTGCTCTCGGTGCGGGTTCAAATGTACAAAAGATGTTTGAACTATGTTGTGAGTGGCAACCTAAATATG
CGGCGATGGCCGATCCAATTTCTGCTTTAGCTCTTCAACGCCAACTAAAATCAAACTCGATAAGAACTGACGTTTTTTCT
GGAGAAGAAGGTCTATGCCATATTGCTCAACTTGATGAAGTTGATACTGTTATGGCTGCTATTGTCGGTGCTGCTGGCTT
ACTACCGACCATGTCTGCTGTTAAAGCGGGCAAACGTATTCTATTAGCGAATAAAGAAGCGTTGGTGATGTCGGGTCAAT
TATTTATTGATGCTGTTGAAAAATATGGGGCCGAATTACTCCCTGTTGATAGTGAACACAATGCTATATTTCAATGTTTA
CCAGAATCAATTCAAAGGAAATTAGGGCGTTGTGATTTAGATGCTCATGGTGTGAGTTCTATTTTATTAACCGGTTCTGG
TGGTCCATTTCGATATACTGATATTTCAGAATTAGTGTCAGTGACGCCAGAAATGGCAATTGCTCATCCTAATTGGTCTA
TGGGGCCTAAAATATCCGTTGATTCAGCAACGATGATGAATAAAGGATTAGAGTACATTGAAGCTCGTTGGTTATTCAAC
ACCACAAAAGAGCAACTAAAAGTAATTATTCATCCTCAATCTGTTATTCATTCTATGGTCCAATATAAAGACGGTTCTGT
ATTAGCTCAAATGGGACTGCCAGACATGAGAACACCAATAGCGTGTACCATGTCTTACCCTGAGCGTATTAGTTCAGGTG
TTGAACCTCTTGATTTCACTAAAATTGGAGAGCTTTCTTTTTTAGAACCAGATTACTCTCGTTACCCTTGCTTAAAATTA
GCTATTGATGCGTGTTACTCAGGTCAGCATGCGACAACGGGATTGAATGCGGCAAATGAACAGTCGGTTGCCGCATTTTT
AAACAATGAAATTGGTTTTACGGATATCACTCGAATTAATGAGCAGGTTTTGAACAAAGTATGTGCAAACTTCCAAAACC
TTGAGCTAGATAGCTTGGAAAGCCTGATCGACCTAGATAGAATGGCGCGTAATTATGCCGATGAGGCTCTTAAAAAGGTT
TAA

Upstream 100 bases:

>100_bases
CAGCTCTTTACGTAGAGCAACATAAAAAATGATAGGTTTAATACGGCAGATAGTATGATCTGCCGCTTTTCTTTCTTACT
TTCATCATGGTCACTTCATT

Downstream 100 bases:

>100_bases
CTATGTCAGAACTACTTTGGAATTTAGCATCGTTTATCATTGCTCTCGGTATTTTGGTTGCCGTGCATGAGTATGGCCAT
TTCTGGGTAGCTCGCCGTTG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MRKLTVLGATGSIGSSTLSVAKQNSHQFEIVALGAGSNVQKMFELCCEWQPKYAAMADPISALALQRQLKSNSIRTDVFS
GEEGLCHIAQLDEVDTVMAAIVGAAGLLPTMSAVKAGKRILLANKEALVMSGQLFIDAVEKYGAELLPVDSEHNAIFQCL
PESIQRKLGRCDLDAHGVSSILLTGSGGPFRYTDISELVSVTPEMAIAHPNWSMGPKISVDSATMMNKGLEYIEARWLFN
TTKEQLKVIIHPQSVIHSMVQYKDGSVLAQMGLPDMRTPIACTMSYPERISSGVEPLDFTKIGELSFLEPDYSRYPCLKL
AIDACYSGQHATTGLNAANEQSVAAFLNNEIGFTDITRINEQVLNKVCANFQNLELDSLESLIDLDRMARNYADEALKKV

Sequences:

