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The map label for this gene is csrD [H]

Identifier: 209694062

GI number: 209694062

Start: 520546

End: 522531

Strand: Direct

Name: csrD [H]

Synonym: VSAL_I0465

Alternate gene names: 209694062

Gene position: 520546-522531 (Clockwise)

Preceding gene: 209694058

Following gene: 209694063

Centisome position: 15.65

GC content: 36.86

Gene sequence:

>1986_bases
ATGAGAAAAACCCCTAATTTACGATTAAGTAACCGCCTTATTTCCTTTGTTACTTTAATGGTTTCTGCTGCTATTTTTGT
TTTATTCGTGGGTGGAGCAATATCCTTTAAACAAATTGGAACCGAATACTTAGATCATTATTTGGTTGGTGTTGTTAATG
TGGTTGATGAAGAGCTTCTAGAACCAGAAGAAGCGACATCAATGGCGAAATGGTTACCAAAATTATTAAAAGCCAGTAGT
GTAATGAGCATGGAATTGTCATCAGAATCAGGTCCTATTTATGCTTTTCAATCGTTAGCCATCCTTCCCGATGATAATTT
ACTTTATCAAAAAACGTATCCCCTCGATCTTAATAAAGGGTATTCGATTACCTTTAAATCTTTACCTCCTTATAGTGCGT
TTACTTATTCGTTAGGTGCTTTGTTTTCTATCACTGCAGCCATTGCCATTATTGTTGTTTCTCTACTTTGGGGAGTGGTG
TGGTTAAGAAAGCAACTTTATGGCTCGGAGCTCTTAGAAGAAAGGGGGAGAATGCTTTTGGCCGGAAAGGTCGATAGTTA
TGAAGTGGGTAGTGAAGAAGAGTGGCCCGCGACCGCAAGTTTGGCGTTAGATAATGTGATCGCTGAATTAAAAGATGCAC
GTAAAGAGCGCAGTCGATTTGATACATTTATTCGAACTCATACCTTTTTAGATCAATTGACGGGCTCTGCAAATAGAGTC
TTGTTTGACAGTAAATTAGAATCCACATTGCAAGAATCTGAAAGTCAGGGTGTTTTACTTCTGTTGAGAATTAATGGATG
GGAAGATCTGATTGAAGAACAAGGAAAGCGAGCGGGTGATGAGTTAATTGTCGAATTAGGGAAGCAGTTAAATAATTTGA
TTCAACGTTATAGTGATAGTGTACTTTCGCGTTATTACACATCTGAATTTGCTCTTCTTATTCCTCAACAGTCATTAAAA
GAAGCGAAATTACTGTCTTCTCAGTGCTTAAAAATGGTAGAGAAAATCATACCTCCAACAAGTTTAGATGCTGATAATTG
GTGTCATATTGGTGTGAGCATGTATGTCAGTGGTGAGCAACGTGGGCGACTGATGAATGAGTTAGATATGGCTCATCGTA
GTGCACTATTACAAAACAACAATAGTTGGTCATTATTTAAAAAACAGCAACAACTAATCGAGAGTTTGGGGAGTGTCCGT
TGGCGTACATTGTTTGATGCTATTTTTGAACAAGAGCAACTCGTGCTTTATAAACAAACTACCTTTTTATTTGAAGGGAA
TAATATAATCCCACTTCACTTGGAGTTATTTTCAAGAATTAAAGATGAAAATGGTATTCAAATAAAAGCGTCTCGCTTTT
TACCCGCGATAGAGCAAGTGGGTTATCAAATAAAGCTTGATAGTGCGGTCTTAAAACAAGCATTTCCATTATTAAATGAT
ACTGAAATGTCTCAACATTCATTTTCTGTCCATTTACATATAAAAAGTTTACAAAATAGTGCATTTATTCGCCAGTTAAG
AGATCGGTTATTACAAACCCCAAGAGAAGAATTACAACGATTAAGTTTTGAATTAGCGGAAGGGCAAGTTGTGACGCATT
TAGATTCAGTACGACCAATTGCAAAAATGTTAAAAAGTTTTGGTTGTAAGCTGGTTGTAGAGCAGGCAGGTCGCACTATT
GTAAGTACTCACTATATTAAAGATTTGCATGTTGATTACGTGAAATTACATCGAAGTTTGATTAAAGACATCCATCAACG
ATATGAAAATCAACTGTTTGTACGAAGCTTATTAGGGGCTTGTGAAACGACAGGGGCTCAGGTTATTGCGGTTGGTATAG
AGAAAGACAAAGAATTAAAACGATTAAAAGAGTTGGGTGTTAAAGGCGGTCAAGGTCGTATTTTTGAGGTTGAAACCAGT
CTTTTTCATCAACAAAAGAAAATCGCGATCCCTAAACGAAGGAATCGTTGGGAAAAACGTTATTGA

Upstream 100 bases:

>100_bases
TAAGTGAAATATTTGTATTATATGTAATACATGTTTAGATGTACCTACTGAAACTAAGGGCATCATATTTTGGTACATAC
CTTCAGGGAAGAAGAGTTCA

Downstream 100 bases:

>100_bases
TCTCATTTTTCAGATAATTCCCATATGTCTTAAGAATAGAATGTTGTATCATTCATGATTAATCCGTCGCGGAAAAAAAG
ACGGGTGTTCAGTGTAATGA

Product: regulatory protein CsrD

Products: NA

Alternate protein names: Regulator of CsrB and CsrC decay CsrD [H]

Number of amino acids: Translated: 661; Mature: 661

Protein sequence:

>661_residues
MRKTPNLRLSNRLISFVTLMVSAAIFVLFVGGAISFKQIGTEYLDHYLVGVVNVVDEELLEPEEATSMAKWLPKLLKASS
VMSMELSSESGPIYAFQSLAILPDDNLLYQKTYPLDLNKGYSITFKSLPPYSAFTYSLGALFSITAAIAIIVVSLLWGVV
WLRKQLYGSELLEERGRMLLAGKVDSYEVGSEEEWPATASLALDNVIAELKDARKERSRFDTFIRTHTFLDQLTGSANRV
LFDSKLESTLQESESQGVLLLLRINGWEDLIEEQGKRAGDELIVELGKQLNNLIQRYSDSVLSRYYTSEFALLIPQQSLK
EAKLLSSQCLKMVEKIIPPTSLDADNWCHIGVSMYVSGEQRGRLMNELDMAHRSALLQNNNSWSLFKKQQQLIESLGSVR
WRTLFDAIFEQEQLVLYKQTTFLFEGNNIIPLHLELFSRIKDENGIQIKASRFLPAIEQVGYQIKLDSAVLKQAFPLLND
TEMSQHSFSVHLHIKSLQNSAFIRQLRDRLLQTPREELQRLSFELAEGQVVTHLDSVRPIAKMLKSFGCKLVVEQAGRTI
VSTHYIKDLHVDYVKLHRSLIKDIHQRYENQLFVRSLLGACETTGAQVIAVGIEKDKELKRLKELGVKGGQGRIFEVETS
LFHQQKKIAIPKRRNRWEKRY

Sequences:

>Translated_661_residues
MRKTPNLRLSNRLISFVTLMVSAAIFVLFVGGAISFKQIGTEYLDHYLVGVVNVVDEELLEPEEATSMAKWLPKLLKASS
VMSMELSSESGPIYAFQSLAILPDDNLLYQKTYPLDLNKGYSITFKSLPPYSAFTYSLGALFSITAAIAIIVVSLLWGVV
WLRKQLYGSELLEERGRMLLAGKVDSYEVGSEEEWPATASLALDNVIAELKDARKERSRFDTFIRTHTFLDQLTGSANRV
LFDSKLESTLQESESQGVLLLLRINGWEDLIEEQGKRAGDELIVELGKQLNNLIQRYSDSVLSRYYTSEFALLIPQQSLK
EAKLLSSQCLKMVEKIIPPTSLDADNWCHIGVSMYVSGEQRGRLMNELDMAHRSALLQNNNSWSLFKKQQQLIESLGSVR
WRTLFDAIFEQEQLVLYKQTTFLFEGNNIIPLHLELFSRIKDENGIQIKASRFLPAIEQVGYQIKLDSAVLKQAFPLLND
TEMSQHSFSVHLHIKSLQNSAFIRQLRDRLLQTPREELQRLSFELAEGQVVTHLDSVRPIAKMLKSFGCKLVVEQAGRTI
VSTHYIKDLHVDYVKLHRSLIKDIHQRYENQLFVRSLLGACETTGAQVIAVGIEKDKELKRLKELGVKGGQGRIFEVETS
LFHQQKKIAIPKRRNRWEKRY
>Mature_661_residues
MRKTPNLRLSNRLISFVTLMVSAAIFVLFVGGAISFKQIGTEYLDHYLVGVVNVVDEELLEPEEATSMAKWLPKLLKASS
VMSMELSSESGPIYAFQSLAILPDDNLLYQKTYPLDLNKGYSITFKSLPPYSAFTYSLGALFSITAAIAIIVVSLLWGVV
WLRKQLYGSELLEERGRMLLAGKVDSYEVGSEEEWPATASLALDNVIAELKDARKERSRFDTFIRTHTFLDQLTGSANRV
LFDSKLESTLQESESQGVLLLLRINGWEDLIEEQGKRAGDELIVELGKQLNNLIQRYSDSVLSRYYTSEFALLIPQQSLK
EAKLLSSQCLKMVEKIIPPTSLDADNWCHIGVSMYVSGEQRGRLMNELDMAHRSALLQNNNSWSLFKKQQQLIESLGSVR
WRTLFDAIFEQEQLVLYKQTTFLFEGNNIIPLHLELFSRIKDENGIQIKASRFLPAIEQVGYQIKLDSAVLKQAFPLLND
TEMSQHSFSVHLHIKSLQNSAFIRQLRDRLLQTPREELQRLSFELAEGQVVTHLDSVRPIAKMLKSFGCKLVVEQAGRTI
VSTHYIKDLHVDYVKLHRSLIKDIHQRYENQLFVRSLLGACETTGAQVIAVGIEKDKELKRLKELGVKGGQGRIFEVETS
LFHQQKKIAIPKRRNRWEKRY

Specific function: Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility ge

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1789650, Length=648, Percent_Identity=31.6358024691358, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI1787541, Length=466, Percent_Identity=20.6008583690987, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1788849, Length=200, Percent_Identity=23.5, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1790496, Length=229, Percent_Identity=23.1441048034935, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 75340; Mature: 75340

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTPNLRLSNRLISFVTLMVSAAIFVLFVGGAISFKQIGTEYLDHYLVGVVNVVDEELL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
EPEEATSMAKWLPKLLKASSVMSMELSSESGPIYAFQSLAILPDDNLLYQKTYPLDLNKG
CCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEEEECCCCCEEEEEECCCCCCCC
YSITFKSLPPYSAFTYSLGALFSITAAIAIIVVSLLWGVVWLRKQLYGSELLEERGRMLL
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
AGKVDSYEVGSEEEWPATASLALDNVIAELKDARKERSRFDTFIRTHTFLDQLTGSANRV
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LFDSKLESTLQESESQGVLLLLRINGWEDLIEEQGKRAGDELIVELGKQLNNLIQRYSDS
EEHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
VLSRYYTSEFALLIPQQSLKEAKLLSSQCLKMVEKIIPPTSLDADNWCHIGVSMYVSGEQ
HHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCHH
RGRLMNELDMAHRSALLQNNNSWSLFKKQQQLIESLGSVRWRTLFDAIFEQEQLVLYKQT
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
TFLFEGNNIIPLHLELFSRIKDENGIQIKASRFLPAIEQVGYQIKLDSAVLKQAFPLLND
EEEEECCCEEEEHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCC
TEMSQHSFSVHLHIKSLQNSAFIRQLRDRLLQTPREELQRLSFELAEGQVVTHLDSVRPI
CCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHH
AKMLKSFGCKLVVEQAGRTIVSTHYIKDLHVDYVKLHRSLIKDIHQRYENQLFVRSLLGA
HHHHHHCCCEEEHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CETTGAQVIAVGIEKDKELKRLKELGVKGGQGRIFEVETSLFHQQKKIAIPKRRNRWEKR
HHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHCCCCHHHCCCCCC
Y
C
>Mature Secondary Structure
MRKTPNLRLSNRLISFVTLMVSAAIFVLFVGGAISFKQIGTEYLDHYLVGVVNVVDEELL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
EPEEATSMAKWLPKLLKASSVMSMELSSESGPIYAFQSLAILPDDNLLYQKTYPLDLNKG
CCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEEEECCCCCEEEEEECCCCCCCC
YSITFKSLPPYSAFTYSLGALFSITAAIAIIVVSLLWGVVWLRKQLYGSELLEERGRMLL
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
AGKVDSYEVGSEEEWPATASLALDNVIAELKDARKERSRFDTFIRTHTFLDQLTGSANRV
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LFDSKLESTLQESESQGVLLLLRINGWEDLIEEQGKRAGDELIVELGKQLNNLIQRYSDS
EEHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
VLSRYYTSEFALLIPQQSLKEAKLLSSQCLKMVEKIIPPTSLDADNWCHIGVSMYVSGEQ
HHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCHH
RGRLMNELDMAHRSALLQNNNSWSLFKKQQQLIESLGSVRWRTLFDAIFEQEQLVLYKQT
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
TFLFEGNNIIPLHLELFSRIKDENGIQIKASRFLPAIEQVGYQIKLDSAVLKQAFPLLND
EEEEECCCEEEEHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCC
TEMSQHSFSVHLHIKSLQNSAFIRQLRDRLLQTPREELQRLSFELAEGQVVTHLDSVRPI
CCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHH
AKMLKSFGCKLVVEQAGRTIVSTHYIKDLHVDYVKLHRSLIKDIHQRYENQLFVRSLLGA
HHHHHHCCCEEEHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CETTGAQVIAVGIEKDKELKRLKELGVKGGQGRIFEVETSLFHQQKKIAIPKRRNRWEKR
HHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHCCCCHHHCCCCCC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 3049542 [H]