Click here to switch to the map view.

The map label for this gene is ydfI [H]

Identifier: 194737678

GI number: 194737678

Start: 1553531

End: 1554997

Strand: Direct

Name: ydfI [H]

Synonym: SeSA_A1610

Alternate gene names: 194737678

Gene position: 1553531-1554997 (Clockwise)

Preceding gene: 194736310

Following gene: 194735134

Centisome position: 32.99

GC content: 55.76

Gene sequence:

>1467_bases
ATGCAAAACAGGCTTTTATCGGCAAAGGCGACGCTTCCTGATTACGATCGTGCGGCGCTGGCGGCGCGGATGGTCCATCT
CGGTTTTGGCGCGTTTCATCGCGCGCATCAGGGGGTTTATACAGATATTCTGGCTGCGGAGCAGCATAGCGACTGGGGCT
ATTATGAGGTTAACCTTATTGGCGGCGAACAGCAGATTGCCGATCTAAAGCAGCAGGATAACCTCTATACCGTGGCGGAG
ATGTCGGCGGATGCCTGGACGGCGCGTGTGGTGGGCGTCGTCAAAGCGGCGTTGCATGTCCAGGTTGATGGTCTGGAACG
TGTGCTGGCGGCGATGTGCGAACCGCAAATAGCGATTGTGTCTCTGACCATTACCGAGAAAGGGTATTGTCATTCGCCAG
CCACGGGCCAACTTCTGCTGGAGCATCCCATGATTGCCGCCGACCTGCAAAATCCGCATCAACCGCTAACGGCACAGGGT
ATTATTGTCGAAGCGTTAGCGCGTCGTAAAGCCGCAGGCTTACCGGCATTTACCGTGATGTCCTGCGATAACATGCCGGA
AAATGGGCATGTGACGCGTCAGGTTGTGACGGCTTACGCCCGGGAGGTGGATGCGGAACTGGCGATATGGATCGAGCAAA
ACGTGACATTTCCGTCAACCATGGTTGATCGGATTGTCCCTGCGGTCACGCCGGAGACGCTGGATAAAATCGAACAACTG
ACCGGCGTGCGCGATCCGGCGGGCGTCGCCTGTGAACCGTTTCGCCAGTGGGTGATAGAAGATACGTTTGTGGCGGGTCG
TCCGCAGTGGGAAAACGCGGGCGCGACGTTGGTCGCCGACGTGGTTCCGTTTGAAGAGATGAAACTGCGAATGCTTAACG
GCAGTCATTCATTCCTGGCTTATCTGGGGTATCTTGCCGGCTATCAGCATATTAATGACTGCATGGCTGACGACAACTAT
CGTCTGACCGCGCAGGCGTTAATGTTACGCGAGCAGGCGCCAACGCTGAAAGTCCAGGGGGTAGATTTACAGCGTTATGC
CGATCAGTTGATTGCGCGTTACCGTAATCCGGCGCTGCGTCATCGTACCTGGCAGATTGCGATGGATGGTAGCCAGAAAC
TTCCGCAGCGTATGCTGGACTCCGTTCGCTGGCATCTTGCTAATCATAGCGATTTTGATTTGCTGGCGCTGGGCGTGGCG
GGGTGGATGCGTTACGTCGGCGGCGTGGATGAACAGGGCAAGGCGATCGACATTAGCGATCCGCTATTGCCGGTTATTCA
GCGCGCCGTGGCAAATAGTGAAGAAGGCGCAAGTCGTGTTAAGGCGCTGCTGGGAATGGCTGAAATTTTCGGCAACGATT
TGCCGCAGGCGGCGCGGTTTACGCAAAAAGTGCAAGAAGCCTATGACAGTTTACTGACATATGGCGCGAAAGCGAGCGTG
GCAAAATATGCCGAGCGGTTGAAGTAG

Upstream 100 bases:

>100_bases
ATGCTGTCCGGTCACTTTTGTTTAATTAGCGTAAATCCAAATGCACCAGGGCAGGCGTTACTCTGCGACTGTTCCGCTTT
CAGAATATAGAGGTTATAAA

Downstream 100 bases:

>100_bases
CGCAACAGAGACCCGGTAGCATTATGCTACCGGGAAGGCCGGGGCGGTTCTTAGCGGCCAGTGGTATCAGTTCATGCCAA
GACGAATCAGTTCGACCGGC

Product: D-mannonate oxidoreductase

Products: D-fructuronate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MQNRLLSAKATLPDYDRAALAARMVHLGFGAFHRAHQGVYTDILAAEQHSDWGYYEVNLIGGEQQIADLKQQDNLYTVAE
MSADAWTARVVGVVKAALHVQVDGLERVLAAMCEPQIAIVSLTITEKGYCHSPATGQLLLEHPMIAADLQNPHQPLTAQG
IIVEALARRKAAGLPAFTVMSCDNMPENGHVTRQVVTAYAREVDAELAIWIEQNVTFPSTMVDRIVPAVTPETLDKIEQL
TGVRDPAGVACEPFRQWVIEDTFVAGRPQWENAGATLVADVVPFEEMKLRMLNGSHSFLAYLGYLAGYQHINDCMADDNY
RLTAQALMLREQAPTLKVQGVDLQRYADQLIARYRNPALRHRTWQIAMDGSQKLPQRMLDSVRWHLANHSDFDLLALGVA
GWMRYVGGVDEQGKAIDISDPLLPVIQRAVANSEEGASRVKALLGMAEIFGNDLPQAARFTQKVQEAYDSLLTYGAKASV
AKYAERLK

Sequences:

>Translated_488_residues
MQNRLLSAKATLPDYDRAALAARMVHLGFGAFHRAHQGVYTDILAAEQHSDWGYYEVNLIGGEQQIADLKQQDNLYTVAE
MSADAWTARVVGVVKAALHVQVDGLERVLAAMCEPQIAIVSLTITEKGYCHSPATGQLLLEHPMIAADLQNPHQPLTAQG
IIVEALARRKAAGLPAFTVMSCDNMPENGHVTRQVVTAYAREVDAELAIWIEQNVTFPSTMVDRIVPAVTPETLDKIEQL
TGVRDPAGVACEPFRQWVIEDTFVAGRPQWENAGATLVADVVPFEEMKLRMLNGSHSFLAYLGYLAGYQHINDCMADDNY
RLTAQALMLREQAPTLKVQGVDLQRYADQLIARYRNPALRHRTWQIAMDGSQKLPQRMLDSVRWHLANHSDFDLLALGVA
GWMRYVGGVDEQGKAIDISDPLLPVIQRAVANSEEGASRVKALLGMAEIFGNDLPQAARFTQKVQEAYDSLLTYGAKASV
AKYAERLK
>Mature_488_residues
MQNRLLSAKATLPDYDRAALAARMVHLGFGAFHRAHQGVYTDILAAEQHSDWGYYEVNLIGGEQQIADLKQQDNLYTVAE
MSADAWTARVVGVVKAALHVQVDGLERVLAAMCEPQIAIVSLTITEKGYCHSPATGQLLLEHPMIAADLQNPHQPLTAQG
IIVEALARRKAAGLPAFTVMSCDNMPENGHVTRQVVTAYAREVDAELAIWIEQNVTFPSTMVDRIVPAVTPETLDKIEQL
TGVRDPAGVACEPFRQWVIEDTFVAGRPQWENAGATLVADVVPFEEMKLRMLNGSHSFLAYLGYLAGYQHINDCMADDNY
RLTAQALMLREQAPTLKVQGVDLQRYADQLIARYRNPALRHRTWQIAMDGSQKLPQRMLDSVRWHLANHSDFDLLALGVA
GWMRYVGGVDEQGKAIDISDPLLPVIQRAVANSEEGASRVKALLGMAEIFGNDLPQAARFTQKVQEAYDSLLTYGAKASV
AKYAERLK

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787823, Length=486, Percent_Identity=81.4814814814815, Blast_Score=827, Evalue=0.0,
Organism=Escherichia coli, GI1790779, Length=472, Percent_Identity=59.5338983050847, Blast_Score=554, Evalue=1e-159,
Organism=Escherichia coli, GI1788497, Length=464, Percent_Identity=56.6810344827586, Blast_Score=553, Evalue=1e-159,
Organism=Escherichia coli, GI48994885, Length=377, Percent_Identity=24.6684350132626, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790028, Length=266, Percent_Identity=25.9398496240602, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324401, Length=490, Percent_Identity=37.9591836734694, Blast_Score=332, Evalue=8e-92,
Organism=Saccharomyces cerevisiae, GI6320765, Length=490, Percent_Identity=37.9591836734694, Blast_Score=332, Evalue=8e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: 1.1.1.57

Molecular weight: Translated: 53943; Mature: 53943

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNRLLSAKATLPDYDRAALAARMVHLGFGAFHRAHQGVYTDILAAEQHSDWGYYEVNLI
CCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEEEE
GGEQQIADLKQQDNLYTVAEMSADAWTARVVGVVKAALHVQVDGLERVLAAMCEPQIAIV
CCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCEEEE
SLTITEKGYCHSPATGQLLLEHPMIAADLQNPHQPLTAQGIIVEALARRKAAGLPAFTVM
EEEEECCCCCCCCCCCCEEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEE
SCDNMPENGHVTRQVVTAYAREVDAELAIWIEQNVTFPSTMVDRIVPAVTPETLDKIEQL
ECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHH
TGVRDPAGVACEPFRQWVIEDTFVAGRPQWENAGATLVADVVPFEEMKLRMLNGSHSFLA
HCCCCCCCCCHHHHHHHHHHHHEECCCCCCCCCCCEEEECCCCHHHHHHHHHCCCHHHHH
YLGYLAGYQHINDCMADDNYRLTAQALMLREQAPTLKVQGVDLQRYADQLIARYRNPALR
HHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCHHHH
HRTWQIAMDGSQKLPQRMLDSVRWHLANHSDFDLLALGVAGWMRYVGGVDEQGKAIDISD
CEEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCC
PLLPVIQRAVANSEEGASRVKALLGMAEIFGNDLPQAARFTQKVQEAYDSLLTYGAKASV
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
AKYAERLK
HHHHHHCC
>Mature Secondary Structure
MQNRLLSAKATLPDYDRAALAARMVHLGFGAFHRAHQGVYTDILAAEQHSDWGYYEVNLI
CCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEEEE
GGEQQIADLKQQDNLYTVAEMSADAWTARVVGVVKAALHVQVDGLERVLAAMCEPQIAIV
CCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCEEEE
SLTITEKGYCHSPATGQLLLEHPMIAADLQNPHQPLTAQGIIVEALARRKAAGLPAFTVM
EEEEECCCCCCCCCCCCEEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEE
SCDNMPENGHVTRQVVTAYAREVDAELAIWIEQNVTFPSTMVDRIVPAVTPETLDKIEQL
ECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHH
TGVRDPAGVACEPFRQWVIEDTFVAGRPQWENAGATLVADVVPFEEMKLRMLNGSHSFLA
HCCCCCCCCCHHHHHHHHHHHHEECCCCCCCCCCCEEEECCCCHHHHHHHHHCCCHHHHH
YLGYLAGYQHINDCMADDNYRLTAQALMLREQAPTLKVQGVDLQRYADQLIARYRNPALR
HHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCHHHH
HRTWQIAMDGSQKLPQRMLDSVRWHLANHSDFDLLALGVAGWMRYVGGVDEQGKAIDISD
CEEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCC
PLLPVIQRAVANSEEGASRVKALLGMAEIFGNDLPQAARFTQKVQEAYDSLLTYGAKASV
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
AKYAERLK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-mannonate; NAD+

Specific reaction: D-mannonate + NAD+ = D-fructuronate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]