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The map label for this gene is menA [H]

Identifier: 209693899

GI number: 209693899

Start: 340286

End: 341194

Strand: Reverse

Name: menA [H]

Synonym: VSAL_I0293

Alternate gene names: 209693899

Gene position: 341194-340286 (Counterclockwise)

Preceding gene: 209693900

Following gene: 209693898

Centisome position: 10.26

GC content: 43.78

Gene sequence:

>909_bases
ATGAAAACTTCTCCTTTTGCTATTTGGCTCAGTGCAGCCCGTCCAAAAACATTACCTTTAGCGCTTGCTTCTATCATGAC
CGGCTCGGCTCTGGCGTATTGGAATAACCATGCTTCTGCAACCATTACCATAATGGCCTTCGTTACCGCCACTTTACTGC
AAATTTTATCCAACCTCGCCAATGATTATGGTGATGCAGTAAAAGGCACAGATAATGATGAACGCCTTGGGCCACAGCGT
GCCATGCAATCCGGCCTTGTCACTCAAGCTACGATGAAGAAAGCCATTGGTATTAATATTGTCTTAACCATTATCAGCGG
TTTAATCTTGGTTTTTAGCTCTCTTCATCAAACCATGGACATTATCGGATTCATTATTCTTGGTCTTTTAGCGATTGGCG
CGGCTATCGCATACACCATGGGTGATAAACCTTATGGGTATCGTGGACTTGGTGATATCTCAGTATTTATCTTTTTTGGT
CTACTGGGGGTTGCAGGAACTTACTACTTACAAACAGGCCATTTGTCCTCCTCTTTGCTTCTGCCTGCTATTGCTTGTGG
CCTTTTGGCTGTTGCCGTCTTAAATATTAATAATCTGCGTGATATTGATAATGACGCCGCCTGTGGGAAAATGACACTGG
CGGTACGCATGGGTCCAAATTGGGGTCGTAAGTATCACGCCATCATCATCGCGATCAGCTTTACGTGTCTCGCCCTATTT
AGCGCAACGCAAATCCACTCTTTAGCTGGTTGGTTATTTTTAATCCCGGCACCTTTTGTACTGAATCATGTTATTTCAGT
GATGCGAGCACCCGATGGCGAAGCCATTAGACCAATGATGGGAACGGTCGTGCAATGTGCTTTATTCACAAATATCTTCT
TCTCACTTGGTTTGTATTTATCTATATAA

Upstream 100 bases:

>100_bases
TAAGATTGGTTAATCTCTTTATTAAAAGATCAGTGACAAACTTGGGTATGTGTCGAAAATAGTGAATAATAGAGAGTCTA
TTCACTATTTTTGCGATGCC

Downstream 100 bases:

>100_bases
CCTTGAGACTTGTCATAGTAATGACCTAGAAAGTACGTATATTAAAATCTTCACACGTTTAACTGCCACCACAACCAGAA
GGTAAGCCTCACGATGGAAT

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MKTSPFAIWLSAARPKTLPLALASIMTGSALAYWNNHASATITIMAFVTATLLQILSNLANDYGDAVKGTDNDERLGPQR
AMQSGLVTQATMKKAIGINIVLTIISGLILVFSSLHQTMDIIGFIILGLLAIGAAIAYTMGDKPYGYRGLGDISVFIFFG
LLGVAGTYYLQTGHLSSSLLLPAIACGLLAVAVLNINNLRDIDNDAACGKMTLAVRMGPNWGRKYHAIIIAISFTCLALF
SATQIHSLAGWLFLIPAPFVLNHVISVMRAPDGEAIRPMMGTVVQCALFTNIFFSLGLYLSI

Sequences:

>Translated_302_residues
MKTSPFAIWLSAARPKTLPLALASIMTGSALAYWNNHASATITIMAFVTATLLQILSNLANDYGDAVKGTDNDERLGPQR
AMQSGLVTQATMKKAIGINIVLTIISGLILVFSSLHQTMDIIGFIILGLLAIGAAIAYTMGDKPYGYRGLGDISVFIFFG
LLGVAGTYYLQTGHLSSSLLLPAIACGLLAVAVLNINNLRDIDNDAACGKMTLAVRMGPNWGRKYHAIIIAISFTCLALF
SATQIHSLAGWLFLIPAPFVLNHVISVMRAPDGEAIRPMMGTVVQCALFTNIFFSLGLYLSI
>Mature_302_residues
MKTSPFAIWLSAARPKTLPLALASIMTGSALAYWNNHASATITIMAFVTATLLQILSNLANDYGDAVKGTDNDERLGPQR
AMQSGLVTQATMKKAIGINIVLTIISGLILVFSSLHQTMDIIGFIILGLLAIGAAIAYTMGDKPYGYRGLGDISVFIFFG
LLGVAGTYYLQTGHLSSSLLLPAIACGLLAVAVLNINNLRDIDNDAACGKMTLAVRMGPNWGRKYHAIIIAISFTCLALF
SATQIHSLAGWLFLIPAPFVLNHVISVMRAPDGEAIRPMMGTVVQCALFTNIFFSLGLYLSI

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=300, Percent_Identity=25.3333333333333, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1790365, Length=293, Percent_Identity=55.6313993174061, Blast_Score=327, Evalue=7e-91,
Organism=Drosophila melanogaster, GI17737429, Length=239, Percent_Identity=30.1255230125523, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32259; Mature: 32259

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTSPFAIWLSAARPKTLPLALASIMTGSALAYWNNHASATITIMAFVTATLLQILSNLA
CCCCCEEEEEECCCCCHHHHHHHHHHCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHH
NDYGDAVKGTDNDERLGPQRAMQSGLVTQATMKKAIGINIVLTIISGLILVFSSLHQTMD
HHHCCCCCCCCCCHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIGFIILGLLAIGAAIAYTMGDKPYGYRGLGDISVFIFFGLLGVAGTYYLQTGHLSSSLL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCHHHH
LPAIACGLLAVAVLNINNLRDIDNDAACGKMTLAVRMGPNWGRKYHAIIIAISFTCLALF
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
SATQIHSLAGWLFLIPAPFVLNHVISVMRAPDGEAIRPMMGTVVQCALFTNIFFSLGLYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SI
CC
>Mature Secondary Structure
MKTSPFAIWLSAARPKTLPLALASIMTGSALAYWNNHASATITIMAFVTATLLQILSNLA
CCCCCEEEEEECCCCCHHHHHHHHHHCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHH
NDYGDAVKGTDNDERLGPQRAMQSGLVTQATMKKAIGINIVLTIISGLILVFSSLHQTMD
HHHCCCCCCCCCCHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIGFIILGLLAIGAAIAYTMGDKPYGYRGLGDISVFIFFGLLGVAGTYYLQTGHLSSSLL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCHHHH
LPAIACGLLAVAVLNINNLRDIDNDAACGKMTLAVRMGPNWGRKYHAIIIAISFTCLALF
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
SATQIHSLAGWLFLIPAPFVLNHVISVMRAPDGEAIRPMMGTVVQCALFTNIFFSLGLYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SI
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]