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The map label for this gene is dxr [H]

Identifier: 194737994

GI number: 194737994

Start: 260179

End: 261462

Strand: Direct

Name: dxr [H]

Synonym: SeSA_A0245

Alternate gene names: 194737994

Gene position: 260179-261462 (Clockwise)

Preceding gene: 194737420

Following gene: 194736697

Centisome position: 5.53

GC content: 55.14

Gene sequence:

>1284_bases
GTGTACAAAGCGCCGCGCAGAAGACATTATCAGGTCTCCTGTGCGGCGTTTTGCTTTTTATTCCGTTTCAACACTTCTGG
ACGTTTCATGAAGCAATTAACCATTCTGGGCTCGACCGGCTCTATTGGTTGCAGCACACTGGACGTAGTGCGCCATAATC
CTGATAGCTTCCGCGTTATCGCGCTGGTGGCGGGTAAAAATGTCGCCCGCATGGCGGAGCAGTGCCTGGAATTCTCGCCG
CGTTATGCCGTGATGGACGATACGTTGAGCGCAGAACAGCTCAAAATAATGCTTCAGCAGCATGGCAGCCGCACCGAGGT
TCTGAGCGGTCAGCAGGCTGCCTGTGAGATGGCGGCGCTTGATGAGGTCGGGCATGTGATGGCGGCCATTGTGGGCGCGG
CTGGTTTACTGCCGACCCTGGCGGCGATTCGCGCAGGGAAGACGATTCTGCTGGCGAATAAAGAATCGCTGGTGACCTGC
GGGCGGCTGTTTATGGACGAAGTAAAACGCAGCAACGCCCGGCTTTTACCCGTCGATAGCGAACATAACGCGATTTTTCA
GAGTTTGCCGCAATCTATTCAGCATAATCTGGGATACGCTGACCTTGAGCAAAATGGTGTAACGTCGATTTTGCTTACCG
GGTCTGGTGGCCCGTTTCGTGAAACGCCAATGTGCGATCTGGCAGCGATGACGCCGGATCAGGCATGTCGTCATCCGAAC
TGGTCGATGGGGCGGAAAATCTCCGTCGACTCCGCCACCATGATGAATAAAGGTCTGGAATACATTGAAGCGCGTTGGTT
ATTTAATGCCAGCGCACGTCAGATGGAAGTGTTGATCCATCCGCAATCGGTCATTCATTCGATGGTGCGTTATCAGGACG
GCAGCGTCCTGGCGCAGCTTGGAGAACCTGACATGCGTACGCCTATTGCGCATACGATGGCATGGCCGAATCGCGTCGCG
TCCGGCGCGCAGCCGCTCGATTTTTGCAAACTCAGCGCGCTGACGTTTAGCGCGCCAGATTATCAGCGTTATCCATGCCT
GAAGCTGGCGATGGAGGCGTTTGAGCAAGGTCAGGCGGCAACGACGGCGCTCAATGCGGCAAACGAAATCACCGTTGCCG
CGTTTCTGGCGCAACAGATTCGTTTTACCGATATCGCCGGGCTCAATTTAGCGGTGCTGGAGAGGATGGATTTACAGGAA
CCGGCAAGCGTTGAGGACGTATTGCAGGTTGACGCCATCGCGCGTGAAGTAGCCAGAAAACAAGTGATACGGCTCTCACG
CTGA

Upstream 100 bases:

>100_bases
GGATGCGGCGTTGGCAGATAAAGAAGCAGAACTGATGCAGTTCTGATTGATCTGTACGCAGATATAAACTCATTCCACCG
CTAAACCTGGCGGATGAGTG

Downstream 100 bases:

>100_bases
CGATTATCCCGCGACAGAAGATCGTGCTATTTGTTAGCGTTGGGCTTCGGTGATATAGTCTGCGCCACCTGATCGCAGGT
TTTTGGCTTTTTTCGGTCAG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MYKAPRRRHYQVSCAAFCFLFRFNTSGRFMKQLTILGSTGSIGCSTLDVVRHNPDSFRVIALVAGKNVARMAEQCLEFSP
RYAVMDDTLSAEQLKIMLQQHGSRTEVLSGQQAACEMAALDEVGHVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTC
GRLFMDEVKRSNARLLPVDSEHNAIFQSLPQSIQHNLGYADLEQNGVTSILLTGSGGPFRETPMCDLAAMTPDQACRHPN
WSMGRKISVDSATMMNKGLEYIEARWLFNASARQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVA
SGAQPLDFCKLSALTFSAPDYQRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAGLNLAVLERMDLQE
PASVEDVLQVDAIAREVARKQVIRLSR

Sequences:

>Translated_427_residues
MYKAPRRRHYQVSCAAFCFLFRFNTSGRFMKQLTILGSTGSIGCSTLDVVRHNPDSFRVIALVAGKNVARMAEQCLEFSP
RYAVMDDTLSAEQLKIMLQQHGSRTEVLSGQQAACEMAALDEVGHVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTC
GRLFMDEVKRSNARLLPVDSEHNAIFQSLPQSIQHNLGYADLEQNGVTSILLTGSGGPFRETPMCDLAAMTPDQACRHPN
WSMGRKISVDSATMMNKGLEYIEARWLFNASARQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVA
SGAQPLDFCKLSALTFSAPDYQRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAGLNLAVLERMDLQE
PASVEDVLQVDAIAREVARKQVIRLSR
>Mature_427_residues
MYKAPRRRHYQVSCAAFCFLFRFNTSGRFMKQLTILGSTGSIGCSTLDVVRHNPDSFRVIALVAGKNVARMAEQCLEFSP
RYAVMDDTLSAEQLKIMLQQHGSRTEVLSGQQAACEMAALDEVGHVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTC
GRLFMDEVKRSNARLLPVDSEHNAIFQSLPQSIQHNLGYADLEQNGVTSILLTGSGGPFRETPMCDLAAMTPDQACRHPN
WSMGRKISVDSATMMNKGLEYIEARWLFNASARQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVA
SGAQPLDFCKLSALTFSAPDYQRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAGLNLAVLERMDLQE
PASVEDVLQVDAIAREVARKQVIRLSR

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=397, Percent_Identity=88.9168765743073, Blast_Score=713, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 46893; Mature: 46893

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKAPRRRHYQVSCAAFCFLFRFNTSGRFMKQLTILGSTGSIGCSTLDVVRHNPDSFRVI
CCCCCCCCCEEHHHHHHHHHHHCCCCCCEEEHEEEECCCCCCCCCCHHHHHCCCCCEEEE
ALVAGKNVARMAEQCLEFSPRYAVMDDTLSAEQLKIMLQQHGSRTEVLSGQQAACEMAAL
EEECCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCHHHHHCCHHHHHHHHHH
DEVGHVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDEVKRSNARLLPVDS
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCC
EHNAIFQSLPQSIQHNLGYADLEQNGVTSILLTGSGGPFRETPMCDLAAMTPDQACRHPN
CHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHCCCCCHHHHCCCC
WSMGRKISVDSATMMNKGLEYIEARWLFNASARQMEVLIHPQSVIHSMVRYQDGSVLAQL
CCCCCEEECCHHHHHHHHHHHHHHHHEECCCCCEEEEEECCHHHHHHHHHCCCCCCEEEC
GEPDMRTPIAHTMAWPNRVASGAQPLDFCKLSALTFSAPDYQRYPCLKLAMEAFEQGQAA
CCCCCCCCHHHHHCCCHHHCCCCCCHHHHHHHHEEECCCCCCCCHHHHHHHHHHHCCCHH
TTALNAANEITVAAFLAQQIRFTDIAGLNLAVLERMDLQEPASVEDVLQVDAIAREVARK
HHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
QVIRLSR
HHHHCCC
>Mature Secondary Structure
MYKAPRRRHYQVSCAAFCFLFRFNTSGRFMKQLTILGSTGSIGCSTLDVVRHNPDSFRVI
CCCCCCCCCEEHHHHHHHHHHHCCCCCCEEEHEEEECCCCCCCCCCHHHHHCCCCCEEEE
ALVAGKNVARMAEQCLEFSPRYAVMDDTLSAEQLKIMLQQHGSRTEVLSGQQAACEMAAL
EEECCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCHHHHHCCHHHHHHHHHH
DEVGHVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDEVKRSNARLLPVDS
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCC
EHNAIFQSLPQSIQHNLGYADLEQNGVTSILLTGSGGPFRETPMCDLAAMTPDQACRHPN
CHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHCCCCCHHHHCCCC
WSMGRKISVDSATMMNKGLEYIEARWLFNASARQMEVLIHPQSVIHSMVRYQDGSVLAQL
CCCCCEEECCHHHHHHHHHHHHHHHHEECCCCCEEEEEECCHHHHHHHHHCCCCCCEEEC
GEPDMRTPIAHTMAWPNRVASGAQPLDFCKLSALTFSAPDYQRYPCLKLAMEAFEQGQAA
CCCCCCCCHHHHHCCCHHHCCCCCCHHHHHHHHEEECCCCCCCCHHHHHHHHHHHCCCHH
TTALNAANEITVAAFLAQQIRFTDIAGLNLAVLERMDLQEPASVEDVLQVDAIAREVARK
HHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
QVIRLSR
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA