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The map label for this gene is cmtA [H]

Identifier: 194736091

GI number: 194736091

Start: 3142488

End: 3143867

Strand: Reverse

Name: cmtA [H]

Synonym: SeSA_A3253

Alternate gene names: 194736091

Gene position: 3143867-3142488 (Counterclockwise)

Preceding gene: 194735202

Following gene: 194734296

Centisome position: 66.76

GC content: 48.62

Gene sequence:

>1380_bases
ATGGAACACAAGTCTGCTCGTGCAAAGGTCCAGGCTTTTGGGGGATTTTTGACCGCGATGGTCATTCCCAATATCGGCGC
TTTTATTGCCTGGGGTTTTATCACTGCATTATTTATTCCAACCGGATGGATGCCAAATGAGCATTTCGCCAAAATTGTCG
GCCCGATGATTACTTATTTACTGCCGGTGATGATTGGTTCTACCGGTGGACATCTGGTCGGTGGAAAGCGTGGCGCCGTG
ATGGGGGGAATTGGCACCATTGGCGTTATCATCGGTGCTGATATCCCCATGTTTCTTGGCTCAATGATTATGGGACCTCT
CGGCGGTCTGGTCATTAAATATATTGATCGGTTGCTGGAAAAGCGGATTCCCGCCGGTTTTGAGATGGTGATTAATAACT
TCTCGCTGGGTATCGCCGGGATGATTTTGTGCCTGCTGGGTTTTGAAGTGATTGGTCCGGCGGTACTTATTGCCAATAAC
TTTGTGAAGGAGTGTATTGAATCATTGGTACATGCGGGCTATCTGCCGCTGTTGTCTTTAATCAATGAACCGGCAAAAAT
CCTCTTTTTGAACAATGCCATCGATCAGGGCGTTTATTATCCGTTGGGAATGCAACAGGCGTCGGAAACCGGAAAATCCA
TTTTCTTTATGGTGGCCTCTAACCCGGGGCCTGGCTTAGGTTTGCTGCTTGCCTTTACGCTATTTGGCAAAGGAATGGCA
AAGAAATCTGCGCCTGGCGCCATGATTATCCATTTCCTCGGGGGGATTCATGAGCTCTATTTCCCCTATGTGCTGATGAA
GCCATTAACACTCATCGCCATGATTGCCGGCGGGATGAGCGGAACATGGGTGTTTAACCTGCTGGATGGCGGCCTGGTTG
CAGGGCCAAGCCCGGGGTCAATTTTCGCTTACCTGGCGCTGACGCCGAAAGGTTCTTTCCTTGCTACGATTGCTGGCGTA
ACGGCGGGAACGGCAGTGACCTTTATTATCACCGCTTTCATTTTGAAAATGGAAAAAAGTAGCGAAGCCGACAGCGAAGA
TACTTTTAGTGATTCCGCTAAAGCGGTGAAAGCCATGAAGCAAGAAGGCAAATTTTCATATCGCGACGTGAAACGTATCG
CCTTTGTCTGCGATGCGGGGATGGGCTCCAGCGCAATGGGCGCCACAACGTTCCGCCGACGTCTGGAAAAGGCGGGCCTG
ACTATCGACGTTAAACATTACGCTATCGAAAATGTACCGGATGATGCCGATATTATCGTTACCCACGCCAGCCTTGAAGG
ACGTGTTAAGCGAGTCAGCGATAAGCCCTTAATACTTATTAAAAACTATATTGGCGATCCGTGCCTTGATGATTTATTTA
ACCATTTGACATCGAATTAA

Upstream 100 bases:

>100_bases
AGAGGATGTTTTAGCGGCGTTATTAGCTGCGAAATCAGAAAAAGAGCTGGCGGATATTATAGCTCGCGCATAATTATTCT
CTCCTTTACAGGATATTAAT

Downstream 100 bases:

>100_bases
TATTTCAGGTTTCTGGAGTAAATATGAAAACGAAAGTAGCTGCTATATATGGCAAGCGGGATGTCCGTATCCGTGAGTTT
GAATTACCCGACATTACGGA

Product: pts system mannitol-specific eiicba component

Products: NA

Alternate protein names: EIICB-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MEHKSARAKVQAFGGFLTAMVIPNIGAFIAWGFITALFIPTGWMPNEHFAKIVGPMITYLLPVMIGSTGGHLVGGKRGAV
MGGIGTIGVIIGADIPMFLGSMIMGPLGGLVIKYIDRLLEKRIPAGFEMVINNFSLGIAGMILCLLGFEVIGPAVLIANN
FVKECIESLVHAGYLPLLSLINEPAKILFLNNAIDQGVYYPLGMQQASETGKSIFFMVASNPGPGLGLLLAFTLFGKGMA
KKSAPGAMIIHFLGGIHELYFPYVLMKPLTLIAMIAGGMSGTWVFNLLDGGLVAGPSPGSIFAYLALTPKGSFLATIAGV
TAGTAVTFIITAFILKMEKSSEADSEDTFSDSAKAVKAMKQEGKFSYRDVKRIAFVCDAGMGSSAMGATTFRRRLEKAGL
TIDVKHYAIENVPDDADIIVTHASLEGRVKRVSDKPLILIKNYIGDPCLDDLFNHLTSN

Sequences:

>Translated_459_residues
MEHKSARAKVQAFGGFLTAMVIPNIGAFIAWGFITALFIPTGWMPNEHFAKIVGPMITYLLPVMIGSTGGHLVGGKRGAV
MGGIGTIGVIIGADIPMFLGSMIMGPLGGLVIKYIDRLLEKRIPAGFEMVINNFSLGIAGMILCLLGFEVIGPAVLIANN
FVKECIESLVHAGYLPLLSLINEPAKILFLNNAIDQGVYYPLGMQQASETGKSIFFMVASNPGPGLGLLLAFTLFGKGMA
KKSAPGAMIIHFLGGIHELYFPYVLMKPLTLIAMIAGGMSGTWVFNLLDGGLVAGPSPGSIFAYLALTPKGSFLATIAGV
TAGTAVTFIITAFILKMEKSSEADSEDTFSDSAKAVKAMKQEGKFSYRDVKRIAFVCDAGMGSSAMGATTFRRRLEKAGL
TIDVKHYAIENVPDDADIIVTHASLEGRVKRVSDKPLILIKNYIGDPCLDDLFNHLTSN
>Mature_459_residues
MEHKSARAKVQAFGGFLTAMVIPNIGAFIAWGFITALFIPTGWMPNEHFAKIVGPMITYLLPVMIGSTGGHLVGGKRGAV
MGGIGTIGVIIGADIPMFLGSMIMGPLGGLVIKYIDRLLEKRIPAGFEMVINNFSLGIAGMILCLLGFEVIGPAVLIANN
FVKECIESLVHAGYLPLLSLINEPAKILFLNNAIDQGVYYPLGMQQASETGKSIFFMVASNPGPGLGLLLAFTLFGKGMA
KKSAPGAMIIHFLGGIHELYFPYVLMKPLTLIAMIAGGMSGTWVFNLLDGGLVAGPSPGSIFAYLALTPKGSFLATIAGV
TAGTAVTFIITAFILKMEKSSEADSEDTFSDSAKAVKAMKQEGKFSYRDVKRIAFVCDAGMGSSAMGATTFRRRLEKAGL
TIDVKHYAIENVPDDADIIVTHASLEGRVKRVSDKPLILIKNYIGDPCLDDLFNHLTSN

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1789301, Length=459, Percent_Identity=89.5424836601307, Blast_Score=838, Evalue=0.0,
Organism=Escherichia coli, GI1790027, Length=465, Percent_Identity=53.5483870967742, Blast_Score=462, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 48852; Mature: 48852

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHKSARAKVQAFGGFLTAMVIPNIGAFIAWGFITALFIPTGWMPNEHFAKIVGPMITYL
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LPVMIGSTGGHLVGGKRGAVMGGIGTIGVIIGADIPMFLGSMIMGPLGGLVIKYIDRLLE
HHHHHCCCCCCEECCCCCCEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KRIPAGFEMVINNFSLGIAGMILCLLGFEVIGPAVLIANNFVKECIESLVHAGYLPLLSL
HHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
INEPAKILFLNNAIDQGVYYPLGMQQASETGKSIFFMVASNPGPGLGLLLAFTLFGKGMA
HCCCCEEEEEECHHCCCCCCCCCCHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCC
KKSAPGAMIIHFLGGIHELYFPYVLMKPLTLIAMIAGGMSGTWVFNLLDGGLVAGPSPGS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEECCCCCCC
IFAYLALTPKGSFLATIAGVTAGTAVTFIITAFILKMEKSSEADSEDTFSDSAKAVKAMK
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
QEGKFSYRDVKRIAFVCDAGMGSSAMGATTFRRRLEKAGLTIDVKHYAIENVPDDADIIV
HCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCEEE
THASLEGRVKRVSDKPLILIKNYIGDPCLDDLFNHLTSN
EECCCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MEHKSARAKVQAFGGFLTAMVIPNIGAFIAWGFITALFIPTGWMPNEHFAKIVGPMITYL
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LPVMIGSTGGHLVGGKRGAVMGGIGTIGVIIGADIPMFLGSMIMGPLGGLVIKYIDRLLE
HHHHHCCCCCCEECCCCCCEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KRIPAGFEMVINNFSLGIAGMILCLLGFEVIGPAVLIANNFVKECIESLVHAGYLPLLSL
HHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
INEPAKILFLNNAIDQGVYYPLGMQQASETGKSIFFMVASNPGPGLGLLLAFTLFGKGMA
HCCCCEEEEEECHHCCCCCCCCCCHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCC
KKSAPGAMIIHFLGGIHELYFPYVLMKPLTLIAMIAGGMSGTWVFNLLDGGLVAGPSPGS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEECCCCCCC
IFAYLALTPKGSFLATIAGVTAGTAVTFIITAFILKMEKSSEADSEDTFSDSAKAVKAMK
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
QEGKFSYRDVKRIAFVCDAGMGSSAMGATTFRRRLEKAGLTIDVKHYAIENVPDDADIIV
HCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCEEE
THASLEGRVKRVSDKPLILIKNYIGDPCLDDLFNHLTSN
EECCCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]