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The map label for this gene is invA

Identifier: 194736186

GI number: 194736186

Start: 2945596

End: 2947653

Strand: Reverse

Name: invA

Synonym: SeSA_A3049

Alternate gene names: 194736186

Gene position: 2947653-2945596 (Counterclockwise)

Preceding gene: 194737917

Following gene: 194735438

Centisome position: 62.6

GC content: 45.53

Gene sequence:

>2058_bases
GTGCTGCTTTCTCTACTTAACAGTGCTCGTTTACGACCTGAATTACTGATTCTGGTACTAATGGTGATGATCATTTCTAT
GTTCGTCATTCCATTACCTACCTATCTGGTTGATTTCCTGATCGCACTGAATATCGTACTGGCGATATTGGTGTTTATGG
GGTCGTTCTACATTGACAGAATCCTCAGTTTTTCAACGTTTCCTGCGGTACTGTTAATTACCACGCTCTTTCGTCTGGCA
TTATCGATCAGTACCAGCCGTCTTATATTGATTGAAGCCGATGCCGGTGAAATTATCGCCACGTTCGGGCAATTCGTTAT
TGGCGATAGCCTGGCGGTGGGTTTTGTTGTCTTCTCTATTGTCACCGTGGTCCAGTTTATCGTTATTACCAAAGGTTCAG
AACGCGTCGCGGAAGTCGCGGCCCGATTTTCTCTGGATGGTATGCCCGGTAAACAGATGAGTATTGATGCCGATTTGAAG
GCCGGTATTATTGATGCGGATGCCGCGCGCGAACGGCGAAGTGTACTGGAAAGGGAAAGCCAGCTTTACGGTTCCTTTGA
CGGTGCGATGAAGTTTATCAAAGGTGACGCTATTGCCGGCATCATTATTATCTTTGTGAACTTTATTGGCGGTATTTCGG
TGGGGATGACCCGCCATGGTATGGATTTGTCCTCCGCCCTGTCTACTTATACCATGCTGACCATTGGTGATGGTCTTGTC
GCCCAGATCCCCGCATTGTTGATTGCGATTAGTGCCGGTTTTATCGTGACTCGCGTAAATGGCGATAGCGATAATATGGG
GCGGAATATCATGACGCAGCTGTTGAACAACCCATTTGTATTGGTTGTTACGGCTATTTTGACCATTTCAATGGGAACTC
TGCCGGGATTCCCGCTGCCGGTATTTGTTATTTTATCGGTGGTTTTAAGCGTACTCTTCTATTTTAAATTCCGTGAAGCA
AAACGTAGCGCCGCCAAACCTAAAACCAGTAAAGGCGAGCAGCCGCTCAGTATTGAGGAAAAAGAAGGGTCGTCGTTGGG
ACTGATTGGCGATCTCGATAAAGTCTCTACAGAAACCGTACCGTTGATATTACTTGTGCCGAAGAGCCGGCGTGAAGATC
TGGAAAAAGCTCAACTTGCGGAGCGTCTACGTAGTCAGTTCTTTATTGATTATGGCGTGCGCCTGCCGGAAGTATTGTTA
CGCGATGGCGAGGGTCTGGACGATAACAGCATCGTATTGTTGATTAATGAGATCCGTGTTGAACAATTTACGGTCTATTT
TGATTTGATGCGAGTGGTAAATTATTCCGATGAAGTTGTTTCCTTTGGCATTAATCCAACAATCCATCAGCAAGGTAGCA
GTCAGTATTTCTGGGTAACGCATGAAGAGGGGGAGAAACTGCGGGAGCTTGGCTATGTGTTGCGGAACGCGCTTGATGAG
CTTTACCACTGTCTGGCGGTGACGCTGGCGCGCAACGTCAATGAATATTTCGGTATTCAGGAAACAAAACATATGCTGGA
CCAACTGGAAGCGAAATTTCCTGATTTACTTAAAGAAGTGCTCAGACATGCCACGGTACAACGTATATCTGAAGTTTTGC
AGCGTTTGTTAAGCGAACGTGTTTCCGTGCGTAATATGAAATTAATTATGGAAGCGCTCGCATTGTGGGCGCCAAGAGAA
AAAGATGTCATTAACCTTGTGGAGCATATTCGTGGGGCAATGGCGCGTTATATTTGCCATAAATTCGCCAATGGCGGCGA
ATTACGAGCAGTAATGGTATCTGCTGAAGTTGAGGATGTTATTCGCAAAGGGATCCGTCAGACCTCTGGCAGTACCTTCC
TCAGCCTTGACCCGGAAGCCTCCGCTAATTTGATGGATCTCATTACACTTAAGTTGGATGATTTATTGATTGCACATAAA
GATCTTGTCCTCCTTACGTCTGTCGATGTCCGTCGATTTATTAAGAAAATGATTGAAGGTCGTTTTCCGGATCTGGAGGT
TTTATCTTTCGGTGAGATAGCAGATAGCAAGTCAGTGAATGTTATAAAAACAATATAA

Upstream 100 bases:

>100_bases
GTTACGTAGTATGACCGATATTGCCTACAAGCATGAAATGGCAGAACAGCGTCGTACTATTGAAAAGCTGTCTTAATTTA
ATATTAACAGGATACCTATA

Downstream 100 bases:

>100_bases
GGGCTTAATTAAGGAAAAGATCTATGCAACATTTGGATATCGCTGAATTAGTTCGTTCCGCACTGGAAGTAAGTGGTTGC
GATCCTTCACTCATCGGAGG

Product: invasion protein InvA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 685; Mature: 685

Protein sequence:

>685_residues
MLLSLLNSARLRPELLILVLMVMIISMFVIPLPTYLVDFLIALNIVLAILVFMGSFYIDRILSFSTFPAVLLITTLFRLA
LSISTSRLILIEADAGEIIATFGQFVIGDSLAVGFVVFSIVTVVQFIVITKGSERVAEVAARFSLDGMPGKQMSIDADLK
AGIIDADAARERRSVLERESQLYGSFDGAMKFIKGDAIAGIIIIFVNFIGGISVGMTRHGMDLSSALSTYTMLTIGDGLV
AQIPALLIAISAGFIVTRVNGDSDNMGRNIMTQLLNNPFVLVVTAILTISMGTLPGFPLPVFVILSVVLSVLFYFKFREA
KRSAAKPKTSKGEQPLSIEEKEGSSLGLIGDLDKVSTETVPLILLVPKSRREDLEKAQLAERLRSQFFIDYGVRLPEVLL
RDGEGLDDNSIVLLINEIRVEQFTVYFDLMRVVNYSDEVVSFGINPTIHQQGSSQYFWVTHEEGEKLRELGYVLRNALDE
LYHCLAVTLARNVNEYFGIQETKHMLDQLEAKFPDLLKEVLRHATVQRISEVLQRLLSERVSVRNMKLIMEALALWAPRE
KDVINLVEHIRGAMARYICHKFANGGELRAVMVSAEVEDVIRKGIRQTSGSTFLSLDPEASANLMDLITLKLDDLLIAHK
DLVLLTSVDVRRFIKKMIEGRFPDLEVLSFGEIADSKSVNVIKTI

Sequences:

>Translated_685_residues
MLLSLLNSARLRPELLILVLMVMIISMFVIPLPTYLVDFLIALNIVLAILVFMGSFYIDRILSFSTFPAVLLITTLFRLA
LSISTSRLILIEADAGEIIATFGQFVIGDSLAVGFVVFSIVTVVQFIVITKGSERVAEVAARFSLDGMPGKQMSIDADLK
AGIIDADAARERRSVLERESQLYGSFDGAMKFIKGDAIAGIIIIFVNFIGGISVGMTRHGMDLSSALSTYTMLTIGDGLV
AQIPALLIAISAGFIVTRVNGDSDNMGRNIMTQLLNNPFVLVVTAILTISMGTLPGFPLPVFVILSVVLSVLFYFKFREA
KRSAAKPKTSKGEQPLSIEEKEGSSLGLIGDLDKVSTETVPLILLVPKSRREDLEKAQLAERLRSQFFIDYGVRLPEVLL
RDGEGLDDNSIVLLINEIRVEQFTVYFDLMRVVNYSDEVVSFGINPTIHQQGSSQYFWVTHEEGEKLRELGYVLRNALDE
LYHCLAVTLARNVNEYFGIQETKHMLDQLEAKFPDLLKEVLRHATVQRISEVLQRLLSERVSVRNMKLIMEALALWAPRE
KDVINLVEHIRGAMARYICHKFANGGELRAVMVSAEVEDVIRKGIRQTSGSTFLSLDPEASANLMDLITLKLDDLLIAHK
DLVLLTSVDVRRFIKKMIEGRFPDLEVLSFGEIADSKSVNVIKTI
>Mature_685_residues
MLLSLLNSARLRPELLILVLMVMIISMFVIPLPTYLVDFLIALNIVLAILVFMGSFYIDRILSFSTFPAVLLITTLFRLA
LSISTSRLILIEADAGEIIATFGQFVIGDSLAVGFVVFSIVTVVQFIVITKGSERVAEVAARFSLDGMPGKQMSIDADLK
AGIIDADAARERRSVLERESQLYGSFDGAMKFIKGDAIAGIIIIFVNFIGGISVGMTRHGMDLSSALSTYTMLTIGDGLV
AQIPALLIAISAGFIVTRVNGDSDNMGRNIMTQLLNNPFVLVVTAILTISMGTLPGFPLPVFVILSVVLSVLFYFKFREA
KRSAAKPKTSKGEQPLSIEEKEGSSLGLIGDLDKVSTETVPLILLVPKSRREDLEKAQLAERLRSQFFIDYGVRLPEVLL
RDGEGLDDNSIVLLINEIRVEQFTVYFDLMRVVNYSDEVVSFGINPTIHQQGSSQYFWVTHEEGEKLRELGYVLRNALDE
LYHCLAVTLARNVNEYFGIQETKHMLDQLEAKFPDLLKEVLRHATVQRISEVLQRLLSERVSVRNMKLIMEALALWAPRE
KDVINLVEHIRGAMARYICHKFANGGELRAVMVSAEVEDVIRKGIRQTSGSTFLSLDPEASANLMDLITLKLDDLLIAHK
DLVLLTSVDVRRFIKKMIEGRFPDLEVLSFGEIADSKSVNVIKTI

Specific function: Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the invE protein

COG id: COG4789

COG function: function code U; Type III secretory pathway, component EscV

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family

Homologues:

Organism=Escherichia coli, GI1788187, Length=676, Percent_Identity=34.0236686390533, Blast_Score=369, Evalue=1e-103,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): INVA_SALTI (P0A1I4)

Other databases:

- EMBL:   AL627276
- EMBL:   AE014613
- RefSeq:   NP_457290.1
- RefSeq:   NP_806499.1
- PRIDE:   P0A1I4
- GeneID:   1068855
- GeneID:   1249325
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t2798
- KEGG:   sty:STY3019
- HOGENOM:   HBG595253
- OMA:   GRNIMSQ
- ProtClustDB:   PRK15337
- BioCyc:   SENT209261:T2798-MONOMER
- BioCyc:   SENT220341:STY3019-MONOMER
- GO:   GO:0009405
- InterPro:   IPR001712
- InterPro:   IPR006302
- PRINTS:   PR00949
- TIGRFAMs:   TIGR01399

Pfam domain/function: PF00771 FHIPEP

EC number: NA

Molecular weight: Translated: 76056; Mature: 76056

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00994 FHIPEP

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x209b137c)-; HASH(0x20da645c)-; HASH(0x201488c0)-; HASH(0x2045d394)-; HASH(0x210fb380)-; HASH(0x1f912b00)-; HASH(0x20dd6fa8)-; HASH(0x2112e298)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSLLNSARLRPELLILVLMVMIISMFVIPLPTYLVDFLIALNIVLAILVFMGSFYIDR
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSFSTFPAVLLITTLFRLALSISTSRLILIEADAGEIIATFGQFVIGDSLAVGFVVFSI
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHH
VTVVQFIVITKGSERVAEVAARFSLDGMPGKQMSIDADLKAGIIDADAARERRSVLERES
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHH
QLYGSFDGAMKFIKGDAIAGIIIIFVNFIGGISVGMTRHGMDLSSALSTYTMLTIGDGLV
HHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHCCHHCCCCHHHHHHHHHHEEECCCHH
AQIPALLIAISAGFIVTRVNGDSDNMGRNIMTQLLNNPFVLVVTAILTISMGTLPGFPLP
HHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHH
VFVILSVVLSVLFYFKFREAKRSAAKPKTSKGEQPLSIEEKEGSSLGLIGDLDKVSTETV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECHHHCCCCCC
PLILLVPKSRREDLEKAQLAERLRSQFFIDYGVRLPEVLLRDGEGLDDNSIVLLINEIRV
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCEEEEEEHHHH
EQFTVYFDLMRVVNYSDEVVSFGINPTIHQQGSSQYFWVTHEEGEKLRELGYVLRNALDE
HHHHHHHHHHHHHCCCCHHHEECCCCCEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
LYHCLAVTLARNVNEYFGIQETKHMLDQLEAKFPDLLKEVLRHATVQRISEVLQRLLSER
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSVRNMKLIMEALALWAPREKDVINLVEHIRGAMARYICHKFANGGELRAVMVSAEVEDV
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHH
IRKGIRQTSGSTFLSLDPEASANLMDLITLKLDDLLIAHKDLVLLTSVDVRRFIKKMIEG
HHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHCC
RFPDLEVLSFGEIADSKSVNVIKTI
CCCCCCEEECCCCCCCCCCCEEECH
>Mature Secondary Structure
MLLSLLNSARLRPELLILVLMVMIISMFVIPLPTYLVDFLIALNIVLAILVFMGSFYIDR
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSFSTFPAVLLITTLFRLALSISTSRLILIEADAGEIIATFGQFVIGDSLAVGFVVFSI
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHH
VTVVQFIVITKGSERVAEVAARFSLDGMPGKQMSIDADLKAGIIDADAARERRSVLERES
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHH
QLYGSFDGAMKFIKGDAIAGIIIIFVNFIGGISVGMTRHGMDLSSALSTYTMLTIGDGLV
HHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHCCHHCCCCHHHHHHHHHHEEECCCHH
AQIPALLIAISAGFIVTRVNGDSDNMGRNIMTQLLNNPFVLVVTAILTISMGTLPGFPLP
HHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHH
VFVILSVVLSVLFYFKFREAKRSAAKPKTSKGEQPLSIEEKEGSSLGLIGDLDKVSTETV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECHHHCCCCCC
PLILLVPKSRREDLEKAQLAERLRSQFFIDYGVRLPEVLLRDGEGLDDNSIVLLINEIRV
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCEEEEEEHHHH
EQFTVYFDLMRVVNYSDEVVSFGINPTIHQQGSSQYFWVTHEEGEKLRELGYVLRNALDE
HHHHHHHHHHHHHCCCCHHHEECCCCCEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
LYHCLAVTLARNVNEYFGIQETKHMLDQLEAKFPDLLKEVLRHATVQRISEVLQRLLSER
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSVRNMKLIMEALALWAPREKDVINLVEHIRGAMARYICHKFANGGELRAVMVSAEVEDV
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHH
IRKGIRQTSGSTFLSLDPEASANLMDLITLKLDDLLIAHKDLVLLTSVDVRRFIKKMIEG
HHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHCC
RFPDLEVLSFGEIADSKSVNVIKTI
CCCCCCEEECCCCCCCCCCCEEECH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504