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The map label for this gene is moaA [H]

Identifier: 209695344

GI number: 209695344

Start: 2013073

End: 2014062

Strand: Direct

Name: moaA [H]

Synonym: VSAL_I1877

Alternate gene names: 209695344

Gene position: 2013073-2014062 (Clockwise)

Preceding gene: 209695342

Following gene: 209695345

Centisome position: 60.54

GC content: 39.39

Gene sequence:

>990_bases
GTGGCGAAACAATTTGAAGATAACTACAACCGTAAGTTTTATTATTTACGGTTGTCGATTACAGACGTCTGTAATTTTAA
ATGTACTTATTGCTTACCTGATGGTTATCGACCTGAAAATGGTAAGCGAGAGTCCTTCCTAGAGCTTGATGAAATCGAAC
GTACTGTGAGTGCGTTTGCCCGCTGTGGTACGTCAAAAGTGCGTATTACAGGGGGAGAGCCAAGCCTTCGTAAAGATTTC
ACTGACATTATCCGTACTGTGGCTTCTCAGCCGGGGATAACTAAAGTTGCTACGACAACAAATGGTTATCGGATGGAAAA
ACATGTCGCTGAATGGCGTGAAGCAGGTTTAACGAATATCAATGTCAGTGTTGATAGCTTAAATCCAAATATGTTTTATC
AGATCACAGGTGAAAATAAATTCGCCGAAGTTATGGCTGGTATTGATAAAGCAATTGAAGTGGGTTTTAAGCAAGTCAAA
GTGAATACGGTATTACTGAAAGATCTCAACAGCACCGAATTACCTCTCTTTTTAAAGTGGATCCAAACTCGTCCTATTCA
ATTGCGTTTTATTGAGTTGATGCAAACGGGTGAAATGGACGATCTTTTCAAAAATCATCATCAATCTGGTGTCTCGATCC
GTAATCACTTAATTGCGAATAACTGGATATTAAAAGCTCGTGGCGAAAGTGATGGCCCAGCTCAAGTTTTTATTCATCCA
GATTATATGGGTGAAATAGGGTTAATAATGCCTTACGAAAAAGATTTCTGTCAGAGTTGTAATCGATTACGAGTATCAGC
AAAAGGTAAGTTACATATGTGCCTATTTGGTGATTACGGTGTTGAATTACGTGATTTATTGCAAGCTGATACTCAGCAAG
ACGAGTTAATTCAGCGCATTCAAACGCAATTAGATAATAAAGCAGAAGGCCACTTTTTACATGATGGCCACGCTGGAATG
ACCCCTCATTTAGCCTCTATTGGCGGATAA

Upstream 100 bases:

>100_bases
GTTCTAAGAAATATTCAATATGTAGTGTGAGCCAGTGACAATTCGGTCACAAGGGTTTGTTTGGAAATGAACAAGCCTCC
CGTGTTTGGAAAGGTGTTCC

Downstream 100 bases:

>100_bases
TAAAGAAGAATTATGTCAAATTTTACTCATATTAATGCCTCTGGTGAGGCGAACATGGTTGATGTATCAGCAAAACAAGA
AACCGTTCGTGAAGCGCGTG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MAKQFEDNYNRKFYYLRLSITDVCNFKCTYCLPDGYRPENGKRESFLELDEIERTVSAFARCGTSKVRITGGEPSLRKDF
TDIIRTVASQPGITKVATTTNGYRMEKHVAEWREAGLTNINVSVDSLNPNMFYQITGENKFAEVMAGIDKAIEVGFKQVK
VNTVLLKDLNSTELPLFLKWIQTRPIQLRFIELMQTGEMDDLFKNHHQSGVSIRNHLIANNWILKARGESDGPAQVFIHP
DYMGEIGLIMPYEKDFCQSCNRLRVSAKGKLHMCLFGDYGVELRDLLQADTQQDELIQRIQTQLDNKAEGHFLHDGHAGM
TPHLASIGG

Sequences:

