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The map label for this gene is garR [H]

Identifier: 194734463

GI number: 194734463

Start: 3323652

End: 3324542

Strand: Reverse

Name: garR [H]

Synonym: SeSA_A3441

Alternate gene names: 194734463

Gene position: 3324542-3323652 (Counterclockwise)

Preceding gene: 194734144

Following gene: 194734605

Centisome position: 70.6

GC content: 56.68

Gene sequence:

>891_bases
ATGACGATGAAAGTTGGCTTTATTGGCTTAGGCATCATGGGTAAGCCCATGAGCAAAAACTTACTGAAAGCAGGGTATTC
GCTGGTGGTGTCCGATCGTAATCCTGAAGCGATTGCCGACGTCATTGCCGCAGGCGCGGAAACGGCCTCTACGGCGAAGG
CGATCGCTGAACAGTGTGACGTCATCATCACGATGCTGCCTAACTCTCCGCATGTGAAAGAAGTTGCGCTGGGCGAGAAC
GGTATCATCGAAGGCGCGAAGCCGGGAACCGTATTGATTGATATGAGTTCTATCGCGCCGCTGGCAAGCCGTGAAATCAG
CGATGCGCTGAAGGCGAAGGGCGTTGAGATGTTGGATGCGCCGGTCAGCGGCGGCGAGCCGAAGGCGATTGATGGCACGC
TGTCGGTGATGGTGGGGGGCGATAAAGCCATTTTCGACAAGTACTACGACCTGATGAAAGCGATGGCGGGTTCCGTGGTG
CATACCGGCGATATCGGCGCAGGCAACGTCACAAAACTGGCTAACCAGGTGATCGTGGCGTTGAATATCGCCGCCATGTC
TGAAGCGCTGACGCTGGCGACTAAAGCGGGCGTCAACCCGGATCTGGTCTATCAGGCGATTCGCGGCGGTCTGGCTGGCA
GCACGGTACTGGATGCGAAAGCGCCGATGGTCATGGACCGAAACTTTAAGCCAGGTTTCCGTATCGATCTGCACATTAAA
GATCTGGCGAATGCGCTGGATACCTCCCACGGCGTTGGCGCGCAGCTCCCGCTGACCGCCGCCGTTATGGAAATGATGCA
GGCGTTACGCGCGGATGGACACGGTAATGACGACCATAGCGCGCTGGCGTGCTACTACGAAAAACTGGCGAAAGTGGAAG
TCACTCGCTAA

Upstream 100 bases:

>100_bases
TTTGTCGCCGTTGGCAGCGATTTAGGCGCATTCCGCGCCAGCACGCAGAAACTTGCCGACACCTTTAAAAAATAATCCTG
GTATGGAAAGAGAGAACGCT

Downstream 100 bases:

>100_bases
CGACGTTGTGCCCGGATGGCGTGTAGCGATCCGGGCCTGAATTTCAGGCTGGATAAGTGAAACGCCATCCGGCGTTGTGC
AGTAACAGGCTACCACTATG

Product: tartronate semialdehyde reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTMKVGFIGLGIMGKPMSKNLLKAGYSLVVSDRNPEAIADVIAAGAETASTAKAIAEQCDVIITMLPNSPHVKEVALGEN
GIIEGAKPGTVLIDMSSIAPLASREISDALKAKGVEMLDAPVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVV
HTGDIGAGNVTKLANQVIVALNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIK
DLANALDTSHGVGAQLPLTAAVMEMMQALRADGHGNDDHSALACYYEKLAKVEVTR

Sequences:

>Translated_296_residues
MTMKVGFIGLGIMGKPMSKNLLKAGYSLVVSDRNPEAIADVIAAGAETASTAKAIAEQCDVIITMLPNSPHVKEVALGEN
GIIEGAKPGTVLIDMSSIAPLASREISDALKAKGVEMLDAPVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVV
HTGDIGAGNVTKLANQVIVALNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIK
DLANALDTSHGVGAQLPLTAAVMEMMQALRADGHGNDDHSALACYYEKLAKVEVTR
>Mature_295_residues
TMKVGFIGLGIMGKPMSKNLLKAGYSLVVSDRNPEAIADVIAAGAETASTAKAIAEQCDVIITMLPNSPHVKEVALGENG
IIEGAKPGTVLIDMSSIAPLASREISDALKAKGVEMLDAPVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVH
TGDIGAGNVTKLANQVIVALNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIKD
LANALDTSHGVGAQLPLTAAVMEMMQALRADGHGNDDHSALACYYEKLAKVEVTR

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=285, Percent_Identity=35.4385964912281, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI40556376, Length=283, Percent_Identity=28.6219081272085, Blast_Score=139, Evalue=2e-33,
Organism=Escherichia coli, GI145693186, Length=294, Percent_Identity=97.2789115646258, Blast_Score=573, Evalue=1e-165,
Organism=Escherichia coli, GI1786719, Length=288, Percent_Identity=43.75, Blast_Score=239, Evalue=1e-64,
Organism=Escherichia coli, GI1790315, Length=280, Percent_Identity=36.7857142857143, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1789092, Length=282, Percent_Identity=34.0425531914894, Blast_Score=144, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17557316, Length=275, Percent_Identity=33.0909090909091, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24655230, Length=285, Percent_Identity=32.280701754386, Blast_Score=141, Evalue=4e-34,
Organism=Drosophila melanogaster, GI19922568, Length=285, Percent_Identity=32.280701754386, Blast_Score=141, Evalue=4e-34,
Organism=Drosophila melanogaster, GI28574115, Length=279, Percent_Identity=25.4480286738351, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30729; Mature: 30598

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMKVGFIGLGIMGKPMSKNLLKAGYSLVVSDRNPEAIADVIAAGAETASTAKAIAEQCD
CEEEEEEEEECCCCCCHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHCC
VIITMLPNSPHVKEVALGENGIIEGAKPGTVLIDMSSIAPLASREISDALKAKGVEMLDA
EEEEECCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHHHCCCCEEEC
PVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVHTGDIGAGNVTKLANQVIVA
CCCCCCCCEECCEEEEEECCCHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHE
LNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIK
EHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCEEECCCCCCCCEEEEEHH
DLANALDTSHGVGAQLPLTAAVMEMMQALRADGHGNDDHSALACYYEKLAKVEVTR
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEECCC
>Mature Secondary Structure 
TMKVGFIGLGIMGKPMSKNLLKAGYSLVVSDRNPEAIADVIAAGAETASTAKAIAEQCD
EEEEEEEEECCCCCCHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHCC
VIITMLPNSPHVKEVALGENGIIEGAKPGTVLIDMSSIAPLASREISDALKAKGVEMLDA
EEEEECCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHHHCCCCEEEC
PVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVHTGDIGAGNVTKLANQVIVA
CCCCCCCCEECCEEEEEECCCHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHE
LNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIK
EHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCEEECCCCCCCCEEEEEHH
DLANALDTSHGVGAQLPLTAAVMEMMQALRADGHGNDDHSALACYYEKLAKVEVTR
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]