Click here to switch to the map view.

The map label for this gene is gor [H]

Identifier: 209693743

GI number: 209693743

Start: 154286

End: 155641

Strand: Reverse

Name: gor [H]

Synonym: VSAL_I0120

Alternate gene names: 209693743

Gene position: 155641-154286 (Counterclockwise)

Preceding gene: 209693744

Following gene: 209693741

Centisome position: 4.68

GC content: 43.36

Gene sequence:

>1356_bases
ATGGCTACTCATTTTGATTATATCTGTATCGGCGGTGGTTCTGGCGGTATCGCATCAGCAAACCGTGCGGCTATGCACGG
CGCAAAAGTTGCTCTTATTGAAGCGCAAGAACTTGGCGGTACGTGTGTAAACGTGGGCTGTGTTCCTAAAAAAGTAATGT
GGCACGGTGCTCAAGTTGCTGAAGCCATTAATTTATACGCTGAAGATTACGGCTTTGATGTTGAACTGAAAAAATTCAAT
TGGAGCAAGATGGTTGAAAACCGCCAAGCGTACATTGGTCGTATTCACGAATCTTACGATCGCGTTCTTGGTAACAATAA
AATAAACGTAATTAAAGGCTTCGCTAAGTTTGTAGACGCTAATACTGTTGAAGTAAATGGCGAACATTACACAGCGGATC
ATATCCTTATTGCTGTTGGTGGTCGTCCAACAATCCCTAATATCCCAGGCGCAGAGCACGGTATTGATTCAAATGGTTTC
TTTGACATCACAGAACAGCCAAAACGCGTTGCGATTATTGGTGCAGGTTACATTGCGGTAGAAATTGCTGGTGTACTTCA
TTCTCTAGGCACAGAAACTCATTTATTTGTTCGTAAAGAATCTCCACTTCGTAGCTTTGATCCAATGATCATCGATACGC
TAGTTGAAGTGATGAACACAGAAGGCCCAACCCTTCATACTCACTCTGTACCAAAAGAAGTGGTTAAAGAAGCCGATGGC
AGCCTAACACTTCATCTAGAAAATGGTGAAACACAAAACGTTGATACTCTAATTTGGGCAATTGGTCGTCACCCTGCGAC
TGACGCTATCAATCTAGAAAAAACAGGCGTTGCTATTAACGATCGCGGTTACATCAAAGTTGATGAATACCAATCAACAA
ACGTAAAAGGCATCTACTGTGTTGGCGACATCATGGAAGGCGGCATCGAGCTAACTCCTATCGCAGTTAAAGCCGGTCGT
TTACTGTCTGAGCGTTTATTCAACGGTCAAACAAACGCAAAAATGGACTACACACTAGTTCCTACTGTTGTGTTTAGCCA
CCCACCGATTGGGACGATTGGTCTTACAGAACAAGAAGCTGACGAACAATACGGCAAAGATAACGTAAAAGTGTACACAT
CAGGCTTCACAGCTATGTACACCGCCGTTACTAAGCACCGTCAACCTTGTAAAATGAAACTGGTTTGTGCTGGCGAAAAC
GAAAAAGTGGTTGGCCTACACGGTATCGGTTTCACGGTTGATGAAATGATCCAAGGTTTTGCAGTAGCAATGAAGATGGG
CGCAACTAAGGCTGATTTCGATGCCGTTGTTGCTATTCATCCAACAGGTTCTGAAGAATTTGTAACGATGAGATAG

Upstream 100 bases:

>100_bases
TAGTAGACCTTGAAGCTCGTACACCTTGAAAAAGAAAAATTTGGTCGCATTTCATACATAGTATGTAAAAAAGAATTAAA
AACTTATTGGAGAGAAAGTA

Downstream 100 bases:

