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The map label for this gene is zraR [H]

Identifier: 197117067

GI number: 197117067

Start: 793286

End: 794695

Strand: Direct

Name: zraR [H]

Synonym: Gbem_0671

Alternate gene names: 197117067

Gene position: 793286-794695 (Clockwise)

Preceding gene: 197117057

Following gene: 197117068

Centisome position: 17.19

GC content: 59.72

Gene sequence:

>1410_bases
ATGAATATTCTCGTGGTTGATGATGAGTCTGTGATCAGAGATGGCCTTGCCAGAATACTGGAGGGAGATTCTTTCACGGT
GGATACGGCAAAGAGTGGTCATGTCGCCATTGAGCATCTCCAGCAAAAAGAATTCGACCTGATAATAACCGACCTGAAGA
TGCCGGGGGTGAGCGGATTCGAGGTCCTTGCCGCGGTGAAGACGCTGCAGCCGGATACCCCGGTCATCATGATCACCGGC
TTCGCCACTGTGGAGACTGCGGTCGATGCGATGAAAAACGGCACGGTCGACTACATCGTGAAGCCCTTCACCCCGGAACA
GATACTGGAAAAGGTGCACCTGGCGCTGGAGCAGAAAAAGAACACGGTGGAAGATCTCTATGTGAAGAAGGAGATCGACT
GCCATCACGGCTTCGACCAGTTCATCGGCGACAGCCGGGAGATGCAGAAGGTCTACCGCCGCATCATGCAGGTTGCCGCC
ACCGACTCAACCGTCCTCATCACCGGGGAGAGCGGCACCGGAAAGGAACTGGCGGCGCGGGCGATCCACAAGAACAGCCC
GAGAAGGGACCTTCCCTTCGTCGCCGTCGATTGCACGGCACTTGCCGAAAACCTCCTGGAGAGCGAGCTGTTCGGGCACG
TGAAGGGTTCCTTCACCGGCGCGATGCAGACCAAGATGGGGCTCTTCATGGTCGCCGACGGCGGCACGCTGTTCCTGGAC
GAGGTCTCCAACATAAGCCTCGCCACACAGGCGAAGCTCTTGCGGGCCCTGCAGGAGAGGCAGGTGACTCCCATCGGCGG
GACGCAGCCGGTCTCCTTCAACATACACCTCGTAGCCGCGACCAACCGCAACCTGAAGACCATGGTGTCGGAGGGGATCT
TCCGCGAAGACCTTTATTTTCGGCTCAACATCATCCCCCTGGACCTCCCCCCCCTGAGGGAGCGCAAGGGGGACATCCCG
CTTTTGGTCCGCCACTTCATGAACAAGTTCATGGAGGAGGTAGGGAAGGACCTGCGCGGCATCTCGCCCGAGGCGATGCA
GTTTTTGGAAAACTACTCCTACCCCGGCAACGTCAGGGAACTGGTGAACACCCTGGAGCGCGCCGTGGTGCTGGCCGAGG
GGGACGTGATCCAGAAGGAGAACCTGGAGCTGGGGGATTCCGCCGAGACCGAGCTTTGCACCGGGTTCGACGGCTTCGTG
CCGACCAGCGCCGAGGCCTTGAAGGAGATGAAGCGCCACATCCGCGACCGCTCGGTGGAAAACGTCGAGAAAGCCTTCGT
CATCAACGCGCTCAAGCGGAGCAACTGGAACATCTCCCGCGCCGCCGAGGATACCGGGATGCTGCGCCCCAACTTCCAGA
CCATGCTGAAGCGGCTGGGGATCTCGGTGAAGGACTACTTCGGCAAGTAA

Upstream 100 bases:

>100_bases
GCAACTTTCAGGACAAAGTGGCTGCACCAGGCTCAACAACCTCGTCTAACCTCATGACAACGTGGCGCATCTATAACTGA
AGTATGAAATGGTGGCTTGC

Downstream 100 bases:

>100_bases
TCACTGCAGAGCAACTGGTTTGAAACTGGCAAGTCGATCCCTGGCGCACTCATCTGTTCCTTTCCCGCAACATCTCCCCA
GTTCTCACTGGACCTGCCGC

Product: sigma-54-dependent transcriptional response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MNILVVDDESVIRDGLARILEGDSFTVDTAKSGHVAIEHLQQKEFDLIITDLKMPGVSGFEVLAAVKTLQPDTPVIMITG
FATVETAVDAMKNGTVDYIVKPFTPEQILEKVHLALEQKKNTVEDLYVKKEIDCHHGFDQFIGDSREMQKVYRRIMQVAA
TDSTVLITGESGTGKELAARAIHKNSPRRDLPFVAVDCTALAENLLESELFGHVKGSFTGAMQTKMGLFMVADGGTLFLD
EVSNISLATQAKLLRALQERQVTPIGGTQPVSFNIHLVAATNRNLKTMVSEGIFREDLYFRLNIIPLDLPPLRERKGDIP
LLVRHFMNKFMEEVGKDLRGISPEAMQFLENYSYPGNVRELVNTLERAVVLAEGDVIQKENLELGDSAETELCTGFDGFV
PTSAEALKEMKRHIRDRSVENVEKAFVINALKRSNWNISRAAEDTGMLRPNFQTMLKRLGISVKDYFGK

Sequences:

>Translated_469_residues
MNILVVDDESVIRDGLARILEGDSFTVDTAKSGHVAIEHLQQKEFDLIITDLKMPGVSGFEVLAAVKTLQPDTPVIMITG
FATVETAVDAMKNGTVDYIVKPFTPEQILEKVHLALEQKKNTVEDLYVKKEIDCHHGFDQFIGDSREMQKVYRRIMQVAA
TDSTVLITGESGTGKELAARAIHKNSPRRDLPFVAVDCTALAENLLESELFGHVKGSFTGAMQTKMGLFMVADGGTLFLD
EVSNISLATQAKLLRALQERQVTPIGGTQPVSFNIHLVAATNRNLKTMVSEGIFREDLYFRLNIIPLDLPPLRERKGDIP
LLVRHFMNKFMEEVGKDLRGISPEAMQFLENYSYPGNVRELVNTLERAVVLAEGDVIQKENLELGDSAETELCTGFDGFV
PTSAEALKEMKRHIRDRSVENVEKAFVINALKRSNWNISRAAEDTGMLRPNFQTMLKRLGISVKDYFGK
>Mature_469_residues
MNILVVDDESVIRDGLARILEGDSFTVDTAKSGHVAIEHLQQKEFDLIITDLKMPGVSGFEVLAAVKTLQPDTPVIMITG
FATVETAVDAMKNGTVDYIVKPFTPEQILEKVHLALEQKKNTVEDLYVKKEIDCHHGFDQFIGDSREMQKVYRRIMQVAA
TDSTVLITGESGTGKELAARAIHKNSPRRDLPFVAVDCTALAENLLESELFGHVKGSFTGAMQTKMGLFMVADGGTLFLD
EVSNISLATQAKLLRALQERQVTPIGGTQPVSFNIHLVAATNRNLKTMVSEGIFREDLYFRLNIIPLDLPPLRERKGDIP
LLVRHFMNKFMEEVGKDLRGISPEAMQFLENYSYPGNVRELVNTLERAVVLAEGDVIQKENLELGDSAETELCTGFDGFV
PTSAEALKEMKRHIRDRSVENVEKAFVINALKRSNWNISRAAEDTGMLRPNFQTMLKRLGISVKDYFGK

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=463, Percent_Identity=40.6047516198704, Blast_Score=344, Evalue=7e-96,
Organism=Escherichia coli, GI1790437, Length=458, Percent_Identity=40.6113537117904, Blast_Score=340, Evalue=2e-94,
Organism=Escherichia coli, GI1790299, Length=467, Percent_Identity=37.2591006423983, Blast_Score=308, Evalue=5e-85,
Organism=Escherichia coli, GI1788905, Length=465, Percent_Identity=35.6989247311828, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI87082117, Length=339, Percent_Identity=43.6578171091445, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1789233, Length=242, Percent_Identity=49.5867768595041, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI1789087, Length=327, Percent_Identity=42.5076452599388, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI87082152, Length=326, Percent_Identity=41.7177914110429, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI87081872, Length=321, Percent_Identity=37.6947040498442, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1786524, Length=239, Percent_Identity=43.5146443514644, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1787583, Length=328, Percent_Identity=32.6219512195122, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1789828, Length=311, Percent_Identity=30.5466237942122, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87081858, Length=339, Percent_Identity=25.0737463126844, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1786599, Length=113, Percent_Identity=33.6283185840708, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786784, Length=118, Percent_Identity=29.6610169491525, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87082012, Length=118, Percent_Identity=28.8135593220339, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790552, Length=124, Percent_Identity=25.8064516129032, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790860, Length=120, Percent_Identity=27.5, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789809, Length=147, Percent_Identity=27.2108843537415, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1788191, Length=124, Percent_Identity=33.8709677419355, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789402, Length=121, Percent_Identity=28.9256198347107, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52274; Mature: 52274

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILVVDDESVIRDGLARILEGDSFTVDTAKSGHVAIEHLQQKEFDLIITDLKMPGVSGF
CEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCHH
EVLAAVKTLQPDTPVIMITGFATVETAVDAMKNGTVDYIVKPFTPEQILEKVHLALEQKK
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHC
NTVEDLYVKKEIDCHHGFDQFIGDSREMQKVYRRIMQVAATDSTVLITGESGTGKELAAR
CHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
AIHKNSPRRDLPFVAVDCTALAENLLESELFGHVKGSFTGAMQTKMGLFMVADGGTLFLD
HHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCEEEEE
EVSNISLATQAKLLRALQERQVTPIGGTQPVSFNIHLVAATNRNLKTMVSEGIFREDLYF
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHCCCHHCCEEE
RLNIIPLDLPPLRERKGDIPLLVRHFMNKFMEEVGKDLRGISPEAMQFLENYSYPGNVRE
EEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHH
LVNTLERAVVLAEGDVIQKENLELGDSAETELCTGFDGFVPTSAEALKEMKRHIRDRSVE
HHHHHHHHEEEECCCEEECCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCHH
NVEKAFVINALKRSNWNISRAAEDTGMLRPNFQTMLKRLGISVKDYFGK
HHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHCCCHHHHCCC
>Mature Secondary Structure
MNILVVDDESVIRDGLARILEGDSFTVDTAKSGHVAIEHLQQKEFDLIITDLKMPGVSGF
CEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCHH
EVLAAVKTLQPDTPVIMITGFATVETAVDAMKNGTVDYIVKPFTPEQILEKVHLALEQKK
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHC
NTVEDLYVKKEIDCHHGFDQFIGDSREMQKVYRRIMQVAATDSTVLITGESGTGKELAAR
CHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
AIHKNSPRRDLPFVAVDCTALAENLLESELFGHVKGSFTGAMQTKMGLFMVADGGTLFLD
HHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCEEEEE
EVSNISLATQAKLLRALQERQVTPIGGTQPVSFNIHLVAATNRNLKTMVSEGIFREDLYF
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHCCCHHCCEEE
RLNIIPLDLPPLRERKGDIPLLVRHFMNKFMEEVGKDLRGISPEAMQFLENYSYPGNVRE
EEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHH
LVNTLERAVVLAEGDVIQKENLELGDSAETELCTGFDGFVPTSAEALKEMKRHIRDRSVE
HHHHHHHHEEEECCCEEECCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCHH
NVEKAFVINALKRSNWNISRAAEDTGMLRPNFQTMLKRLGISVKDYFGK
HHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]