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The map label for this gene is helD [H]

Identifier: 194735557

GI number: 194735557

Start: 1125319

End: 1127373

Strand: Direct

Name: helD [H]

Synonym: SeSA_A1138

Alternate gene names: 194735557

Gene position: 1125319-1127373 (Clockwise)

Preceding gene: 194734303

Following gene: 194736723

Centisome position: 23.9

GC content: 55.18

Gene sequence:

>2055_bases
ATGGAACTGAAAGCTACTTCTCTTGGAAAACGTCTGGCGCAACACCCGTATGATCGTGCCGTGATCCTCAACGCTGGGGT
GAAAGTGTCTGGCGACAGGCATGAATATCTTATTCCATTCAATCAGTTATTGGCGATTCACTGTAAGCGTGGGCTGGTAT
GGGGCGAGCTGGAGTTTGTCCTGCCGGAGGATAAAGTCGTGCGTTTGCATGGTACTGAGTGGTCGGAAACCCAGCAATTC
CATCGCTATCTGGACGCGCACTGGCGTCGCTGGAGCCAGGAGATGAGTGATGTCGCCGCGCAGGCATTGCAGGAGCAATG
GGAGCGTATTAGTGAGCGAACGGGCGAAAACCAATGGCTTACCCGTGAACGCGTTCGGGGGCTGGAACACGAAATTCGCC
AGACGTTTGCCGCCTTGCCGCTGCCGGTCTCACGTCTGGAGGAGTTTGCTCACTGTCGCGAGATATGGCGTAAGTGTCTG
GCCTGGTTACAGGATAGCGAGGGAAGTCGGCAGCAGCATAATCAGGCGTATGCTGATGCCATGCTGGAAGCGCATGCCGA
CTTTTTTACGCAGATAGAATCTTCTCCGCTTAATCCTTCCCAGGCCAGGGCGGTGGTTAACGGCGAATCATCGTTACTGG
TACTGGCGGGCGCGGGAAGCGGTAAGACCTCGGTGCTGGTGGCGCGCGCGGGTTGGCTGTTGGCGCGCGGACAAGCAGAT
GCGGGGCAAATTCTTTTACTGGCGTTTGGTCGCAAGGCGGCAGAGGAGATGGATGAGCGTATCCGCGAGCGCTTACATAC
GGAAGAGATTACTGCCCGTACGTTCCATTCGCTGGCGCTGTATATTATTCAGCAAGGCAGTAAAAAAGCGCCGGTTGTCA
GTAAGCTGGAAAGTGACGCCACCGCGCGGCATCAGCTATTTCTGCGCACCTGGCGTCAGCAGTGTAGCGAGAAAAAAGCG
CAGGCCAAAGGCTGGCGTCAGTGGCTGGAAGAGGAGATGCAGTGGGTAGTGCCGGAAGGTAATTTCTGGGACGATGAGAC
ATTGCAGCGGCGTCTGGCCCCTCGCCTGGATCGTTGGGTCAGCTTGATGCGTATGCACGGCGGCGCGCAGGCAGAAATGA
TCGCTGGCGCGCCAGAGGAGTGCCGCGAGCTGTTTGGCAAACGCATTAAGCTGATGGCGCCGCTGCTGAAGGCCTGGAAA
AGCGCGTTGAAAGCGGAAAATGCCGTTGATTTCTCCGGTCTGATCCATCAGGCAATGGTGATCCTCGAAAAAGGGCGTTT
TATCAGCCCGTGGAAGCATATTCTGGTCGATGAATTTCAGGATATTTCCCCGCAACGGGCGGCGCTGTTAGAAGCACTGC
GCAAGCAGAATAGCCAGACTACGCTGTTTGCCGTGGGCGATGACTGGCAGGCGATTTACCGTTTTAGCGGGGCGCAGCTC
TCCTTAACGACGGCGTTTCATCAGATGTTCGGCGAGGGCGAGCATTGCCACCTGGACACCACGTACCGTTTTAACAGTCG
GATTGGCGATATTGCCAATCGCTTTGTACAGCAGAATCCGCACCAGCTTAAAAAACCGTTAAATAGTCTGACCCCAGGCG
ATAAAAAAGCGGTGACGTTATTAGATGAAAGCCAGTTGGACGCGTTACTGGATAAATTATCCGGCTATGCGAAGGAAGAT
GAACGTATCCTGGTGCTGGCGCGCTATCATCATCTGAAACCCGCGAGTCTACAAAAAGCGGCGACTCGCTGGCCGAAGTT
ACAGATAGACTTCATGACTATCCATGCCAGCAAAGGCCAACAGGCCGATTACGTGATTCTTGTCGGATTGCAGGAGGGTA
ACGACGGTTTCCCCGCCCCGGCGCGAGAATCCATTATGGAAAGTGCGCTTCTTCCTCAGGTTGAGGATTTTCCGGACGCT
GAAGAGCGGCGTTTGTTATATGTGGCGTTGACGCGCGCGCGTGCGCGGGTCTGGCTGCTTTTTAATAAAGATAATCCCTC
GCGCTTTGTGGAGGCGCTTAAACAGCTGGATGTGCCGGTGGCGAGGAAGCCCTAA

Upstream 100 bases:

>100_bases
TCTATCACTGCGGGCAATTGTAACGTTTTTTTAGACTGGAGCACGTTTTCTCTGGCGGTTACACTGATAAGCACATCTTT
ACGTCTGGATTCGCTGAGTC

Downstream 100 bases:

>100_bases
AGCGCGGGCGGTACAGCATCCCGCCCGCGTAGCGGTTATTTCAGGCCGCGTAGCGGTTATTTCAGGCGCTCGGCCAGATA
ACGCGCATAATCCGGAATAA

Product: DNA helicase IV

Products: NA

Alternate protein names: 75 kDa helicase [H]

Number of amino acids: Translated: 684; Mature: 684

Protein sequence:

>684_residues
MELKATSLGKRLAQHPYDRAVILNAGVKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFVLPEDKVVRLHGTEWSETQQF
HRYLDAHWRRWSQEMSDVAAQALQEQWERISERTGENQWLTRERVRGLEHEIRQTFAALPLPVSRLEEFAHCREIWRKCL
AWLQDSEGSRQQHNQAYADAMLEAHADFFTQIESSPLNPSQARAVVNGESSLLVLAGAGSGKTSVLVARAGWLLARGQAD
AGQILLLAFGRKAAEEMDERIRERLHTEEITARTFHSLALYIIQQGSKKAPVVSKLESDATARHQLFLRTWRQQCSEKKA
QAKGWRQWLEEEMQWVVPEGNFWDDETLQRRLAPRLDRWVSLMRMHGGAQAEMIAGAPEECRELFGKRIKLMAPLLKAWK
SALKAENAVDFSGLIHQAMVILEKGRFISPWKHILVDEFQDISPQRAALLEALRKQNSQTTLFAVGDDWQAIYRFSGAQL
SLTTAFHQMFGEGEHCHLDTTYRFNSRIGDIANRFVQQNPHQLKKPLNSLTPGDKKAVTLLDESQLDALLDKLSGYAKED
ERILVLARYHHLKPASLQKAATRWPKLQIDFMTIHASKGQQADYVILVGLQEGNDGFPAPARESIMESALLPQVEDFPDA
EERRLLYVALTRARARVWLLFNKDNPSRFVEALKQLDVPVARKP

Sequences:

>Translated_684_residues
MELKATSLGKRLAQHPYDRAVILNAGVKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFVLPEDKVVRLHGTEWSETQQF
HRYLDAHWRRWSQEMSDVAAQALQEQWERISERTGENQWLTRERVRGLEHEIRQTFAALPLPVSRLEEFAHCREIWRKCL
AWLQDSEGSRQQHNQAYADAMLEAHADFFTQIESSPLNPSQARAVVNGESSLLVLAGAGSGKTSVLVARAGWLLARGQAD
AGQILLLAFGRKAAEEMDERIRERLHTEEITARTFHSLALYIIQQGSKKAPVVSKLESDATARHQLFLRTWRQQCSEKKA
QAKGWRQWLEEEMQWVVPEGNFWDDETLQRRLAPRLDRWVSLMRMHGGAQAEMIAGAPEECRELFGKRIKLMAPLLKAWK
SALKAENAVDFSGLIHQAMVILEKGRFISPWKHILVDEFQDISPQRAALLEALRKQNSQTTLFAVGDDWQAIYRFSGAQL
SLTTAFHQMFGEGEHCHLDTTYRFNSRIGDIANRFVQQNPHQLKKPLNSLTPGDKKAVTLLDESQLDALLDKLSGYAKED
ERILVLARYHHLKPASLQKAATRWPKLQIDFMTIHASKGQQADYVILVGLQEGNDGFPAPARESIMESALLPQVEDFPDA
EERRLLYVALTRARARVWLLFNKDNPSRFVEALKQLDVPVARKP
>Mature_684_residues
MELKATSLGKRLAQHPYDRAVILNAGVKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFVLPEDKVVRLHGTEWSETQQF
HRYLDAHWRRWSQEMSDVAAQALQEQWERISERTGENQWLTRERVRGLEHEIRQTFAALPLPVSRLEEFAHCREIWRKCL
AWLQDSEGSRQQHNQAYADAMLEAHADFFTQIESSPLNPSQARAVVNGESSLLVLAGAGSGKTSVLVARAGWLLARGQAD
AGQILLLAFGRKAAEEMDERIRERLHTEEITARTFHSLALYIIQQGSKKAPVVSKLESDATARHQLFLRTWRQQCSEKKA
QAKGWRQWLEEEMQWVVPEGNFWDDETLQRRLAPRLDRWVSLMRMHGGAQAEMIAGAPEECRELFGKRIKLMAPLLKAWK
SALKAENAVDFSGLIHQAMVILEKGRFISPWKHILVDEFQDISPQRAALLEALRKQNSQTTLFAVGDDWQAIYRFSGAQL
SLTTAFHQMFGEGEHCHLDTTYRFNSRIGDIANRFVQQNPHQLKKPLNSLTPGDKKAVTLLDESQLDALLDKLSGYAKED
ERILVLARYHHLKPASLQKAATRWPKLQIDFMTIHASKGQQADYVILVGLQEGNDGFPAPARESIMESALLPQVEDFPDA
EERRLLYVALTRARARVWLLFNKDNPSRFVEALKQLDVPVARKP

Specific function: Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase ATP-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787196, Length=684, Percent_Identity=84.2105263157895, Blast_Score=1200, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=341, Percent_Identity=29.9120234604106, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI2367296, Length=339, Percent_Identity=28.023598820059, Blast_Score=94, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000212
- InterPro:   IPR014016
- InterPro:   IPR022161
- InterPro:   IPR003661 [H]

Pfam domain/function: PF12462 Nucleolin_N; PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 78203; Mature: 78203

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKATSLGKRLAQHPYDRAVILNAGVKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFV
CCCCHHHHHHHHHHCCCCCEEEEECCEEECCCCCEEECCHHHHHHHHHHCCCEEEEEEEE
LPEDKVVRLHGTEWSETQQFHRYLDAHWRRWSQEMSDVAAQALQEQWERISERTGENQWL
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
TRERVRGLEHEIRQTFAALPLPVSRLEEFAHCREIWRKCLAWLQDSEGSRQQHNQAYADA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MLEAHADFFTQIESSPLNPSQARAVVNGESSLLVLAGAGSGKTSVLVARAGWLLARGQAD
HHHHHHHHHHHHCCCCCCHHHCEEEEECCCCEEEEEECCCCCCEEEEEECCEEEECCCCC
AGQILLLAFGRKAAEEMDERIRERLHTEEITARTFHSLALYIIQQGSKKAPVVSKLESDA
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCH
TARHQLFLRTWRQQCSEKKAQAKGWRQWLEEEMQWVVPEGNFWDDETLQRRLAPRLDRWV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHH
SLMRMHGGAQAEMIAGAPEECRELFGKRIKLMAPLLKAWKSALKAENAVDFSGLIHQAMV
HHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ILEKGRFISPWKHILVDEFQDISPQRAALLEALRKQNSQTTLFAVGDDWQAIYRFSGAQL
HHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCEE
SLTTAFHQMFGEGEHCHLDTTYRFNSRIGDIANRFVQQNPHQLKKPLNSLTPGDKKAVTL
HHHHHHHHHHCCCCEEEEECEEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEE
LDESQLDALLDKLSGYAKEDERILVLARYHHLKPASLQKAATRWPKLQIDFMTIHASKGQ
ECHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEEECCCCC
QADYVILVGLQEGNDGFPAPARESIMESALLPQVEDFPDAEERRLLYVALTRARARVWLL
CCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHCEEEEEEEHHCCEEEEEE
FNKDNPSRFVEALKQLDVPVARKP
EECCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MELKATSLGKRLAQHPYDRAVILNAGVKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFV
CCCCHHHHHHHHHHCCCCCEEEEECCEEECCCCCEEECCHHHHHHHHHHCCCEEEEEEEE
LPEDKVVRLHGTEWSETQQFHRYLDAHWRRWSQEMSDVAAQALQEQWERISERTGENQWL
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
TRERVRGLEHEIRQTFAALPLPVSRLEEFAHCREIWRKCLAWLQDSEGSRQQHNQAYADA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MLEAHADFFTQIESSPLNPSQARAVVNGESSLLVLAGAGSGKTSVLVARAGWLLARGQAD
HHHHHHHHHHHHCCCCCCHHHCEEEEECCCCEEEEEECCCCCCEEEEEECCEEEECCCCC
AGQILLLAFGRKAAEEMDERIRERLHTEEITARTFHSLALYIIQQGSKKAPVVSKLESDA
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCH
TARHQLFLRTWRQQCSEKKAQAKGWRQWLEEEMQWVVPEGNFWDDETLQRRLAPRLDRWV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHH
SLMRMHGGAQAEMIAGAPEECRELFGKRIKLMAPLLKAWKSALKAENAVDFSGLIHQAMV
HHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ILEKGRFISPWKHILVDEFQDISPQRAALLEALRKQNSQTTLFAVGDDWQAIYRFSGAQL
HHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCEE
SLTTAFHQMFGEGEHCHLDTTYRFNSRIGDIANRFVQQNPHQLKKPLNSLTPGDKKAVTL
HHHHHHHHHHCCCCEEEEECEEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEE
LDESQLDALLDKLSGYAKEDERILVLARYHHLKPASLQKAATRWPKLQIDFMTIHASKGQ
ECHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEEECCCCC
QADYVILVGLQEGNDGFPAPARESIMESALLPQVEDFPDAEERRLLYVALTRARARVWLL
CCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHCEEEEEEEHHCCEEEEEE
FNKDNPSRFVEALKQLDVPVARKP
EECCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2542273; 8905232; 9278503 [H]