Click here to switch to the map view.

The map label for this gene is hemA

Identifier: 209694371

GI number: 209694371

Start: 875199

End: 876455

Strand: Direct

Name: hemA

Synonym: VSAL_I0789

Alternate gene names: 209694371

Gene position: 875199-876455 (Clockwise)

Preceding gene: 209694365

Following gene: 209694372

Centisome position: 26.32

GC content: 40.57

Gene sequence:

>1257_bases
ATGTCATTGCTTGTTATTGGAATTAATCATACTTCAGCCACAGTTGATTTACGTGAGAAAGTTGCCTTTTCTCCTGATAA
ATTAACCAAAGCGCTAGATGAATTAAAAAACAGTGATGCAATTAAAAGTGGCGTAATTTTATCGACCTGTAATCGCACTG
AAATCTACTGTGAAGTGAAATTAGGCATTAGCAGTGGCTACGTCATCAATTGGCTCGCTGAATTTCATCATGTGGCATTA
GATTTACTCATGCCGAGTATTTATATCTATGAAGAACAAGCCGCCGTTAAGCACCTTATGCGAGTGTCTTGTGGTTTGGA
TTCTTTGGTTCTCGGAGAGCCTCAAATTCTTGGGCAAGTAAAAAAAGCGTTTGCTGATGCTAGAGAACACAATGCGGTTG
AAGGTGTCGTTGAAAAATTATTTCAAAGTGACTTTTCAGTCGCTAAACGAGTCCGTACTGAAACGAATATTGGTGGTAAC
GCGGTGTCTGTTGCTTATGCAGCATGTACATTAGCTCGACAAATATTTGAGTCTCTTGCTGAATCAACTGTCATGTTGGT
TGGAGCAGGAGAAACCATTGAATTAGTCGCGAAACATTTAAATGATGCCGGCTGTAAACAATTGATTGTGGCGAATAGAA
CTCGAGAAAGAGCCATGATATTAGCCGACCAATTTAATGCTGATGTGATCAGCCTGCCCGAGATCCCTGAGCACCTTTCT
AAAGCGGATATCATTATTAGCTCAACCGCCAGTCCGTTACCTATTATCGGTAAAGGAATGGTTGAAAGCGCACTAAAACA
GCGCAGACACCAACCTATGTTATTTGTGGATATTGCGGTTCCGCGTGATATCGAAAGTGAAGTCGCGGATCTTAATGACG
TCTACTTGTATTCAGTTGATGATCTTAAATCGATCATTGACCATAATATTGAACAACGAAAAATTGAAGCGATTCAAGCT
GAAGCGATAGTCAGTGAAGAAAGTGCAGGGTTTATGACGTGGATACGTTCTCGTCAAGCTGTTAACAGTATTCGCCAATA
CCGAGAGAATTCAGAATCTATTCGTATCGAATTATTGCAAAAAAGTATTCAGGCCCTAGCTTCTGGTCAAAATGCAGAAA
AAGTTTTAGCAGAATTAAGCAATAAATTAACGAATAAACTCATTCATGCACCAACACTTGCGATGCAGCAGGCCGCCAAA
AATGGTGAGCCGGACAAACTTGCTGTGATCCGTACCAGTATTGGTCTAGACAACTAA

Upstream 100 bases:

>100_bases
TCACTAATTTTCGATGTAGAAGCTCTGATGCCTTTTAAAATTCGGCTTCATCAAGTAAAATCCGCCCTTGTTATTTTTCT
AAATTGGTCTTGTTTGCCGA

Downstream 100 bases:

>100_bases
GTGTAGCTTCTGCTACCAACATAAAGAATCAATTATAATATGAAAGCATCAATTCGAGTAAAATTGGAAACGCTGGTTGA
GCGTTATGAAGAAGTACAGC

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MSLLVIGINHTSATVDLREKVAFSPDKLTKALDELKNSDAIKSGVILSTCNRTEIYCEVKLGISSGYVINWLAEFHHVAL
DLLMPSIYIYEEQAAVKHLMRVSCGLDSLVLGEPQILGQVKKAFADAREHNAVEGVVEKLFQSDFSVAKRVRTETNIGGN
AVSVAYAACTLARQIFESLAESTVMLVGAGETIELVAKHLNDAGCKQLIVANRTRERAMILADQFNADVISLPEIPEHLS
KADIIISSTASPLPIIGKGMVESALKQRRHQPMLFVDIAVPRDIESEVADLNDVYLYSVDDLKSIIDHNIEQRKIEAIQA
EAIVSEESAGFMTWIRSRQAVNSIRQYRENSESIRIELLQKSIQALASGQNAEKVLAELSNKLTNKLIHAPTLAMQQAAK
NGEPDKLAVIRTSIGLDN

Sequences:

>Translated_418_residues
MSLLVIGINHTSATVDLREKVAFSPDKLTKALDELKNSDAIKSGVILSTCNRTEIYCEVKLGISSGYVINWLAEFHHVAL
DLLMPSIYIYEEQAAVKHLMRVSCGLDSLVLGEPQILGQVKKAFADAREHNAVEGVVEKLFQSDFSVAKRVRTETNIGGN
AVSVAYAACTLARQIFESLAESTVMLVGAGETIELVAKHLNDAGCKQLIVANRTRERAMILADQFNADVISLPEIPEHLS
KADIIISSTASPLPIIGKGMVESALKQRRHQPMLFVDIAVPRDIESEVADLNDVYLYSVDDLKSIIDHNIEQRKIEAIQA
EAIVSEESAGFMTWIRSRQAVNSIRQYRENSESIRIELLQKSIQALASGQNAEKVLAELSNKLTNKLIHAPTLAMQQAAK
NGEPDKLAVIRTSIGLDN
>Mature_417_residues
SLLVIGINHTSATVDLREKVAFSPDKLTKALDELKNSDAIKSGVILSTCNRTEIYCEVKLGISSGYVINWLAEFHHVALD
LLMPSIYIYEEQAAVKHLMRVSCGLDSLVLGEPQILGQVKKAFADAREHNAVEGVVEKLFQSDFSVAKRVRTETNIGGNA
VSVAYAACTLARQIFESLAESTVMLVGAGETIELVAKHLNDAGCKQLIVANRTRERAMILADQFNADVISLPEIPEHLSK
ADIIISSTASPLPIIGKGMVESALKQRRHQPMLFVDIAVPRDIESEVADLNDVYLYSVDDLKSIIDHNIEQRKIEAIQAE
AIVSEESAGFMTWIRSRQAVNSIRQYRENSESIRIELLQKSIQALASGQNAEKVLAELSNKLTNKLIHAPTLAMQQAAKN
GEPDKLAVIRTSIGLDN

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=418, Percent_Identity=58.3732057416268, Blast_Score=488, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_ALISL (B6EHH4)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262299.1
- ProteinModelPortal:   B6EHH4
- GeneID:   6986666
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0789
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR003462
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR13812
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 45894; Mature: 45763

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 108-108 BINDING 119-119

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLVIGINHTSATVDLREKVAFSPDKLTKALDELKNSDAIKSGVILSTCNRTEIYCEVK
CEEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCHHHCCCEEEECCCEEEEEEEE
LGISSGYVINWLAEFHHVALDLLMPSIYIYEEQAAVKHLMRVSCGLDSLVLGEPQILGQV
ECCCCCHHHHHHHHHHHHHHHHHCCHHEEEEHHHHHHHHHHHHCCCCHHCCCCHHHHHHH
KKAFADAREHNAVEGVVEKLFQSDFSVAKRVRTETNIGGNAVSVAYAACTLARQIFESLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
ESTVMLVGAGETIELVAKHLNDAGCKQLIVANRTRERAMILADQFNADVISLPEIPEHLS
HCEEEEEECCCHHHHHHHHHCHHHHHHHHHHCCCHHHHEEEECCCCCCEEECCCHHHHHC
KADIIISSTASPLPIIGKGMVESALKQRRHQPMLFVDIAVPRDIESEVADLNDVYLYSVD
CCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHCCCCCEEEEEHH
DLKSIIDHNIEQRKIEAIQAEAIVSEESAGFMTWIRSRQAVNSIRQYRENSESIRIELLQ
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
KSIQALASGQNAEKVLAELSNKLTNKLIHAPTLAMQQAAKNGEPDKLAVIRTSIGLDN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
SLLVIGINHTSATVDLREKVAFSPDKLTKALDELKNSDAIKSGVILSTCNRTEIYCEVK
EEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCHHHCCCEEEECCCEEEEEEEE
LGISSGYVINWLAEFHHVALDLLMPSIYIYEEQAAVKHLMRVSCGLDSLVLGEPQILGQV
ECCCCCHHHHHHHHHHHHHHHHHCCHHEEEEHHHHHHHHHHHHCCCCHHCCCCHHHHHHH
KKAFADAREHNAVEGVVEKLFQSDFSVAKRVRTETNIGGNAVSVAYAACTLARQIFESLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
ESTVMLVGAGETIELVAKHLNDAGCKQLIVANRTRERAMILADQFNADVISLPEIPEHLS
HCEEEEEECCCHHHHHHHHHCHHHHHHHHHHCCCHHHHEEEECCCCCCEEECCCHHHHHC
KADIIISSTASPLPIIGKGMVESALKQRRHQPMLFVDIAVPRDIESEVADLNDVYLYSVD
CCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHCCCCCEEEEEHH
DLKSIIDHNIEQRKIEAIQAEAIVSEESAGFMTWIRSRQAVNSIRQYRENSESIRIELLQ
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
KSIQALASGQNAEKVLAELSNKLTNKLIHAPTLAMQQAAKNGEPDKLAVIRTSIGLDN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA