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The map label for this gene is thiL [H]

Identifier: 197117002

GI number: 197117002

Start: 727516

End: 728490

Strand: Direct

Name: thiL [H]

Synonym: Gbem_0605

Alternate gene names: 197117002

Gene position: 727516-728490 (Clockwise)

Preceding gene: 197117001

Following gene: 197117005

Centisome position: 15.76

GC content: 65.64

Gene sequence:

>975_bases
TTGAGACTGGCGGAACTGGGCGAATTCGGCCTGATCGACCGCATCAAGAAAAATGTCGCCGCGTCCCCCTCGGTGCTTCT
AGGCATCGGGGATGACGCGGCGGCTCTCGTTCCTGCTCCGGAATGTGTCACCCTGATCACCTGCGACATGCTTCTCGAGT
CTGTCCACTTCGACCTCTCCTTTTGCGACCCGGAAAGCCTCGGCAGAAAATCCCTTTCGGTGAATCTCTCGGACCTGGCG
GCGATGGGTGCCCACCCACGCCAGTTCCTGCTCGGCATCGCCCTCGGGAAGGAAGTCCCGATCGAGTTCATGGACCGCTT
CATGGCGGGGGTGCTGGAGCAGGCCGAGCGCTTCGGCGCCACCCTGGTAGGGGGCGACACCTGCGCCTCCAAGGGGGGGA
TAGCCATCTCCATCACGGCCTTGGGCGAGCAGCGCCCGGAGCTGGTGCTGAAGCGAAGCGGCGCGCGTCCGGGGGACCTC
ATCTGCCTATCCGGTACGGTGGGCGACGCAGCGGCGGGGCTTGTGGCGCTTCGACAAGGGGTGCGGGAAGGTTTTCTGGT
GTCGCGCCAGCTCGACCCGACCCCCAGGGTTGCCGCCGGGGTGGCGCTCGCCGAAGGCGGGCTCGCCACTGCGATGATCG
ACGTAAGTGACGGTGTTTTGGGGGATTTGGGGCACATCCGCGAGATGTCCGGGGTGGGCGCCAGGCTTGAACTCGCCAAG
CTGCCGCTTTCGGACGAGTACCGGGCCGCCTGCGGCGACGACCCGTATGCGCTGGCGCTTTCGGGAGGGGAGGACTACGA
GCTTTTGTTCTGTATCGCCCCGGGAAAGAGGGGGGAGGTGGAGGCGCTTTTCGCTAAGCTGGCGCTTAGGCTTTCGGTGA
TCGGCGAGATTACCGCCACCCCGGAAGTAAAGCTCGTCACCCCCGGTGGGGGCGTCTACGCCCCGGGCCACGGCGGCTTC
GACCATTTCGGGTAA

Upstream 100 bases:

>100_bases
CTCGGGCGGCCTCGAAGCCCAAGCCCTCCAAGACCGAGCCCCCGAAGAGCAAGGTTGCCCGACGGGTCACCGTTCCCCCC
ACCGGGGTGAGGGGCAAGGC

Downstream 100 bases:

>100_bases
AGGCAGTTTTTTCTATTCGCCGCAGATTTTCACCGCGACGCGGCGCTCCCTGGGGCCGTCGAACTCGCAGAAGTAAAGCA
CCTGCCAGGTTCCCAAAAGA

Product: thiamin monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MRLAELGEFGLIDRIKKNVAASPSVLLGIGDDAAALVPAPECVTLITCDMLLESVHFDLSFCDPESLGRKSLSVNLSDLA
AMGAHPRQFLLGIALGKEVPIEFMDRFMAGVLEQAERFGATLVGGDTCASKGGIAISITALGEQRPELVLKRSGARPGDL
ICLSGTVGDAAAGLVALRQGVREGFLVSRQLDPTPRVAAGVALAEGGLATAMIDVSDGVLGDLGHIREMSGVGARLELAK
LPLSDEYRAACGDDPYALALSGGEDYELLFCIAPGKRGEVEALFAKLALRLSVIGEITATPEVKLVTPGGGVYAPGHGGF
DHFG

Sequences:

>Translated_324_residues
MRLAELGEFGLIDRIKKNVAASPSVLLGIGDDAAALVPAPECVTLITCDMLLESVHFDLSFCDPESLGRKSLSVNLSDLA
AMGAHPRQFLLGIALGKEVPIEFMDRFMAGVLEQAERFGATLVGGDTCASKGGIAISITALGEQRPELVLKRSGARPGDL
ICLSGTVGDAAAGLVALRQGVREGFLVSRQLDPTPRVAAGVALAEGGLATAMIDVSDGVLGDLGHIREMSGVGARLELAK
LPLSDEYRAACGDDPYALALSGGEDYELLFCIAPGKRGEVEALFAKLALRLSVIGEITATPEVKLVTPGGGVYAPGHGGF
DHFG
>Mature_324_residues
MRLAELGEFGLIDRIKKNVAASPSVLLGIGDDAAALVPAPECVTLITCDMLLESVHFDLSFCDPESLGRKSLSVNLSDLA
AMGAHPRQFLLGIALGKEVPIEFMDRFMAGVLEQAERFGATLVGGDTCASKGGIAISITALGEQRPELVLKRSGARPGDL
ICLSGTVGDAAAGLVALRQGVREGFLVSRQLDPTPRVAAGVALAEGGLATAMIDVSDGVLGDLGHIREMSGVGARLELAK
LPLSDEYRAACGDDPYALALSGGEDYELLFCIAPGKRGEVEALFAKLALRLSVIGEITATPEVKLVTPGGGVYAPGHGGF
DHFG

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=326, Percent_Identity=39.5705521472393, Blast_Score=181, Evalue=8e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 33566; Mature: 33566

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLAELGEFGLIDRIKKNVAASPSVLLGIGDDAAALVPAPECVTLITCDMLLESVHFDLS
CCCHHCCCCCHHHHHHHHHCCCCCEEEEECCCCEEECCCCHHHHHHHHHHHHHHHCCCEE
FCDPESLGRKSLSVNLSDLAAMGAHPRQFLLGIALGKEVPIEFMDRFMAGVLEQAERFGA
ECCHHHHCCCEEEEEHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
TLVGGDTCASKGGIAISITALGEQRPELVLKRSGARPGDLICLSGTVGDAAAGLVALRQG
EEECCCCCCCCCCEEEEEEECCCCCCHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
VREGFLVSRQLDPTPRVAAGVALAEGGLATAMIDVSDGVLGDLGHIREMSGVGARLELAK
HHHCEEEECCCCCCCCHHHHHEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEE
LPLSDEYRAACGDDPYALALSGGEDYELLFCIAPGKRGEVEALFAKLALRLSVIGEITAT
CCCCCCHHHHCCCCCEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHEECC
PEVKLVTPGGGVYAPGHGGFDHFG
CCEEEECCCCCEECCCCCCCCCCC
>Mature Secondary Structure
MRLAELGEFGLIDRIKKNVAASPSVLLGIGDDAAALVPAPECVTLITCDMLLESVHFDLS
CCCHHCCCCCHHHHHHHHHCCCCCEEEEECCCCEEECCCCHHHHHHHHHHHHHHHCCCEE
FCDPESLGRKSLSVNLSDLAAMGAHPRQFLLGIALGKEVPIEFMDRFMAGVLEQAERFGA
ECCHHHHCCCEEEEEHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
TLVGGDTCASKGGIAISITALGEQRPELVLKRSGARPGDLICLSGTVGDAAAGLVALRQG
EEECCCCCCCCCCEEEEEEECCCCCCHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
VREGFLVSRQLDPTPRVAAGVALAEGGLATAMIDVSDGVLGDLGHIREMSGVGARLELAK
HHHCEEEECCCCCCCCHHHHHEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEE
LPLSDEYRAACGDDPYALALSGGEDYELLFCIAPGKRGEVEALFAKLALRLSVIGEITAT
CCCCCCHHHHCCCCCEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHEECC
PEVKLVTPGGGVYAPGHGGFDHFG
CCEEEECCCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]