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The map label for this gene is gyrA [H]

Identifier: 194735318

GI number: 194735318

Start: 2379489

End: 2382125

Strand: Reverse

Name: gyrA [H]

Synonym: SeSA_A2498

Alternate gene names: 194735318

Gene position: 2382125-2379489 (Counterclockwise)

Preceding gene: 194735769

Following gene: 194734600

Centisome position: 50.59

GC content: 55.71

Gene sequence:

>2637_bases
ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAAGAGCTGAAGAGCTCCTATCTGGATTATGCGATGTC
GGTCATTGTTGGCCGTGCGCTGCCGGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACG
TATTGGGCAATGACTGGAACAAAGCCTATAAAAAATCTGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCATCCCCAC
GGCGATTTCGCAGTGTATGGCACCATCGTTCGTATGGCGCAGCCATTCTCGCTGCGTTACATGCTGGTGGATGGTCAGGG
TAACTTCGGTTCTATTGACGGCGACTCCGCGGCGGCAATGCGTTATACGGAGATCCGTCTGGCGAAAATCGCCCACGAAC
TGATGGCCGATCTCGAAAAAGAGACGGTGGATTTCGTGGATAACTATGACGGTACGGAAAAAATTCCGGACGTCATGCCG
ACCAAAATTCCGAATCTGCTGGTGAACGGTTCTTCCGGTATCGCAGTAGGTATGGCGACGAATATCCCGCCGCACAACCT
GACGGAAGTGATTAACGGCTGCCTGGCGTATATCGACAACGAAGACATCAGCATTGAAGGGCTGATGGAACATATTCCGG
GTCCGGACTTCCCGACCGCCGCGATCATCAACGGTCGTCGTGGTATCGAAGAAGCCTACCGTACCGGTCGTGGCAAAGTG
TACATCCGCGCCCGCGCGGAAGTTGAAGCTGACGCCAAAACGGGCCGCGAAACCATCATCGTCCATGAAATTCCCTATCA
GGTGAACAAAGCGCGCCTGATCGAGAAAATCGCCGAGCTGGTGAAAGATAAACGCGTGGAAGGCATCAGCGCGCTGCGTG
ACGAATCCGATAAAGACGGGATGCGCATCGTGATTGAAGTGAAACGCGATGCGGTGGGCGAGGTGGTGCTTAATAATCTC
TACTCCCAGACCCAGCTACAGGTTTCCTTCGGTATTAACATGGTGGCGCTGCATCACGGCCAGCCGAAGATCATGAACCT
GAAAGACATCATTTCAGCGTTCGTGCGCCACCGCCGTGAAGTGGTGACGCGTCGTACTATTTTTGAACTGCGTAAAGCCC
GTGACCGCGCGCATATCCTTGAAGCTCTGGCGATTGCGCTAGCTAACATCGACCCGATTATCGAACTGATTCGCCGCGCG
CCAACGCCGGCAGAAGCAAAAGCGGCGCTGATTTCGCGTCCGTGGGATCTGGGCAACGTTGCTGCGATGCTGGAGCGCGC
TGGTGATGACGCTGCGCGTCCGGAATGGCTGGAGCCAGAATTTGGCGTGCGTGACGGTCAGTACTACCTGACTGAGCAGC
AGGCGCAGGCGATTCTGGATCTGCGTTTGCAGAAACTGACCGGCCTGGAGCATGAAAAACTGCTCGACGAATACAAAGAG
TTGCTGGAGCAGATTGCTGAACTGCTGCACATTCTGGGCAGCGCCGATCGCCTGATGGAAGTGATCCGCGAAGAGATGGA
GTTAATTCGCGATCAGTTCGGCGATGAGCGTCGTACCGAAATCACCGCTAACAGCGCCGATATTAATATCGAAGATCTGA
TTAGCCAGGAAGATGTTGTCGTGACGCTGTCTCACCAGGGTTACGTCAAATATCAACCGCTGACGGATTACGAAGCGCAA
CGTCGTGGTGGGAAAGGTAAATCTGCCGCGCGTATTAAAGAAGAAGACTTTATCGACCGCCTGCTGGTGGCCAACACTCA
TGACACCATCCTCTGCTTCTCCAGCCGGGGCCGTCTGTACTGGATGAAGGTCTATCAGTTGCCGGAAGCCAGTCGTGGCG
CGCGCGGTCGTCCGATCGTCAACCTGCTGCCGCTGGAAGCCAACGAACGTATCACCGCGATTCTGCCGGTTCGTGAGTAC
GAAGAAGGCGTGAACGTCTTTATGGCGACCGCCAGCGGTACCGTGAAGAAAACGGCGCTGACCGAATTCAGCCGTCCGCG
TTCCGCCGGTATTATCGCGGTGAACCTCAACGACGGCGACGAGCTGATTGGCGTTGACCTGACTTCTGGTTCTGACGAAG
TCATGCTGTTCTCGGCCGCGGGTAAAGTGGTGCGCTTCAAAGAAGACGCCGTCCGTGCGATGGGGCGTACCGCGACCGGT
GTGCGCGGTATTAAGCTGGCGGGAGACGATAAAGTCGTCTCTCTGATCATCCCACGCGGCGAAGGGGCAATCCTGACCGT
CACGCAGAATGGTTACGGCAAACGCACCGCAGCTGAAGAGTATCCAACCAAGTCGCGTGCGACGCAAGGCGTTATCTCTA
TCAAAGTCACCGAGCGCAACGGTTCCGTTGTTGGCGCGGTACAGGTGGACGATTGCGACCAGATCATGATGATCACGGAT
GCCGGTACTCTGGTGCGTACCCGTGTGTCCGAGATCAGCGTAGTGGGACGTAATACCCAGGGCGTTATCCTTATCCGCAC
GGCGGAAGATGAAAACGTGGTGGGTCTACAACGCGTTGCTGAACCGGTAGATGACGAAGAACTCGACGCTATCGACGGCA
GCGTGGCGGAAGGGGATGAGGATATCGCCCCGGAAGCGGAAAGCGATGACGACGTTGCGGATGACGCTGACGAGTAA

Upstream 100 bases:

>100_bases
TAAAGCATTGTCTGGCTGCATTCCGTTTACCAGTACGTGGGCGAATGTGTTATAATTTGCGACCTTTGAATCCGGGATAC
AGTAGAGGGATAGCGGTTAG

Downstream 100 bases:

>100_bases
TGTTATTGCTGTGCGAGGGCCGGATATCCGGCCCTTTTTCTTTGCCGTTGCGGGCTACGTCATTTACCGCTACCTTAGTC
ACACTCTATTTACATCCTGA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 878; Mature: 877

Protein sequence:

>878_residues
MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPH
GDFAVYGTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMP
TKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKV
YIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNL
YSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRA
PTPAEAKAALISRPWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
LLEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVVVTLSHQGYVKYQPLTDYEAQ
RRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREY
EEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATG
VRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAAEEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITD
AGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSVAEGDEDIAPEAESDDDVADDADE

Sequences:

>Translated_878_residues
MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPH
GDFAVYGTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMP
TKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKV
YIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNL
YSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRA
PTPAEAKAALISRPWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
LLEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVVVTLSHQGYVKYQPLTDYEAQ
RRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREY
EEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATG
VRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAAEEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITD
AGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSVAEGDEDIAPEAESDDDVADDADE
>Mature_877_residues
SDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHG
DFAVYGTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPT
KIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVY
IRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLY
SQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAP
TPAEAKAALISRPWDLGNVAAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKEL
LEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVVVTLSHQGYVKYQPLTDYEAQR
RGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYE
EGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATGV
RGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAAEEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDA
GTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDAIDGSVAEGDEDIAPEAESDDDVADDADE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=341, Percent_Identity=26.6862170087977, Blast_Score=82, Evalue=3e-15,
Organism=Homo sapiens, GI19913406, Length=319, Percent_Identity=26.3322884012539, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI1788562, Length=871, Percent_Identity=91.7336394948335, Blast_Score=1628, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=715, Percent_Identity=35.9440559440559, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17535065, Length=167, Percent_Identity=33.5329341317365, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=166, Percent_Identity=33.1325301204819, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212645845, Length=371, Percent_Identity=26.1455525606469, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=349, Percent_Identity=25.7879656160458, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 97082; Mature: 96950

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWN
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHH
KAYKKSARVVGDVIGKYHPHGDFAVYGTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEC
NIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKV
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCEEEECCCCCHHHHHHCCCCEE
YIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDG
EEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRRE
CEEEEEECCHHHHHHHHHHHHHHCEEEEEECCEEEEEECCCCCEECHHHHHHHHHHHHHH
VVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAALISRPWDLGNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHH
AAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHCCCCCEE
VTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLY
EEEECCCEEEECCCCCHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCCCEEEEECCCCCEE
WMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGVNVFMATASGTVKKTAL
EEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEECHHHHHCCCEEEEEECCCCCHHHHH
TEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATG
HHCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEECCCCEEEEHHHHHHHHCCCCCC
VRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAAEEYPTKSRATQGVISIKVTERN
CCEEEECCCCEEEEEEEECCCCEEEEEECCCCCCCCCHHHCCCHHHCCCCEEEEEEEECC
GSVVGAVQVDDCDQIMMITDAGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVA
CCEEEEEEECCCCEEEEEECCCHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCHHHHHC
EPVDDEELDAIDGSVAEGDEDIAPEAESDDDVADDADE
CCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWN
CCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHH
KAYKKSARVVGDVIGKYHPHGDFAVYGTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEC
NIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKV
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCEEEECCCCCHHHHHHCCCCEE
YIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDG
EEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRRE
CEEEEEECCHHHHHHHHHHHHHHCEEEEEECCEEEEEECCCCCEECHHHHHHHHHHHHHH
VVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAALISRPWDLGNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHH
AAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHCCCCCEE
VTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLY
EEEECCCEEEECCCCCHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCCCEEEEECCCCCEE
WMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGVNVFMATASGTVKKTAL
EEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEECHHHHHCCCEEEEEECCCCCHHHHH
TEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATG
HHCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEECCCCEEEEHHHHHHHHCCCCCC
VRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAAEEYPTKSRATQGVISIKVTERN
CCEEEECCCCEEEEEEEECCCCEEEEEECCCCCCCCCHHHCCCHHHCCCCEEEEEEEECC
GSVVGAVQVDDCDQIMMITDAGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVA
CCEEEEEEECCCCEEEEEECCCHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCHHHHHC
EPVDDEELDAIDGSVAEGDEDIAPEAESDDDVADDADE
CCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 8849216 [H]