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The map label for this gene is mtnA

Identifier: 197120007

GI number: 197120007

Start: 4171184

End: 4172224

Strand: Direct

Name: mtnA

Synonym: Gbem_3646

Alternate gene names: 197120007

Gene position: 4171184-4172224 (Clockwise)

Preceding gene: 197120006

Following gene: 197120008

Centisome position: 90.38

GC content: 64.75

Gene sequence:

>1041_bases
ATGTCCTTCAGAACCATAGAGTGGCGCGACAACAAGGTGATCATGATAGACCAGACCAGGCTCCCGGCCGAGGAGGTCTA
CAACGAGTACACCGACTTTCAGGGTGTGGCCCAGGCCATTCGCGGCATGGTGGTGCGCGGAGCTCCCGCCATCGGCATCG
CCGCCGCCATGGGGGTCGCTCTCGGGGCGCGCGAGATCATCGCCGACAGCTTCGACACCTTCTACCGCCAGCTCGAAAAC
GTCTGCGAAGTGATCGGACGCACCCGCCCCACCGCGGTCAACCTCTTCTGGGGCCTGGAGCGGATGAAGCGGGTCGCCCT
GCAGCATAAGGAGCTGAATCTCAACTCGATCCGGGAACTGCTGAAGGCGGAGGCGATCAGCATCGAGACCGAGGACCTCG
CCATCTGCAAGGAGATCGGCAGGCACGGCGCCGCGCTGGTCAAGGAGGGCGCCTCCATCCTCACCCACTGCAACGCAGGC
GGGCTGGCGACGGCAGGTTACGGCACCGCGCTCGGCGTCATCCGCGGCGCGCACGAGGCGGGCAAGGGGATCCGCGTCTT
CGCCGACGAAACCCGCCCCTGGCTCCAGGGCGCGCGCCTCACCGCCTGGGAGCTGATGAAGGACTCGATCCCGGTGACGC
TGATCTCCGACAACATGGCAGGCTGGCTCATGAAGACCGGCCAGATAGACTTCTGCGTGGTCGGCGCCGACCGCATCGCG
GCGAACGGCGACACCGCCAACAAGATCGGCACCTACTCGGTCGCCGTCCTCGCCAAGGAAAACCGCATTCCGTTCTACGT
CGCGGCCCCGATATCCACGCTCGACCTGAAGCTTGCCAACGGCGACCTGATCCCGATCGAGGAGCGCGCCTCCGAGGAAG
TGACCCAGATCAAGGGGATCCAGATCGCGCCCGAAGGGGTTAAGGTAAGAAATCCCGCCTTCGACGTCACCCCCGCCCGC
TACATCACCGGAATCATCACAGAAAAAGGGGTGGTGCGCGGCGATTACGAAAGGGAGCTGAAGGCGCTGGTCGGGCAATG
A

Upstream 100 bases:

>100_bases
GGTGAAGCTGCCACCGGATCAGCCGTGGCGCCTTCCCCCCCCACCCCGACCCTCCCCCGCCAGGGGGGAGGGAGCAAAGA
CAGTGCTTTCGAGGTAGACG

Downstream 100 bases:

>100_bases
CGCGCCGCCAGTCGGATCTGGCGGGGGCGCTCCTCGCCGCGCTGTCGCAGCGCCAGGGGAGCGGGCTCGCACAGCTGCTC
GAACAGGGAGGCTACAGCTA

Product: S-methyl-5-thio-alpha-D-ribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSFRTIEWRDNKVIMIDQTRLPAEEVYNEYTDFQGVAQAIRGMVVRGAPAIGIAAAMGVALGAREIIADSFDTFYRQLEN
VCEVIGRTRPTAVNLFWGLERMKRVALQHKELNLNSIRELLKAEAISIETEDLAICKEIGRHGAALVKEGASILTHCNAG
GLATAGYGTALGVIRGAHEAGKGIRVFADETRPWLQGARLTAWELMKDSIPVTLISDNMAGWLMKTGQIDFCVVGADRIA
ANGDTANKIGTYSVAVLAKENRIPFYVAAPISTLDLKLANGDLIPIEERASEEVTQIKGIQIAPEGVKVRNPAFDVTPAR
YITGIITEKGVVRGDYERELKALVGQ

Sequences:

>Translated_346_residues
MSFRTIEWRDNKVIMIDQTRLPAEEVYNEYTDFQGVAQAIRGMVVRGAPAIGIAAAMGVALGAREIIADSFDTFYRQLEN
VCEVIGRTRPTAVNLFWGLERMKRVALQHKELNLNSIRELLKAEAISIETEDLAICKEIGRHGAALVKEGASILTHCNAG
GLATAGYGTALGVIRGAHEAGKGIRVFADETRPWLQGARLTAWELMKDSIPVTLISDNMAGWLMKTGQIDFCVVGADRIA
ANGDTANKIGTYSVAVLAKENRIPFYVAAPISTLDLKLANGDLIPIEERASEEVTQIKGIQIAPEGVKVRNPAFDVTPAR
YITGIITEKGVVRGDYERELKALVGQ
>Mature_345_residues
SFRTIEWRDNKVIMIDQTRLPAEEVYNEYTDFQGVAQAIRGMVVRGAPAIGIAAAMGVALGAREIIADSFDTFYRQLENV
CEVIGRTRPTAVNLFWGLERMKRVALQHKELNLNSIRELLKAEAISIETEDLAICKEIGRHGAALVKEGASILTHCNAGG
LATAGYGTALGVIRGAHEAGKGIRVFADETRPWLQGARLTAWELMKDSIPVTLISDNMAGWLMKTGQIDFCVVGADRIAA
NGDTANKIGTYSVAVLAKENRIPFYVAAPISTLDLKLANGDLIPIEERASEEVTQIKGIQIAPEGVKVRNPAFDVTPARY
ITGIITEKGVVRGDYERELKALVGQ

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=346, Percent_Identity=41.907514450867, Blast_Score=237, Evalue=9e-63,
Organism=Homo sapiens, GI23943880, Length=336, Percent_Identity=37.202380952381, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI4503503, Length=229, Percent_Identity=30.1310043668122, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17557462, Length=328, Percent_Identity=38.4146341463415, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17557123, Length=279, Percent_Identity=26.5232974910394, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325375, Length=407, Percent_Identity=35.1351351351351, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6322878, Length=272, Percent_Identity=28.6764705882353, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357667, Length=353, Percent_Identity=39.6600566572238, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24651647, Length=353, Percent_Identity=39.6600566572238, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_GEOBB (B5ED21)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002140434.1
- ProteinModelPortal:   B5ED21
- SMR:   B5ED21
- GeneID:   6780510
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_3646
- HOGENOM:   HBG682649
- OMA:   ERVYACE
- ProtClustDB:   CLSK829258
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 37680; Mature: 37549

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: ACT_SITE 237-237 BINDING 89-89 BINDING 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFRTIEWRDNKVIMIDQTRLPAEEVYNEYTDFQGVAQAIRGMVVRGAPAIGIAAAMGVA
CCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCEEECCCCHHHHHHHHHHH
LGAREIIADSFDTFYRQLENVCEVIGRTRPTAVNLFWGLERMKRVALQHKELNLNSIREL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHH
LKAEAISIETEDLAICKEIGRHGAALVKEGASILTHCNAGGLATAGYGTALGVIRGAHEA
HHHHHHCCCCHHHHHHHHHHHCHHHHHHCCCHHEEECCCCCCEECCCHHHHHHHHCHHHH
GKGIRVFADETRPWLQGARLTAWELMKDSIPVTLISDNMAGWLMKTGQIDFCVVGADRIA
CCCEEEEECCCCHHHCCCCHHHHHHHHCCCCEEEEECCCCCCEEECCCEEEEEEECCCEE
ANGDTANKIGTYSVAVLAKENRIPFYVAAPISTLDLKLANGDLIPIEERASEEVTQIKGI
CCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEEECCCCEEECHHHHHHHHHHHCCC
QIAPEGVKVRNPAFDVTPARYITGIITEKGVVRGDYERELKALVGQ
EECCCCCEECCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SFRTIEWRDNKVIMIDQTRLPAEEVYNEYTDFQGVAQAIRGMVVRGAPAIGIAAAMGVA
CCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCEEECCCCHHHHHHHHHHH
LGAREIIADSFDTFYRQLENVCEVIGRTRPTAVNLFWGLERMKRVALQHKELNLNSIREL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHH
LKAEAISIETEDLAICKEIGRHGAALVKEGASILTHCNAGGLATAGYGTALGVIRGAHEA
HHHHHHCCCCHHHHHHHHHHHCHHHHHHCCCHHEEECCCCCCEECCCHHHHHHHHCHHHH
GKGIRVFADETRPWLQGARLTAWELMKDSIPVTLISDNMAGWLMKTGQIDFCVVGADRIA
CCCEEEEECCCCHHHCCCCHHHHHHHHCCCCEEEEECCCCCCEEECCCEEEEEEECCCEE
ANGDTANKIGTYSVAVLAKENRIPFYVAAPISTLDLKLANGDLIPIEERASEEVTQIKGI
CCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEEECCCCEEECHHHHHHHHHHHCCC
QIAPEGVKVRNPAFDVTPARYITGIITEKGVVRGDYERELKALVGQ
EECCCCCEECCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA