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The map label for this gene is tyrR [H]

Identifier: 194734622

GI number: 194734622

Start: 1749355

End: 1750896

Strand: Reverse

Name: tyrR [H]

Synonym: SeSA_A1808

Alternate gene names: 194734622

Gene position: 1750896-1749355 (Counterclockwise)

Preceding gene: 194734584

Following gene: 194738379

Centisome position: 37.18

GC content: 53.24

Gene sequence:

>1542_bases
ATGCGTCTGGAAGTCTTTTGTGAAGACCGACTTGGTCTGACCCGCGAATTACTTGATTTACTGGTGTTACGTAGCATTGA
TTTACGCGGAATCGAGATTGATCCCATTGGGCGAATTTATCTTAATTTTGCTGAGCTGGAATTCACCGACTTTAGCAGCC
TGATGGCCGAAATCCGCCGTATTTCCGGCGTAACGGATGTCCGTACCGTTCCCTGGATGCCGTCCGAACGTGAACATCTG
GCCCTGAGCGCGCTGCTTGAGGCGTTGCCGGAGCCGGTGCTCTCATTGGATATGAAGAGTAAAGTGGAGATGGCGAACCC
GGCGAGTTGTCAGCTTTTTGCCCAGAGCCAGGAGCGAATGCGGCACCATACCGCCGCACAATTAATCAATGGCTTCAATT
TTCAGCGCTGGCTGGACGGTAATCCGCAAAGCTCCCATAACGAACATGTCGTGATCAACGGGCAAAACTTCCTGATGGAG
ATTACGCCGGTACATTTACAAAACGAAAATGACGAATACGTGTTGACCGGGGCGGTCGTGATGTTGCGTTCCACTATTCG
TATGGGGCAGCAGCTACAGAATTTGTCCACGCAGGATCTGAGCGCGTTTAGTCAGATTATTGCCGTGAGCGCAAAGATGA
AGCACGTCGTTGAGCAGGCGCGCAAACTGGCGATGCTCAGCGCGCCGCTGCTGATTACCGGCGATACGGGAACCGGCAAA
GATCTTTTCGCCTATGCCTGTCATCAGGCAAGCCCTCGTTCAGCGAAGCCGTATCTGGCGCTCAACTGCGCTTCAATCCC
GGAAGATGCGGTAGAAAGCGAACTATTTGGCCATGCGCCGGAAGGTAAAAAAGGCTTTTTTGAACAGGCGAATGGCGGTT
CGGTGCTGCTGGATGAAATTGGCGAAATGTCGCCGCGTATGCAGGCGAAGCTGCTACGTTTTCTCAACGATGGTACGTTC
CGTCGCGTCGGCGAAGATCACGAAATTCATGTTGATGTCCGCGTTATCTGCGCCACGCAGAAAAATCTGGTGGAGCTGGT
GCAAAAAGGACTGTTCCGCGAAGATCTCTATTATCGACTTAACGTTCTGACGCTTAATTTGCCGCCGTTGCGCGATTGTC
CGCAGGATATTATGCCGTTGACCGAACTGTTCGTGGCGCGTTTTGCCGACGAACAGGGCGTTCCGCGACCGAAACTGTCT
GCCGATCTGAGTACGGTCCTCACTCGTTACGGCTGGCCGGGTAACGTTCGCCAGCTTAAAAATGCGATTTACCGGGCGCT
GACGCAACTGGAAGGGTATGAGCTGCGTCCGCAGGATATCCTGCTGCCTGACTACGATGCCGCGACGGTGGCAGTCGGCG
AAGATGCGATGGAAGGTTCGCTGGATGACATTACCAGTCGTTTTGAACGTTCTGTCCTGACCCAGCTTTATCGTAGCTAT
CCGAGTACGCGTAAACTGGCGAAACGGTTGGGGGTATCGCACACCGCGATTGCCAATAAGCTGCGTGAATATGGTCTGAG
CCAGAAGAAGGGTGAAGAGTAG

Upstream 100 bases:

>100_bases
TTTCCGTCATGCTGTCAATATTTGTTGACAGAATCCTTCCTGCCAGCCGAATAGTGGCTTATCATCTATTTAATGGTTCA
TTATTCAGGTGAAGGTTCCC

Downstream 100 bases:

>100_bases
AAAAAAAGAAGGCCTCTGGATAGAGGCCTTCTTGTGACAAAAGAGCACCGCCTGTAGCACTGACAAACGTAGCGCCAGCA
GTCGCTGGCTTATGCCTTCA

Product: DNA-binding transcriptional regulator TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MRLEVFCEDRLGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFAELEFTDFSSLMAEIRRISGVTDVRTVPWMPSEREHL
ALSALLEALPEPVLSLDMKSKVEMANPASCQLFAQSQERMRHHTAAQLINGFNFQRWLDGNPQSSHNEHVVINGQNFLME
ITPVHLQNENDEYVLTGAVVMLRSTIRMGQQLQNLSTQDLSAFSQIIAVSAKMKHVVEQARKLAMLSAPLLITGDTGTGK
DLFAYACHQASPRSAKPYLALNCASIPEDAVESELFGHAPEGKKGFFEQANGGSVLLDEIGEMSPRMQAKLLRFLNDGTF
RRVGEDHEIHVDVRVICATQKNLVELVQKGLFREDLYYRLNVLTLNLPPLRDCPQDIMPLTELFVARFADEQGVPRPKLS
ADLSTVLTRYGWPGNVRQLKNAIYRALTQLEGYELRPQDILLPDYDAATVAVGEDAMEGSLDDITSRFERSVLTQLYRSY
PSTRKLAKRLGVSHTAIANKLREYGLSQKKGEE

Sequences:

>Translated_513_residues
MRLEVFCEDRLGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFAELEFTDFSSLMAEIRRISGVTDVRTVPWMPSEREHL
ALSALLEALPEPVLSLDMKSKVEMANPASCQLFAQSQERMRHHTAAQLINGFNFQRWLDGNPQSSHNEHVVINGQNFLME
ITPVHLQNENDEYVLTGAVVMLRSTIRMGQQLQNLSTQDLSAFSQIIAVSAKMKHVVEQARKLAMLSAPLLITGDTGTGK
DLFAYACHQASPRSAKPYLALNCASIPEDAVESELFGHAPEGKKGFFEQANGGSVLLDEIGEMSPRMQAKLLRFLNDGTF
RRVGEDHEIHVDVRVICATQKNLVELVQKGLFREDLYYRLNVLTLNLPPLRDCPQDIMPLTELFVARFADEQGVPRPKLS
ADLSTVLTRYGWPGNVRQLKNAIYRALTQLEGYELRPQDILLPDYDAATVAVGEDAMEGSLDDITSRFERSVLTQLYRSY
PSTRKLAKRLGVSHTAIANKLREYGLSQKKGEE
>Mature_513_residues
MRLEVFCEDRLGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFAELEFTDFSSLMAEIRRISGVTDVRTVPWMPSEREHL
ALSALLEALPEPVLSLDMKSKVEMANPASCQLFAQSQERMRHHTAAQLINGFNFQRWLDGNPQSSHNEHVVINGQNFLME
ITPVHLQNENDEYVLTGAVVMLRSTIRMGQQLQNLSTQDLSAFSQIIAVSAKMKHVVEQARKLAMLSAPLLITGDTGTGK
DLFAYACHQASPRSAKPYLALNCASIPEDAVESELFGHAPEGKKGFFEQANGGSVLLDEIGEMSPRMQAKLLRFLNDGTF
RRVGEDHEIHVDVRVICATQKNLVELVQKGLFREDLYYRLNVLTLNLPPLRDCPQDIMPLTELFVARFADEQGVPRPKLS
ADLSTVLTRYGWPGNVRQLKNAIYRALTQLEGYELRPQDILLPDYDAATVAVGEDAMEGSLDDITSRFERSVLTQLYRSY
PSTRKLAKRLGVSHTAIANKLREYGLSQKKGEE

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=513, Percent_Identity=92.2027290448343, Blast_Score=969, Evalue=0.0,
Organism=Escherichia coli, GI1788550, Length=337, Percent_Identity=38.2789317507418, Blast_Score=218, Evalue=8e-58,
Organism=Escherichia coli, GI1790299, Length=358, Percent_Identity=37.9888268156425, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI87082152, Length=338, Percent_Identity=37.5739644970414, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1790437, Length=304, Percent_Identity=37.171052631579, Blast_Score=194, Evalue=2e-50,
Organism=Escherichia coli, GI87082117, Length=348, Percent_Identity=35.9195402298851, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI1789087, Length=340, Percent_Identity=36.4705882352941, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1788905, Length=226, Percent_Identity=44.2477876106195, Blast_Score=188, Evalue=7e-49,
Organism=Escherichia coli, GI1789233, Length=312, Percent_Identity=33.974358974359, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1786524, Length=234, Percent_Identity=43.1623931623932, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI87081872, Length=220, Percent_Identity=40.4545454545455, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789828, Length=244, Percent_Identity=35.2459016393443, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI87081858, Length=328, Percent_Identity=26.5243902439024, Blast_Score=112, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 57681; Mature: 57681

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEVFCEDRLGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFAELEFTDFSSLMAEIRR
CCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEHHEEHHHHHHHHHHHHH
ISGVTDVRTVPWMPSEREHLALSALLEALPEPVLSLDMKSKVEMANPASCQLFAQSQERM
HCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCCHHHHHHHHHHHH
RHHTAAQLINGFNFQRWLDGNPQSSHNEHVVINGQNFLMEITPVHLQNENDEYVLTGAVV
HHHHHHHHHCCCCCHHHCCCCCCCCCCCEEEECCCCEEEEEEEEEEECCCCCEEEHHHHH
MLRSTIRMGQQLQNLSTQDLSAFSQIIAVSAKMKHVVEQARKLAMLSAPLLITGDTGTGK
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCH
DLFAYACHQASPRSAKPYLALNCASIPEDAVESELFGHAPEGKKGFFEQANGGSVLLDEI
HHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHH
GEMSPRMQAKLLRFLNDGTFRRVGEDHEIHVDVRVICATQKNLVELVQKGLFREDLYYRL
HCCCHHHHHHHHHHHCCCCHHHCCCCCEEEEEEEEEECCHHHHHHHHHHCCHHHHHEEEE
NVLTLNLPPLRDCPQDIMPLTELFVARFADEQGVPRPKLSADLSTVLTRYGWPGNVRQLK
EEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHH
NAIYRALTQLEGYELRPQDILLPDYDAATVAVGEDAMEGSLDDITSRFERSVLTQLYRSY
HHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHC
PSTRKLAKRLGVSHTAIANKLREYGLSQKKGEE
CHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRLEVFCEDRLGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFAELEFTDFSSLMAEIRR
CCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEHHEEHHHHHHHHHHHHH
ISGVTDVRTVPWMPSEREHLALSALLEALPEPVLSLDMKSKVEMANPASCQLFAQSQERM
HCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCCHHHHHHHHHHHH
RHHTAAQLINGFNFQRWLDGNPQSSHNEHVVINGQNFLMEITPVHLQNENDEYVLTGAVV
HHHHHHHHHCCCCCHHHCCCCCCCCCCCEEEECCCCEEEEEEEEEEECCCCCEEEHHHHH
MLRSTIRMGQQLQNLSTQDLSAFSQIIAVSAKMKHVVEQARKLAMLSAPLLITGDTGTGK
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCH
DLFAYACHQASPRSAKPYLALNCASIPEDAVESELFGHAPEGKKGFFEQANGGSVLLDEI
HHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHH
GEMSPRMQAKLLRFLNDGTFRRVGEDHEIHVDVRVICATQKNLVELVQKGLFREDLYYRL
HCCCHHHHHHHHHHHCCCCHHHCCCCCEEEEEEEEEECCHHHHHHHHHHCCHHHHHEEEE
NVLTLNLPPLRDCPQDIMPLTELFVARFADEQGVPRPKLSADLSTVLTRYGWPGNVRQLK
EEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHH
NAIYRALTQLEGYELRPQDILLPDYDAATVAVGEDAMEGSLDDITSRFERSVLTQLYRSY
HHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHC
PSTRKLAKRLGVSHTAIANKLREYGLSQKKGEE
CHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA