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The map label for this gene is tyrP [H]

Identifier: 209694867

GI number: 209694867

Start: 1452557

End: 1453711

Strand: Direct

Name: tyrP [H]

Synonym: VSAL_I1337

Alternate gene names: 209694867

Gene position: 1452557-1453711 (Clockwise)

Preceding gene: 209694865

Following gene: 209694868

Centisome position: 43.68

GC content: 39.83

Gene sequence:

>1155_bases
ATGAATTTAAAATTAATTGGCAGCTCGCTTATTATTTCAGGTACTGCGTTAGGCGCAGGCATGCTTGCTATACCTATGGT
ACTGGCTCAATTTGGGCTCTTGTGGGGAACAGCATTAATGCTGTTTATCTGTATCGGTACAACCTATGCGGCACTATTAT
TACTTGAAGCAAGTATTAATGTCGGCGGTGGGTTAGGAATGAACACGATTGCGCGTAAAACCTTAGGTAAAGGTGGGCAA
GTTGTGACGAATGGTTTGCTGTATGCATTACTGATTTGTTTATTAATGGCGTACATCTTAGGGGCCGGTGATTTACTCAA
TAAACTTGTTCGTAGTATTGGGATGGACTTGAGCCTTGTTCAAAGTCAAATTGCATTTACCTTAATTGCAGGGGCGATTG
TTGCTTCAGGTACGGCGGTTATTGATAAACTGAACCGAGTTTTATTTGCGGTGATGTTAGGTATGCTGCTATTGACGTTA
GTTTTCTTAGTGCCTGGTATTTCTGCTGAAAATATGGTGCAAGTGTCTAATTCTAATATGCCCGATCTCATTAAGACCAG
CTCAATTATCTTCACCAGTTTTGGTTTTATGGTTGTGATCCCATCATTAGTTTCTTATAACCATGAAGCGACGCATAAGC
AATTGAGAAATATGGTCATTGTTGGCTCTCTTATTCCGCTTGTGTGTTACTTAGTTTGGTTATATGCGGTTGTTGGTAAT
TTAACCTCTAAGCAATTAGTCGAGTTTTCTAATGTCTCTGAATTGATTTCGGTCTTCAGTGCAGAGCATGCTTTCATTAA
TGTAGTGTTGTCGAGCTTTACTGGTCTTGCTTTATTAACGTCATTCTTAGGGGTGGCAATGGCTTTGTTTACTCAAAACC
AAGATACTTTCAAGCAAAATAAAGTGATCACTTATGTGATTAGTTTTATCTTCCCATTAGCGGGTGCCATTTTAGCGGCA
GATAAGTTCTTAGCCGTATTAAGTTATGCAGGGATCATCCTTGTGTTCCTTGCTGTCTTTGTTCCGTTAGCGATGGTTGT
TAAATTAAGACAGAAAGAAACGAACGAACAGGGATATAAAGCTGAGGGTGGAGTAGCAATGCTGGCATTCTCTTTTGCAT
TCGGTAGCTTCTTACTCGTTTCTCAAGTGTTATAA

Upstream 100 bases:

>100_bases
AATTTTAACGCTGTCGCCTAGTAAAGGTGCTGTTTTGTATGCGTTGAATTTATAAAAAATAAAATAAATTTACTCGAATT
AAACATAGGAAATAAACACA

Downstream 100 bases:

>100_bases
CTCTTTTAATGCCCTAATCATGGTATTAGGGTATTCATTTATACTGTGACTGTTTTTCCATTTTATATATTAAGAATACA
CAATGAATTTTAAATTATTT

Product: tyrosine-specific transport protein (tyrosine permease)

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MNLKLIGSSLIISGTALGAGMLAIPMVLAQFGLLWGTALMLFICIGTTYAALLLLEASINVGGGLGMNTIARKTLGKGGQ
VVTNGLLYALLICLLMAYILGAGDLLNKLVRSIGMDLSLVQSQIAFTLIAGAIVASGTAVIDKLNRVLFAVMLGMLLLTL
VFLVPGISAENMVQVSNSNMPDLIKTSSIIFTSFGFMVVIPSLVSYNHEATHKQLRNMVIVGSLIPLVCYLVWLYAVVGN
LTSKQLVEFSNVSELISVFSAEHAFINVVLSSFTGLALLTSFLGVAMALFTQNQDTFKQNKVITYVISFIFPLAGAILAA
DKFLAVLSYAGIILVFLAVFVPLAMVVKLRQKETNEQGYKAEGGVAMLAFSFAFGSFLLVSQVL

