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The map label for this gene is cls [H]

Identifier: 194735331

GI number: 194735331

Start: 1810255

End: 1811715

Strand: Direct

Name: cls [H]

Synonym: SeSA_A1873

Alternate gene names: 194735331

Gene position: 1810255-1811715 (Clockwise)

Preceding gene: 194733929

Following gene: 194737781

Centisome position: 38.44

GC content: 53.66

Gene sequence:

>1461_bases
ATGACAACCTTCTACACCGTGGTGAGTTGGCTGGTCATTTTGGGATACTGGGTTCTCATTGCCGGCGTCACATTACGTAT
TCTAATGAAACGGCGCGCAGTTCCCTCCGCAATGGCCTGGTTATTAATCATCTATATCCTTCCGCTGGTCGGGATCATCG
CCTATTTGTCCGTGGGCGAATTGCATTTAGGCAAACGTCGCGCCGAGCGTGCCCGTGCCATGTGGCCGTCTACCGCCAAA
TGGTTGAATGACCTCAAAGCCTGCAAACACATTTTCGCGCAAGAAAACAGTAGCGTCGCATCGTCCTTGTTTAAGCTGTG
CGAACGACGTCAGGGGATTGCGGGCGTCAAAGGCAACCAGTTGCAATTGCTTACCGACTCCGATGATGTCATGCAGGCGC
TTATTCGCGATATCCAACTGGCGCGGCATAATATCGAAATGGTATTTTACATCTGGCAGCCAGGCGGCATGGCGGATCAG
GTCGCTGAATCGTTAATGGCCGCCGCCCGCCGCGGCATCCACTGCCGGCTTATGCTGGATTCCGCGGGTAGCGTCGCTTT
CTTCCGCAGCCCCTGGGCGGCCATGATGCGTAACGCTGGCATTGAAGTCGTAGAGGCGCTGAAGGTGAATCTGATGCGCG
TCTTTTTACGCCGTATGGATCTTCGCCAGCACCGTAAAATGGTGATGATTGACAATTACATCGCCTATACCGGCAGTATG
AATATGGTGGACCCGCGTTTTTTCAAACAGGATGCCGGCGTTGGGCAATGGGTCGATTTAATGGCGCGGATGGAGGGCCC
CGTGGCGACAGCAATGGGGATTGTTTACTCCTGCGATTGGGAAATTGAGACGGGTAAACGCATTCTGCCTCCCCCGCCGG
ATGTGAATATTATGCCGTTTGAGCAGGCCAGCGGGCATACCATTCATACCATTGCTTCCGGTCCTGGTTTTCCGGAGGAT
CTCATTCACCAGGCACTATTAACCGCCACCTATGCTGCGCGCGAATATTTAATTATGACCACGCCATATTTCGTCCCCAG
CGACGATCTGCTGCACGCCATTTGTACCGCTGCGCAGCGCGGCGTGGATGTCAGTATTATCCTGCCGCGTAAAAATGATT
CACTGCTCGTCGGCTGGGCCAGTCGCGCCTTTTTCAGCGAGTTACTGGCGGCGGGCGTGAAAATCTATCAGTTCGAAGGC
GGGCTGTTGCATACCAAAAGCGTGCTGGTCGATGGCGAACTGAGCCTGGTCGGTACCGTGAATCTCGACATGCGTAGCCT
GTGGCTTAATTTCGAGATTACGCTGGTCATTGATGATACGGGTTTCGGCGCCGATCTGGCTGCGGTACAGGACGATTATA
TTTCGCGCTCCCGCCTGTTAGATGCGCGTTTGTGGGTAAAACGTCCGTTATGGCAGCGTATTACCGAGCGATTGTTTTAC
TTCTTTAGTCCATTGCTGTAA

Upstream 100 bases:

>100_bases
CGCCGGATGCAGACCAGCGCTTTTCCCGTGTTTTTATTTGCCATGTGAATCCTGACGCGTAAACTCTTAACAACACGCTT
TCTAAAGGATTTTTAAAGTT

Downstream 100 bases:

>100_bases
AACGTGACCAACATGAGTAAACAGGTAGTCACTATGGAAATGGATCTGAACAATCGCCTGACTGAAGACGAAACGCTTGA
GCAGGCTTACGATATTTTTC

Product: cardiolipin synthetase

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTTFYTVVSWLVILGYWVLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLSVGELHLGKRRAERARAMWPSTAK
WLNDLKACKHIFAQENSSVASSLFKLCERRQGIAGVKGNQLQLLTDSDDVMQALIRDIQLARHNIEMVFYIWQPGGMADQ
VAESLMAAARRGIHCRLMLDSAGSVAFFRSPWAAMMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMVMIDNYIAYTGSM
NMVDPRFFKQDAGVGQWVDLMARMEGPVATAMGIVYSCDWEIETGKRILPPPPDVNIMPFEQASGHTIHTIASGPGFPED
LIHQALLTATYAAREYLIMTTPYFVPSDDLLHAICTAAQRGVDVSIILPRKNDSLLVGWASRAFFSELLAAGVKIYQFEG
GLLHTKSVLVDGELSLVGTVNLDMRSLWLNFEITLVIDDTGFGADLAAVQDDYISRSRLLDARLWVKRPLWQRITERLFY
FFSPLL

Sequences:

>Translated_486_residues
MTTFYTVVSWLVILGYWVLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLSVGELHLGKRRAERARAMWPSTAK
WLNDLKACKHIFAQENSSVASSLFKLCERRQGIAGVKGNQLQLLTDSDDVMQALIRDIQLARHNIEMVFYIWQPGGMADQ
VAESLMAAARRGIHCRLMLDSAGSVAFFRSPWAAMMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMVMIDNYIAYTGSM
NMVDPRFFKQDAGVGQWVDLMARMEGPVATAMGIVYSCDWEIETGKRILPPPPDVNIMPFEQASGHTIHTIASGPGFPED
LIHQALLTATYAAREYLIMTTPYFVPSDDLLHAICTAAQRGVDVSIILPRKNDSLLVGWASRAFFSELLAAGVKIYQFEG
GLLHTKSVLVDGELSLVGTVNLDMRSLWLNFEITLVIDDTGFGADLAAVQDDYISRSRLLDARLWVKRPLWQRITERLFY
FFSPLL
>Mature_485_residues
TTFYTVVSWLVILGYWVLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLSVGELHLGKRRAERARAMWPSTAKW
LNDLKACKHIFAQENSSVASSLFKLCERRQGIAGVKGNQLQLLTDSDDVMQALIRDIQLARHNIEMVFYIWQPGGMADQV
AESLMAAARRGIHCRLMLDSAGSVAFFRSPWAAMMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMVMIDNYIAYTGSMN
MVDPRFFKQDAGVGQWVDLMARMEGPVATAMGIVYSCDWEIETGKRILPPPPDVNIMPFEQASGHTIHTIASGPGFPEDL
IHQALLTATYAAREYLIMTTPYFVPSDDLLHAICTAAQRGVDVSIILPRKNDSLLVGWASRAFFSELLAAGVKIYQFEGG
LLHTKSVLVDGELSLVGTVNLDMRSLWLNFEITLVIDDTGFGADLAAVQDDYISRSRLLDARLWVKRPLWQRITERLFYF
FSPLL

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=486, Percent_Identity=94.4444444444444, Blast_Score=961, Evalue=0.0,
Organism=Escherichia coli, GI1787007, Length=386, Percent_Identity=26.6839378238342, Blast_Score=105, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 54735; Mature: 54604

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFYTVVSWLVILGYWVLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLSVGE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCH
LHLGKRRAERARAMWPSTAKWLNDLKACKHIFAQENSSVASSLFKLCERRQGIAGVKGNQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCE
LQLLTDSDDVMQALIRDIQLARHNIEMVFYIWQPGGMADQVAESLMAAARRGIHCRLMLD
EEEEECCHHHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEC
SAGSVAFFRSPWAAMMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMVMIDNYIAYTGSM
CCCCEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECEEEEECCC
NMVDPRFFKQDAGVGQWVDLMARMEGPVATAMGIVYSCDWEIETGKRILPPPPDVNIMPF
CCCCCHHHHHCCCCCHHHHHHHHHCCCHHHHHHEEEEECEEECCCCCCCCCCCCCEEEEC
EQASGHTIHTIASGPGFPEDLIHQALLTATYAAREYLIMTTPYFVPSDDLLHAICTAAQR
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHC
GVDVSIILPRKNDSLLVGWASRAFFSELLAAGVKIYQFEGGLLHTKSVLVDGELSLVGTV
CCEEEEEEECCCCCEEEEEHHHHHHHHHHHCCEEEEEECCCEEEECEEEECCCEEEEEEE
NLDMRSLWLNFEITLVIDDTGFGADLAAVQDDYISRSRLLDARLWVKRPLWQRITERLFY
CCCCEEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
FFSPLL
HHHCCC
>Mature Secondary Structure 
TTFYTVVSWLVILGYWVLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLSVGE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCH
LHLGKRRAERARAMWPSTAKWLNDLKACKHIFAQENSSVASSLFKLCERRQGIAGVKGNQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCE
LQLLTDSDDVMQALIRDIQLARHNIEMVFYIWQPGGMADQVAESLMAAARRGIHCRLMLD
EEEEECCHHHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEC
SAGSVAFFRSPWAAMMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMVMIDNYIAYTGSM
CCCCEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECEEEEECCC
NMVDPRFFKQDAGVGQWVDLMARMEGPVATAMGIVYSCDWEIETGKRILPPPPDVNIMPF
CCCCCHHHHHCCCCCHHHHHHHHHCCCHHHHHHEEEEECEEECCCCCCCCCCCCCEEEEC
EQASGHTIHTIASGPGFPEDLIHQALLTATYAAREYLIMTTPYFVPSDDLLHAICTAAQR
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHC
GVDVSIILPRKNDSLLVGWASRAFFSELLAAGVKIYQFEGGLLHTKSVLVDGELSLVGTV
CCEEEEEEECCCCCEEEEEHHHHHHHHHHHCCEEEEEECCCEEEECEEEECCCEEEEEEE
NLDMRSLWLNFEITLVIDDTGFGADLAAVQDDYISRSRLLDARLWVKRPLWQRITERLFY
CCCCEEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
FFSPLL
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA