Click here to switch to the map view.

The map label for this gene is gcvP-2 [H]

Identifier: 197116796

GI number: 197116796

Start: 473457

End: 474896

Strand: Direct

Name: gcvP-2 [H]

Synonym: Gbem_0398

Alternate gene names: 197116796

Gene position: 473457-474896 (Clockwise)

Preceding gene: 197116795

Following gene: 197116797

Centisome position: 10.26

GC content: 64.38

Gene sequence:

>1440_bases
ATGCAGCTGATATTCGAAAAATCGGTGCCGGGACGCAACGGGGTGCGGGTTCCCCTCTCCGACGTCCCGAAGGCGTCCCC
CTTCCCCGATGCGCTTCGGCGCAAGGAGCCGGTCCTCCTGCCGGAGGTGAGCGAACTGGACCTGGTGCGGCATTACACCA
ACCTTTCCCGGAGGAACTTCTCCGTGGACACCAACTTCTATCCCCTGGGCTCCTGCACCATGAAGTACAACACCAAGGTG
ACCGAGAACGCGGGGGGGCTCTTCGCCGGATGCCACCCGTTCCTGCCGCTGCTTCCCGGCGGCGAGCGGTTGGTGCAGGG
ACCGCTCTCGCTCGTCCACGGCCTGGAGCAGCAATTGGCCGAGATCACCGGCATGGACGAGGTGACCACCCAGCCCCTGG
CGGGTGCGCACGGCGAGATGACCGGAATCATGGTGATAGCCGCCTACCACAAGGCGCGCGGAGACAAAAAGCGCAAGTAC
GTCATCGTTCCCGACTCCTCGCATGGGACCAACCCGGCCAGCGCCGCTATGGCGGGGTACGAGATCGTCACCATACCGAC
CGCTCCCTACGGCGACATGGACCTGGAGCAGTTCAAGAATGCGATGAACGACGAGGTTGCTGCGGTGATGATGACCTGCC
CCAACACCCTGGGGCTCTTCAACCCGCACATAGCCGAGATCTGCGCCATAGCCCATCAGGCGGGCGCGCTCACCTATTAC
GACGGGGCCAACCTGAACGCGATCCTGGGGAAGGTGCGCCCGGGCGACGTCGGCTTCGACGTCATCCACGTCAACCTGCA
CAAGACCTTCAGCACTCCGCACGGCGGGGGAGGGCCGGGGAGCGGCCCGGTCGGGGTGAAGAAGGGGCTGATCCCCTACC
TCCCCACCCCCCGCGTGCAGCGTAAAGGGGACGGGAGCTTCGCCGTCGAGGCGCATCCCGAGGGAATCGGGAGGGTTTCC
GACTTCTTCGGCAACTTCGCCATCATGGCGCGCGCCTACGCCTACATCACGCTTTTGGGGCGCGAGGGGCTGATCGAGGT
GAGCGAACACGCGGTCTTGAACGCCAACTACATCATGGCTCGGCTCAAAGGAGAGTACGAGCTTCCCTTCGACCAGACCT
GCATGCACGAGTGCGTCTTTTCGGCGAGCCGGCAACTGCAGGACGGGGTACACGCCATCGACATCGCCAAGTACCTGATC
GACCGCGGCTTCCATCCCCCGACTGTCTATTTCCCCTTGAACGTCAAGGAGGCGATCATGATCGAGCCGACCGAGACGGA
GAGTAAGCAGACCATGGACCTCTTCATCGACGTGATGCTGGAGGCGGCGAGGATAGCCAGGGAGGACCCGGAGGCCCTGC
ATCGGGCGCCGGTCACGACCCCGGTCGGGCGGTTGGACGAGACCCGGGCGGCAAGGGCGCAGCAGGTCTGCTGCGAATAA

Upstream 100 bases:

>100_bases
AGTACTATCCGGGCATGGATAACGCGCTGACGGTAACGGTAACGGAGAAACGGAGCAAGGCGGAGATCGACCGACTGGCA
GCTCTCTTGGAGGAGGCGCT

Downstream 100 bases:

>100_bases
AGCAGAGGCAGAACAGGAAGCATCGGCCACGGAGAAAATCTGAGGGATCACGTCAGATTCCCTTTGATTTCTCCGTGGCT
GTTTTGTTAGATAGGTCTGG

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MQLIFEKSVPGRNGVRVPLSDVPKASPFPDALRRKEPVLLPEVSELDLVRHYTNLSRRNFSVDTNFYPLGSCTMKYNTKV
TENAGGLFAGCHPFLPLLPGGERLVQGPLSLVHGLEQQLAEITGMDEVTTQPLAGAHGEMTGIMVIAAYHKARGDKKRKY
VIVPDSSHGTNPASAAMAGYEIVTIPTAPYGDMDLEQFKNAMNDEVAAVMMTCPNTLGLFNPHIAEICAIAHQAGALTYY
DGANLNAILGKVRPGDVGFDVIHVNLHKTFSTPHGGGGPGSGPVGVKKGLIPYLPTPRVQRKGDGSFAVEAHPEGIGRVS
DFFGNFAIMARAYAYITLLGREGLIEVSEHAVLNANYIMARLKGEYELPFDQTCMHECVFSASRQLQDGVHAIDIAKYLI
DRGFHPPTVYFPLNVKEAIMIEPTETESKQTMDLFIDVMLEAARIAREDPEALHRAPVTTPVGRLDETRAARAQQVCCE

Sequences:

>Translated_479_residues
MQLIFEKSVPGRNGVRVPLSDVPKASPFPDALRRKEPVLLPEVSELDLVRHYTNLSRRNFSVDTNFYPLGSCTMKYNTKV
TENAGGLFAGCHPFLPLLPGGERLVQGPLSLVHGLEQQLAEITGMDEVTTQPLAGAHGEMTGIMVIAAYHKARGDKKRKY
VIVPDSSHGTNPASAAMAGYEIVTIPTAPYGDMDLEQFKNAMNDEVAAVMMTCPNTLGLFNPHIAEICAIAHQAGALTYY
DGANLNAILGKVRPGDVGFDVIHVNLHKTFSTPHGGGGPGSGPVGVKKGLIPYLPTPRVQRKGDGSFAVEAHPEGIGRVS
DFFGNFAIMARAYAYITLLGREGLIEVSEHAVLNANYIMARLKGEYELPFDQTCMHECVFSASRQLQDGVHAIDIAKYLI
DRGFHPPTVYFPLNVKEAIMIEPTETESKQTMDLFIDVMLEAARIAREDPEALHRAPVTTPVGRLDETRAARAQQVCCE
>Mature_479_residues
MQLIFEKSVPGRNGVRVPLSDVPKASPFPDALRRKEPVLLPEVSELDLVRHYTNLSRRNFSVDTNFYPLGSCTMKYNTKV
TENAGGLFAGCHPFLPLLPGGERLVQGPLSLVHGLEQQLAEITGMDEVTTQPLAGAHGEMTGIMVIAAYHKARGDKKRKY
VIVPDSSHGTNPASAAMAGYEIVTIPTAPYGDMDLEQFKNAMNDEVAAVMMTCPNTLGLFNPHIAEICAIAHQAGALTYY
DGANLNAILGKVRPGDVGFDVIHVNLHKTFSTPHGGGGPGSGPVGVKKGLIPYLPTPRVQRKGDGSFAVEAHPEGIGRVS
DFFGNFAIMARAYAYITLLGREGLIEVSEHAVLNANYIMARLKGEYELPFDQTCMHECVFSASRQLQDGVHAIDIAKYLI
DRGFHPPTVYFPLNVKEAIMIEPTETESKQTMDLFIDVMLEAARIAREDPEALHRAPVTTPVGRLDETRAARAQQVCCE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=426, Percent_Identity=40.6103286384976, Blast_Score=265, Evalue=7e-71,
Organism=Escherichia coli, GI1789269, Length=427, Percent_Identity=39.8126463700234, Blast_Score=262, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17535605, Length=419, Percent_Identity=38.6634844868735, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI32564013, Length=382, Percent_Identity=38.2198952879581, Blast_Score=231, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6323843, Length=433, Percent_Identity=42.0323325635104, Blast_Score=291, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24645648, Length=417, Percent_Identity=40.0479616306954, Blast_Score=261, Evalue=8e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 52161; Mature: 52161

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLIFEKSVPGRNGVRVPLSDVPKASPFPDALRRKEPVLLPEVSELDLVRHYTNLSRRNF
CCEEEECCCCCCCCCCCCHHHCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCE
SVDTNFYPLGSCTMKYNTKVTENAGGLFAGCHPFLPLLPGGERLVQGPLSLVHGLEQQLA
ECCCCEEECCCEEEEECCEEECCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EITGMDEVTTQPLAGAHGEMTGIMVIAAYHKARGDKKRKYVIVPDSSHGTNPASAAMAGY
HHCCCCHHCCCCCCCCCCCCCEEEEEEEEHHHCCCCCCEEEEEECCCCCCCHHHHHHCCE
EIVTIPTAPYGDMDLEQFKNAMNDEVAAVMMTCPNTLGLFNPHIAEICAIAHQAGALTYY
EEEEECCCCCCCCCHHHHHHHHCHHHEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEE
DGANLNAILGKVRPGDVGFDVIHVNLHKTFSTPHGGGGPGSGPVGVKKGLIPYLPTPRVQ
CCCCCHHHEECCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHCCCCCCCCCCCCC
RKGDGSFAVEAHPEGIGRVSDFFGNFAIMARAYAYITLLGREGLIEVSEHAVLNANYIMA
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCEEECCCEEECCCEEEE
RLKGEYELPFDQTCMHECVFSASRQLQDGVHAIDIAKYLIDRGFHPPTVYFPLNVKEAIM
EECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEE
IEPTETESKQTMDLFIDVMLEAARIAREDPEALHRAPVTTPVGRLDETRAARAQQVCCE
ECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MQLIFEKSVPGRNGVRVPLSDVPKASPFPDALRRKEPVLLPEVSELDLVRHYTNLSRRNF
CCEEEECCCCCCCCCCCCHHHCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCE
SVDTNFYPLGSCTMKYNTKVTENAGGLFAGCHPFLPLLPGGERLVQGPLSLVHGLEQQLA
ECCCCEEECCCEEEEECCEEECCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EITGMDEVTTQPLAGAHGEMTGIMVIAAYHKARGDKKRKYVIVPDSSHGTNPASAAMAGY
HHCCCCHHCCCCCCCCCCCCCEEEEEEEEHHHCCCCCCEEEEEECCCCCCCHHHHHHCCE
EIVTIPTAPYGDMDLEQFKNAMNDEVAAVMMTCPNTLGLFNPHIAEICAIAHQAGALTYY
EEEEECCCCCCCCCHHHHHHHHCHHHEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEE
DGANLNAILGKVRPGDVGFDVIHVNLHKTFSTPHGGGGPGSGPVGVKKGLIPYLPTPRVQ
CCCCCHHHEECCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHCCCCCCCCCCCCC
RKGDGSFAVEAHPEGIGRVSDFFGNFAIMARAYAYITLLGREGLIEVSEHAVLNANYIMA
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCEEECCCEEECCCEEEE
RLKGEYELPFDQTCMHECVFSASRQLQDGVHAIDIAKYLIDRGFHPPTVYFPLNVKEAIM
EECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEE
IEPTETESKQTMDLFIDVMLEAARIAREDPEALHRAPVTTPVGRLDETRAARAQQVCCE
ECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]