Sequences:

>Translated_384_residues
MNLKLIGSSLIISGTALGAGMLAIPMVLAQFGLLWGTALMLFICIGTTYAALLLLEASINVGGGLGMNTIARKTLGKGGQ
VVTNGLLYALLICLLMAYILGAGDLLNKLVRSIGMDLSLVQSQIAFTLIAGAIVASGTAVIDKLNRVLFAVMLGMLLLTL
VFLVPGISAENMVQVSNSNMPDLIKTSSIIFTSFGFMVVIPSLVSYNHEATHKQLRNMVIVGSLIPLVCYLVWLYAVVGN
LTSKQLVEFSNVSELISVFSAEHAFINVVLSSFTGLALLTSFLGVAMALFTQNQDTFKQNKVITYVISFIFPLAGAILAA
DKFLAVLSYAGIILVFLAVFVPLAMVVKLRQKETNEQGYKAEGGVAMLAFSFAFGSFLLVSQVL
>Mature_384_residues
MNLKLIGSSLIISGTALGAGMLAIPMVLAQFGLLWGTALMLFICIGTTYAALLLLEASINVGGGLGMNTIARKTLGKGGQ
VVTNGLLYALLICLLMAYILGAGDLLNKLVRSIGMDLSLVQSQIAFTLIAGAIVASGTAVIDKLNRVLFAVMLGMLLLTL
VFLVPGISAENMVQVSNSNMPDLIKTSSIIFTSFGFMVVIPSLVSYNHEATHKQLRNMVIVGSLIPLVCYLVWLYAVVGN
LTSKQLVEFSNVSELISVFSAEHAFINVVLSSFTGLALLTSFLGVAMALFTQNQDTFKQNKVITYVISFIFPLAGAILAA
DKFLAVLSYAGIILVFLAVFVPLAMVVKLRQKETNEQGYKAEGGVAMLAFSFAFGSFLLVSQVL

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=391, Percent_Identity=34.7826086956522, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789552, Length=370, Percent_Identity=25.6756756756757, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1790145, Length=377, Percent_Identity=26.2599469496021, Blast_Score=112, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 40859; Mature: 40859

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKLIGSSLIISGTALGAGMLAIPMVLAQFGLLWGTALMLFICIGTTYAALLLLEASIN
CCCEEECCHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VGGGLGMNTIARKTLGKGGQVVTNGLLYALLICLLMAYILGAGDLLNKLVRSIGMDLSLV
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHH
QSQIAFTLIAGAIVASGTAVIDKLNRVLFAVMLGMLLLTLVFLVPGISAENMVQVSNSNM
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCEEEECCCCC
PDLIKTSSIIFTSFGFMVVIPSLVSYNHEATHKQLRNMVIVGSLIPLVCYLVWLYAVVGN
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTSKQLVEFSNVSELISVFSAEHAFINVVLSSFTGLALLTSFLGVAMALFTQNQDTFKQN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
KVITYVISFIFPLAGAILAADKFLAVLSYAGIILVFLAVFVPLAMVVKLRQKETNEQGYK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AEGGVAMLAFSFAFGSFLLVSQVL
CCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLKLIGSSLIISGTALGAGMLAIPMVLAQFGLLWGTALMLFICIGTTYAALLLLEASIN
CCCEEECCHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VGGGLGMNTIARKTLGKGGQVVTNGLLYALLICLLMAYILGAGDLLNKLVRSIGMDLSLV
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHH
QSQIAFTLIAGAIVASGTAVIDKLNRVLFAVMLGMLLLTLVFLVPGISAENMVQVSNSNM
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCEEEECCCCC
PDLIKTSSIIFTSFGFMVVIPSLVSYNHEATHKQLRNMVIVGSLIPLVCYLVWLYAVVGN
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTSKQLVEFSNVSELISVFSAEHAFINVVLSSFTGLALLTSFLGVAMALFTQNQDTFKQN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
KVITYVISFIFPLAGAILAADKFLAVLSYAGIILVFLAVFVPLAMVVKLRQKETNEQGYK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AEGGVAMLAFSFAFGSFLLVSQVL
CCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]