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The map label for this gene is trpD [H]

Identifier: 194736540

GI number: 194736540

Start: 1797491

End: 1799086

Strand: Direct

Name: trpD [H]

Synonym: SeSA_A1856

Alternate gene names: 194736540

Gene position: 1797491-1799086 (Clockwise)

Preceding gene: 194735813

Following gene: 194737024

Centisome position: 38.17

GC content: 57.27

Gene sequence:

>1596_bases
ATGGCTGATATTCTGCTGCTCGATAACATCGACTCGTTTACCTGGAACCTGGCAGATCAGCTACGGACCAACGGTCATAA
CGTGGTGATTTACCGTAACCATATTCCGGCGCAGACCCTTATCGATCGCCTGGCGACAATGAAAAATCCGGTGCTAATGC
TCTCCCCCGGTCCGGGCGTTCCCAGCGAGGCAGGCTGTATGCCGGAGCTGCTGACCCGACTACGCGGCAAGTTACCGATC
ATCGGCATTTGTCTGGGGCATCAGGCGATTGTCGAAGCTTACGGCGGTTATGTCGGTCAGGCGGGAGAAATCCTGCATGG
CAAAGCCTCCAGCATTGAGCATGACGGTCAGGCGATGTTCGCCGGGCTGGCGAATCCGCTACCGGTCGCGCGTTATCATT
CGCTGGTCGGCAGTAATGTTCCTGCCGGGCTGACCATTAACGCCCATTTCAACGGCATGGTGATGGCGGTACGTCATGAT
GCGGATCGCGTTTGCGGTTTTCAATTTCATCCTGAGTCCATACTGACGACACAGGGCGCGCGTCTGCTGGAGCAAACATT
AGCCTGGGCGCAGCAAAAGCTGGAACCGACCAACACCCTACAGCCGATTCTGGAGAAACTCTATCAGGCGCAAACTCTGA
CGCAACAAGAGAGCCATCAGTTGTTTTCGGCGGTCGTCCGCGGCGAACTTAAGCCTGAACAGCTCGCCGCCGCGCTGGTG
AGCATGAAAATTCGCGGCGAGCATCCCAATGAAATTGCCGGCGCCGCCACTGCGTTGCTGGAAAATGCCGCTCCGTTCCC
GCGCCCGGAGTATCTGTTTGCGGATATCGTTGGTACCGGCGGCGATGGCAGTAACAGTATCAATATCTCTACCGCCAGCG
CCTTTGTCGCGGCGGCCTGTGGACTGAAAGTGGCGAAACACGGCAACCGCAGCGTGTCCAGCAAATCGGGGTCATCCGAT
CTGCTGGCGGCGTTCGGTATTAATCTGGATATGAACGCCGATAAATCACGTCAGGCGTTAGATGAACTGGGCGTCTGTTT
CCTGTTCGCGCCGAAATATCACACCGGATTCCGTCACGCGATGCCGGTTCGCCAACAGTTAAAAACGCGAACCCTGTTCA
ACGTACTCGGCCCGCTGATCAACCCGGCGCATCCGCCGCTGGCATTGATTGGCGTCTATAGTCCGGAACTGGTGCTGCCG
ATTGCGGAAACCTTACGGGTACTGGGCTATCAGCGCGCGGCGGTAGTACATAGCGGCGGCATGGATGAGGTTTCGCTCCA
TGCGCCGACGATTGTCGCGGAGCTGCATGACGGCGAAATTAAAAGCTATCAACTTACGGCGGAGGATTTTGGCCTGACGC
CTTACCATCAGGATCAGTTGGCTGGCGGCACGCCGGAAGAAAACCGTGACATTCTGACGCGGTTATTACAAGGTAAAGGC
GATGCCGCGCATGAGGCCGCCGTCGCCGCCAACGTGGCGATGCTGATGCGTCTGCATGGTCAGGAAGATCTCAAAGCCAA
CGCGCAAGCCGTGCTTGATGTTCTGCGCAACGGCACCGCATATGACAGAGTCACCGCACTGGCGGCAAGAGGGTAA

Upstream 100 bases:

>100_bases
TGGACTCTGTTCCGCAGTCTGAAGCCGATGAAACCCGTAATAAAGCGCGCGCCGTATTGCGTGCTATCGCCACCGCGCAT
CATGCACAGGAGACCTTCTG

Downstream 100 bases:

>100_bases
ATAATGCAAACCGTTTTAGCGAAAATCGTCGCAGACAAGGCGATTTGGGTAGAAGCCCGCAAACAGCAACAGCCGCTGGC
CAGTTTTCAAAATGAGATCC

Product: bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: Glutamine amidotransferase; Anthranilate phosphoribosyltransferase [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MADILLLDNIDSFTWNLADQLRTNGHNVVIYRNHIPAQTLIDRLATMKNPVLMLSPGPGVPSEAGCMPELLTRLRGKLPI
IGICLGHQAIVEAYGGYVGQAGEILHGKASSIEHDGQAMFAGLANPLPVARYHSLVGSNVPAGLTINAHFNGMVMAVRHD
ADRVCGFQFHPESILTTQGARLLEQTLAWAQQKLEPTNTLQPILEKLYQAQTLTQQESHQLFSAVVRGELKPEQLAAALV
SMKIRGEHPNEIAGAATALLENAAPFPRPEYLFADIVGTGGDGSNSINISTASAFVAAACGLKVAKHGNRSVSSKSGSSD
LLAAFGINLDMNADKSRQALDELGVCFLFAPKYHTGFRHAMPVRQQLKTRTLFNVLGPLINPAHPPLALIGVYSPELVLP
IAETLRVLGYQRAAVVHSGGMDEVSLHAPTIVAELHDGEIKSYQLTAEDFGLTPYHQDQLAGGTPEENRDILTRLLQGKG
DAAHEAAVAANVAMLMRLHGQEDLKANAQAVLDVLRNGTAYDRVTALAARG

Sequences:

>Translated_531_residues
MADILLLDNIDSFTWNLADQLRTNGHNVVIYRNHIPAQTLIDRLATMKNPVLMLSPGPGVPSEAGCMPELLTRLRGKLPI
IGICLGHQAIVEAYGGYVGQAGEILHGKASSIEHDGQAMFAGLANPLPVARYHSLVGSNVPAGLTINAHFNGMVMAVRHD
ADRVCGFQFHPESILTTQGARLLEQTLAWAQQKLEPTNTLQPILEKLYQAQTLTQQESHQLFSAVVRGELKPEQLAAALV
SMKIRGEHPNEIAGAATALLENAAPFPRPEYLFADIVGTGGDGSNSINISTASAFVAAACGLKVAKHGNRSVSSKSGSSD
LLAAFGINLDMNADKSRQALDELGVCFLFAPKYHTGFRHAMPVRQQLKTRTLFNVLGPLINPAHPPLALIGVYSPELVLP
IAETLRVLGYQRAAVVHSGGMDEVSLHAPTIVAELHDGEIKSYQLTAEDFGLTPYHQDQLAGGTPEENRDILTRLLQGKG
DAAHEAAVAANVAMLMRLHGQEDLKANAQAVLDVLRNGTAYDRVTALAARG
>Mature_530_residues
ADILLLDNIDSFTWNLADQLRTNGHNVVIYRNHIPAQTLIDRLATMKNPVLMLSPGPGVPSEAGCMPELLTRLRGKLPII
GICLGHQAIVEAYGGYVGQAGEILHGKASSIEHDGQAMFAGLANPLPVARYHSLVGSNVPAGLTINAHFNGMVMAVRHDA
DRVCGFQFHPESILTTQGARLLEQTLAWAQQKLEPTNTLQPILEKLYQAQTLTQQESHQLFSAVVRGELKPEQLAAALVS
MKIRGEHPNEIAGAATALLENAAPFPRPEYLFADIVGTGGDGSNSINISTASAFVAAACGLKVAKHGNRSVSSKSGSSDL
LAAFGINLDMNADKSRQALDELGVCFLFAPKYHTGFRHAMPVRQQLKTRTLFNVLGPLINPAHPPLALIGVYSPELVLPI
AETLRVLGYQRAAVVHSGGMDEVSLHAPTIVAELHDGEIKSYQLTAEDFGLTPYHQDQLAGGTPEENRDILTRLLQGKGD
AAHEAAVAANVAMLMRLHGQEDLKANAQAVLDVLRNGTAYDRVTALAARG

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787517, Length=531, Percent_Identity=96.9868173258004, Blast_Score=1016, Evalue=0.0,
Organism=Escherichia coli, GI1789760, Length=187, Percent_Identity=45.9893048128342, Blast_Score=158, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6322638, Length=227, Percent_Identity=37.4449339207048, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6320561, Length=277, Percent_Identity=33.9350180505415, Blast_Score=125, Evalue=2e-29,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005940
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR006221 [H]

Pfam domain/function: PF00117 GATase; PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3 [H]

EC number: =4.1.3.27; =2.4.2.18 [H]

Molecular weight: Translated: 56923; Mature: 56792

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADILLLDNIDSFTWNLADQLRTNGHNVVIYRNHIPAQTLIDRLATMKNPVLMLSPGPGV
CCCEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCC
PSEAGCMPELLTRLRGKLPIIGICLGHQAIVEAYGGYVGQAGEILHGKASSIEHDGQAMF
CCCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHCCCCCCCCCEECCCCCCCCCCCHHHH
AGLANPLPVARYHSLVGSNVPAGLTINAHFNGMVMAVRHDADRVCGFQFHPESILTTQGA
HHCCCCCCHHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCCHHCCCEECCHHHHHHHHH
RLLEQTLAWAQQKLEPTNTLQPILEKLYQAQTLTQQESHQLFSAVVRGELKPEQLAAALV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SMKIRGEHPNEIAGAATALLENAAPFPRPEYLFADIVGTGGDGSNSINISTASAFVAAAC
HHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEEHHHHHHHHHH
GLKVAKHGNRSVSSKSGSSDLLAAFGINLDMNADKSRQALDELGVCFLFAPKYHTGFRHA
HHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCEEEEECCCCCCCCHHH
MPVRQQLKTRTLFNVLGPLINPAHPPLALIGVYSPELVLPIAETLRVLGYQRAAVVHSGG
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHEEEECCC
MDEVSLHAPTIVAELHDGEIKSYQLTAEDFGLTPYHQDQLAGGTPEENRDILTRLLQGKG
CCCEEECCCEEEEEECCCCCCEEEEEHHHCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCC
DAAHEAAVAANVAMLMRLHGQEDLKANAQAVLDVLRNGTAYDRVTALAARG
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure 
ADILLLDNIDSFTWNLADQLRTNGHNVVIYRNHIPAQTLIDRLATMKNPVLMLSPGPGV
CCEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCC
PSEAGCMPELLTRLRGKLPIIGICLGHQAIVEAYGGYVGQAGEILHGKASSIEHDGQAMF
CCCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHCCCCCCCCCEECCCCCCCCCCCHHHH
AGLANPLPVARYHSLVGSNVPAGLTINAHFNGMVMAVRHDADRVCGFQFHPESILTTQGA
HHCCCCCCHHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCCHHCCCEECCHHHHHHHHH
RLLEQTLAWAQQKLEPTNTLQPILEKLYQAQTLTQQESHQLFSAVVRGELKPEQLAAALV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SMKIRGEHPNEIAGAATALLENAAPFPRPEYLFADIVGTGGDGSNSINISTASAFVAAAC
HHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEEHHHHHHHHHH
GLKVAKHGNRSVSSKSGSSDLLAAFGINLDMNADKSRQALDELGVCFLFAPKYHTGFRHA
HHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCEEEEECCCCCCCCHHH
MPVRQQLKTRTLFNVLGPLINPAHPPLALIGVYSPELVLPIAETLRVLGYQRAAVVHSGG
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHEEEECCC
MDEVSLHAPTIVAELHDGEIKSYQLTAEDFGLTPYHQDQLAGGTPEENRDILTRLLQGKG
CCCEEECCCEEEEEECCCCCCEEEEEHHHCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCC
DAAHEAAVAANVAMLMRLHGQEDLKANAQAVLDVLRNGTAYDRVTALAARG
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7038627; 6283099; 9097039; 9278503; 4594441 [H]