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The map label for this gene is fbaA [H]

Identifier: 209694150

GI number: 209694150

Start: 610409

End: 611485

Strand: Direct

Name: fbaA [H]

Synonym: VSAL_I0557

Alternate gene names: 209694150

Gene position: 610409-611485 (Clockwise)

Preceding gene: 209694149

Following gene: 209694153

Centisome position: 18.36

GC content: 43.73

Gene sequence:

>1077_bases
ATGTCTAAGATCTTCGATTTTGTAAAACCTGGTGTTATTTCTGGCGACGACGTACAGAAAGTATTTGCAGTAGCAAAAGA
AAACAAATTTGCTCTTCCTGCGGTAAACGTAGTGAATACTGATACTATCAATGCGGTTCTTGAAGCTGCTTCTAAAGCTA
AAGCACCAGTTGTTGTTCAGTTCTCTAATGGCGGTGCTGGTTTCTTCGCTGGTAAAGGCGTTAAACTTGAAGGTCAAGGT
GCACAAATCCTTGGCGCTGTAGCGGGTGCAAAATACGTTCACGCAGTTGCTGAATCTTACGGTGTTCCAGTTATTCTTCA
TACTGACCATGCTGCTAAGAAACTTCTTCCATGGATCGACGGACTACTAGACGCTGGTGAAGTATTCTTCGCTGAAACTG
GTAAGCCTTTATTCTCTTCACACATGCTAGACCTTTCTGAAGAGTCTCTAGAAGAGAACATCGAAACTTGTGCTAAGTAC
CTAGAGCGCATGGCTAAAATGAACATGACAATCGAGATTGAACTTGGTTGTACTGGTGGCGAAGAAGACGGCGTTGATAA
CTCTGATATGGACGCATCTGAGCTTTACACTTCTCCTGAAGATGTTGCATACGCATACGAAAAACTAACGGCTATCAGCC
CACGTTTCACTATCGCTGCATCTTTCGGTAACGTACACGGTGTTTACCAAGCAGGTAATGTTGTTCTTACTCCAACTATC
CTACGTGATTCTCAAGCTTACTGTGCTGAGAAATTTGGTATTGCATCTGATGCACTTAACTTCGTATTCCACGGTGGTTC
TGGTTCTTCTGAAGCAGAAATCCAAGAATCTATCGGTTACGGCGTTATCAAAATGAACATCGATACTGATACTCAGTGGG
CTTCATGGGATGGCGTTCGTGCATACGAAGCTGAAAACCGTGATTTCCTACAAGGTCAAATCGGTAACCCAACTGGCGAA
TCTGCGCCTAACAAGAAGTACTACGATCCACGCGTTTGGTTACGTGCAGGTCAAGCTTCTATGGTTACGCGTCTTGAAAA
AGCATTTGCTGACCTTAACGCAATCGACGTACTATAA

Upstream 100 bases:

>100_bases
TGTTTATTGATACAATAGAAAAAGTTGTGAGCAAACGTTTGCAAAAATTTGAACGTAAGTTTTTTAATTTTAAAACGATA
GAATAAATAGGACTACTTCC

Downstream 100 bases:

>100_bases
TTTTTATTATAGACCGCTCGAATTGAGTTAATAAAAACCCGCTGATTAGCGGGTTTTTTTATGTTTGTAAAAAGGGACTA
GAGGCGAGGATTTAGGGACG

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; Fructose-bisphosphate aldolase class II [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSKIFDFVKPGVISGDDVQKVFAVAKENKFALPAVNVVNTDTINAVLEAASKAKAPVVVQFSNGGAGFFAGKGVKLEGQG
AQILGAVAGAKYVHAVAESYGVPVILHTDHAAKKLLPWIDGLLDAGEVFFAETGKPLFSSHMLDLSEESLEENIETCAKY
LERMAKMNMTIEIELGCTGGEEDGVDNSDMDASELYTSPEDVAYAYEKLTAISPRFTIAASFGNVHGVYQAGNVVLTPTI
LRDSQAYCAEKFGIASDALNFVFHGGSGSSEAEIQESIGYGVIKMNIDTDTQWASWDGVRAYEAENRDFLQGQIGNPTGE
SAPNKKYYDPRVWLRAGQASMVTRLEKAFADLNAIDVL

Sequences:

>Translated_358_residues
MSKIFDFVKPGVISGDDVQKVFAVAKENKFALPAVNVVNTDTINAVLEAASKAKAPVVVQFSNGGAGFFAGKGVKLEGQG
AQILGAVAGAKYVHAVAESYGVPVILHTDHAAKKLLPWIDGLLDAGEVFFAETGKPLFSSHMLDLSEESLEENIETCAKY
LERMAKMNMTIEIELGCTGGEEDGVDNSDMDASELYTSPEDVAYAYEKLTAISPRFTIAASFGNVHGVYQAGNVVLTPTI
LRDSQAYCAEKFGIASDALNFVFHGGSGSSEAEIQESIGYGVIKMNIDTDTQWASWDGVRAYEAENRDFLQGQIGNPTGE
SAPNKKYYDPRVWLRAGQASMVTRLEKAFADLNAIDVL
>Mature_357_residues
SKIFDFVKPGVISGDDVQKVFAVAKENKFALPAVNVVNTDTINAVLEAASKAKAPVVVQFSNGGAGFFAGKGVKLEGQGA
QILGAVAGAKYVHAVAESYGVPVILHTDHAAKKLLPWIDGLLDAGEVFFAETGKPLFSSHMLDLSEESLEENIETCAKYL
ERMAKMNMTIEIELGCTGGEEDGVDNSDMDASELYTSPEDVAYAYEKLTAISPRFTIAASFGNVHGVYQAGNVVLTPTIL
RDSQAYCAEKFGIASDALNFVFHGGSGSSEAEIQESIGYGVIKMNIDTDTQWASWDGVRAYEAENRDFLQGQIGNPTGES
APNKKYYDPRVWLRAGQASMVTRLEKAFADLNAIDVL

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=359, Percent_Identity=76.6016713091922, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI87082041, Length=327, Percent_Identity=26.2996941896024, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1789526, Length=317, Percent_Identity=28.0757097791798, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788072, Length=296, Percent_Identity=26.3513513513513, Blast_Score=75, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322790, Length=351, Percent_Identity=51.8518518518518, Blast_Score=390, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38448; Mature: 38316

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIFDFVKPGVISGDDVQKVFAVAKENKFALPAVNVVNTDTINAVLEAASKAKAPVVVQ
CCCHHHHHCCCCCCCHHHHHHHHHHCCCCEECCEEEEECCHHHHHHHHHHHHCCCCEEEE
FSNGGAGFFAGKGVKLEGQGAQILGAVAGAKYVHAVAESYGVPVILHTDHAAKKLLPWID
ECCCCCEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHH
GLLDAGEVFFAETGKPLFSSHMLDLSEESLEENIETCAKYLERMAKMNMTIEIELGCTGG
HHHCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
EEDGVDNSDMDASELYTSPEDVAYAYEKLTAISPRFTIAASFGNVHGVYQAGNVVLTPTI
CCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCEEEEEHE
LRDSQAYCAEKFGIASDALNFVFHGGSGSSEAEIQESIGYGVIKMNIDTDTQWASWDGVR
ECCCHHHHHHHCCCHHHCEEEEEECCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCCEE
AYEAENRDFLQGQIGNPTGESAPNKKYYDPRVWLRAGQASMVTRLEKAFADLNAIDVL
EECCCCCCEEECCCCCCCCCCCCCCCCCCCHHEEECCCHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
SKIFDFVKPGVISGDDVQKVFAVAKENKFALPAVNVVNTDTINAVLEAASKAKAPVVVQ
CCHHHHHCCCCCCCHHHHHHHHHHCCCCEECCEEEEECCHHHHHHHHHHHHCCCCEEEE
FSNGGAGFFAGKGVKLEGQGAQILGAVAGAKYVHAVAESYGVPVILHTDHAAKKLLPWID
ECCCCCEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHH
GLLDAGEVFFAETGKPLFSSHMLDLSEESLEENIETCAKYLERMAKMNMTIEIELGCTGG
HHHCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
EEDGVDNSDMDASELYTSPEDVAYAYEKLTAISPRFTIAASFGNVHGVYQAGNVVLTPTI
CCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCEEEEEHE
LRDSQAYCAEKFGIASDALNFVFHGGSGSSEAEIQESIGYGVIKMNIDTDTQWASWDGVR
ECCCHHHHHHHCCCHHHCEEEEEECCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCCEE
AYEAENRDFLQGQIGNPTGESAPNKKYYDPRVWLRAGQASMVTRLEKAFADLNAIDVL
EECCCCCCEEECCCCCCCCCCCCCCCCCCCHHEEECCCHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]