>Translated_400_residues
MRKLTVLGATGSIGSSTLSVAKQNSHQFEIVALGAGSNVQKMFELCCEWQPKYAAMADPISALALQRQLKSNSIRTDVFS
GEEGLCHIAQLDEVDTVMAAIVGAAGLLPTMSAVKAGKRILLANKEALVMSGQLFIDAVEKYGAELLPVDSEHNAIFQCL
PESIQRKLGRCDLDAHGVSSILLTGSGGPFRYTDISELVSVTPEMAIAHPNWSMGPKISVDSATMMNKGLEYIEARWLFN
TTKEQLKVIIHPQSVIHSMVQYKDGSVLAQMGLPDMRTPIACTMSYPERISSGVEPLDFTKIGELSFLEPDYSRYPCLKL
AIDACYSGQHATTGLNAANEQSVAAFLNNEIGFTDITRINEQVLNKVCANFQNLELDSLESLIDLDRMARNYADEALKKV
>Mature_400_residues
MRKLTVLGATGSIGSSTLSVAKQNSHQFEIVALGAGSNVQKMFELCCEWQPKYAAMADPISALALQRQLKSNSIRTDVFS
GEEGLCHIAQLDEVDTVMAAIVGAAGLLPTMSAVKAGKRILLANKEALVMSGQLFIDAVEKYGAELLPVDSEHNAIFQCL
PESIQRKLGRCDLDAHGVSSILLTGSGGPFRYTDISELVSVTPEMAIAHPNWSMGPKISVDSATMMNKGLEYIEARWLFN
TTKEQLKVIIHPQSVIHSMVQYKDGSVLAQMGLPDMRTPIACTMSYPERISSGVEPLDFTKIGELSFLEPDYSRYPCLKL
AIDACYSGQHATTGLNAANEQSVAAFLNNEIGFTDITRINEQVLNKVCANFQNLELDSLESLIDLDRMARNYADEALKKV

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=400, Percent_Identity=59.25, Blast_Score=468, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_ALISL (B6EK51)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263775.1
- GeneID:   6988436
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2421
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 43601; Mature: 43601

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: BINDING 125-125 BINDING 152-152 BINDING 186-186 BINDING 209-209 BINDING 231-231

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLTVLGATGSIGSSTLSVAKQNSHQFEIVALGAGSNVQKMFELCCEWQPKYAAMADPI
CCEEEEEECCCCCCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHH
SALALQRQLKSNSIRTDVFSGEEGLCHIAQLDEVDTVMAAIVGAAGLLPTMSAVKAGKRI
HHHHHHHHHHCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLANKEALVMSGQLFIDAVEKYGAELLPVDSEHNAIFQCLPESIQRKLGRCDLDAHGVSS
EEECCCEEEEECHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEE
ILLTGSGGPFRYTDISELVSVTPEMAIAHPNWSMGPKISVDSATMMNKGLEYIEARWLFN
EEEECCCCCEEECCHHHHHHCCCCCEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHHC
TTKEQLKVIIHPQSVIHSMVQYKDGSVLAQMGLPDMRTPIACTMSYPERISSGVEPLDFT
CCHHHEEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECCHHHHHCCCCCCCCC
KIGELSFLEPDYSRYPCLKLAIDACYSGQHATTGLNAANEQSVAAFLNNEIGFTDITRIN
CCCCCEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHH
EQVLNKVCANFQNLELDSLESLIDLDRMARNYADEALKKV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKLTVLGATGSIGSSTLSVAKQNSHQFEIVALGAGSNVQKMFELCCEWQPKYAAMADPI
CCEEEEEECCCCCCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHH
SALALQRQLKSNSIRTDVFSGEEGLCHIAQLDEVDTVMAAIVGAAGLLPTMSAVKAGKRI
HHHHHHHHHHCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLANKEALVMSGQLFIDAVEKYGAELLPVDSEHNAIFQCLPESIQRKLGRCDLDAHGVSS
EEECCCEEEEECHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEE
ILLTGSGGPFRYTDISELVSVTPEMAIAHPNWSMGPKISVDSATMMNKGLEYIEARWLFN
EEEECCCCCEEECCHHHHHHCCCCCEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHHC
TTKEQLKVIIHPQSVIHSMVQYKDGSVLAQMGLPDMRTPIACTMSYPERISSGVEPLDFT
CCHHHEEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECCHHHHHCCCCCCCCC
KIGELSFLEPDYSRYPCLKLAIDACYSGQHATTGLNAANEQSVAAFLNNEIGFTDITRIN
CCCCCEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHH
EQVLNKVCANFQNLELDSLESLIDLDRMARNYADEALKKV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA