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The map label for this gene is bioC [H]

Identifier: 197117225

GI number: 197117225

Start: 984302

End: 985105

Strand: Direct

Name: bioC [H]

Synonym: Gbem_0833

Alternate gene names: 197117225

Gene position: 984302-985105 (Clockwise)

Preceding gene: 197117224

Following gene: 197117227

Centisome position: 21.33

GC content: 66.04

Gene sequence:

>804_bases
ATGGCGGCAAAGATAGACAGGCAGAAGGTACAGGATTCCTTTCACCGGCAGGCGAACGACTACGACTGCCACGCGGTGGT
GCAGTGCCGGGTGGTGGAAAAAGTGGTGGGGATGCTGCAAGCGCAGCAGCTTGCCCCTGCGCGGCTTTTGGACATAGGGG
CCGGGACCGGCCGCCTGCTGGGGAGGGTGACGGAGCTCTACCCCGAAGCCAGCGCAGTCGGCGCGGACCTCGCCCCGGGG
ATGTGCCGCGCGGCTGCCGAAAACCTCGCCGGAAAACGGGTGGAGATGGTGAACGCCGACGCCGAAAATCTCCCCTTTGC
CCCGGAGAGCTTCGACCTGGTCCTCTCCACCTCGACCTACCAGTGGCTCAGCTCGCTCGACCAGGCCTTCTCCGAGGCGA
GCCGGGTGCTCGTGCCGGGCGGGCTCTTTTGCTTCGCGCTCTTCGGCGAGAGGACGCTGTTCGAGCTGCGCGATTCCTAC
CGGAGCGCCTTAAGCGGTGCCTCTGACCGCAGCCACAGTTTCTTTTCCAGGTCTGAAGTCGAGGAGGCCCTGGAGAGGGT
CGGCTTTGCCGGCGCCACGGTAACCTCGGAACTGGAAGTGGAGATGCACCCGGACGTACCGGAGCTGCTCCGCTCGCTCA
AGCGGATCGGGGCCGGCACCACCGCGCCGGTCGCAGCCAACGGGCTCTCGGAGCGCCGGATCATGCTGGACATGATGGCG
GCCTACCGCAGCGACTTCGGGCGCGAGGACGGGATACCGGCAACCTACGAGGTCATCTACGGCGTGGCCCGCAAAGCAAA
GTAG

Upstream 100 bases:

>100_bases
TCCTAACTGGGTGAGGGGGCGCTGTGCAACTGATCTGCCCCCGGCGGGGGGAAGGGGCTGGCGACACTTTAACGATTCAG
ATAATCCGGGCGGTTTATAG

Downstream 100 bases:

>100_bases
CACCCTTTTCCACTCCTCCTCGCCGTGGGGGGGCGGTTCCTGCTCCCTCTCCCTCTGGGAGAGGGTATATCTGGCAGGAT
GCAAAGCGGGAGCTTGGGAA

Product: biotin biosynthesis methyltransferase BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MAAKIDRQKVQDSFHRQANDYDCHAVVQCRVVEKVVGMLQAQQLAPARLLDIGAGTGRLLGRVTELYPEASAVGADLAPG
MCRAAAENLAGKRVEMVNADAENLPFAPESFDLVLSTSTYQWLSSLDQAFSEASRVLVPGGLFCFALFGERTLFELRDSY
RSALSGASDRSHSFFSRSEVEEALERVGFAGATVTSELEVEMHPDVPELLRSLKRIGAGTTAPVAANGLSERRIMLDMMA
AYRSDFGREDGIPATYEVIYGVARKAK

Sequences:

>Translated_267_residues
MAAKIDRQKVQDSFHRQANDYDCHAVVQCRVVEKVVGMLQAQQLAPARLLDIGAGTGRLLGRVTELYPEASAVGADLAPG
MCRAAAENLAGKRVEMVNADAENLPFAPESFDLVLSTSTYQWLSSLDQAFSEASRVLVPGGLFCFALFGERTLFELRDSY
RSALSGASDRSHSFFSRSEVEEALERVGFAGATVTSELEVEMHPDVPELLRSLKRIGAGTTAPVAANGLSERRIMLDMMA
AYRSDFGREDGIPATYEVIYGVARKAK
>Mature_266_residues
AAKIDRQKVQDSFHRQANDYDCHAVVQCRVVEKVVGMLQAQQLAPARLLDIGAGTGRLLGRVTELYPEASAVGADLAPGM
CRAAAENLAGKRVEMVNADAENLPFAPESFDLVLSTSTYQWLSSLDQAFSEASRVLVPGGLFCFALFGERTLFELRDSYR
SALSGASDRSHSFFSRSEVEEALERVGFAGATVTSELEVEMHPDVPELLRSLKRIGAGTTAPVAANGLSERRIMLDMMAA
YRSDFGREDGIPATYEVIYGVARKAK

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=247, Percent_Identity=31.1740890688259, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI86792933, Length=151, Percent_Identity=33.7748344370861, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786994, Length=262, Percent_Identity=27.0992366412214, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17535003, Length=248, Percent_Identity=25, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19922210, Length=221, Percent_Identity=31.2217194570136, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 29044; Mature: 28913

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKIDRQKVQDSFHRQANDYDCHAVVQCRVVEKVVGMLQAQQLAPARLLDIGAGTGRLL
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHH
GRVTELYPEASAVGADLAPGMCRAAAENLAGKRVEMVNADAENLPFAPESFDLVLSTSTY
HHHHHHCCCHHHCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEEECHHH
QWLSSLDQAFSEASRVLVPGGLFCFALFGERTLFELRDSYRSALSGASDRSHSFFSRSEV
HHHHHHHHHHHHHCCEECCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
EEALERVGFAGATVTSELEVEMHPDVPELLRSLKRIGAGTTAPVAANGLSERRIMLDMMA
HHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHH
AYRSDFGREDGIPATYEVIYGVARKAK
HHHHHCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAKIDRQKVQDSFHRQANDYDCHAVVQCRVVEKVVGMLQAQQLAPARLLDIGAGTGRLL
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHH
GRVTELYPEASAVGADLAPGMCRAAAENLAGKRVEMVNADAENLPFAPESFDLVLSTSTY
HHHHHHCCCHHHCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEEECHHH
QWLSSLDQAFSEASRVLVPGGLFCFALFGERTLFELRDSYRSALSGASDRSHSFFSRSEV
HHHHHHHHHHHHHCCEECCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
EEALERVGFAGATVTSELEVEMHPDVPELLRSLKRIGAGTTAPVAANGLSERRIMLDMMA
HHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHH
AYRSDFGREDGIPATYEVIYGVARKAK
HHHHHCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]