>100_bases
TCTATTTTTAGACTATTTTAAATAAAAAACGCCGCTAAGGTTAACCCTGGCGGCATTTTTGTTTGTTCTCTAATTCGTAT
TAAAACTTAATGTGAGTGAT

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MATHFDYICIGGGSGGIASANRAAMHGAKVALIEAQELGGTCVNVGCVPKKVMWHGAQVAEAINLYAEDYGFDVELKKFN
WSKMVENRQAYIGRIHESYDRVLGNNKINVIKGFAKFVDANTVEVNGEHYTADHILIAVGGRPTIPNIPGAEHGIDSNGF
FDITEQPKRVAIIGAGYIAVEIAGVLHSLGTETHLFVRKESPLRSFDPMIIDTLVEVMNTEGPTLHTHSVPKEVVKEADG
SLTLHLENGETQNVDTLIWAIGRHPATDAINLEKTGVAINDRGYIKVDEYQSTNVKGIYCVGDIMEGGIELTPIAVKAGR
LLSERLFNGQTNAKMDYTLVPTVVFSHPPIGTIGLTEQEADEQYGKDNVKVYTSGFTAMYTAVTKHRQPCKMKLVCAGEN
EKVVGLHGIGFTVDEMIQGFAVAMKMGATKADFDAVVAIHPTGSEEFVTMR

Sequences:

>Translated_451_residues
MATHFDYICIGGGSGGIASANRAAMHGAKVALIEAQELGGTCVNVGCVPKKVMWHGAQVAEAINLYAEDYGFDVELKKFN
WSKMVENRQAYIGRIHESYDRVLGNNKINVIKGFAKFVDANTVEVNGEHYTADHILIAVGGRPTIPNIPGAEHGIDSNGF
FDITEQPKRVAIIGAGYIAVEIAGVLHSLGTETHLFVRKESPLRSFDPMIIDTLVEVMNTEGPTLHTHSVPKEVVKEADG
SLTLHLENGETQNVDTLIWAIGRHPATDAINLEKTGVAINDRGYIKVDEYQSTNVKGIYCVGDIMEGGIELTPIAVKAGR
LLSERLFNGQTNAKMDYTLVPTVVFSHPPIGTIGLTEQEADEQYGKDNVKVYTSGFTAMYTAVTKHRQPCKMKLVCAGEN
EKVVGLHGIGFTVDEMIQGFAVAMKMGATKADFDAVVAIHPTGSEEFVTMR
>Mature_450_residues
ATHFDYICIGGGSGGIASANRAAMHGAKVALIEAQELGGTCVNVGCVPKKVMWHGAQVAEAINLYAEDYGFDVELKKFNW
SKMVENRQAYIGRIHESYDRVLGNNKINVIKGFAKFVDANTVEVNGEHYTADHILIAVGGRPTIPNIPGAEHGIDSNGFF
DITEQPKRVAIIGAGYIAVEIAGVLHSLGTETHLFVRKESPLRSFDPMIIDTLVEVMNTEGPTLHTHSVPKEVVKEADGS
LTLHLENGETQNVDTLIWAIGRHPATDAINLEKTGVAINDRGYIKVDEYQSTNVKGIYCVGDIMEGGIELTPIAVKAGRL
LSERLFNGQTNAKMDYTLVPTVVFSHPPIGTIGLTEQEADEQYGKDNVKVYTSGFTAMYTAVTKHRQPCKMKLVCAGENE
KVVGLHGIGFTVDEMIQGFAVAMKMGATKADFDAVVAIHPTGSEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=52.4945770065076, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI22035672, Length=459, Percent_Identity=39.2156862745098, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI148277071, Length=455, Percent_Identity=35.3846153846154, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI148277065, Length=455, Percent_Identity=35.3846153846154, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI33519430, Length=455, Percent_Identity=35.3846153846154, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI33519428, Length=455, Percent_Identity=35.3846153846154, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI33519426, Length=455, Percent_Identity=35.3846153846154, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI291045266, Length=458, Percent_Identity=33.6244541484716, Blast_Score=242, Evalue=5e-64,
Organism=Homo sapiens, GI291045268, Length=458, Percent_Identity=30.1310043668122, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=28.5403050108932, Blast_Score=162, Evalue=8e-40,
Organism=Escherichia coli, GI1789915, Length=451, Percent_Identity=69.6230598669623, Blast_Score=647, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=444, Percent_Identity=28.3783783783784, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI87082354, Length=425, Percent_Identity=26.3529411764706, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI87081717, Length=455, Percent_Identity=26.3736263736264, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=56, Blast_Score=452, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI71983429, Length=449, Percent_Identity=56.1247216035635, Blast_Score=452, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=36.4978902953587, Blast_Score=293, Evalue=9e-80,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=34.3035343035343, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI32565766, Length=471, Percent_Identity=30.5732484076433, Blast_Score=173, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=50, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321091, Length=464, Percent_Identity=27.5862068965517, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=479, Percent_Identity=22.964509394572, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=39.2324093816631, Blast_Score=295, Evalue=6e-80,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=39.2324093816631, Blast_Score=294, Evalue=7e-80,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=39.2324093816631, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI17737741, Length=471, Percent_Identity=36.9426751592357, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI21358499, Length=461, Percent_Identity=29.9349240780911, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48907; Mature: 48776

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATHFDYICIGGGSGGIASANRAAMHGAKVALIEAQELGGTCVNVGCVPKKVMWHGAQVA
CCCEEEEEEEECCCCCCCCCCHHHHCCCEEEEEEHHHCCCEEEEECCCCHHHHHCCHHHH
EAINLYAEDYGFDVELKKFNWSKMVENRQAYIGRIHESYDRVLGNNKINVIKGFAKFVDA
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCC
NTVEVNGEHYTADHILIAVGGRPTIPNIPGAEHGIDSNGFFDITEQPKRVAIIGAGYIAV
CEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHH
EIAGVLHSLGTETHLFVRKESPLRSFDPMIIDTLVEVMNTEGPTLHTHSVPKEVVKEADG
HHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHCCC
SLTLHLENGETQNVDTLIWAIGRHPATDAINLEKTGVAINDRGYIKVDEYQSTNVKGIYC
CEEEEECCCCCCCCEEEEEEECCCCCCCCEEEEECCEEECCCCCEEEECCCCCCCCEEEE
VGDIMEGGIELTPIAVKAGRLLSERLFNGQTNAKMDYTLVPTVVFSHPPIGTIGLTEQEA
EEEHHHCCEEEEEEEEHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCEECCCCHHH
DEQYGKDNVKVYTSGFTAMYTAVTKHRQPCKMKLVCAGENEKVVGLHGIGFTVDEMIQGF
HHHHCCCCEEEEECCCHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHH
AVAMKMGATKADFDAVVAIHPTGSEEFVTMR
HHHHHCCCCCCCCCEEEEEECCCCCCEEEEC
>Mature Secondary Structure 
ATHFDYICIGGGSGGIASANRAAMHGAKVALIEAQELGGTCVNVGCVPKKVMWHGAQVA
CCEEEEEEEECCCCCCCCCCHHHHCCCEEEEEEHHHCCCEEEEECCCCHHHHHCCHHHH
EAINLYAEDYGFDVELKKFNWSKMVENRQAYIGRIHESYDRVLGNNKINVIKGFAKFVDA
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCC
NTVEVNGEHYTADHILIAVGGRPTIPNIPGAEHGIDSNGFFDITEQPKRVAIIGAGYIAV
CEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHH
EIAGVLHSLGTETHLFVRKESPLRSFDPMIIDTLVEVMNTEGPTLHTHSVPKEVVKEADG
HHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHCCC
SLTLHLENGETQNVDTLIWAIGRHPATDAINLEKTGVAINDRGYIKVDEYQSTNVKGIYC
CEEEEECCCCCCCCEEEEEEECCCCCCCCEEEEECCEEECCCCCEEEECCCCCCCCEEEE
VGDIMEGGIELTPIAVKAGRLLSERLFNGQTNAKMDYTLVPTVVFSHPPIGTIGLTEQEA
EEEHHHCCEEEEEEEEHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCEECCCCHHH
DEQYGKDNVKVYTSGFTAMYTAVTKHRQPCKMKLVCAGENEKVVGLHGIGFTVDEMIQGF
HHHHCCCCEEEEECCCHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHH
AVAMKMGATKADFDAVVAIHPTGSEEFVTMR
HHHHHCCCCCCCCCEEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]