>Translated_329_residues
MAKQFEDNYNRKFYYLRLSITDVCNFKCTYCLPDGYRPENGKRESFLELDEIERTVSAFARCGTSKVRITGGEPSLRKDF
TDIIRTVASQPGITKVATTTNGYRMEKHVAEWREAGLTNINVSVDSLNPNMFYQITGENKFAEVMAGIDKAIEVGFKQVK
VNTVLLKDLNSTELPLFLKWIQTRPIQLRFIELMQTGEMDDLFKNHHQSGVSIRNHLIANNWILKARGESDGPAQVFIHP
DYMGEIGLIMPYEKDFCQSCNRLRVSAKGKLHMCLFGDYGVELRDLLQADTQQDELIQRIQTQLDNKAEGHFLHDGHAGM
TPHLASIGG
>Mature_328_residues
AKQFEDNYNRKFYYLRLSITDVCNFKCTYCLPDGYRPENGKRESFLELDEIERTVSAFARCGTSKVRITGGEPSLRKDFT
DIIRTVASQPGITKVATTTNGYRMEKHVAEWREAGLTNINVSVDSLNPNMFYQITGENKFAEVMAGIDKAIEVGFKQVKV
NTVLLKDLNSTELPLFLKWIQTRPIQLRFIELMQTGEMDDLFKNHHQSGVSIRNHLIANNWILKARGESDGPAQVFIHPD
YMGEIGLIMPYEKDFCQSCNRLRVSAKGKLHMCLFGDYGVELRDLLQADTQQDELIQRIQTQLDNKAEGHFLHDGHAGMT
PHLASIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=309, Percent_Identity=36.2459546925566, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI22027536, Length=309, Percent_Identity=36.2459546925566, Blast_Score=199, Evalue=3e-51,
Organism=Escherichia coli, GI1786999, Length=329, Percent_Identity=63.2218844984802, Blast_Score=444, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI32566331, Length=337, Percent_Identity=34.4213649851632, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI32566329, Length=313, Percent_Identity=35.7827476038339, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17561210, Length=318, Percent_Identity=37.7358490566038, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI28574490, Length=314, Percent_Identity=32.8025477707006, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI28574488, Length=312, Percent_Identity=33.0128205128205, Blast_Score=187, Evalue=7e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37418; Mature: 37287

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQFEDNYNRKFYYLRLSITDVCNFKCTYCLPDGYRPENGKRESFLELDEIERTVSAFA
CCCCCCCCCCCEEEEEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
RCGTSKVRITGGEPSLRKDFTDIIRTVASQPGITKVATTTNGYRMEKHVAEWREAGLTNI
HCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHCCCCEE
NVSVDSLNPNMFYQITGENKFAEVMAGIDKAIEVGFKQVKVNTVLLKDLNSTELPLFLKW
EEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHCHHHEEEEEEEEECCCCCCCHHHHHH
IQTRPIQLRFIELMQTGEMDDLFKNHHQSGVSIRNHLIANNWILKARGESDGPAQVFIHP
HHCCCEEEEEEHHHHCCCHHHHHHHHCCCCCHHHHHEEECCEEEEECCCCCCCEEEEECC
DYMGEIGLIMPYEKDFCQSCNRLRVSAKGKLHMCLFGDYGVELRDLLQADTQQDELIQRI
CCCCCCCEEECCCHHHHHHHHHEEEECCCCEEEEEECCCCCHHHHHHHCCCCHHHHHHHH
QTQLDNKAEGHFLHDGHAGMTPHLASIGG
HHHHCCCCCCCEEECCCCCCCCCHHCCCC
>Mature Secondary Structure 
AKQFEDNYNRKFYYLRLSITDVCNFKCTYCLPDGYRPENGKRESFLELDEIERTVSAFA
CCCCCCCCCCEEEEEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
RCGTSKVRITGGEPSLRKDFTDIIRTVASQPGITKVATTTNGYRMEKHVAEWREAGLTNI
HCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHCCCCEE
NVSVDSLNPNMFYQITGENKFAEVMAGIDKAIEVGFKQVKVNTVLLKDLNSTELPLFLKW
EEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHCHHHEEEEEEEEECCCCCCCHHHHHH
IQTRPIQLRFIELMQTGEMDDLFKNHHQSGVSIRNHLIANNWILKARGESDGPAQVFIHP
HHCCCEEEEEEHHHHCCCHHHHHHHHCCCCCHHHHHEEECCEEEEECCCCCCCEEEEECC
DYMGEIGLIMPYEKDFCQSCNRLRVSAKGKLHMCLFGDYGVELRDLLQADTQQDELIQRI
CCCCCCCEEECCCHHHHHHHHHEEEECCCCEEEEEECCCCCHHHHHHHCCCCHHHHHHHH
QTQLDNKAEGHFLHDGHAGMTPHLASIGG
HHHHCCCCCCCEEECCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]