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The map label for this gene is trx-5 [H]

Identifier: 197116802

GI number: 197116802

Start: 480328

End: 480657

Strand: Reverse

Name: trx-5 [H]

Synonym: Gbem_0404

Alternate gene names: 197116802

Gene position: 480657-480328 (Counterclockwise)

Preceding gene: 197116809

Following gene: 197116801

Centisome position: 10.41

GC content: 57.27

Gene sequence:

>330_bases
ATGGCCAGCGAAAACGTACACACCTTTACCGACGACAACTTTGAGAAGGAAGTACTCCAGTCCAACATCCCGGTGCTGGT
TGACTTCTGGGCCACCTGGTGCGCCCCCTGCAAAGCGATCGCTCCCCTCATCGATACCATAGCGTCGGAGTACGACGGAC
GCATAAAAGTAGGCAAGGTAAACGTCGACGACAACCCGGGTACTCCGGCAAAATACGGGGTGCGCGGCATCCCCACGGTC
ATCCTGCTGAAGGACGGTAAAGTCGTGGACCAAGTGGTCGGCGCGATACCCAAAGCACAGCTGGAGGCCCTGATCAAGAA
GGCGCTCTAA

Upstream 100 bases:

>100_bases
GGCCCGTTAATGTCCCCTAACCCCGCGACAAGTTACCCCTTGCATTTTTCATCGGCTCATTTATAGTAGGAATCACTTTT
TTTATTAAAGGAGAGGGTTC

Downstream 100 bases:

>100_bases
AAATGAAAAGGCAGATCCCGTCTAAGAAGTTTGCAGCAAAAATTATCCCCTTAGCGCTTGCCGGCCTGCTGCTATCCACG
CAGCCGGCAGCCGCCATCCT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MASENVHTFTDDNFEKEVLQSNIPVLVDFWATWCAPCKAIAPLIDTIASEYDGRIKVGKVNVDDNPGTPAKYGVRGIPTV
ILLKDGKVVDQVVGAIPKAQLEALIKKAL

Sequences:

>Translated_109_residues
MASENVHTFTDDNFEKEVLQSNIPVLVDFWATWCAPCKAIAPLIDTIASEYDGRIKVGKVNVDDNPGTPAKYGVRGIPTV
ILLKDGKVVDQVVGAIPKAQLEALIKKAL
>Mature_108_residues
ASENVHTFTDDNFEKEVLQSNIPVLVDFWATWCAPCKAIAPLIDTIASEYDGRIKVGKVNVDDNPGTPAKYGVRGIPTVI
LLKDGKVVDQVVGAIPKAQLEALIKKAL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=39.1752577319588, Blast_Score=86, Evalue=5e-18,
Organism=Homo sapiens, GI21361657, Length=85, Percent_Identity=37.6470588235294, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI5031973, Length=86, Percent_Identity=34.8837209302326, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=107, Percent_Identity=50.4672897196262, Blast_Score=124, Evalue=1e-30,
Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=37.6344086021505, Blast_Score=95, Evalue=1e-21,
Organism=Escherichia coli, GI87081747, Length=110, Percent_Identity=31.8181818181818, Blast_Score=76, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI212646193, Length=98, Percent_Identity=33.6734693877551, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17554386, Length=108, Percent_Identity=39.8148148148148, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=86, Percent_Identity=36.046511627907, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=98, Percent_Identity=36.734693877551, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=89, Percent_Identity=37.0786516853933, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=85, Percent_Identity=38.8235294117647, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=98, Percent_Identity=36.734693877551, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=37.1794871794872, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=88, Percent_Identity=39.7727272727273, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=88, Percent_Identity=39.7727272727273, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI193209454, Length=88, Percent_Identity=39.7727272727273, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25144092, Length=90, Percent_Identity=35.5555555555556, Blast_Score=61, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6323072, Length=99, Percent_Identity=39.3939393939394, Blast_Score=71, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=80, Percent_Identity=45, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=91, Percent_Identity=34.0659340659341, Blast_Score=64, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=37, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24639826, Length=85, Percent_Identity=41.1764705882353, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664269, Length=75, Percent_Identity=41.3333333333333, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21358065, Length=98, Percent_Identity=37.7551020408163, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24658597, Length=100, Percent_Identity=39, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17648013, Length=82, Percent_Identity=37.8048780487805, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24583090, Length=82, Percent_Identity=37.8048780487805, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19921434, Length=81, Percent_Identity=35.8024691358025, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11805; Mature: 11674

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASENVHTFTDDNFEKEVLQSNIPVLVDFWATWCAPCKAIAPLIDTIASEYDGRIKVGKV
CCCCCCCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
NVDDNPGTPAKYGVRGIPTVILLKDGKVVDQVVGAIPKAQLEALIKKAL
ECCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ASENVHTFTDDNFEKEVLQSNIPVLVDFWATWCAPCKAIAPLIDTIASEYDGRIKVGKV
CCCCCCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
NVDDNPGTPAKYGVRGIPTVILLKDGKVVDQVVGAIPKAQLEALIKKAL
ECCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]