Click here to switch to the map view.

The map label for this gene is ddhA [H]

Identifier: 197117247

GI number: 197117247

Start: 1010531

End: 1011301

Strand: Direct

Name: ddhA [H]

Synonym: Gbem_0855

Alternate gene names: 197117247

Gene position: 1010531-1011301 (Clockwise)

Preceding gene: 197117246

Following gene: 308535198

Centisome position: 21.9

GC content: 59.66

Gene sequence:

>771_bases
ATGAAGGTGGTGATACTTGCGGGAGGGCTGGGCACACGCTTGAGCGAGGAGACGGTGCTGAAGCCCAAACCGATGGTGGA
GATCGGCGGGAAGCCTATCCTCTGGCATATTATGAAAATCTACTCCCATTATGGGTTCAACGACTTCATCATCTGCCTCG
GCTTCAAGGGGTACGTGATCAAGGAGTACTTCTCGAACTATTTCCTGCATATGAGCAATGTCACGTTTGACTTCGCCAAC
AACTCCATGGAGGTGCACGAGCAGTACGCCGAGCCGTGGCGGGTCACCTTGGTGGATACCGGCCAGGAGTCCATGACCGG
CGGCAGGGTGCGGCGCGTGGCCCCGTACCTCGATGGAGAGACCTTCATGCTGACCTACGGCGACGGGGTGGCTGACGTGA
ACATCGCCGAGCTTGTCGCCTTTCACAAACAGCATGGCAAGCTGGCGACGGTAACCTCCACCCAGCCGGCCGGCCGCTTC
GGCGCGCTGCACCTCACCGCGGACAACTCCGTAGCTTCCTTTCACGAAAAACCGGTCGGTGACGGCGCCTGGATCAACGG
TGGCTTCTTCGTGCTGCAGCGCAGCATGATCGACCATATCGCCTGCGATGCCACCGTCTTCGAGAAAGAGCCGCTGGAGA
GGCTGGCAGCCGAGGGGGAGTTGGTGGCCTACAAGCACGGCGGTTTCTGGCAGCCGATGGACACCCTCAGGGACAAGATG
CACCTGGAAGATCTCTGGGAGAGCGGGAAGGCCCCGTGGAAATTATGGTAG

Upstream 100 bases:

>100_bases
TTGTTTGATAACATGCGCAAAGTATTTGCAAAGTACAGTTCTTGATAAGGTACTCGCTTTAGAGTAATGATAGTCGTCTG
GAACTGGATGCGGAGGGAAC

Downstream 100 bases:

>100_bases
TGAAGAGACACGGTGAGGAAGGGGGCCTGCTGGACAGCTGCTTCTGGCGCGGCAAGAAAGTGTTTCTGACCGGGCACACC
GGGTTCAAGGGGGGCTGGCT

Product: glucose-1-phosphate cytidylyltransferase

Products: NA

Alternate protein names: CDP-glucose pyrophosphorylase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MKVVILAGGLGTRLSEETVLKPKPMVEIGGKPILWHIMKIYSHYGFNDFIICLGFKGYVIKEYFSNYFLHMSNVTFDFAN
NSMEVHEQYAEPWRVTLVDTGQESMTGGRVRRVAPYLDGETFMLTYGDGVADVNIAELVAFHKQHGKLATVTSTQPAGRF
GALHLTADNSVASFHEKPVGDGAWINGGFFVLQRSMIDHIACDATVFEKEPLERLAAEGELVAYKHGGFWQPMDTLRDKM
HLEDLWESGKAPWKLW

Sequences:

>Translated_256_residues
MKVVILAGGLGTRLSEETVLKPKPMVEIGGKPILWHIMKIYSHYGFNDFIICLGFKGYVIKEYFSNYFLHMSNVTFDFAN
NSMEVHEQYAEPWRVTLVDTGQESMTGGRVRRVAPYLDGETFMLTYGDGVADVNIAELVAFHKQHGKLATVTSTQPAGRF
GALHLTADNSVASFHEKPVGDGAWINGGFFVLQRSMIDHIACDATVFEKEPLERLAAEGELVAYKHGGFWQPMDTLRDKM
HLEDLWESGKAPWKLW
>Mature_256_residues
MKVVILAGGLGTRLSEETVLKPKPMVEIGGKPILWHIMKIYSHYGFNDFIICLGFKGYVIKEYFSNYFLHMSNVTFDFAN
NSMEVHEQYAEPWRVTLVDTGQESMTGGRVRRVAPYLDGETFMLTYGDGVADVNIAELVAFHKQHGKLATVTSTQPAGRF
GALHLTADNSVASFHEKPVGDGAWINGGFFVLQRSMIDHIACDATVFEKEPLERLAAEGELVAYKHGGFWQPMDTLRDKM
HLEDLWESGKAPWKLW

Specific function: Involved in the biosynthesis of the tyvelose, a 3,6- dideoxyhexose found in the O-antigen of the surface lipopolysaccharides. It catalyzes the transfer of a CMP moiety from CTP to glucose 1-phosphate. This enzyme can utilize either CTP or UTP as the nucle

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate cytidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=246, Percent_Identity=28.0487804878049, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI11761619, Length=246, Percent_Identity=28.0487804878049, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI133931050, Length=248, Percent_Identity=29.0322580645161, Blast_Score=97, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6320148, Length=268, Percent_Identity=29.4776119402985, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013446
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.33 [H]

Molecular weight: Translated: 28806; Mature: 28806

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVILAGGLGTRLSEETVLKPKPMVEIGGKPILWHIMKIYSHYGFNDFIICLGFKGYVI
CEEEEEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCHHH
KEYFSNYFLHMSNVTFDFANNSMEVHEQYAEPWRVTLVDTGQESMTGGRVRRVAPYLDGE
HHHHHHHEEEECCEEEEECCCCHHHHHHHCCCEEEEEEECCCCCCCCCCEEEECCCCCCC
TFMLTYGDGVADVNIAELVAFHKQHGKLATVTSTQPAGRFGALHLTADNSVASFHEKPVG
EEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCCHHHHHCCCCC
DGAWINGGFFVLQRSMIDHIACDATVFEKEPLERLAAEGELVAYKHGGFWQPMDTLRDKM
CCCEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHH
HLEDLWESGKAPWKLW
HHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKVVILAGGLGTRLSEETVLKPKPMVEIGGKPILWHIMKIYSHYGFNDFIICLGFKGYVI
CEEEEEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCHHH
KEYFSNYFLHMSNVTFDFANNSMEVHEQYAEPWRVTLVDTGQESMTGGRVRRVAPYLDGE
HHHHHHHEEEECCEEEEECCCCHHHHHHHCCCEEEEEEECCCCCCCCCCEEEECCCCCCC
TFMLTYGDGVADVNIAELVAFHKQHGKLATVTSTQPAGRFGALHLTADNSVASFHEKPVG
EEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCCHHHHHCCCCC
DGAWINGGFFVLQRSMIDHIACDATVFEKEPLERLAAEGELVAYKHGGFWQPMDTLRDKM
CCCEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHH
HLEDLWESGKAPWKLW
HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]