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The map label for this gene is tpm

Identifier: 209695287

GI number: 209695287

Start: 1937360

End: 1938001

Strand: Direct

Name: tpm

Synonym: VSAL_I1814

Alternate gene names: 209695287

Gene position: 1937360-1938001 (Clockwise)

Preceding gene: 209695285

Following gene: 209695291

Centisome position: 58.26

GC content: 40.81

Gene sequence:

>642_bases
ATGGATCAAGAATTTTGGCAAAAAAAATGGGCGAGTAACGTCATTGGTTTTCATTTACCAGATACCAATCCCGTCTTGTC
GGAGTTTTGGAAAGCCTTAAACCCCACTCGTGAACAAACAGTGTTTGTACCATTATGTGGCAAATCAATGGATCTAGATT
GGCTTGCAGAGAGACACAATTCAGTTTCTGGGGTTGAGTTAAGCCAAATTGCAGTACGTGCATTTTTTGCAGAGCGTTTA
TACACACCGACGGTGACGACATTAAGTAGTACGCTTGAGCTGTATGATTTTGACGAATTTACTATTTTTGCTGGCGATTA
TTTTACTGCACCCATTGAGGCGACCGATCTAATTTATGATCGTGCAGCCTTAGTGGCGTTGCCTAAAGAGATGCGATCTG
AATACGTGCAAGTATTACGTTCTCGTTTAAAAGAGGGAGGGCGTATCTTGTTAGTGACATTAGATTATGACCAAAATGAA
ATGTCAGGGCCTCCTTTCTCAGTACCAGAGGATGAAGTACGTTCGTTGTTTTCAGGTATGAGCATCACAAAATTACAACG
TGATGAAGCAGATGCTGATCATCCTAGAATTAAAAAAGGATTAACTCGCTTTGCAGAAGAAGTGTGGTTGATTAAGAGTT
AG

Upstream 100 bases:

>100_bases
TTTAAGTCAATAAGCTCCCTGAAATAGAGAATCTATAGAACAGAAGGAGGGGATGAGTTACCCTTTCTAAATAATAAAAA
GTTATCAAAAAGGAAAACAA

Downstream 100 bases:

>100_bases
AAAACGAAAAATTTTTGAACAATAAAAAAGCCGTCAGATGATTAATTTGACGGCTTTTTTATTGAGTACCATGAGTGCAT
TTCAATATTTATGAGTGCAT

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MDQEFWQKKWASNVIGFHLPDTNPVLSEFWKALNPTREQTVFVPLCGKSMDLDWLAERHNSVSGVELSQIAVRAFFAERL
YTPTVTTLSSTLELYDFDEFTIFAGDYFTAPIEATDLIYDRAALVALPKEMRSEYVQVLRSRLKEGGRILLVTLDYDQNE
MSGPPFSVPEDEVRSLFSGMSITKLQRDEADADHPRIKKGLTRFAEEVWLIKS

Sequences:

>Translated_213_residues
MDQEFWQKKWASNVIGFHLPDTNPVLSEFWKALNPTREQTVFVPLCGKSMDLDWLAERHNSVSGVELSQIAVRAFFAERL
YTPTVTTLSSTLELYDFDEFTIFAGDYFTAPIEATDLIYDRAALVALPKEMRSEYVQVLRSRLKEGGRILLVTLDYDQNE
MSGPPFSVPEDEVRSLFSGMSITKLQRDEADADHPRIKKGLTRFAEEVWLIKS
>Mature_213_residues
MDQEFWQKKWASNVIGFHLPDTNPVLSEFWKALNPTREQTVFVPLCGKSMDLDWLAERHNSVSGVELSQIAVRAFFAERL
YTPTVTTLSSTLELYDFDEFTIFAGDYFTAPIEATDLIYDRAALVALPKEMRSEYVQVLRSRLKEGGRILLVTLDYDQNE
MSGPPFSVPEDEVRSLFSGMSITKLQRDEADADHPRIKKGLTRFAEEVWLIKS

Specific function: Unknown

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family

Homologues:

Organism=Homo sapiens, GI4507653, Length=220, Percent_Identity=30.4545454545455, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPMT_ALISL (B6ENK8)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263216.1
- ProteinModelPortal:   B6ENK8
- GeneID:   6987393
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I1814
- HOGENOM:   HBG444929
- OMA:   PPFAVSP
- ProtClustDB:   PRK13255
- GO:   GO:0005737
- HAMAP:   MF_00812
- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822
- PIRSF:   PIRSF023956
- TIGRFAMs:   TIGR03840

Pfam domain/function: PF05724 TPMT

EC number: =2.1.1.67

Molecular weight: Translated: 24407; Mature: 24407

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: BINDING 10-10 BINDING 45-45 BINDING 66-66 BINDING 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQEFWQKKWASNVIGFHLPDTNPVLSEFWKALNPTREQTVFVPLCGKSMDLDWLAERHN
CCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHCC
SVSGVELSQIAVRAFFAERLYTPTVTTLSSTLELYDFDEFTIFAGDYFTAPIEATDLIYD
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCEEEEECCEEECCCCHHHHHHH
RAALVALPKEMRSEYVQVLRSRLKEGGRILLVTLDYDQNEMSGPPFSVPEDEVRSLFSGM
HHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCC
SITKLQRDEADADHPRIKKGLTRFAEEVWLIKS
CHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDQEFWQKKWASNVIGFHLPDTNPVLSEFWKALNPTREQTVFVPLCGKSMDLDWLAERHN
CCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHCC
SVSGVELSQIAVRAFFAERLYTPTVTTLSSTLELYDFDEFTIFAGDYFTAPIEATDLIYD
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCEEEEECCEEECCCCHHHHHHH
RAALVALPKEMRSEYVQVLRSRLKEGGRILLVTLDYDQNEMSGPPFSVPEDEVRSLFSGM
HHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCC
SITKLQRDEADADHPRIKKGLTRFAEEVWLIKS
CHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA