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The map label for this gene is alkK [H]

Identifier: 197104137

GI number: 197104137

Start: 726429

End: 728012

Strand: Direct

Name: alkK [H]

Synonym: PHZ_c0671

Alternate gene names: 197104137

Gene position: 726429-728012 (Clockwise)

Preceding gene: 197104136

Following gene: 197104138

Centisome position: 18.18

GC content: 73.23

Gene sequence:

>1584_bases
ATGATCGACGGAGCCATGCAGCCTTTCGCGCTGACGCTCGACAAGTTCCTGGAGCACGCCGCCAAGTGGCGTCCGACTTC
GGAAGTGGTCACGGCCCGGGAAGGCGGAAAGGTCGACCGGATCGGCTATGCGGACCTGAAGGCGCGCAGCCAGAAGGTCT
CGGCCGTGCTGGCCGGGCTGGGCGTCGGCCTCGGCTGCCGGGTGGCCACGCTCGCCTGGAACACCCAGGCCCACGTGGAG
GCCTGGTACGGGGTCATGGGCATGGGGGCGGTCTGCCACACGCTGAACCCGCGCCTGACGCCCAACGACCTGGCGGCCAT
GGTGGAGCGCTCGGCCGCGCGGATCCTGATCGCCAGCGCCGACCTGCTGCCGCTGGCCCGCGAGATCGCCGAGCGCGTCT
CGGCCCCGCCACGGCTGCTGGTCATCGACGGGGAGGGCGAGGGCGACGCGGCCGCCCTGGAGCCGATGATCGCCGGTGCG
GCCGAGGGGCTGGCCTGGGGCGGCTTCGACGAGACCGCGCCGTGCGGCCTGTGCTTCACCTCGGGGACGACGGGCGCCCC
CAAGGGCGTGACCTACACCCACCGCGCCAGCTACCTGCACACCCTGCGCTCGCTGCAGGTGGACACCATGGCCCTGGCGG
GGGGCGATGCGGTGCTGACCGTGGTGCCGATGTTCCACGCCAACGCCTGGGGCCTGCCGTTCGCCGCCCCGGCGGTGGGG
GCCAAGCTGGTCCTGCCGGGCCGGAACGCCGACGGCGCCAGCCTCGCCCGGCTGATCCGGGCCGAGGACGTGACGGTGGC
GGTGGGCGTGCCGACCGTCTGGCTGGGCCTTCTGGAGCACCTAGAGGCCGAGGGCGGCGAGGTCCCGAGCCTGAAGCGGA
TCCTGGTGGGCGGGGCGCCCATGCCCCCGGCCCTGATGGCCCGGCTGGAGGCGCGGCTGGGCGTGGTCGTCCAGACCAGC
TGGGGGATGACCGAGCTGTCGCCGTCGGGGACGGTGATGTCGGCCGCCGACCCCGGGCGCACCGCCGCCCAGGCCGGCCG
TCCGGCGGTGGGCGTGGACCTGATGGTCGCCGATTCCGAGGGCCGGCCGCTGCCCGAGCAGCGCAACGTCGAGGGCCACC
TGCACGTGCGCGGCGCGGCGGTGATCGAGCGCTACTTCGGCGAGACGAAGCCGGCCGTGGACGCCGAGGGATGGTTCGCC
ACGGGCGACCTTGCGCGTATCGACGAGGCCGGCAACCTCTACATCACCGGCCGGGCCAAGGACCTCATCAAATCGGGCGG
CGAGTGGATCAACCCCGCAGAGATCGAGGCGGTGGTCAGCGCGCTGCCCGAGGTGTCCCTGGCGGCGGTCATCGGGCGCC
AGGATCCGAAGTGGGGCGAGCGGCCGATCCTGCTGGTCGAGCTGCGCGAGCCGAAGGCGAGCGACGCGGCCCTGCTGGAG
CCGCTGAAGGGCAAGGTGGCGAGCTGGTGGATTCCCGACGAGGTTGTCCGCCTGAAGAGCATGCCGCTGGCCGCGACGGG
CAAGATCGACAAGCTGAAGCTCAGGGCCGAGTACGGCGCGGGCGCCGCGGAGGCGGCGACTTGA

Upstream 100 bases:

>100_bases
AGGACGTCGTCGGCCGCCGCCGGGCGCAAGGCGACACCCCCTGGAACTGGAACGTCGGCGTGGTTTCGCCGGTCCTGCCG
CCCAAGAGTACGGAGCGCCG

Downstream 100 bases:

>100_bases
CGGCGCCGGCGGGCGGCCCGAAACAGCCCGGCATGCCGGAGAGCGCCAAACCGCGTCGACGCACGAAGAAGGCCGAGCAG
CGCGCCGAGTCGATGGAGCA

Product: medium-chain-fatty-acid-CoA ligase

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MIDGAMQPFALTLDKFLEHAAKWRPTSEVVTAREGGKVDRIGYADLKARSQKVSAVLAGLGVGLGCRVATLAWNTQAHVE
AWYGVMGMGAVCHTLNPRLTPNDLAAMVERSAARILIASADLLPLAREIAERVSAPPRLLVIDGEGEGDAAALEPMIAGA
AEGLAWGGFDETAPCGLCFTSGTTGAPKGVTYTHRASYLHTLRSLQVDTMALAGGDAVLTVVPMFHANAWGLPFAAPAVG
AKLVLPGRNADGASLARLIRAEDVTVAVGVPTVWLGLLEHLEAEGGEVPSLKRILVGGAPMPPALMARLEARLGVVVQTS
WGMTELSPSGTVMSAADPGRTAAQAGRPAVGVDLMVADSEGRPLPEQRNVEGHLHVRGAAVIERYFGETKPAVDAEGWFA
TGDLARIDEAGNLYITGRAKDLIKSGGEWINPAEIEAVVSALPEVSLAAVIGRQDPKWGERPILLVELREPKASDAALLE
PLKGKVASWWIPDEVVRLKSMPLAATGKIDKLKLRAEYGAGAAEAAT

Sequences:

>Translated_527_residues
MIDGAMQPFALTLDKFLEHAAKWRPTSEVVTAREGGKVDRIGYADLKARSQKVSAVLAGLGVGLGCRVATLAWNTQAHVE
AWYGVMGMGAVCHTLNPRLTPNDLAAMVERSAARILIASADLLPLAREIAERVSAPPRLLVIDGEGEGDAAALEPMIAGA
AEGLAWGGFDETAPCGLCFTSGTTGAPKGVTYTHRASYLHTLRSLQVDTMALAGGDAVLTVVPMFHANAWGLPFAAPAVG
AKLVLPGRNADGASLARLIRAEDVTVAVGVPTVWLGLLEHLEAEGGEVPSLKRILVGGAPMPPALMARLEARLGVVVQTS
WGMTELSPSGTVMSAADPGRTAAQAGRPAVGVDLMVADSEGRPLPEQRNVEGHLHVRGAAVIERYFGETKPAVDAEGWFA
TGDLARIDEAGNLYITGRAKDLIKSGGEWINPAEIEAVVSALPEVSLAAVIGRQDPKWGERPILLVELREPKASDAALLE
PLKGKVASWWIPDEVVRLKSMPLAATGKIDKLKLRAEYGAGAAEAAT
>Mature_527_residues
MIDGAMQPFALTLDKFLEHAAKWRPTSEVVTAREGGKVDRIGYADLKARSQKVSAVLAGLGVGLGCRVATLAWNTQAHVE
AWYGVMGMGAVCHTLNPRLTPNDLAAMVERSAARILIASADLLPLAREIAERVSAPPRLLVIDGEGEGDAAALEPMIAGA
AEGLAWGGFDETAPCGLCFTSGTTGAPKGVTYTHRASYLHTLRSLQVDTMALAGGDAVLTVVPMFHANAWGLPFAAPAVG
AKLVLPGRNADGASLARLIRAEDVTVAVGVPTVWLGLLEHLEAEGGEVPSLKRILVGGAPMPPALMARLEARLGVVVQTS
WGMTELSPSGTVMSAADPGRTAAQAGRPAVGVDLMVADSEGRPLPEQRNVEGHLHVRGAAVIERYFGETKPAVDAEGWFA
TGDLARIDEAGNLYITGRAKDLIKSGGEWINPAEIEAVVSALPEVSLAAVIGRQDPKWGERPILLVELREPKASDAALLE
PLKGKVASWWIPDEVVRLKSMPLAATGKIDKLKLRAEYGAGAAEAAT

Specific function: Unknown

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=550, Percent_Identity=25.2727272727273, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI187761345, Length=529, Percent_Identity=26.0869565217391, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI187761343, Length=529, Percent_Identity=26.0869565217391, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI38505220, Length=497, Percent_Identity=26.9617706237425, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI42544132, Length=517, Percent_Identity=23.21083172147, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI115511026, Length=463, Percent_Identity=24.622030237581, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI157311624, Length=524, Percent_Identity=24.618320610687, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI157311622, Length=524, Percent_Identity=24.618320610687, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI58082049, Length=528, Percent_Identity=24.4318181818182, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI122937307, Length=515, Percent_Identity=23.6893203883495, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI28416953, Length=537, Percent_Identity=23.8361266294227, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI12669909, Length=241, Percent_Identity=25.7261410788382, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI4758332, Length=241, Percent_Identity=25.7261410788382, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI57165410, Length=153, Percent_Identity=31.3725490196078, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI57165412, Length=153, Percent_Identity=31.3725490196078, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI145693145, Length=349, Percent_Identity=33.810888252149, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI221142682, Length=501, Percent_Identity=24.1516966067864, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1786810, Length=356, Percent_Identity=31.7415730337079, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788107, Length=506, Percent_Identity=25.098814229249, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1788595, Length=468, Percent_Identity=26.7094017094017, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789201, Length=361, Percent_Identity=26.8698060941828, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1790505, Length=554, Percent_Identity=23.4657039711191, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1786801, Length=431, Percent_Identity=24.8259860788863, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17558820, Length=492, Percent_Identity=26.4227642276423, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71994694, Length=531, Percent_Identity=26.1770244821092, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71994690, Length=531, Percent_Identity=26.1770244821092, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71994703, Length=531, Percent_Identity=26.1770244821092, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI32563687, Length=490, Percent_Identity=24.4897959183673, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17560308, Length=519, Percent_Identity=25.4335260115607, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17531443, Length=513, Percent_Identity=23.5867446393762, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17538037, Length=352, Percent_Identity=29.2613636363636, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17557194, Length=361, Percent_Identity=28.5318559556787, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71985884, Length=353, Percent_Identity=28.328611898017, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17559526, Length=353, Percent_Identity=26.0623229461756, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71996755, Length=352, Percent_Identity=27.2727272727273, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25141359, Length=424, Percent_Identity=23.1132075471698, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560140, Length=472, Percent_Identity=22.2457627118644, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17564090, Length=206, Percent_Identity=29.6116504854369, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71983001, Length=531, Percent_Identity=25.2354048964218, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71982997, Length=531, Percent_Identity=25.2354048964218, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6319699, Length=361, Percent_Identity=27.9778393351801, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320852, Length=174, Percent_Identity=32.7586206896552, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24581924, Length=363, Percent_Identity=30.8539944903581, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21355181, Length=432, Percent_Identity=27.0833333333333, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21356947, Length=397, Percent_Identity=26.448362720403, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI18859661, Length=470, Percent_Identity=26.1702127659574, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI281365686, Length=449, Percent_Identity=20.9354120267261, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21358303, Length=287, Percent_Identity=27.5261324041812, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356441, Length=438, Percent_Identity=23.7442922374429, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI20130357, Length=497, Percent_Identity=23.7424547283702, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24653035, Length=395, Percent_Identity=24.8101265822785, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24648260, Length=309, Percent_Identity=29.4498381877023, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI161076582, Length=412, Percent_Identity=24.5145631067961, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24648255, Length=458, Percent_Identity=22.0524017467249, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24648253, Length=458, Percent_Identity=22.0524017467249, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19922652, Length=436, Percent_Identity=24.5412844036697, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921316, Length=538, Percent_Identity=23.6059479553903, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24667959, Length=393, Percent_Identity=25.1908396946565, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI62472339, Length=393, Percent_Identity=25.1908396946565, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24667955, Length=393, Percent_Identity=25.1908396946565, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656500, Length=432, Percent_Identity=23.8425925925926, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 55256; Mature: 55256

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDGAMQPFALTLDKFLEHAAKWRPTSEVVTAREGGKVDRIGYADLKARSQKVSAVLAGL
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHEEECCCCCEEECCCHHHHHHHHHHHHHHHHH
GVGLGCRVATLAWNTQAHVEAWYGVMGMGAVCHTLNPRLTPNDLAAMVERSAARILIASA
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEECC
DLLPLAREIAERVSAPPRLLVIDGEGEGDAAALEPMIAGAAEGLAWGGFDETAPCGLCFT
CHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCEEEE
SGTTGAPKGVTYTHRASYLHTLRSLQVDTMALAGGDAVLTVVPMFHANAWGLPFAAPAVG
CCCCCCCCCCEEHHHHHHHHHHHHCCEEEEEEECCCEEEEEEEHHCCCCCCCCCCCCCCC
AKLVLPGRNADGASLARLIRAEDVTVAVGVPTVWLGLLEHLEAEGGEVPSLKRILVGGAP
CEEEECCCCCCHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHEECCCC
MPPALMARLEARLGVVVQTSWGMTELSPSGTVMSAADPGRTAAQAGRPAVGVDLMVADSE
CCHHHHHHHHHHCCEEEEECCCCEEECCCCCEEECCCCCCHHHHCCCCCCCEEEEEECCC
GRPLPEQRNVEGHLHVRGAAVIERYFGETKPAVDAEGWFATGDLARIDEAGNLYITGRAK
CCCCCHHCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCEECCCHHEECCCCCEEEECCHH
DLIKSGGEWINPAEIEAVVSALPEVSLAAVIGRQDPKWGERPILLVELREPKASDAALLE
HHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHH
PLKGKVASWWIPDEVVRLKSMPLAATGKIDKLKLRAEYGAGAAEAAT
HHCCCEEEECCCHHHHHHHCCCCEECCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MIDGAMQPFALTLDKFLEHAAKWRPTSEVVTAREGGKVDRIGYADLKARSQKVSAVLAGL
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHEEECCCCCEEECCCHHHHHHHHHHHHHHHHH
GVGLGCRVATLAWNTQAHVEAWYGVMGMGAVCHTLNPRLTPNDLAAMVERSAARILIASA
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEECC
DLLPLAREIAERVSAPPRLLVIDGEGEGDAAALEPMIAGAAEGLAWGGFDETAPCGLCFT
CHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCEEEE
SGTTGAPKGVTYTHRASYLHTLRSLQVDTMALAGGDAVLTVVPMFHANAWGLPFAAPAVG
CCCCCCCCCCEEHHHHHHHHHHHHCCEEEEEEECCCEEEEEEEHHCCCCCCCCCCCCCCC
AKLVLPGRNADGASLARLIRAEDVTVAVGVPTVWLGLLEHLEAEGGEVPSLKRILVGGAP
CEEEECCCCCCHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHEECCCC
MPPALMARLEARLGVVVQTSWGMTELSPSGTVMSAADPGRTAAQAGRPAVGVDLMVADSE
CCHHHHHHHHHHCCEEEEECCCCEEECCCCCEEECCCCCCHHHHCCCCCCCEEEEEECCC
GRPLPEQRNVEGHLHVRGAAVIERYFGETKPAVDAEGWFATGDLARIDEAGNLYITGRAK
CCCCCHHCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCEECCCHHEECCCCCEEEECCHH
DLIKSGGEWINPAEIEAVVSALPEVSLAAVIGRQDPKWGERPILLVELREPKASDAALLE
HHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHH
PLKGKVASWWIPDEVVRLKSMPLAATGKIDKLKLRAEYGAGAAEAAT
HHCCCEEEECCCHHHHHHHCCCCEECCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]