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The map label for this gene is parE [H]

Identifier: 194737821

GI number: 194737821

Start: 3250198

End: 3252090

Strand: Reverse

Name: parE [H]

Synonym: SeSA_A3367

Alternate gene names: 194737821

Gene position: 3252090-3250198 (Counterclockwise)

Preceding gene: 194736103

Following gene: 194734053

Centisome position: 69.06

GC content: 55.68

Gene sequence:

>1893_bases
ATGACGCAAACTTATAACGCTGATGCCATTGAGGTACTCACTGGGCTTGAGCCGGTACGCCGCCGCCCGGGGATGTACAC
CGATACGACCCGCCCCAACCATTTGGGTCAGGAAGTGATTGATAATAGTGTGGATGAAGCACTCGCAGGTCACGCCAAAC
GCGTGGATGTCATTTTACATGCCGATCAATCGCTGGAAGTGATTGACGACGGACGCGGGATGCCGGTGGATATCCATCCG
GAAGAGGGGGTTCCGGCGGTAGAACTGATCCTCTGTCGGCTTCATGCCGGCGGTAAATTCTCCAATAAGAACTATCAGTT
CTCTGGTGGTCTGCATGGGGTGGGGATTTCGGTCGTGAATGCCCTGTCAAAGCGCGTGGAAGTGACCGTGCGCCGCGACG
GTCAGGTCTATAACATCGCGTTTGAAAACGGCGAAAAAGTGCAGGATTTGCAGGTTGTCGGCACCTGCGGTAAACGTAAT
ACTGGCACCAGCGTCCATTTCTGGCCCGACGAAAGTTTCTTCGACAGCCCGCGTTTTTCTGTCTCTCGCTTAATGCACGT
TCTGAAAGCAAAAGCGGTGCTGTGTCCCGGCGTGGAAATCACTTTTAAAGATGAAGTGAATAACAGCGAGCAGCGCTGGT
GCTACCAGGATGGCCTGAACGACTATCTGGGCGAAGCGGTAAACGGCCTGCCGACGCTGCCGGAAAAACCGTTTATCGGT
AATTTTAACGGTGAAACGGAAGCGGTTGACTGGGCGCTATTGTGGCTGCCGGAAGGCGGCGAATTACTGACGGAAAGCTA
CGTCAACCTGATCCCGACCATGCAGGGGGGGACGCACGTCAACGGTCTGCGCCAGGGCCTGCTCGACGCGATGCGCGAAT
TTTGCGAATACCGCAATATTCTGCCGCGCGGCGTCAAACTGTCGGCGGAAGATATCTGGGATCGCTGCGCTTATGTGCTC
TCCGTGAAAATGCAGGACCCGCAATTTGCCGGGCAGACTAAAGAGCGTCTGTCGTCGCGTCAATGTGCGGCATTTGTTTC
CGGCGTGGTGAAAGATGCCTTCAGCCTGTGGCTGAACCAGAACGTGCAGGCGGCGGAACAACTGGCAGAGATGGCGATTG
CCAGCGCGCAGCGGCGACTGCGCGCCGCAAAAAAAGTGGTGCGCAAAAAGCTCACCAGCGGTCCGGCGTTGCCGGGGAAA
CTGGCGGACTGTACCGCGCAGGATCTTAATCGGACCGAGTTGTTCCTTGTCGAAGGGGATTCGGCGGGCGGTTCCGCCAA
GCAGGCGCGCGATCGCGAATATCAGGCGATCATGCCGCTCAAAGGTAAGATCCTTAACACCTGGGAAGTCTCTTCCGATG
AAGTGCTGGCCCCGCAAGAGGTGCATGATATCTCCGTGGCGATCGGTATCGATCCGGACAGCGACGATCTGAGTCAGCTG
CGCTACGGCAAGATCTGTATCCTGGCGGATGCGGACTCCGATGGTTTGCATATCGCTACTCTGCTTTGCGCGCTGTTTGT
CAGACATTTCCGCGCGCTGGTGAAGAATGGTCATGTCTACGTCGCGCTACCGCCGCTATACCGTATCGATTTGGGTAAAG
AGGTCTATTACGCGCTGACGGAAGAAGAGAAGGCGGGCGTACTGGAACAACTGAAGCGTAAGAAAGGCAAGCCGAACGTA
CAGCGTTTCAAAGGCCTGGGTGAAATGAACCCGATGCAGTTACGCGAAACCACGCTTGATCCAAATACTCGCCGCCTGGT
GCAGCTCACCATTAGCGATGAAGACGATCAGCGTACTAATGCGATGATGGATATGCTGCTGGCGAAGAAACGTTCTGAAG
ATCGACGCAACTGGCTACAGGAAAAAGGCGATCTCGCGGATCTCGACGTGTAA

Upstream 100 bases:

>100_bases
TAATCACGCATTCACGGGCTTCGAAGATTATTTCAACCAGATTGTCGATTTTCTTGGACTGCACAGTTGCTGACAATCAA
TTCGAATTGCTAATTAAACC

Downstream 100 bases:

>100_bases
CGGTTGTTGCACGCTTTATCCGGTCTGCATGCCGCAGGCCGGATAAGCGAATCCGACATGACGCCGCAGCCTGATGGCGA
CACTTGCGCATCGCATCAGG

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 630; Mature: 629

Protein sequence:

>630_residues
MTQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILHADQSLEVIDDGRGMPVDIHP
EEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVTVRRDGQVYNIAFENGEKVQDLQVVGTCGKRN
TGTSVHFWPDESFFDSPRFSVSRLMHVLKAKAVLCPGVEITFKDEVNNSEQRWCYQDGLNDYLGEAVNGLPTLPEKPFIG
NFNGETEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNILPRGVKLSAEDIWDRCAYVL
SVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLNQNVQAAEQLAEMAIASAQRRLRAAKKVVRKKLTSGPALPGK
LADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLAPQEVHDISVAIGIDPDSDDLSQL
RYGKICILADADSDGLHIATLLCALFVRHFRALVKNGHVYVALPPLYRIDLGKEVYYALTEEEKAGVLEQLKRKKGKPNV
QRFKGLGEMNPMQLRETTLDPNTRRLVQLTISDEDDQRTNAMMDMLLAKKRSEDRRNWLQEKGDLADLDV

Sequences:

>Translated_630_residues
MTQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILHADQSLEVIDDGRGMPVDIHP
EEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVTVRRDGQVYNIAFENGEKVQDLQVVGTCGKRN
TGTSVHFWPDESFFDSPRFSVSRLMHVLKAKAVLCPGVEITFKDEVNNSEQRWCYQDGLNDYLGEAVNGLPTLPEKPFIG
NFNGETEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNILPRGVKLSAEDIWDRCAYVL
SVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLNQNVQAAEQLAEMAIASAQRRLRAAKKVVRKKLTSGPALPGK
LADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLAPQEVHDISVAIGIDPDSDDLSQL
RYGKICILADADSDGLHIATLLCALFVRHFRALVKNGHVYVALPPLYRIDLGKEVYYALTEEEKAGVLEQLKRKKGKPNV
QRFKGLGEMNPMQLRETTLDPNTRRLVQLTISDEDDQRTNAMMDMLLAKKRSEDRRNWLQEKGDLADLDV
>Mature_629_residues
TQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILHADQSLEVIDDGRGMPVDIHPE
EGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVTVRRDGQVYNIAFENGEKVQDLQVVGTCGKRNT
GTSVHFWPDESFFDSPRFSVSRLMHVLKAKAVLCPGVEITFKDEVNNSEQRWCYQDGLNDYLGEAVNGLPTLPEKPFIGN
FNGETEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNILPRGVKLSAEDIWDRCAYVLS
VKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLNQNVQAAEQLAEMAIASAQRRLRAAKKVVRKKLTSGPALPGKL
ADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLAPQEVHDISVAIGIDPDSDDLSQLR
YGKICILADADSDGLHIATLLCALFVRHFRALVKNGHVYVALPPLYRIDLGKEVYYALTEEEKAGVLEQLKRKKGKPNVQ
RFKGLGEMNPMQLRETTLDPNTRRLVQLTISDEDDQRTNAMMDMLLAKKRSEDRRNWLQEKGDLADLDV

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=577, Percent_Identity=25.1299826689775, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI19913406, Length=594, Percent_Identity=24.0740740740741, Blast_Score=123, Evalue=6e-28,
Organism=Escherichia coli, GI1789408, Length=630, Percent_Identity=96.5079365079365, Blast_Score=1268, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=555, Percent_Identity=40.5405405405405, Blast_Score=381, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI212645845, Length=600, Percent_Identity=24.8333333333333, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17535065, Length=602, Percent_Identity=24.0863787375415, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI212645657, Length=228, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=685, Percent_Identity=23.6496350364963, Blast_Score=143, Evalue=9e-35,
Organism=Drosophila melanogaster, GI17136538, Length=594, Percent_Identity=22.5589225589226, Blast_Score=114, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 70100; Mature: 69968

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILH
CCCCCCCCHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEE
ADQSLEVIDDGRGMPVDIHPEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVN
CCCCCEEEECCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHH
ALSKRVEVTVRRDGQVYNIAFENGEKVQDLQVVGTCGKRNTGTSVHFWPDESFFDSPRFS
HHHHHEEEEEECCCEEEEEEECCCCCEEHEEEEECCCCCCCCCEEEECCCCCCCCCCCHH
VSRLMHVLKAKAVLCPGVEITFKDEVNNSEQRWCYQDGLNDYLGEAVNGLPTLPEKPFIG
HHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCC
NFNGETEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNI
CCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
LPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLNQ
CCCCCEECHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NVQAAEQLAEMAIASAQRRLRAAKKVVRKKLTSGPALPGKLADCTAQDLNRTELFLVEGD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHCCCCEEEEEEECC
SAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLAPQEVHDISVAIGIDPDSDDLSQL
CCCCCHHHHHCCCCEEECCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHH
RYGKICILADADSDGLHIATLLCALFVRHFRALVKNGHVYVALPPLYRIDLGKEVYYALT
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCEEEEEEC
EEEKAGVLEQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLTISDEDDQRTN
CHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHCCCCCCCEEEEEEEECCCCCHHHH
AMMDMLLAKKRSEDRRNWLQEKGDLADLDV
HHHHHHHHHHCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILH
CCCCCCCHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEE
ADQSLEVIDDGRGMPVDIHPEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVN
CCCCCEEEECCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHH
ALSKRVEVTVRRDGQVYNIAFENGEKVQDLQVVGTCGKRNTGTSVHFWPDESFFDSPRFS
HHHHHEEEEEECCCEEEEEEECCCCCEEHEEEEECCCCCCCCCEEEECCCCCCCCCCCHH
VSRLMHVLKAKAVLCPGVEITFKDEVNNSEQRWCYQDGLNDYLGEAVNGLPTLPEKPFIG
HHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCC
NFNGETEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNI
CCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
LPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLNQ
CCCCCEECHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NVQAAEQLAEMAIASAQRRLRAAKKVVRKKLTSGPALPGKLADCTAQDLNRTELFLVEGD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHCCCCEEEEEEECC
SAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLAPQEVHDISVAIGIDPDSDDLSQL
CCCCCHHHHHCCCCEEECCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHH
RYGKICILADADSDGLHIATLLCALFVRHFRALVKNGHVYVALPPLYRIDLGKEVYYALT
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCEEEEEEC
EEEKAGVLEQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLTISDEDDQRTN
CHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHCCCCCCCEEEEEEEECCCCCHHHH
AMMDMLLAKKRSEDRRNWLQEKGDLADLDV
HHHHHHHHHHCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2170028; 8388096; 9278503; 8227000; 8980775 [H]