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The map label for this gene is mutH [H]

Identifier: 209694160

GI number: 209694160

Start: 624417

End: 625085

Strand: Reverse

Name: mutH [H]

Synonym: VSAL_I0568

Alternate gene names: 209694160

Gene position: 625085-624417 (Counterclockwise)

Preceding gene: 209694166

Following gene: 209694154

Centisome position: 18.8

GC content: 41.26

Gene sequence:

>669_bases
ATGACTCCCTTACCACCTAAAACAATTGATGAACTGTTGTCTAGAGCAGAAAGCATTGCTGGTTATACGTTGGCTGAACT
TGCGCTGCAAGCTGGAATACCCGTTCCTGAAAATTTAAAGCGCGATAAAGGCTGGGTAGGTCAATTACTCGAATGGCATC
TTGGTGCGTCAGCAGGCAGTAAACCTGTACCTGATTTCATTGATCTTGATATTGAATTAAAAACAATTCCAATCAGTCAT
TCTGGTAAACCATTAGAGACCACCTTTGTGTGTGTCGCGCCCTTAACTGGCGTACATAGCCTACAATGGAAAGAATCACA
CGTTAGACACAAGCTCTCTCATGTATTGTGGATCCCCGTGGAAGGTGAAAGAGAAATTCCGGTCGGTGATCGTCATGTCG
GTTACCCAGTACTTTGGAAACCATCAATCAAAGAAGAACAACAATTACAACAAGATTGGGAAGAGTTAATGGATCTCATC
GTGTTAGGAAAAGTAGAATCGATTACGGCAAGGCATGGGGAAGTATTACAACTAAGACCAAAAGCAGCAAACAGTAGAGC
ATTAACAGAAGCCTATGGTGATAATGGTCAGCCAATAAAAACCTTACCTAGAGGGTTTTACTTAAAAACGCACTTTACCC
ACTCTATATTAACATCCTTTTTTAACTAA

Upstream 100 bases:

>100_bases
AAATATAGCATAATGTGGATAACTTTATTCGATCCAGACAAACTCAAAAAAAAATGAAGAATATGGTAATCTTATCTTTT
ATCTAATCAATTTAAGGCCT

Downstream 100 bases:

>100_bases
AAAAGCCACTGTATTTATAAATACAATGGCTTTAAACATGAGTGAGTTACTCGCTTACTGTACGAATTAACTGTATGTTC
TTGGCTCAGAAATAAGGTTA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MTPLPPKTIDELLSRAESIAGYTLAELALQAGIPVPENLKRDKGWVGQLLEWHLGASAGSKPVPDFIDLDIELKTIPISH
SGKPLETTFVCVAPLTGVHSLQWKESHVRHKLSHVLWIPVEGEREIPVGDRHVGYPVLWKPSIKEEQQLQQDWEELMDLI
VLGKVESITARHGEVLQLRPKAANSRALTEAYGDNGQPIKTLPRGFYLKTHFTHSILTSFFN

Sequences:

>Translated_222_residues
MTPLPPKTIDELLSRAESIAGYTLAELALQAGIPVPENLKRDKGWVGQLLEWHLGASAGSKPVPDFIDLDIELKTIPISH
SGKPLETTFVCVAPLTGVHSLQWKESHVRHKLSHVLWIPVEGEREIPVGDRHVGYPVLWKPSIKEEQQLQQDWEELMDLI
VLGKVESITARHGEVLQLRPKAANSRALTEAYGDNGQPIKTLPRGFYLKTHFTHSILTSFFN
>Mature_221_residues
TPLPPKTIDELLSRAESIAGYTLAELALQAGIPVPENLKRDKGWVGQLLEWHLGASAGSKPVPDFIDLDIELKTIPISHS
GKPLETTFVCVAPLTGVHSLQWKESHVRHKLSHVLWIPVEGEREIPVGDRHVGYPVLWKPSIKEEQQLQQDWEELMDLIV
LGKVESITARHGEVLQLRPKAANSRALTEAYGDNGQPIKTLPRGFYLKTHFTHSILTSFFN

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair [H]

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family [H]

Homologues:

Organism=Escherichia coli, GI1789196, Length=217, Percent_Identity=64.5161290322581, Blast_Score=292, Evalue=1e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335 [H]

Pfam domain/function: PF02976 MutH [H]

EC number: NA

Molecular weight: Translated: 24839; Mature: 24708

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLPPKTIDELLSRAESIAGYTLAELALQAGIPVPENLKRDKGWVGQLLEWHLGASAGS
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHHCCCCCC
KPVPDFIDLDIELKTIPISHSGKPLETTFVCVAPLTGVHSLQWKESHVRHKLSHVLWIPV
CCCCCCEECEEEEEEEECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHEEEEEC
EGEREIPVGDRHVGYPVLWKPSIKEEQQLQQDWEELMDLIVLGKVESITARHGEVLQLRP
CCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEECC
KAANSRALTEAYGDNGQPIKTLPRGFYLKTHFTHSILTSFFN
CCCCCHHHHHHHCCCCCCHHHCCCCEEEEHHHHHHHHHHHCC
>Mature Secondary Structure 
TPLPPKTIDELLSRAESIAGYTLAELALQAGIPVPENLKRDKGWVGQLLEWHLGASAGS
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHHCCCCCC
KPVPDFIDLDIELKTIPISHSGKPLETTFVCVAPLTGVHSLQWKESHVRHKLSHVLWIPV
CCCCCCEECEEEEEEEECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHEEEEEC
EGEREIPVGDRHVGYPVLWKPSIKEEQQLQQDWEELMDLIVLGKVESITARHGEVLQLRP
CCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEECC
KAANSRALTEAYGDNGQPIKTLPRGFYLKTHFTHSILTSFFN
CCCCCHHHHHHHCCCCCCHHHCCCCEEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA