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The map label for this gene is bkdA [H]

Identifier: 197116857

GI number: 197116857

Start: 552356

End: 553411

Strand: Direct

Name: bkdA [H]

Synonym: Gbem_0459

Alternate gene names: 197116857

Gene position: 552356-553411 (Clockwise)

Preceding gene: 197116856

Following gene: 197116858

Centisome position: 11.97

GC content: 66.48

Gene sequence:

>1056_bases
ATGCCCGAAGAAGTCCTTGCCACTTTCCAAGTTAAACGCGTAAGCGTTCTTAATGAGAACGGCAGCGCCGATCTCGACCT
CATGCCTGAGTTGTCGGCTGACCAGATCTGGCGCATGTACCAGCTCATGGTGCTCTCGCGCTGCTTCGACGAGCGTGCCG
TTTCGTTACAGCGGGAGGGGCGCCTGGGAACCTACCCGCCCATACGGGGACAGGAGGCGGCCCAGGTGGGGAGCGCCTTC
GCGCTCAAGGCCGACGACTGGGTGTTCCCCTCTTTCCGCGAGATGGGGGTGCACCTGACGCTGGGGTATCCCATCCCGCA
GCTCCTCCAGTACTGGGCCGGCGACGAGCGGGCCCAGAAGACGCCGCCGCAGCTGAACATCTTTCCCTTCTGCGTGGCCG
TCGGAAGCCAAATCCCCCATGCTGTAGGGGCTGCGCTCGCCGCCCGCTACCGGCGGGATTCGGCCGCCGTGGCGGTCTAC
TTCGGCGACGGGGCGACATCGAAGGGGGACTTCCACGAGGCGATGAACATGGCCGGGGTCTACCAGCTGCCGATAGTCTT
CATCTGCCAGAACAACCAGTGGGCCATCTCGGTCCCGCTCAAGGGGCAGACGGCTTCGGCGTCGCTGGCACAGAAGGCGC
TCGCCTACGGGTTCGAAGGGGTGCAGGTGGACGGCAACGACGTCCTCGCGGTCTACCGCGCCACCAAGCAGGCGCTGGAA
AAGGCGACAAGCGGCGGTGGCCCCACCTTCCTGGAATGCCTCACCTACCGCATGGCCGACCACACCACGGCCGACGACGC
GGGGCGCTACCGCTCCGACGAGGAGGTGGCGCTTTGGAATGGGCGGGATCCCATCCTCAGGCTGGAGCGCTTCTTAGCTG
CGAGCGGCGCCTGGACCCCGGAACAGGGGAGGGGGGTCAAGGAGGAGGCGACCTCGCTGATCGACCGGGGGGTAGGGGAG
ATGGAGGCTGTACCGCCCCCCGACCCGGCAGAACTCTTCGACGCGACCCTGGCGGCACTCACACCGCGGCAGGCCGGGCA
AAGAAAGGGACGCTGA

Upstream 100 bases:

>100_bases
GAAAGTCCCTCCTTTTTTTAAACTCGTTTTTGACATCCTCCAAGTGTGCATTTACACTCTCGTAATTCTTTGATCGCCAC
CTCCGCGGAAGGGGCCGACC

Downstream 100 bases:

>100_bases
CATGGCGCAACTGAACATGGTACAGGCGATAAACCAGGCCCTCGCCGACGAGATGGCGCGCGACGACCGGGTGGTGCTCC
TCGGGGAGGACGTGGGGCGG

Product: branched-chain 2-oxoacid dehydrogenase complex, E1 protein subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MPEEVLATFQVKRVSVLNENGSADLDLMPELSADQIWRMYQLMVLSRCFDERAVSLQREGRLGTYPPIRGQEAAQVGSAF
ALKADDWVFPSFREMGVHLTLGYPIPQLLQYWAGDERAQKTPPQLNIFPFCVAVGSQIPHAVGAALAARYRRDSAAVAVY
FGDGATSKGDFHEAMNMAGVYQLPIVFICQNNQWAISVPLKGQTASASLAQKALAYGFEGVQVDGNDVLAVYRATKQALE
KATSGGGPTFLECLTYRMADHTTADDAGRYRSDEEVALWNGRDPILRLERFLAASGAWTPEQGRGVKEEATSLIDRGVGE
MEAVPPPDPAELFDATLAALTPRQAGQRKGR

Sequences:

>Translated_351_residues
MPEEVLATFQVKRVSVLNENGSADLDLMPELSADQIWRMYQLMVLSRCFDERAVSLQREGRLGTYPPIRGQEAAQVGSAF
ALKADDWVFPSFREMGVHLTLGYPIPQLLQYWAGDERAQKTPPQLNIFPFCVAVGSQIPHAVGAALAARYRRDSAAVAVY
FGDGATSKGDFHEAMNMAGVYQLPIVFICQNNQWAISVPLKGQTASASLAQKALAYGFEGVQVDGNDVLAVYRATKQALE
KATSGGGPTFLECLTYRMADHTTADDAGRYRSDEEVALWNGRDPILRLERFLAASGAWTPEQGRGVKEEATSLIDRGVGE
MEAVPPPDPAELFDATLAALTPRQAGQRKGR
>Mature_350_residues
PEEVLATFQVKRVSVLNENGSADLDLMPELSADQIWRMYQLMVLSRCFDERAVSLQREGRLGTYPPIRGQEAAQVGSAFA
LKADDWVFPSFREMGVHLTLGYPIPQLLQYWAGDERAQKTPPQLNIFPFCVAVGSQIPHAVGAALAARYRRDSAAVAVYF
GDGATSKGDFHEAMNMAGVYQLPIVFICQNNQWAISVPLKGQTASASLAQKALAYGFEGVQVDGNDVLAVYRATKQALEK
ATSGGGPTFLECLTYRMADHTTADDAGRYRSDEEVALWNGRDPILRLERFLAASGAWTPEQGRGVKEEATSLIDRGVGEM
EAVPPPDPAELFDATLAALTPRQAGQRKGR

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=315, Percent_Identity=36.1904761904762, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI258645172, Length=315, Percent_Identity=36.1904761904762, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI4885543, Length=342, Percent_Identity=29.8245614035088, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI4505685, Length=342, Percent_Identity=26.9005847953216, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI291084742, Length=342, Percent_Identity=26.9005847953216, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI291084744, Length=270, Percent_Identity=28.5185185185185, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI291084757, Length=336, Percent_Identity=24.702380952381, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI86563357, Length=331, Percent_Identity=33.8368580060423, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI86563355, Length=331, Percent_Identity=33.8368580060423, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17536047, Length=319, Percent_Identity=29.4670846394984, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32564172, Length=319, Percent_Identity=29.4670846394984, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6321026, Length=315, Percent_Identity=28.8888888888889, Blast_Score=131, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21355903, Length=350, Percent_Identity=33.7142857142857, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24639748, Length=331, Percent_Identity=29.607250755287, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24639744, Length=322, Percent_Identity=27.9503105590062, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI28571106, Length=322, Percent_Identity=27.9503105590062, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24639740, Length=322, Percent_Identity=27.9503105590062, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24639746, Length=254, Percent_Identity=28.3464566929134, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38330; Mature: 38199

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEEVLATFQVKRVSVLNENGSADLDLMPELSADQIWRMYQLMVLSRCFDERAVSLQREG
CCHHHHHHHHHHEEEEECCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RLGTYPPIRGQEAAQVGSAFALKADDWVFPSFREMGVHLTLGYPIPQLLQYWAGDERAQK
CCCCCCCCCCCHHHHHCCEEEECCCCCCCCCHHHCCEEEEECCCHHHHHHHHCCCCHHHC
TPPQLNIFPFCVAVGSQIPHAVGAALAARYRRDSAAVAVYFGDGATSKGDFHEAMNMAGV
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCE
YQLPIVFICQNNQWAISVPLKGQTASASLAQKALAYGFEGVQVDGNDVLAVYRATKQALE
EECCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEECCCCEEEHHHHHHHHHH
KATSGGGPTFLECLTYRMADHTTADDAGRYRSDEEVALWNGRDPILRLERFLAASGAWTP
HHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCC
EQGRGVKEEATSLIDRGVGEMEAVPPPDPAELFDATLAALTPRQAGQRKGR
HHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCC
>Mature Secondary Structure 
PEEVLATFQVKRVSVLNENGSADLDLMPELSADQIWRMYQLMVLSRCFDERAVSLQREG
CHHHHHHHHHHEEEEECCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RLGTYPPIRGQEAAQVGSAFALKADDWVFPSFREMGVHLTLGYPIPQLLQYWAGDERAQK
CCCCCCCCCCCHHHHHCCEEEECCCCCCCCCHHHCCEEEEECCCHHHHHHHHCCCCHHHC
TPPQLNIFPFCVAVGSQIPHAVGAALAARYRRDSAAVAVYFGDGATSKGDFHEAMNMAGV
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCE
YQLPIVFICQNNQWAISVPLKGQTASASLAQKALAYGFEGVQVDGNDVLAVYRATKQALE
EECCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEECCCCEEEHHHHHHHHHH
KATSGGGPTFLECLTYRMADHTTADDAGRYRSDEEVALWNGRDPILRLERFLAASGAWTP
HHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCC
EQGRGVKEEATSLIDRGVGEMEAVPPPDPAELFDATLAALTPRQAGQRKGR
HHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA