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The map label for this gene is mutT [H]

Identifier: 197104231

GI number: 197104231

Start: 844967

End: 845371

Strand: Direct

Name: mutT [H]

Synonym: PHZ_c0765

Alternate gene names: 197104231

Gene position: 844967-845371 (Clockwise)

Preceding gene: 197104229

Following gene: 197104232

Centisome position: 21.14

GC content: 69.38

Gene sequence:

>405_bases
ATGACCAAGCCCATGGTGCTCGTGGCCGCCGCGGCCCTCATCGATCCCGACGGCCGGGTGCTGATCTGCCAGCGGCCCGA
AGGCAAGCAGCTGGCCGGCCTCTGGGAGTTTCCCGGCGGCAAGGTCGAACCCGGCGAGACCCCCGAGGCCTGCCTGATCC
GCGAGCTGGACGAGGAGCTGGGGATCCGGGTGACGAAGTCGTGCCTCGCGTCCTTCGTTTTCGCCAGCCACGAGTACGAG
AGCTTCCACCTGCTGATGCCGCTCTACCTGATCCGCCGCTGGGAGGGCCGGGTGACGGCGCGCGAGCACAAGGCGATCGC
CTGGGTGAAGCCCGTGAAGCTCGCCGACTACGAGATGCCGCCGGCCGATGCGCCGCTGGTGGCCTGGCTGCGGGACTTCG
TGTGA

Upstream 100 bases:

>100_bases
AGGACCGCACATCGGGGTTCTGGGCGGCGAAGTCAACCCAGCGCGACCATTCGGCGAGCGCCTGTGGCCGAATTGGCGCC
ATCGGGGTAAGTGCCGGCCC

Downstream 100 bases:

>100_bases
TGAAGCAGGCGGCCCGCACGCTCACGGTCCAGACGCCCGGCCAGGGCCTGCACGAGATCACCCGCGAGGTCGCGGCCTTC
GTCGCCGACGAGGGGATGGC

Product: NTP pyrophosphohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 134; Mature: 133

Protein sequence:

>134_residues
MTKPMVLVAAAALIDPDGRVLICQRPEGKQLAGLWEFPGGKVEPGETPEACLIRELDEELGIRVTKSCLASFVFASHEYE
SFHLLMPLYLIRRWEGRVTAREHKAIAWVKPVKLADYEMPPADAPLVAWLRDFV

Sequences:

>Translated_134_residues
MTKPMVLVAAAALIDPDGRVLICQRPEGKQLAGLWEFPGGKVEPGETPEACLIRELDEELGIRVTKSCLASFVFASHEYE
SFHLLMPLYLIRRWEGRVTAREHKAIAWVKPVKLADYEMPPADAPLVAWLRDFV
>Mature_133_residues
TKPMVLVAAAALIDPDGRVLICQRPEGKQLAGLWEFPGGKVEPGETPEACLIRELDEELGIRVTKSCLASFVFASHEYES
FHLLMPLYLIRRWEGRVTAREHKAIAWVKPVKLADYEMPPADAPLVAWLRDFV

Specific function: Specific for pyrimidine substrates. Acts on 5-methyl- dCTP, CTP and dCTP in decreasing order [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=119, Percent_Identity=42.8571428571429, Blast_Score=91, Evalue=2e-20,
Organism=Escherichia coli, GI1786288, Length=124, Percent_Identity=33.8709677419355, Blast_Score=82, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 15086; Mature: 14955

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPMVLVAAAALIDPDGRVLICQRPEGKQLAGLWEFPGGKVEPGETPEACLIRELDEEL
CCCCHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
GIRVTKSCLASFVFASHEYESFHLLMPLYLIRRWEGRVTAREHKAIAWVKPVKLADYEMP
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEECCCCCC
PADAPLVAWLRDFV
CCCCHHHHHHHHCC
>Mature Secondary Structure 
TKPMVLVAAAALIDPDGRVLICQRPEGKQLAGLWEFPGGKVEPGETPEACLIRELDEEL
CCCHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
GIRVTKSCLASFVFASHEYESFHLLMPLYLIRRWEGRVTAREHKAIAWVKPVKLADYEMP
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEECCCCCC
PADAPLVAWLRDFV
CCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 11053429 [H]